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Protein

SH3 domain-binding protein 2

Gene

Sh3bp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism (By similarity).By similarity

GO - Molecular functioni

  • SH3 domain binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding protein 2
Short name:
3BP-2
Gene namesi
Name:Sh3bp2
Synonyms:3bp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1346349. Sh3bp2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559SH3 domain-binding protein 2PRO_0000064366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741Phosphotyrosine; by SYK1 Publication
Modified residuei183 – 1831Phosphotyrosine; by SYK1 Publication
Modified residuei277 – 2771PhosphoserineBy similarity
Modified residuei414 – 4141PhosphoserineBy similarity
Modified residuei446 – 4461Phosphotyrosine; by SYK1 Publication

Post-translational modificationi

Phosphorylated. Phosphorylation at Tyr-446 may stimulate the activity of the LYN kinase.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06649.
PaxDbiQ06649.
PRIDEiQ06649.

PTM databases

PhosphoSiteiQ06649.

Expressioni

Gene expression databases

CleanExiMM_SH3BP2.
GenevestigatoriQ06649.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TNKS2Q9H2K26EBI-5323518,EBI-4398527From a different organism.

Protein-protein interaction databases

IntActiQ06649. 7 interactions.
MINTiMINT-1512951.

Structurei

3D structure databases

ProteinModelPortaliQ06649.
SMRiQ06649. Positions 25-122, 442-558.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 130105PHPROSITE-ProRule annotationAdd
BLAST
Domaini455 – 55399SH2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi201 – 21010SH3-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi205 – 2128Poly-Pro
Compositional biasi236 – 2405Poly-Pro

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3-binding

Phylogenomic databases

eggNOGiNOG42035.
HOGENOMiHOG000190359.
HOVERGENiHBG000016.
InParanoidiQ06649.
PhylomeDBiQ06649.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000980. SH2.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEEMQWPV PMKAIGAQNL LTMPGGVAKA GYLHKKGGTQ LQLLKWPLRF
60 70 80 90 100
VIIHKRCIYY FKSSTSASPQ GAFSLSGYNR VMRAAEETTS NNVFPFKIIH
110 120 130 140 150
ISKKHRTWFF SASSEDERKS WMAFVRREIG HFHEKKELPL DTSDSSSDTD
160 170 180 190 200
SFYGAVERPI DISLSSYPMD NEDYEHEDED DSYLEPDSPG PMKLEDALTY
210 220 230 240 250
PPAYPPPPVP VPRKPAFSDL PRAHSFTSKS PSPLLPPPPP KRGLPDTGSA
260 270 280 290 300
PEDAKDALGL RRVEPGLRVP ATPRRMSDPP MSNVPTVPNL RKHPCFRDSV
310 320 330 340 350
NPGLEPWTPG HGTSSVSSST TMAVATSRNC DKLKSFHLSS RGPPTSEPPP
360 370 380 390 400
VPANKPKFLK IAEEPSPREA AKFAPVPPVA PRPPVQKMPM PEATVRPAVL
410 420 430 440 450
PRPENTPLPH LQRSPPDGQS FRGFSFEKAR QPSQADTGEE DSDEDYEKVP
460 470 480 490 500
LPNSVFVNTT ESCEVERLFK ATDPRGEPQD GLYCIRNSST KSGKVLVVWD
510 520 530 540 550
ESSNKVRNYR IFEKDSKFYL EGEVLFASVG SMVEHYHTHV LPSHQSLLLR

HPYGYAGPR
Length:559
Mass (Da):62,208
Last modified:October 1, 1996 - v1
Checksum:iEDFE1F11B259646E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14543 mRNA. Translation: AAA37121.1.
CCDSiCCDS19215.1.
PIRiI49444.
UniGeneiMm.5012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14543 mRNA. Translation: AAA37121.1.
CCDSiCCDS19215.1.
PIRiI49444.
UniGeneiMm.5012.

3D structure databases

ProteinModelPortaliQ06649.
SMRiQ06649. Positions 25-122, 442-558.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ06649. 7 interactions.
MINTiMINT-1512951.

PTM databases

PhosphoSiteiQ06649.

Proteomic databases

MaxQBiQ06649.
PaxDbiQ06649.
PRIDEiQ06649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1346349. Sh3bp2.

Phylogenomic databases

eggNOGiNOG42035.
HOGENOMiHOG000190359.
HOVERGENiHBG000016.
InParanoidiQ06649.
PhylomeDBiQ06649.

Miscellaneous databases

ChiTaRSiSh3bp2. mouse.
PROiQ06649.
SOURCEiSearch...

Gene expression databases

CleanExiMM_SH3BP2.
GenevestigatoriQ06649.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000980. SH2.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a ten-amino acid proline-rich SH3 binding site."
    Ren R., Mayer B.J., Cicchetti P., Baltimore D.
    Science 259:1157-1161(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase."
    Maeno K., Sada K., Kyo S., Miah S.M., Kawauchi-Kamata K., Qu X., Shi Y., Yamamura H.
    J. Biol. Chem. 278:24912-24920(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-174; TYR-183 AND TYR-446.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry namei3BP2_MOUSE
AccessioniPrimary (citable) accession number: Q06649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 4, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.