Reviewed, UniProtKB/Swiss-Prot Q06652 (GPX4_CITSI)

Names and origin

Protein names

Recommended name:
    Probable phospholipid hydroperoxide glutathione peroxidase
      Short name=PHGPx
    EC=1.11.1.12
Alternative name(s):
    Salt-associated protein

Gene names

Name:

CSA

Organism

Citrus sinensis (Sweet orange)

Taxonomic identifier

2711 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Sapindales › Rutaceae › Citrus

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione By similarity.
Catalytic activity	2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O.
Subcellular location	CytoplasmPotential.
Induction	By salt stress.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Molecular function	Oxidoreductase Peroxidase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: InterPro phospholipid-hydroperoxide glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Probable phospholipid hydroperoxide glutathione peroxidase		PRO_0000066627
Sites
	Active site	41	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q06652-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: DB6BBDDC363F3260	FASTA	167	18,596
	10 20 30 40 50 60 MASQSKTSVH DFTVKDAKGQ DVDLSIYKGK LLLIVNVASQ CGLTNSNYTE LSQLYDKYKN 70 80 90 100 110 120 QGLEILAFPC NQFGAQEPGD NEQIQEFACT RFKAEFPIFD KVDVNGDNAA PLYKHLKSSK 130 140 150 160 GGLFGDSIKW NFSKFLVDKE GNVVERYAPT TSPLSIEKDI KKLLETA

References

[1]

"Molecular characterization of salt-stress-associated protein in citrus: protein and cDNA sequence homology to mammalian glutathione peroxidases." Holland D., Ben-Hayyim G., Faltin Z., Camoin L., Strosberg A.D., Eshdat Y. Plant Mol. Biol. 21:923-927(1993) [PubMed: 8467085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X66377 mRNA. Translation: CAA47018.1.
PIR	S33618.
3D structure databases
HSSP	HSSP built from PDB template 1GP1 based on UniProtKB P00435.
ModBase	Search...
Protein family/group databases
PeroxiBase	2618. CsGPx06.
Family and domain databases
InterPro	IPR000889. Glut_peroxidase. IPR001452. SH3. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE. PR00452. SH3DOMAIN.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX4_CITSI

Accession

Primary (citable) accession number: Q06652

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	November 25, 2008
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)