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Q06678

- RM35_YEAST

UniProt

Q06678 - RM35_YEAST

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Protein

54S ribosomal protein L35, mitochondrial

Gene

MRPL35

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. mitochondrial translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29879-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L35, mitochondrial
Alternative name(s):
YmL35
Gene namesi
Name:MRPL35
Ordered Locus Names:YDR322W
ORF Names:D9798.5
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR322w.
SGDiS000002730. MRPL35.

Subcellular locationi

Mitochondrion 2 Publications

GO - Cellular componenti

  1. mitochondrial large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
BLAST
Chaini30 – 36733854S ribosomal protein L35, mitochondrialPRO_0000023284Add
BLAST

Proteomic databases

MaxQBiQ06678.
PaxDbiQ06678.
PeptideAtlasiQ06678.

Expressioni

Gene expression databases

GenevestigatoriQ06678.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S).2 Publications

Protein-protein interaction databases

BioGridi32379. 45 interactions.
DIPiDIP-6832N.
IntActiQ06678. 12 interactions.
MINTiMINT-640904.
STRINGi4932.YDR322W.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VW4electron microscopy3.2011-367[»]
ProteinModelPortaliQ06678.
SMRiQ06678. Positions 20-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG323873.
HOGENOMiHOG000001057.
InParanoidiQ06678.
KOiK17439.
OMAiFPFSTGV.
OrthoDBiEOG7ZWDCC.

Family and domain databases

Gene3Di3.90.280.10. 1 hit.
InterProiIPR008914. PtdEtn-bd_prot_PEBP.
[Graphical view]
PfamiPF01161. PBP. 1 hit.
[Graphical view]
SUPFAMiSSF49777. SSF49777. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06678-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRRSIHTTK ILQKPNATSH IWSDFTTRPS SLSIQSSKVK NYLFQKKASL
60 70 80 90 100
DPPSISRRSN RIKYSPPEHI DEIFRMSYDF LEQRSSKFYE LANKTKNPLK
110 120 130 140 150
KDALLIKAEI NNPEVQYNFQ FNNKLNNVKD IIDYDVPVYR HLGKQHWESY
160 170 180 190 200
GQMLLMQRLE TLAAIPDTLP TLVPRAEVNI KFPFSTGVNK WIEPGEFLSS
210 220 230 240 250
NVTSMRPIFK IQEYELVNVE KQLYTVLIVN PDVPDLSNDS FKTALCYGLV
260 270 280 290 300
NINLTYNDNL IDPRKFHSSN IIADYLPPVP EKNAGKQRFV VWVFRQPLIE
310 320 330 340 350
DKQGPNMLEI DRKELSRDDF DIRQFTKKYN LTAIGAHIWR SEWDAKVAAV
360
REKYGLPPGR VFSRVRR
Length:367
Mass (Da):42,825
Last modified:November 1, 1996 - v1
Checksum:iC6A2C973121FF555
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131P → D AA sequence (PubMed:9151978)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32517 Genomic DNA. Translation: AAB64758.1.
BK006938 Genomic DNA. Translation: DAA12164.1.
PIRiS59788.
RefSeqiNP_010608.1. NM_001180630.1.

Genome annotation databases

EnsemblFungiiYDR322W; YDR322W; YDR322W.
GeneIDi851921.
KEGGisce:YDR322W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32517 Genomic DNA. Translation: AAB64758.1 .
BK006938 Genomic DNA. Translation: DAA12164.1 .
PIRi S59788.
RefSeqi NP_010608.1. NM_001180630.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VW4 electron microscopy 3.20 1 1-367 [» ]
ProteinModelPortali Q06678.
SMRi Q06678. Positions 20-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32379. 45 interactions.
DIPi DIP-6832N.
IntActi Q06678. 12 interactions.
MINTi MINT-640904.
STRINGi 4932.YDR322W.

Proteomic databases

MaxQBi Q06678.
PaxDbi Q06678.
PeptideAtlasi Q06678.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR322W ; YDR322W ; YDR322W .
GeneIDi 851921.
KEGGi sce:YDR322W.

Organism-specific databases

CYGDi YDR322w.
SGDi S000002730. MRPL35.

Phylogenomic databases

eggNOGi NOG323873.
HOGENOMi HOG000001057.
InParanoidi Q06678.
KOi K17439.
OMAi FPFSTGV.
OrthoDBi EOG7ZWDCC.

Enzyme and pathway databases

BioCyci YEAST:G3O-29879-MONOMER.

Miscellaneous databases

NextBioi 969965.

Gene expression databases

Genevestigatori Q06678.

Family and domain databases

Gene3Di 3.90.280.10. 1 hit.
InterProi IPR008914. PtdEtn-bd_prot_PEBP.
[Graphical view ]
Pfami PF01161. PBP. 1 hit.
[Graphical view ]
SUPFAMi SSF49777. SSF49777. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The yeast mitochondrial degradosome. Its composition, interplay between RNA helicase and RNase activities and the role in mitochondrial RNA metabolism."
    Dziembowski A., Piwowarski J., Hoser R., Minczuk M., Dmochowska A., Siep M., van der Spek H., Grivell L.A., Stepien P.P.
    J. Biol. Chem. 278:1603-1611(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 64-84; 130-140; 159-175 AND 289-295.
  4. "Identification and characterization of the genes for mitochondrial ribosomal proteins of Saccharomyces cerevisiae."
    Kitakawa M., Graack H.-R., Grohmann L., Goldschmidt-Reisin S., Herfurth E., Wittmann-Liebold B., Nishimura T., Isono K.
    Eur. J. Biochem. 245:449-456(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 108-116, SUBUNIT.
    Strain: 07173.
  5. "Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components."
    Gan X., Kitakawa M., Yoshino K., Oshiro N., Yonezawa K., Isono K.
    Eur. J. Biochem. 269:5203-5214(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOMAL LARGE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.

Entry informationi

Entry nameiRM35_YEAST
AccessioniPrimary (citable) accession number: Q06678
Secondary accession number(s): D6VSV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7700 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3