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Protein

ATP synthase F(0) complex subunit C1, mitochondrial

Gene

Atp5g1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Miscellaneous

There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences. They are expressed in a tissue-specific manner.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei119Reversibly protonated during proton transportBy similarity1

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • ATP metabolic process Source: RGD
  • ATP synthesis coupled proton transport Source: GO_Central
  • response to ethanol Source: RGD

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-163210. Formation of ATP by chemiosmotic coupling.
R-RNO-8949613. Cristae formation.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase F(0) complex subunit C1, mitochondrial
Alternative name(s):
ATP synthase lipid-binding protein
ATP synthase proteolipid P1
ATPase protein 9
ATPase subunit c
Gene namesi
Name:Atp5g1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi61933. Atp5g1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: RGD
  • mitochondrion Source: RGD

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 61MitochondrionAdd BLAST61
ChainiPRO_000000255962 – 136ATP synthase F(0) complex subunit C1, mitochondrialAdd BLAST75

Proteomic databases

PaxDbiQ06645.
PRIDEiQ06645.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007235.
GenevisibleiQ06645. RN.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009815.

Structurei

3D structure databases

ProteinModelPortaliQ06645.
SMRiQ06645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase C chain family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3025. Eukaryota.
COG0636. LUCA.
GeneTreeiENSGT00390000006210.
HOGENOMiHOG000235246.
HOVERGENiHBG050605.
InParanoidiQ06645.
KOiK02128.
OMAiIRCCTRD.
OrthoDBiEOG091G13J1.
PhylomeDBiQ06645.
TreeFamiTF300140.

Family and domain databases

Gene3Di1.20.20.10. 1 hit.
HAMAPiMF_01396. ATP_synth_c_bact. 1 hit.
InterProiView protein in InterPro
IPR000454. ATP_synth_F0_csu.
IPR020537. ATP_synth_F0_csu_DDCD_BS.
IPR002379. ATPase_proteolipid_c-like_dom.
PANTHERiPTHR10031. PTHR10031. 1 hit.
PfamiView protein in Pfam
PF00137. ATP-synt_C. 1 hit.
PRINTSiPR00124. ATPASEC.
SUPFAMiSSF81333. SSF81333. 1 hit.
PROSITEiView protein in PROSITE
PS00605. ATPASE_C. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTTKALLIS PVLIRSCTRG LIRPVSASLL SRPEAPSKKP SCCSSPLQVA
60 70 80 90 100
RREFQTSVIS RDIDTAAKFI GAGAATVGVA GSGAGIGTVF GSLIIGYARN
110 120 130
PSLKQQLFSY AILGFALSEA MGLFCLMVAF LILFAM
Length:136
Mass (Da):14,244
Last modified:June 1, 1994 - v1
Checksum:i91060591516D6AF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13123 mRNA. Translation: BAA02425.1.
PIRiJS0740.
RefSeqiNP_059007.1. NM_017311.1.
XP_006247250.1. XM_006247188.3.
XP_006247251.1. XM_006247189.1.
UniGeneiRn.3357.

Genome annotation databases

EnsembliENSRNOT00000009815; ENSRNOP00000009815; ENSRNOG00000007235.
GeneIDi29754.
KEGGirno:29754.
UCSCiRGD:61933. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAT5G1_RAT
AccessioniPrimary (citable) accession number: Q06645
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 7, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families