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Q06649

- 3BP2_MOUSE

UniProt

Q06649 - 3BP2_MOUSE

Protein

SH3 domain-binding protein 2

Gene

Sh3bp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. SH3 domain binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH3 domain-binding protein 2
    Short name:
    3BP-2
    Gene namesi
    Name:Sh3bp2
    Synonyms:3bp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1346349. Sh3bp2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559SH3 domain-binding protein 2PRO_0000064366Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei174 – 1741Phosphotyrosine; by SYK1 Publication
    Modified residuei183 – 1831Phosphotyrosine; by SYK1 Publication
    Modified residuei277 – 2771PhosphoserineBy similarity
    Modified residuei446 – 4461Phosphotyrosine; by SYK1 Publication

    Post-translational modificationi

    Phosphorylated. Phosphorylation at Tyr-446 may stimulate the activity of the LYN kinase.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ06649.
    PRIDEiQ06649.

    PTM databases

    PhosphoSiteiQ06649.

    Expressioni

    Gene expression databases

    CleanExiMM_SH3BP2.
    GenevestigatoriQ06649.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TNKS2Q9H2K26EBI-5323518,EBI-4398527From a different organism.

    Protein-protein interaction databases

    IntActiQ06649. 7 interactions.
    MINTiMINT-1512951.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06649.
    SMRiQ06649. Positions 25-122, 442-558.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 130105PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini455 – 55399SH2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi201 – 21010SH3-binding

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi205 – 2128Poly-Pro
    Compositional biasi236 – 2405Poly-Pro

    Sequence similaritiesi

    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3-binding

    Phylogenomic databases

    eggNOGiNOG42035.
    HOGENOMiHOG000190359.
    HOVERGENiHBG000016.
    InParanoidiQ06649.
    PhylomeDBiQ06649.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000980. SH2.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06649-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAEEMQWPV PMKAIGAQNL LTMPGGVAKA GYLHKKGGTQ LQLLKWPLRF    50
    VIIHKRCIYY FKSSTSASPQ GAFSLSGYNR VMRAAEETTS NNVFPFKIIH 100
    ISKKHRTWFF SASSEDERKS WMAFVRREIG HFHEKKELPL DTSDSSSDTD 150
    SFYGAVERPI DISLSSYPMD NEDYEHEDED DSYLEPDSPG PMKLEDALTY 200
    PPAYPPPPVP VPRKPAFSDL PRAHSFTSKS PSPLLPPPPP KRGLPDTGSA 250
    PEDAKDALGL RRVEPGLRVP ATPRRMSDPP MSNVPTVPNL RKHPCFRDSV 300
    NPGLEPWTPG HGTSSVSSST TMAVATSRNC DKLKSFHLSS RGPPTSEPPP 350
    VPANKPKFLK IAEEPSPREA AKFAPVPPVA PRPPVQKMPM PEATVRPAVL 400
    PRPENTPLPH LQRSPPDGQS FRGFSFEKAR QPSQADTGEE DSDEDYEKVP 450
    LPNSVFVNTT ESCEVERLFK ATDPRGEPQD GLYCIRNSST KSGKVLVVWD 500
    ESSNKVRNYR IFEKDSKFYL EGEVLFASVG SMVEHYHTHV LPSHQSLLLR 550
    HPYGYAGPR 559
    Length:559
    Mass (Da):62,208
    Last modified:October 1, 1996 - v1
    Checksum:iEDFE1F11B259646E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14543 mRNA. Translation: AAA37121.1.
    CCDSiCCDS19215.1.
    PIRiI49444.
    UniGeneiMm.5012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14543 mRNA. Translation: AAA37121.1 .
    CCDSi CCDS19215.1.
    PIRi I49444.
    UniGenei Mm.5012.

    3D structure databases

    ProteinModelPortali Q06649.
    SMRi Q06649. Positions 25-122, 442-558.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q06649. 7 interactions.
    MINTi MINT-1512951.

    PTM databases

    PhosphoSitei Q06649.

    Proteomic databases

    PaxDbi Q06649.
    PRIDEi Q06649.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1346349. Sh3bp2.

    Phylogenomic databases

    eggNOGi NOG42035.
    HOGENOMi HOG000190359.
    HOVERGENi HBG000016.
    InParanoidi Q06649.
    PhylomeDBi Q06649.

    Miscellaneous databases

    PROi Q06649.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_SH3BP2.
    Genevestigatori Q06649.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000980. SH2.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a ten-amino acid proline-rich SH3 binding site."
      Ren R., Mayer B.J., Cicchetti P., Baltimore D.
      Science 259:1157-1161(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase."
      Maeno K., Sada K., Kyo S., Miah S.M., Kawauchi-Kamata K., Qu X., Shi Y., Yamamura H.
      J. Biol. Chem. 278:24912-24920(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-174; TYR-183 AND TYR-446.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry namei3BP2_MOUSE
    AccessioniPrimary (citable) accession number: Q06649
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3