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Q06682 (UBX5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UBX domain-containing protein 5
Gene names
Name:UBX5
Ordered Locus Names:YDR330W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway By similarity.

Subunit structure

Interacts with CDC48. Ref.5

Subcellular location

Nucleus. Cytoplasm Ref.3.

Miscellaneous

Present with 6630 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Contains 1 UBX domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCytoplasm
Nucleus
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processubiquitin-dependent protein catabolic process

Inferred from expression pattern. Source: SGD

   Cellular componentcytoplasm

Inferred from direct assay Ref.3. Source: SGD

nucleus

Inferred from direct assay Ref.3. Source: SGD

   Molecular functionprotein binding

Inferred from physical interaction Ref.5. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CDC48P256943EBI-32041,EBI-4308

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500UBX domain-containing protein 5
PRO_0000211002

Regions

Domain415 – 49379UBX

Amino acid modifications

Modified residue691Phosphoserine Ref.7
Modified residue1391Phosphoserine Ref.6 Ref.7

Sequences

Sequence LengthMass (Da)Tools
Q06682 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6B3DD79D98950523

FASTA50056,737
        10         20         30         40         50         60 
MSEGKVDEFM AITGADDAAI ATQFIEMADG NLNTAISLFF ENGGAALLSS NNTPTPSNST 

        70         80         90        100        110        120 
PMAPTSVDSD ADAQLAERLQ REAYQQQQPD QDYVRPPDEA RHEVLTETSG FPISYGGIGG 

       130        140        150        160        170        180 
RFEPLHRVND MFDEGRPESI FNQRLDDTNT NTYINDNSSD SLDSEEENDD DEYEYVEEPV 

       190        200        210        220        230        240 
IELDEDGNIK EYTKLVRKPK TISKEQKLAL LFRPPFSIMS KLDLDAAKQK ARAKQKWIMI 

       250        260        270        280        290        300 
NIQDSGIFQC QALNRDLWSS RPVKTIIKEN FVFLQYQYES RNAQPYLQFY HLNNKDDLPH 

       310        320        330        340        350        360 
IAILDPITGE RVKQWNRVVP IPEQFISEIN EFLASFSLDP KVPNPTVNEP LPKVDPTTLT 

       370        380        390        400        410        420 
EEQQMELAIK ESLNNNSSKS NQEEVPSTGE EQKRVQEPDP FSTIEARVHP EPPNKPGITT 

       430        440        450        460        470        480 
RIQIRTGDGS RLVRRFNALE DTVRTIYEVI KTEMDGFADS RFTLNDHQRE DLIDKLNMTI 

       490        500 
ADAGLKNSSL LLEKLDPEIE

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed: 9169867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation."
Schuberth C., Richly H., Rumpf S., Buchberger A.
EMBO Rep. 5:818-824(2004) [PubMed: 15258615] [Abstract]
Cited for: INTERACTION WITH CDC48.
[6]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed: 17330950] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, MASS SPECTROMETRY.
Strain: ADR376.
[7]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69 AND SER-139, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U32517 Genomic DNA. Translation: AAB64765.1.
BK006938 Genomic DNA. Translation: DAA12172.1.
PIRS59795.
RefSeqNP_010617.1. NM_001180638.1.

3D structure databases

ProteinModelPortalQ06682.
SMRQ06682. Positions 1-44, 197-340, 414-495.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-3938N.
IntActQ06682. 12 interactions.
MINTMINT-540958.
STRINGQ06682.

Proteomic databases

PeptideAtlasQ06682.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR330W; YDR330W; YDR330W.
GeneID851930.
KEGGsce:YDR330W.
NMPDRfig|4932.3.peg.1383.

Organism-specific databases

CYGDYDR330w.
SGDS000002738. UBX5.

Phylogenomic databases

eggNOGfuNOG05542.
GeneTreeEFGT00050000005206.
HOGENOMHBG395858.
OMARTIYEVI.
OrthoDBEOG45F0ZH.

Gene expression databases

ArrayExpressQ06682.
GenevestigatorQ06682.
GermOnlineYDR330W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR009060. UBA-like.
IPR001012. UBX.
[Graphical view]
PfamPF00789. UBX. 1 hit.
[Graphical view]
SMARTSM00166. UBX. 1 hit.
[Graphical view]
SUPFAMSSF46934. UBA_like. 1 hit.
PROSITEPS50033. UBX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio969989.

Entry information

Entry nameUBX5_YEAST
AccessionPrimary (citable) accession number: Q06682
Secondary accession number(s): D6VSW2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1996
Last modified: December 14, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

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