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Protein

Putative ATP-dependent helicase IRC3

Gene

IRC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 668ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • mitochondrial DNA metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29888-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent helicase IRC3 (EC:3.6.4.-)
Alternative name(s):
Increased recombination centers protein 3
Gene namesi
Name:IRC3
Ordered Locus Names:YDR332W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR332W.
SGDiS000002740. IRC3.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689Putative ATP-dependent helicase IRC3PRO_0000253816Add
BLAST

Proteomic databases

MaxQBiQ06683.

Interactioni

Protein-protein interaction databases

BioGridi32389. 58 interactions.
DIPiDIP-5241N.
MINTiMINT-536971.

Structurei

3D structure databases

ProteinModelPortaliQ06683.
SMRiQ06683. Positions 32-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 211166Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini265 – 438174Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi158 – 1614DEAH box

Sequence similaritiesi

Belongs to the helicase family. IRC3 subfamily.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000180925.
InParanoidiQ06683.
KOiK17677.
OMAiLMNCGIF.
OrthoDBiEOG7XSTP7.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTLATRLS TYSISLILQR IKIIKRCYSA PVLRDYQQDA IDACVNSIRQ
60 70 80 90 100
GTKRIGVSLA TGGGKTVIFS NLINQLRQNY FKERQGNFKS LILVHRRELA
110 120 130 140 150
LQATATLKKI FPDLKVHIEM GKYDCDIEDS DVIVASVQTL IRRLHKYDTN
160 170 180 190 200
SVNLIIIDEA HHSVANSYRS ILDHFKASTA ETKIPVIGFS ATFERADKRA
210 220 230 240 250
LSMVMDKIVY HRGILEMIDD KWLCEAKFTS VKIEADLSDV KSTADDFQLA
260 270 280 290 300
PLSSLMNTKE INEVILKTYL HKKQEKSLKS TLLFGVDKAH VQSLHKLFKD
310 320 330 340 350
NGINTDYVTS DTKQIERDNI IQKFKNGETE VLMNCGIFTE GTDMPNIDCI
360 370 380 390 400
LLCRPTKSRS LLIQMIGRGL RLHHSKDHCH IIDFIGASSV GVVSAPTLLG
410 420 430 440 450
IRSDDIEFDD ATVEDLKAIQ GEIIAKQQKI DERLRALFQT DEAAMENVTE
460 470 480 490 500
RNSVADWIHS ANSVDLTLCS FDSFRNFTQS NNSYPSGKEF DEASEAVKEM
510 520 530 540 550
ELLMNSQYPW VKFASNAWGL PLKGKNHLRI YKEKSEDKLS MVYHLKMYRQ
560 570 580 590 600
LPCFITNKYA DYVPKSIIKD ANLWNVMSKV EKIINTLNSD LEGQTMQYQA
610 620 630 640 650
ISSKYSKWRQ TVPTSKQRDF VFRKLKKVYG ESSKDFIRLS LDDVTTYVNT
660 670 680
KMTKGDASNL IFASSLAPVY PLKSLLRILE YQKRRSFIK
Length:689
Mass (Da):78,546
Last modified:November 1, 1996 - v1
Checksum:iE3303C88B00706CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32517 Genomic DNA. Translation: AAB64767.1.
BK006938 Genomic DNA. Translation: DAA12174.1.
PIRiS59797.
RefSeqiNP_010619.3. NM_001180640.3.

Genome annotation databases

EnsemblFungiiYDR332W; YDR332W; YDR332W.
GeneIDi851932.
KEGGisce:YDR332W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32517 Genomic DNA. Translation: AAB64767.1.
BK006938 Genomic DNA. Translation: DAA12174.1.
PIRiS59797.
RefSeqiNP_010619.3. NM_001180640.3.

3D structure databases

ProteinModelPortaliQ06683.
SMRiQ06683. Positions 32-389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32389. 58 interactions.
DIPiDIP-5241N.
MINTiMINT-536971.

Proteomic databases

MaxQBiQ06683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR332W; YDR332W; YDR332W.
GeneIDi851932.
KEGGisce:YDR332W.

Organism-specific databases

EuPathDBiFungiDB:YDR332W.
SGDiS000002740. IRC3.

Phylogenomic databases

HOGENOMiHOG000180925.
InParanoidiQ06683.
KOiK17677.
OMAiLMNCGIF.
OrthoDBiEOG7XSTP7.

Enzyme and pathway databases

BioCyciYEAST:G3O-29888-MONOMER.

Miscellaneous databases

NextBioi969995.
PROiQ06683.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIRC3_YEAST
AccessioniPrimary (citable) accession number: Q06683
Secondary accession number(s): D6VSW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 172 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.