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Protein

UBX domain-containing protein 5

Gene

UBX5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.By similarity

GO - Biological processi

  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-29886-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 5
Gene namesi
Name:UBX5
Ordered Locus Names:YDR330W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR330W.
SGDiS000002738. UBX5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500UBX domain-containing protein 5PRO_0000211002Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei139 – 1391PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06682.

PTM databases

iPTMnetiQ06682.

Interactioni

Subunit structurei

Interacts with CDC48.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC48P256943EBI-32041,EBI-4308

Protein-protein interaction databases

BioGridi32387. 35 interactions.
DIPiDIP-3938N.
IntActiQ06682. 12 interactions.
MINTiMINT-540958.

Structurei

3D structure databases

ProteinModelPortaliQ06682.
SMRiQ06682. Positions 204-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini415 – 49379UBXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 UBX domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000018687.
HOGENOMiHOG000180231.
InParanoidiQ06682.
OMAiRIQIRTG.
OrthoDBiEOG761C3R.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00594. UAS. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGKVDEFM AITGADDAAI ATQFIEMADG NLNTAISLFF ENGGAALLSS
60 70 80 90 100
NNTPTPSNST PMAPTSVDSD ADAQLAERLQ REAYQQQQPD QDYVRPPDEA
110 120 130 140 150
RHEVLTETSG FPISYGGIGG RFEPLHRVND MFDEGRPESI FNQRLDDTNT
160 170 180 190 200
NTYINDNSSD SLDSEEENDD DEYEYVEEPV IELDEDGNIK EYTKLVRKPK
210 220 230 240 250
TISKEQKLAL LFRPPFSIMS KLDLDAAKQK ARAKQKWIMI NIQDSGIFQC
260 270 280 290 300
QALNRDLWSS RPVKTIIKEN FVFLQYQYES RNAQPYLQFY HLNNKDDLPH
310 320 330 340 350
IAILDPITGE RVKQWNRVVP IPEQFISEIN EFLASFSLDP KVPNPTVNEP
360 370 380 390 400
LPKVDPTTLT EEQQMELAIK ESLNNNSSKS NQEEVPSTGE EQKRVQEPDP
410 420 430 440 450
FSTIEARVHP EPPNKPGITT RIQIRTGDGS RLVRRFNALE DTVRTIYEVI
460 470 480 490 500
KTEMDGFADS RFTLNDHQRE DLIDKLNMTI ADAGLKNSSL LLEKLDPEIE
Length:500
Mass (Da):56,737
Last modified:November 1, 1996 - v1
Checksum:i6B3DD79D98950523
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32517 Genomic DNA. Translation: AAB64765.1.
BK006938 Genomic DNA. Translation: DAA12172.1.
PIRiS59795.
RefSeqiNP_010617.1. NM_001180638.1.

Genome annotation databases

EnsemblFungiiYDR330W; YDR330W; YDR330W.
GeneIDi851930.
KEGGisce:YDR330W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32517 Genomic DNA. Translation: AAB64765.1.
BK006938 Genomic DNA. Translation: DAA12172.1.
PIRiS59795.
RefSeqiNP_010617.1. NM_001180638.1.

3D structure databases

ProteinModelPortaliQ06682.
SMRiQ06682. Positions 204-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32387. 35 interactions.
DIPiDIP-3938N.
IntActiQ06682. 12 interactions.
MINTiMINT-540958.

PTM databases

iPTMnetiQ06682.

Proteomic databases

MaxQBiQ06682.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR330W; YDR330W; YDR330W.
GeneIDi851930.
KEGGisce:YDR330W.

Organism-specific databases

EuPathDBiFungiDB:YDR330W.
SGDiS000002738. UBX5.

Phylogenomic databases

GeneTreeiENSGT00390000018687.
HOGENOMiHOG000180231.
InParanoidiQ06682.
OMAiRIQIRTG.
OrthoDBiEOG761C3R.

Enzyme and pathway databases

BioCyciYEAST:G3O-29886-MONOMER.

Miscellaneous databases

PROiQ06682.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00594. UAS. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation."
    Schuberth C., Richly H., Rumpf S., Buchberger A.
    EMBO Rep. 5:818-824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDC48.
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUBX5_YEAST
AccessioniPrimary (citable) accession number: Q06682
Secondary accession number(s): D6VSW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6630 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.