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Protein

GTPase-interacting component 2

Gene

GIC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone.

Miscellaneous

Present with 1130 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: SGD
  • phosphatidylinositol-4,5-bisphosphate binding Source: SGD
  • Rho GTPase binding Source: SGD

GO - Biological processi

  • establishment of cell polarity Source: SGD
  • positive regulation of formin-nucleated actin cable assembly Source: SGD
  • regulation of cell shape Source: UniProtKB-KW
  • regulation of exit from mitosis Source: SGD
  • septin ring organization Source: SGD

Keywordsi

Biological processCell shape

Enzyme and pathway databases

BioCyciYEAST:G3O-29868-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase-interacting component 2
Gene namesi
Name:GIC2
Ordered Locus Names:YDR309C
ORF Names:D9740.18
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR309C
SGDiS000002717 GIC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126601 – 383GTPase-interacting component 2Add BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei254PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06648
PaxDbiQ06648
PRIDEiQ06648

PTM databases

iPTMnetiQ06648

Interactioni

Subunit structurei

Interacts with GTP-bound CDC42.

Binary interactionsi

Show more details

GO - Molecular functioni

  • Rho GTPase binding Source: SGD

Protein-protein interaction databases

BioGridi32362, 125 interactors
DIPiDIP-2277N
IntActiQ06648, 26 interactors
MINTiQ06648
STRINGi4932.YDR309C

Structurei

3D structure databases

ProteinModelPortaliQ06648
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 147CRIBPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 102Ser-richAdd BLAST29

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000066862
HOGENOMiHOG000000874
InParanoidiQ06648
OMAiQHISHAD
OrthoDBiEOG092C3HOD

Family and domain databases

CDDicd00132 CRIB, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit

Sequencei

Sequence statusi: Complete.

Q06648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSASITNTG NETMNLPQMR SIWLDEDEEA EKLYGLQAQQ FMGSDDEENL
60 70 80 90 100
GITFINSDKP VLSNKKNIEL PPLSPNSHPS CHHRRSNSNS AKSKESSSSS
110 120 130 140 150
SSANKTNHKK VFLKLNLLKK KLLGAQPDIR GKGISTPFDF QHISHADTRN
160 170 180 190 200
GFQDEQLQEP SSLSTEIKDD YTSSSSKRDS KSLNKAFVTE RIPANRESKL
210 220 230 240 250
ISRSHENKTS RLSVARSISV TSSNYSKNTQ GNNHSINGRV VSTSTMATSI
260 270 280 290 300
FEYSPNASPK QFKNKSHALG HRYTNSTDSS ESSLDFLKNY NFPTLLEDKP
310 320 330 340 350
ILDFLPRSQR SSAYRSLLET PNSNKDSAKA FFPSRQSPLP KRRNSIATPS
360 370 380
PQSKFSYSDS PVNHRKSFDD VLYSFNQLEP LQT
Length:383
Mass (Da):42,852
Last modified:November 1, 1996 - v1
Checksum:iD1BE002BCD48EB03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28374 Genomic DNA Translation: AAB64745.1
AY557791 Genomic DNA Translation: AAS56117.1
BK006938 Genomic DNA Translation: DAA12148.1
PIRiS61195
RefSeqiNP_010595.1, NM_001180617.1

Genome annotation databases

EnsemblFungiiYDR309C; YDR309C; YDR309C
GeneIDi851904
KEGGisce:YDR309C

Similar proteinsi

Entry informationi

Entry nameiGIC2_YEAST
AccessioniPrimary (citable) accession number: Q06648
Secondary accession number(s): D6VST8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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