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Protein

GTPase-interacting component 2

Gene

GIC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone.

GO - Molecular functioni

  • GTPase activator activity Source: SGD
  • phosphatidylinositol-4,5-bisphosphate binding Source: SGD
  • Rho GTPase binding Source: SGD

GO - Biological processi

  • establishment of cell polarity Source: SGD
  • positive regulation of formin-nucleated actin cable assembly Source: SGD
  • regulation of cell shape Source: UniProtKB-KW
  • regulation of exit from mitosis Source: SGD
  • septin ring organization Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell shape

Enzyme and pathway databases

BioCyciYEAST:G3O-29868-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase-interacting component 2
Gene namesi
Name:GIC2
Ordered Locus Names:YDR309C
ORF Names:D9740.18
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR309C.
SGDiS000002717. GIC2.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: UniProtKB-SubCell
  • cellular bud neck Source: UniProtKB-SubCell
  • cellular bud tip Source: SGD
  • cytoskeleton Source: UniProtKB-SubCell
  • incipient cellular bud site Source: SGD
  • mating projection tip Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126601 – 383GTPase-interacting component 2Add BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei254PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06648.
PRIDEiQ06648.

PTM databases

iPTMnetiQ06648.

Interactioni

Subunit structurei

Interacts with GTP-bound CDC42.

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC11P324582EBI-7585,EBI-4178
CDC12P324685EBI-7585,EBI-4182
CDC3P324573EBI-7585,EBI-4429

GO - Molecular functioni

  • Rho GTPase binding Source: SGD

Protein-protein interaction databases

BioGridi32362. 72 interactors.
DIPiDIP-2277N.
IntActiQ06648. 25 interactors.
MINTiMINT-558890.

Structurei

3D structure databases

ProteinModelPortaliQ06648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 147CRIBPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 102Ser-richAdd BLAST29

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated
Contains 1 CRIB domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000066862.
HOGENOMiHOG000000874.
InParanoidiQ06648.
OMAiQHISHAD.
OrthoDBiEOG092C3HOD.

Family and domain databases

InterProiIPR000095. CRIB_dom.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSASITNTG NETMNLPQMR SIWLDEDEEA EKLYGLQAQQ FMGSDDEENL
60 70 80 90 100
GITFINSDKP VLSNKKNIEL PPLSPNSHPS CHHRRSNSNS AKSKESSSSS
110 120 130 140 150
SSANKTNHKK VFLKLNLLKK KLLGAQPDIR GKGISTPFDF QHISHADTRN
160 170 180 190 200
GFQDEQLQEP SSLSTEIKDD YTSSSSKRDS KSLNKAFVTE RIPANRESKL
210 220 230 240 250
ISRSHENKTS RLSVARSISV TSSNYSKNTQ GNNHSINGRV VSTSTMATSI
260 270 280 290 300
FEYSPNASPK QFKNKSHALG HRYTNSTDSS ESSLDFLKNY NFPTLLEDKP
310 320 330 340 350
ILDFLPRSQR SSAYRSLLET PNSNKDSAKA FFPSRQSPLP KRRNSIATPS
360 370 380
PQSKFSYSDS PVNHRKSFDD VLYSFNQLEP LQT
Length:383
Mass (Da):42,852
Last modified:November 1, 1996 - v1
Checksum:iD1BE002BCD48EB03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28374 Genomic DNA. Translation: AAB64745.1.
AY557791 Genomic DNA. Translation: AAS56117.1.
BK006938 Genomic DNA. Translation: DAA12148.1.
PIRiS61195.
RefSeqiNP_010595.1. NM_001180617.1.

Genome annotation databases

EnsemblFungiiYDR309C; YDR309C; YDR309C.
GeneIDi851904.
KEGGisce:YDR309C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28374 Genomic DNA. Translation: AAB64745.1.
AY557791 Genomic DNA. Translation: AAS56117.1.
BK006938 Genomic DNA. Translation: DAA12148.1.
PIRiS61195.
RefSeqiNP_010595.1. NM_001180617.1.

3D structure databases

ProteinModelPortaliQ06648.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32362. 72 interactors.
DIPiDIP-2277N.
IntActiQ06648. 25 interactors.
MINTiMINT-558890.

PTM databases

iPTMnetiQ06648.

Proteomic databases

MaxQBiQ06648.
PRIDEiQ06648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR309C; YDR309C; YDR309C.
GeneIDi851904.
KEGGisce:YDR309C.

Organism-specific databases

EuPathDBiFungiDB:YDR309C.
SGDiS000002717. GIC2.

Phylogenomic databases

GeneTreeiENSGT00530000066862.
HOGENOMiHOG000000874.
InParanoidiQ06648.
OMAiQHISHAD.
OrthoDBiEOG092C3HOD.

Enzyme and pathway databases

BioCyciYEAST:G3O-29868-MONOMER.

Miscellaneous databases

PROiQ06648.

Family and domain databases

InterProiIPR000095. CRIB_dom.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGIC2_YEAST
AccessioniPrimary (citable) accession number: Q06648
Secondary accession number(s): D6VST8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1130 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.