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Protein

ATP synthase F(0) complex subunit C1, mitochondrial

Gene

Atp5g1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei119 – 1191Reversibly protonated during proton transportBy similarity

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • ATP metabolic process Source: RGD
  • ATP synthesis coupled proton transport Source: InterPro
  • response to ethanol Source: RGD
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase F(0) complex subunit C1, mitochondrial
Alternative name(s):
ATP synthase lipid-binding protein
ATP synthase proteolipid P1
ATPase protein 9
ATPase subunit c
Gene namesi
Name:Atp5g1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi61933. Atp5g1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: RGD
  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6161MitochondrionAdd
BLAST
Chaini62 – 13675ATP synthase F(0) complex subunit C1, mitochondrialPRO_0000002559Add
BLAST

Proteomic databases

PaxDbiQ06645.
PRIDEiQ06645.

Expressioni

Gene expression databases

GenevisibleiQ06645. RN.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009815.

Structurei

3D structure databases

ProteinModelPortaliQ06645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase C chain family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3025. Eukaryota.
COG0636. LUCA.
GeneTreeiENSGT00390000006210.
HOGENOMiHOG000235246.
HOVERGENiHBG050605.
InParanoidiQ06645.
KOiK02128.
OMAiNSSKQEC.
OrthoDBiEOG7VHT0K.
PhylomeDBiQ06645.
TreeFamiTF300140.

Family and domain databases

Gene3Di1.20.20.10. 1 hit.
HAMAPiMF_01396. ATP_synth_c_bact.
InterProiIPR000454. ATPase_F0-cplx_csu.
IPR020537. ATPase_F0-cplx_csu_DDCD_BS.
IPR002379. ATPase_proteolipid_c-like_dom.
[Graphical view]
PfamiPF00137. ATP-synt_C. 1 hit.
[Graphical view]
PRINTSiPR00124. ATPASEC.
SUPFAMiSSF81333. SSF81333. 1 hit.
PROSITEiPS00605. ATPASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTTKALLIS PVLIRSCTRG LIRPVSASLL SRPEAPSKKP SCCSSPLQVA
60 70 80 90 100
RREFQTSVIS RDIDTAAKFI GAGAATVGVA GSGAGIGTVF GSLIIGYARN
110 120 130
PSLKQQLFSY AILGFALSEA MGLFCLMVAF LILFAM
Length:136
Mass (Da):14,244
Last modified:June 1, 1994 - v1
Checksum:i91060591516D6AF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13123 mRNA. Translation: BAA02425.1.
PIRiJS0740.
RefSeqiNP_059007.1. NM_017311.1.
XP_006247250.1. XM_006247188.2.
XP_006247251.1. XM_006247189.1.
UniGeneiRn.3357.

Genome annotation databases

EnsembliENSRNOT00000009815; ENSRNOP00000009815; ENSRNOG00000007235.
GeneIDi29754.
KEGGirno:29754.
UCSCiRGD:61933. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13123 mRNA. Translation: BAA02425.1.
PIRiJS0740.
RefSeqiNP_059007.1. NM_017311.1.
XP_006247250.1. XM_006247188.2.
XP_006247251.1. XM_006247189.1.
UniGeneiRn.3357.

3D structure databases

ProteinModelPortaliQ06645.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009815.

Proteomic databases

PaxDbiQ06645.
PRIDEiQ06645.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009815; ENSRNOP00000009815; ENSRNOG00000007235.
GeneIDi29754.
KEGGirno:29754.
UCSCiRGD:61933. rat.

Organism-specific databases

CTDi516.
RGDi61933. Atp5g1.

Phylogenomic databases

eggNOGiKOG3025. Eukaryota.
COG0636. LUCA.
GeneTreeiENSGT00390000006210.
HOGENOMiHOG000235246.
HOVERGENiHBG050605.
InParanoidiQ06645.
KOiK02128.
OMAiNSSKQEC.
OrthoDBiEOG7VHT0K.
PhylomeDBiQ06645.
TreeFamiTF300140.

Enzyme and pathway databases

ReactomeiR-RNO-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

NextBioi610295.
PROiQ06645.

Gene expression databases

GenevisibleiQ06645. RN.

Family and domain databases

Gene3Di1.20.20.10. 1 hit.
HAMAPiMF_01396. ATP_synth_c_bact.
InterProiIPR000454. ATPase_F0-cplx_csu.
IPR020537. ATPase_F0-cplx_csu_DDCD_BS.
IPR002379. ATPase_proteolipid_c-like_dom.
[Graphical view]
PfamiPF00137. ATP-synt_C. 1 hit.
[Graphical view]
PRINTSiPR00124. ATPASEC.
SUPFAMiSSF81333. SSF81333. 1 hit.
PROSITEiPS00605. ATPASE_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequence of cDNAs for the import precursors of oligomycin sensitivity conferring protein, ATPase inhibitor protein, and subunit c of H(+)-ATP synthase in rat mitochondria."
    Higuti T., Kuroiwa K., Kawamura Y., Morimoto K., Tsujita H.
    Biochim. Biophys. Acta 1172:311-314(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of two proteins associated with mammalian ATP synthase."
    Meyer B., Wittig I., Trifilieff E., Karas M., Schaegger H.
    Mol. Cell. Proteomics 6:1690-1699(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE ATP SYNTHASE COMPLEX.

Entry informationi

Entry nameiAT5G1_RAT
AccessioniPrimary (citable) accession number: Q06645
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: December 9, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences. They are expressed in a tissue-specific manner.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.