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Q06649 (3BP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH3 domain-binding protein 2

Short name=3BP-2
Gene names
Name:Sh3bp2
Synonyms:3bp2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism By similarity.

Post-translational modification

Phosphorylated. Phosphorylation at Tyr-446 may stimulate the activity of the LYN kinase. Ref.2

Sequence similarities

Contains 1 PH domain.

Contains 1 SH2 domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TNKS2Q9H2K26EBI-5323518,EBI-4398527From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 559559SH3 domain-binding protein 2
PRO_0000064366

Regions

Domain26 – 130105PH
Domain455 – 55399SH2
Motif201 – 21010SH3-binding
Compositional bias205 – 2128Poly-Pro
Compositional bias236 – 2405Poly-Pro

Amino acid modifications

Modified residue1741Phosphotyrosine; by SYK Ref.2
Modified residue1831Phosphotyrosine; by SYK Ref.2
Modified residue2771Phosphoserine By similarity
Modified residue4461Phosphotyrosine; by SYK Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q06649 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: EDFE1F11B259646E

FASTA55962,208
        10         20         30         40         50         60 
MAAEEMQWPV PMKAIGAQNL LTMPGGVAKA GYLHKKGGTQ LQLLKWPLRF VIIHKRCIYY 

        70         80         90        100        110        120 
FKSSTSASPQ GAFSLSGYNR VMRAAEETTS NNVFPFKIIH ISKKHRTWFF SASSEDERKS 

       130        140        150        160        170        180 
WMAFVRREIG HFHEKKELPL DTSDSSSDTD SFYGAVERPI DISLSSYPMD NEDYEHEDED 

       190        200        210        220        230        240 
DSYLEPDSPG PMKLEDALTY PPAYPPPPVP VPRKPAFSDL PRAHSFTSKS PSPLLPPPPP 

       250        260        270        280        290        300 
KRGLPDTGSA PEDAKDALGL RRVEPGLRVP ATPRRMSDPP MSNVPTVPNL RKHPCFRDSV 

       310        320        330        340        350        360 
NPGLEPWTPG HGTSSVSSST TMAVATSRNC DKLKSFHLSS RGPPTSEPPP VPANKPKFLK 

       370        380        390        400        410        420 
IAEEPSPREA AKFAPVPPVA PRPPVQKMPM PEATVRPAVL PRPENTPLPH LQRSPPDGQS 

       430        440        450        460        470        480 
FRGFSFEKAR QPSQADTGEE DSDEDYEKVP LPNSVFVNTT ESCEVERLFK ATDPRGEPQD 

       490        500        510        520        530        540 
GLYCIRNSST KSGKVLVVWD ESSNKVRNYR IFEKDSKFYL EGEVLFASVG SMVEHYHTHV 

       550 
LPSHQSLLLR HPYGYAGPR 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a ten-amino acid proline-rich SH3 binding site."
Ren R., Mayer B.J., Cicchetti P., Baltimore D.
Science 259:1157-1161(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase."
Maeno K., Sada K., Kyo S., Miah S.M., Kawauchi-Kamata K., Qu X., Shi Y., Yamamura H.
J. Biol. Chem. 278:24912-24920(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT TYR-174; TYR-183 AND TYR-446.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L14543 mRNA. Translation: AAA37121.1.
CCDSCCDS19215.1.
PIRI49444.
UniGeneMm.5012.

3D structure databases

ProteinModelPortalQ06649.
SMRQ06649. Positions 25-122, 442-558.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ06649. 7 interactions.
MINTMINT-1512951.

PTM databases

PhosphoSiteQ06649.

Proteomic databases

PaxDbQ06649.
PRIDEQ06649.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1346349. Sh3bp2.

Phylogenomic databases

eggNOGNOG42035.
HOGENOMHOG000190359.
HOVERGENHBG000016.
InParanoidQ06649.
PhylomeDBQ06649.

Gene expression databases

CleanExMM_SH3BP2.
GenevestigatorQ06649.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000980. SH2.
[Graphical view]
PfamPF00169. PH. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ06649.
SOURCESearch...

Entry information

Entry name3BP2_MOUSE
AccessionPrimary (citable) accession number: Q06649
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot