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Protein

Putative ATP-dependent helicase IRC3

Gene

IRC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 172 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 66ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • mitochondrial DNA metabolic process Source: SGD
  • RNA secondary structure unwinding Source: GO_Central
  • rRNA processing Source: GO_Central

Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29888-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent helicase IRC3 (EC:3.6.4.-)
Alternative name(s):
Increased recombination centers protein 3
Gene namesi
Name:IRC3
Ordered Locus Names:YDR332W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR332W
SGDiS000002740 IRC3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002538161 – 689Putative ATP-dependent helicase IRC3Add BLAST689

Proteomic databases

MaxQBiQ06683
PaxDbiQ06683
PRIDEiQ06683

Interactioni

Protein-protein interaction databases

BioGridi32389, 78 interactors
DIPiDIP-5241N
IntActiQ06683, 1 interactor
MINTiQ06683
STRINGi4932.YDR332W

Structurei

3D structure databases

ProteinModelPortaliQ06683
SMRiQ06683
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 211Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini265 – 438Helicase C-terminalPROSITE-ProRule annotationAdd BLAST174

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi158 – 161DEAH box4

Sequence similaritiesi

Belongs to the helicase family. IRC3 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000180925
InParanoidiQ06683
KOiK17677
OMAiHKGILEM
OrthoDBiEOG092C1DDQ

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q06683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTLATRLS TYSISLILQR IKIIKRCYSA PVLRDYQQDA IDACVNSIRQ
60 70 80 90 100
GTKRIGVSLA TGGGKTVIFS NLINQLRQNY FKERQGNFKS LILVHRRELA
110 120 130 140 150
LQATATLKKI FPDLKVHIEM GKYDCDIEDS DVIVASVQTL IRRLHKYDTN
160 170 180 190 200
SVNLIIIDEA HHSVANSYRS ILDHFKASTA ETKIPVIGFS ATFERADKRA
210 220 230 240 250
LSMVMDKIVY HRGILEMIDD KWLCEAKFTS VKIEADLSDV KSTADDFQLA
260 270 280 290 300
PLSSLMNTKE INEVILKTYL HKKQEKSLKS TLLFGVDKAH VQSLHKLFKD
310 320 330 340 350
NGINTDYVTS DTKQIERDNI IQKFKNGETE VLMNCGIFTE GTDMPNIDCI
360 370 380 390 400
LLCRPTKSRS LLIQMIGRGL RLHHSKDHCH IIDFIGASSV GVVSAPTLLG
410 420 430 440 450
IRSDDIEFDD ATVEDLKAIQ GEIIAKQQKI DERLRALFQT DEAAMENVTE
460 470 480 490 500
RNSVADWIHS ANSVDLTLCS FDSFRNFTQS NNSYPSGKEF DEASEAVKEM
510 520 530 540 550
ELLMNSQYPW VKFASNAWGL PLKGKNHLRI YKEKSEDKLS MVYHLKMYRQ
560 570 580 590 600
LPCFITNKYA DYVPKSIIKD ANLWNVMSKV EKIINTLNSD LEGQTMQYQA
610 620 630 640 650
ISSKYSKWRQ TVPTSKQRDF VFRKLKKVYG ESSKDFIRLS LDDVTTYVNT
660 670 680
KMTKGDASNL IFASSLAPVY PLKSLLRILE YQKRRSFIK
Length:689
Mass (Da):78,546
Last modified:November 1, 1996 - v1
Checksum:iE3303C88B00706CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32517 Genomic DNA Translation: AAB64767.1
BK006938 Genomic DNA Translation: DAA12174.1
PIRiS59797
RefSeqiNP_010619.3, NM_001180640.3

Genome annotation databases

EnsemblFungiiYDR332W; YDR332W; YDR332W
GeneIDi851932
KEGGisce:YDR332W

Similar proteinsi

Entry informationi

Entry nameiIRC3_YEAST
AccessioniPrimary (citable) accession number: Q06683
Secondary accession number(s): D6VSW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health