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Protein

ATP synthase subunit O, mitochondrial

Gene

Atp5o

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

  • protein complex binding Source: RGD
  • proton-transporting ATP synthase activity, rotational mechanism Source: InterPro
  • steroid binding Source: RGD

GO - Biological processi

  • ATP metabolic process Source: RGD
  • ATP synthesis coupled proton transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit O, mitochondrial
Alternative name(s):
Oligomycin sensitivity conferral protein
Short name:
OSCP
Sperm flagella protein 4
Gene namesi
Name:Atp5o
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621379. Atp5o.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: RGD
  • mitochondrion Source: RGD
  • myelin sheath Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23MitochondrionAdd BLAST23
ChainiPRO_000000264924 – 213ATP synthase subunit O, mitochondrialAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60N6-acetyllysineBy similarity1
Modified residuei70N6-acetyllysineBy similarity1
Modified residuei73N6-acetyllysineBy similarity1
Modified residuei90N6-succinyllysineBy similarity1
Modified residuei100N6-acetyllysine; alternateBy similarity1
Modified residuei100N6-succinyllysine; alternateBy similarity1
Modified residuei158N6-acetyllysine; alternateBy similarity1
Modified residuei158N6-succinyllysine; alternateBy similarity1
Modified residuei176N6-acetyllysineBy similarity1
Modified residuei192N6-acetyllysineBy similarity1
Modified residuei199N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ06647.
PRIDEiQ06647.

PTM databases

iPTMnetiQ06647.
PhosphoSitePlusiQ06647.
SwissPalmiQ06647.

Expressioni

Tissue specificityi

Expressed by the principal cells of the epididymis. Detected in flagella of epididymal sperm (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000001991.
GenevisibleiQ06647. RN.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.1 Publication

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

IntActiQ06647. 4 interactors.
MINTiMINT-4997121.
STRINGi10116.ENSRNOP00000002732.

Structurei

3D structure databases

ProteinModelPortaliQ06647.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase delta chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1662. Eukaryota.
COG0712. LUCA.
GeneTreeiENSGT00390000015060.
HOGENOMiHOG000075825.
HOVERGENiHBG004309.
InParanoidiQ06647.
KOiK02137.
OMAiMNPHVKR.
OrthoDBiEOG091G0L4M.
PhylomeDBiQ06647.
TreeFamiTF106241.

Family and domain databases

Gene3Di1.10.520.20. 1 hit.
HAMAPiMF_01416. ATP_synth_delta_bact. 1 hit.
InterProiIPR026015. ATP_synth_OSCP/delta_N.
IPR020781. ATPase_OSCP/d_CS.
IPR000711. ATPase_OSCP/dsu.
[Graphical view]
PANTHERiPTHR11910. PTHR11910. 1 hit.
PfamiPF00213. OSCP. 1 hit.
[Graphical view]
PRINTSiPR00125. ATPASEDELTA.
SUPFAMiSSF47928. SSF47928. 1 hit.
TIGRFAMsiTIGR01145. ATP_synt_delta. 1 hit.
PROSITEiPS00389. ATPASE_DELTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06647-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPATSVLS RQVRSFSTSV VRPFSKLVRP PVQVYGIEGR YATALYSAAS
60 70 80 90 100
KQKRLDQVEK ELLRVGQLLK DPKVSLAVLN PYIKRSIKVK SLKDITTKEK
110 120 130 140 150
FSPLTANLMN LLAENGRLGN TQGVISAFST IMSVHRGEVP CTVTTAFPLD
160 170 180 190 200
EAVLSELKTV LNSFLSKGQI LNLEVKTDPS IMGGMIVRIG EKYVDMSAKS
210
KIQKLSKAMR DLL
Length:213
Mass (Da):23,398
Last modified:June 1, 1994 - v1
Checksum:iBBAB7331A715E686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13127 mRNA. Translation: BAA02429.1.
BC060544 mRNA. Translation: AAH60544.1.
PIRiS30181.
RefSeqiNP_620238.1. NM_138883.1.
UniGeneiRn.1817.

Genome annotation databases

EnsembliENSRNOT00000002732; ENSRNOP00000002732; ENSRNOG00000001991.
GeneIDi192241.
KEGGirno:192241.
UCSCiRGD:621379. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13127 mRNA. Translation: BAA02429.1.
BC060544 mRNA. Translation: AAH60544.1.
PIRiS30181.
RefSeqiNP_620238.1. NM_138883.1.
UniGeneiRn.1817.

3D structure databases

ProteinModelPortaliQ06647.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ06647. 4 interactors.
MINTiMINT-4997121.
STRINGi10116.ENSRNOP00000002732.

PTM databases

iPTMnetiQ06647.
PhosphoSitePlusiQ06647.
SwissPalmiQ06647.

Proteomic databases

PaxDbiQ06647.
PRIDEiQ06647.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002732; ENSRNOP00000002732; ENSRNOG00000001991.
GeneIDi192241.
KEGGirno:192241.
UCSCiRGD:621379. rat.

Organism-specific databases

CTDi539.
RGDi621379. Atp5o.

Phylogenomic databases

eggNOGiKOG1662. Eukaryota.
COG0712. LUCA.
GeneTreeiENSGT00390000015060.
HOGENOMiHOG000075825.
HOVERGENiHBG004309.
InParanoidiQ06647.
KOiK02137.
OMAiMNPHVKR.
OrthoDBiEOG091G0L4M.
PhylomeDBiQ06647.
TreeFamiTF106241.

Enzyme and pathway databases

ReactomeiR-RNO-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

PROiQ06647.

Gene expression databases

BgeeiENSRNOG00000001991.
GenevisibleiQ06647. RN.

Family and domain databases

Gene3Di1.10.520.20. 1 hit.
HAMAPiMF_01416. ATP_synth_delta_bact. 1 hit.
InterProiIPR026015. ATP_synth_OSCP/delta_N.
IPR020781. ATPase_OSCP/d_CS.
IPR000711. ATPase_OSCP/dsu.
[Graphical view]
PANTHERiPTHR11910. PTHR11910. 1 hit.
PfamiPF00213. OSCP. 1 hit.
[Graphical view]
PRINTSiPR00125. ATPASEDELTA.
SUPFAMiSSF47928. SSF47928. 1 hit.
TIGRFAMsiTIGR01145. ATP_synt_delta. 1 hit.
PROSITEiPS00389. ATPASE_DELTA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATPO_RAT
AccessioniPrimary (citable) accession number: Q06647
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.