ID   GPX4_CITSI              Reviewed;         167 AA.
AC   Q06652;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Probable phospholipid hydroperoxide glutathione peroxidase;
DE            Short=PHGPx;
DE            EC=1.11.1.12;
DE   AltName: Full=Salt-associated protein;
GN   Name=CSA;
OS   Citrus sinensis (Sweet orange).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids II; Sapindales; Rutaceae; Citrus.
OX   NCBI_TaxID=2711;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX   MEDLINE=93222490; PubMed=8467085; DOI=10.1007/BF00027124;
RA   Holland D., Ben-Hayyim G., Faltin Z., Camoin L., Strosberg A.D.,
RA   Eshdat Y.;
RT   "Molecular characterization of salt-stress-associated protein in
RT   citrus: protein and cDNA sequence homology to mammalian glutathione
RT   peroxidases.";
RL   Plant Mol. Biol. 21:923-927(1993).
CC   -!- FUNCTION: Protects cells and enzymes from oxidative damage, by
CC       catalyzing the reduction of hydrogen peroxide, lipid peroxides and
CC       organic hydroperoxide, by glutathione (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2 glutathione + a lipid hydroperoxide =
CC       glutathione disulfide + lipid + 2 H(2)O.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- INDUCTION: By salt stress.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
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DR   EMBL; X66377; CAA47018.1; -; mRNA.
DR   PIR; S33618; S33618.
DR   HSSP; P00435; 1GP1.
DR   PeroxiBase; 2618; CsGPx06.
DR   BRENDA; 1.11.1.12; 2265.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR   GO; GO:0047066; F:phospholipid-hydroperoxide glutathione pero...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   PANTHER; PTHR11592; Glut_peroxidase; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Oxidoreductase; Peroxidase;
KW   Stress response.
FT   CHAIN         1    167       Probable phospholipid hydroperoxide
FT                                glutathione peroxidase.
FT                                /FTId=PRO_0000066627.
FT   ACT_SITE     41     41       By similarity.
SQ   SEQUENCE   167 AA;  18596 MW;  DB6BBDDC363F3260 CRC64;
     MASQSKTSVH DFTVKDAKGQ DVDLSIYKGK LLLIVNVASQ CGLTNSNYTE LSQLYDKYKN
     QGLEILAFPC NQFGAQEPGD NEQIQEFACT RFKAEFPIFD KVDVNGDNAA PLYKHLKSSK
     GGLFGDSIKW NFSKFLVDKE GNVVERYAPT TSPLSIEKDI KKLLETA
//