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Protein

Condensin complex subunit 3

Gene

YCG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.

GO - Molecular functioni

  • chromatin binding Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • meiotic chromosome condensation Source: SGD
  • meiotic chromosome separation Source: SGD
  • mitotic chromosome condensation Source: SGD
  • mitotic sister chromatid segregation Source: SGD
  • negative regulation of meiotic DNA double-strand break formation Source: SGD
  • rDNA condensation Source: SGD
  • synaptonemal complex assembly Source: SGD
  • tRNA gene clustering Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29882-MONOMER.
ReactomeiR-SCE-2514853. Condensation of Prometaphase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin complex subunit 3
Alternative name(s):
CAPG homolog
Gene namesi
Name:YCG1
Synonyms:YCS5
Ordered Locus Names:YDR325W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR325W.
SGDiS000002733. YCG1.

Subcellular locationi

  • Nucleus
  • Cytoplasm
  • Chromosome

  • Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nuclear condensin complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000950481 – 1035Condensin complex subunit 3Add BLAST1035

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei198PhosphoserineCombined sources1
Modified residuei933PhosphoserineCombined sources1
Modified residuei981PhosphoserineCombined sources1
Modified residuei1008PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06680.
PRIDEiQ06680.

PTM databases

iPTMnetiQ06680.

Interactioni

Subunit structurei

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRN1, YCS4 and YCG1/YCS5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SMC2P389893EBI-4799,EBI-17412
SMC4Q122672EBI-4799,EBI-17430

Protein-protein interaction databases

BioGridi32383. 28 interactors.
IntActiQ06680. 6 interactors.
MINTiMINT-2492218.

Structurei

3D structure databases

ProteinModelPortaliQ06680.
SMRiQ06680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati113 – 150HEAT 1Add BLAST38
Repeati153 – 191HEAT 2Add BLAST39
Repeati201 – 239HEAT 3Add BLAST39
Repeati597 – 635HEAT 4Add BLAST39
Repeati827 – 864HEAT 5Add BLAST38

Sequence similaritiesi

Belongs to the CND3 (condensin subunit 3) family.Curated
Contains 5 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000001577.
HOGENOMiHOG000001059.
InParanoidiQ06680.
KOiK06678.
OMAiFDQVQST.
OrthoDBiEOG092C0M39.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR027165. CND3.
IPR025977. Cnd3_C.
[Graphical view]
PANTHERiPTHR14418. PTHR14418. 1 hit.
PfamiPF12719. Cnd3. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q06680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDPDGIDIN TKIFNSVAEV FQKAQGSYAG HRKHIAVLKK IQSKAVEQGY
60 70 80 90 100
EDAFNFWFDK LVTKILPLKK NEIIGDRIVK LVAAFIASLE RELILAKKQN
110 120 130 140 150
YKLTNDEEGI FSRFVDQFIR HVLRGVESPD KNVRFRVLQL LAVIMDNIGE
160 170 180 190 200
IDESLFNLLI LSLNKRIYDR EPTVRIQAVF CLTKFQDEEQ TEHLTELSDN
210 220 230 240 250
EENFEATRTL VASIQNDPSA EVRRAAMLNL INDNNTRPYI LERARDVNIV
260 270 280 290 300
NRRLVYSRIL KSMGRKCFDD IEPHIFDQLI EWGLEDRELS VRNACKRLIA
310 320 330 340 350
HDWLNALDGD LIELLEKLDV SRSSVCVKAI EALFQSRPDI LSKIKFPESI
360 370 380 390 400
WKDFTVEIAF LFRAIYLYCL DNNITEMLEE NFPEASKLSE HLNHYILLRY
410 420 430 440 450
HHNDISNDSQ SHFDYNTLEF IIEQLSIAAE RYDYSDEVGR RSMLTVVRNM
460 470 480 490 500
LALTTLSEPL IKIGIRVMKS LSINEKDFVT MAIEIINDIR DDDIEKQEQE
510 520 530 540 550
EKIKSKKINR RNETSVDEED ENGTHNDEVN EDEEDDNISS FHSAVENLVQ
560 570 580 590 600
GNGNVSESDI INNLPPEKEA SSATIVLCLT RSSYMLELVN TPLTENILIA
610 620 630 640 650
SLMDTLITPA VRNTAPNIRE LGVKNLGLCC LLDVKLAIDN MYILGMCVSK
660 670 680 690 700
GNASLKYIAL QVIVDIFSVH GNTVVDGEGK VDSISLHKIF YKVLKNNGLP
710 720 730 740 750
ECQVIAAEGL CKLFLADVFT DDDLFETLVL SYFSPINSSN EALVQAFAFC
760 770 780 790 800
IPVYCFSHPA HQQRMSRTAA DILLRLCVLW DDLQSSVIPE VDREAMLKPN
810 820 830 840 850
IIFQQLLFWT DPRNLVNQTG STKKDTVQLT FLIDVLKIYA QIEKKEIKKM
860 870 880 890 900
IITNINAIFL SSEQDYSTLK ELLEYSDDIA ENDNLDNVSK NALDKLRNNL
910 920 930 940 950
NSLIEEINER SETQTKDENN TANDQYSSIL GNSFNKSSND TIEHAADITD
960 970 980 990 1000
GNNTELTKTT VNISAVDNTT EQSNSRKRTR SEAEQIDTSK NLENMSIQDT
1010 1020 1030
STVAKNVSFV LPDEKSDAMS IDEEDKDSES FSEVC
Length:1,035
Mass (Da):117,851
Last modified:March 1, 2003 - v2
Checksum:iD3EF17EDFA769FF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32517 Genomic DNA. Translation: AAB64761.2.
BK006938 Genomic DNA. Translation: DAA12168.1.
RefSeqiNP_010612.2. NM_001180633.1.

Genome annotation databases

EnsemblFungiiYDR325W; YDR325W; YDR325W.
GeneIDi851925.
KEGGisce:YDR325W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32517 Genomic DNA. Translation: AAB64761.2.
BK006938 Genomic DNA. Translation: DAA12168.1.
RefSeqiNP_010612.2. NM_001180633.1.

3D structure databases

ProteinModelPortaliQ06680.
SMRiQ06680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32383. 28 interactors.
IntActiQ06680. 6 interactors.
MINTiMINT-2492218.

PTM databases

iPTMnetiQ06680.

Proteomic databases

MaxQBiQ06680.
PRIDEiQ06680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR325W; YDR325W; YDR325W.
GeneIDi851925.
KEGGisce:YDR325W.

Organism-specific databases

EuPathDBiFungiDB:YDR325W.
SGDiS000002733. YCG1.

Phylogenomic databases

GeneTreeiENSGT00390000001577.
HOGENOMiHOG000001059.
InParanoidiQ06680.
KOiK06678.
OMAiFDQVQST.
OrthoDBiEOG092C0M39.

Enzyme and pathway databases

BioCyciYEAST:G3O-29882-MONOMER.
ReactomeiR-SCE-2514853. Condensation of Prometaphase Chromosomes.

Miscellaneous databases

PROiQ06680.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR027165. CND3.
IPR025977. Cnd3_C.
[Graphical view]
PANTHERiPTHR14418. PTHR14418. 1 hit.
PfamiPF12719. Cnd3. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCND3_YEAST
AccessioniPrimary (citable) accession number: Q06680
Secondary accession number(s): D6VSV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1920 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.