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Q06650

- BLAC_STRCE

UniProt

Q06650 - BLAC_STRCE

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Protein
Beta-lactamase
Gene
bla
Organism
Streptomyces cellulosae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes benzylpenicillin and cloxacillin (at 10% of the rate of benzylpenicillin).

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:bla
OrganismiStreptomyces cellulosae
Taxonomic identifieri1968 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636Tat-type signal Reviewed prediction
Add
BLAST
Chaini37 – 311275Beta-lactamase
PRO_0000017015Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Structurei

3D structure databases

ProteinModelPortaliQ06650.
SMRiQ06650. Positions 47-308.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni252 – 2543Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06650-1 [UniParc]FASTAAdd to Basket

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MRKPTSSLTR RSVLGAGLGL GGALALGSTT ASAASAGTTP SENPAAVRRL    50
RALEREHQAR IGVFALNLAT GASLLHRAHE LFPMCSVFKT LAAAAVLRDL 100
DHDGSQLARV IRYTEADVTK SGHAPVTKDH IDTGMTIRDL CDATIRYSDN 150
CAANLLLREL GGPTAVTRFC RSLGDPVTRL DRWEPELNSG EPDRRTDTTS 200
PYAIARTYQR LVLGNALNRP DRALLTDWLL RNTTTLTTFR TGLPKGWTVA 250
DKSGGGDTYG TRNEAAIAWT PDGAPVLLTA LTHKPSLPTA PGDTPLIIKL 300
ATVLSEAVAP A 311
Length:311
Mass (Da):33,137
Last modified:October 1, 1994 - v1
Checksum:iF3578EBEEA92A3FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D12653 Genomic DNA. Translation: BAA02176.1.
PIRiJN0520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D12653 Genomic DNA. Translation: BAA02176.1 .
PIRi JN0520.

3D structure databases

ProteinModelPortali Q06650.
SMRi Q06650. Positions 47-308.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
IPR006311. TAT_signal.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of a gene encoding beta-lactamase from Streptomyces cellulosae."
    Ogawara H.
    Gene 124:111-114(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: KCC S0127.

Entry informationi

Entry nameiBLAC_STRCE
AccessioniPrimary (citable) accession number: Q06650
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 16, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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