Reviewed, UniProtKB/Swiss-Prot Q06682 (UBX5_YEAST)

Names and origin

Protein names

Recommended name:
    UBX domain-containing protein 5

Gene names

Name:	UBX5
Ordered Locus Names:	YDR330W

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway By similarity.
Subunit structure	Interacts with CDC48. Ref.4
Subcellular location	Nucleus. Cytoplasm. Ref.2
Miscellaneous	Present with 6630 molecules/cell in log phase SD medium. Ref.3
Sequence similarities	Contains 1 UBX domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from expression pattern. Source: SGD
Cellular component	cytoplasm Ref.2 Inferred from direct assay. Source: SGD nucleus Ref.2 Inferred from direct assay. Source: SGD
Molecular function	protein binding Ref.4 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC48	P25694	2	EBI-32041,EBI-4308

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	UBX domain-containing protein 5		PRO_0000211002
Regions
	Domain	415 – 493	79	UBX
Amino acid modifications
	Modified residue	69	1	Phosphoserine Ref.6
	Modified residue	139	1	Phosphoserine Ref.6 Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q06682-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 6B3DD79D98950523	FASTA	500	56,737
	10 20 30 40 50 60 MSEGKVDEFM AITGADDAAI ATQFIEMADG NLNTAISLFF ENGGAALLSS NNTPTPSNST 70 80 90 100 110 120 PMAPTSVDSD ADAQLAERLQ REAYQQQQPD QDYVRPPDEA RHEVLTETSG FPISYGGIGG 130 140 150 160 170 180 RFEPLHRVND MFDEGRPESI FNQRLDDTNT NTYINDNSSD SLDSEEENDD DEYEYVEEPV 190 200 210 220 230 240 IELDEDGNIK EYTKLVRKPK TISKEQKLAL LFRPPFSIMS KLDLDAAKQK ARAKQKWIMI 250 260 270 280 290 300 NIQDSGIFQC QALNRDLWSS RPVKTIIKEN FVFLQYQYES RNAQPYLQFY HLNNKDDLPH 310 320 330 340 350 360 IAILDPITGE RVKQWNRVVP IPEQFISEIN EFLASFSLDP KVPNPTVNEP LPKVDPTTLT 370 380 390 400 410 420 EEQQMELAIK ESLNNNSSKS NQEEVPSTGE EQKRVQEPDP FSTIEARVHP EPPNKPGITT 430 440 450 460 470 480 RIQIRTGDGS RLVRRFNALE DTVRTIYEVI KTEMDGFADS RFTLNDHQRE DLIDKLNMTI 490 500 ADAGLKNSSL LLEKLDPEIE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P. Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]	"Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation." Schuberth C., Richly H., Rumpf S., Buchberger A. EMBO Rep. 5:818-824(2004) [PubMed: 15258615] [Abstract] Cited for: INTERACTION WITH CDC48.
[5]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed: 17330950] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, MASS SPECTROMETRY.
[6]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69 AND SER-139, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U32517 Genomic DNA. Translation: AAB64765.1.
PIR	S59795.
RefSeq	NP_010617.1.
3D structure databases
HSSP	HSSP built from PDB template 1JRU based on UniProtKB O35987.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:3938N.
IntAct	Q06682. 9 interactions.
Proteomic databases
PeptideAtlas	Q06682.
Genome annotation databases
Ensembl	YDR330W. Saccharomyces cerevisiae. [Contig view]
GeneID	851930.
GenomeReviews	Gene locus YDR330W in contig Z71256_GR.
KEGG	sce:YDR330W.
NMPDR	fig|4932.3.peg.1383.
Organism-specific databases
CYGD	YDR330w.
SGD	S000002738. UBX5.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	Q06682.
OMA	Q06682. FIFLQYQ.
Gene expression databases
ArrayExpress	Q06682.
GermOnline	YDR330W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001012. UBX. [Graphical view]
Pfam	PF00789. UBX. 1 hit. [Graphical view]
SMART	SM00166. UBX. 1 hit. [Graphical view]
PROSITE	PS50033. UBX. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	969989.

Entry information

Entry name

UBX5_YEAST

Accession

Primary (citable) accession number: Q06682

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)