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Q06650

- BLAC_STRCE

UniProt

Q06650 - BLAC_STRCE

Protein

Beta-lactamase

Gene

bla

Organism
Streptomyces cellulosae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    • Comment

    Functioni

    Hydrolyzes benzylpenicillin and cloxacillin (at 10% of the rate of benzylpenicillin).

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase (EC:3.5.2.6)
    Alternative name(s):
    Penicillinase
    Gene namesi
    Name:bla
    OrganismiStreptomyces cellulosae
    Taxonomic identifieri1968 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3636Tat-type signalPROSITE-ProRule annotationAdd
    BLAST
    Chaini37 – 311275Beta-lactamasePRO_0000017015Add
    BLAST

    Post-translational modificationi

    Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06650.
    SMRiQ06650. Positions 47-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni252 – 2543Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    IPR006311. TAT_signal.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 1 hit.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q06650-1 [UniParc]FASTAAdd to Basket

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    MRKPTSSLTR RSVLGAGLGL GGALALGSTT ASAASAGTTP SENPAAVRRL    50
    RALEREHQAR IGVFALNLAT GASLLHRAHE LFPMCSVFKT LAAAAVLRDL 100
    DHDGSQLARV IRYTEADVTK SGHAPVTKDH IDTGMTIRDL CDATIRYSDN 150
    CAANLLLREL GGPTAVTRFC RSLGDPVTRL DRWEPELNSG EPDRRTDTTS 200
    PYAIARTYQR LVLGNALNRP DRALLTDWLL RNTTTLTTFR TGLPKGWTVA 250
    DKSGGGDTYG TRNEAAIAWT PDGAPVLLTA LTHKPSLPTA PGDTPLIIKL 300
    ATVLSEAVAP A 311
    Length:311
    Mass (Da):33,137
    Last modified:October 1, 1994 - v1
    Checksum:iF3578EBEEA92A3FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12653 Genomic DNA. Translation: BAA02176.1.
    PIRiJN0520.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12653 Genomic DNA. Translation: BAA02176.1 .
    PIRi JN0520.

    3D structure databases

    ProteinModelPortali Q06650.
    SMRi Q06650. Positions 47-308.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    IPR006311. TAT_signal.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 1 hit.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a gene encoding beta-lactamase from Streptomyces cellulosae."
      Ogawara H.
      Gene 124:111-114(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: KCC S0127.

    Entry informationi

    Entry nameiBLAC_STRCE
    AccessioniPrimary (citable) accession number: Q06650
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3