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Protein

Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7

Gene

PMT7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.By similarity

Catalytic activityi

Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.Curated
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-29866-MONOMER.
BRENDAi2.4.1.109. 984.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT39. Glycosyltransferase Family 39.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7Curated (EC:2.4.1.109By similarity)
Gene namesi
Name:PMT7Imported
Ordered Locus Names:YDR307WImported
ORF Names:D9740.4Imported
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR307W.
SGDiS000002715. PMT7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26LumenalSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 159CytoplasmicSequence analysisAdd BLAST112
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 195LumenalSequence analysisAdd BLAST15
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 235CytoplasmicSequence analysisAdd BLAST19
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 482LumenalSequence analysisAdd BLAST226
Transmembranei483 – 503HelicalSequence analysisAdd BLAST21
Topological domaini504 – 565CytoplasmicSequence analysisAdd BLAST62
Transmembranei566 – 586HelicalSequence analysisAdd BLAST21
Topological domaini587 – 617LumenalSequence analysisAdd BLAST31
Transmembranei618 – 638HelicalSequence analysisAdd BLAST21
Topological domaini639 – 662CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001214971 – 662Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7Add BLAST662

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ06644.
PRIDEiQ06644.

Interactioni

Protein-protein interaction databases

BioGridi32360. 41 interactors.
DIPiDIP-5150N.
IntActiQ06644. 19 interactors.
MINTiMINT-521790.

Structurei

3D structure databases

ProteinModelPortaliQ06644.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini289 – 344MIR 1PROSITE-ProRule annotationAdd BLAST56
Domaini359 – 418MIR 2PROSITE-ProRule annotationAdd BLAST60
Domaini432 – 488MIR 3PROSITE-ProRule annotationAdd BLAST57

Sequence similaritiesi

Belongs to the glycosyltransferase 39 family.Curated
Contains 3 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ06644.
KOiK00728.
OMAiQEVLCVD.
OrthoDBiEOG092C120U.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39-like.
IPR003342. Glyco_trans_39/83.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDLRLQGPY RKYIPYNIFQ QCGIGHLKTL DYIFAFLIVI TNFTLIWKSH
60 70 80 90 100
SSSFWNRPWD NNSEQELSQL IQFYLDKAFY IHELPPFTIQ FYSIIRRLKI
110 120 130 140 150
AENLRYVSLF LNSSTLGFLF LITRRINCSR LISATGLLIL SNWETFRNEG
160 170 180 190 200
TIISFDSLEW CLFSVVIYSF ISISIAKLGT TNWFANVITL SISLGLAISS
210 220 230 240 250
KFIGIVTWAF VILSFVRQFD RLISDVKVTT IQIIKFVILC LLFVLIIPGS
260 270 280 290 300
IFIISYSNLL SNFKTDTPQF SKYMSTYFKS YLRGPQVQPS RLYYGSTITL
310 320 330 340 350
RHLDSMVGYL ASHDISYPSD VDEQLVALSF EEFAADNEWL IEHPTLNLSF
360 370 380 390 400
SEVYHADQLI PVEFGQSIKL RHKSTGKLLR ASTAKPPISE QDYDFQISCT
410 420 430 440 450
KDSNYEGGMD ERWDVLLIKD EINNDKKDNA DDKYIKPLQS EIRFYNNGQR
460 470 480 490 500
CGLLGHDLRL PEWGRFEQEV LCMEYPVIPR TTFLIDSVQL PVDFQVPMIE
510 520 530 540 550
YYIGKISSSA EFNHTLSWSQ FLYLFKEYIF KQYKYNYYIK YGKNKVTFED
560 570 580 590 600
AFAVEKWPIT LDTDSPVWFN FAWYGSLLSM IIFMCVQCKR MISWNPWTTA
610 620 630 640 650
EPSFSIKWEV YNEFGWECIV GWFLHFYIFT MSPHFNLGKK LYFQSFFFSV
660
LCLLESLDCL AK
Length:662
Mass (Da):77,570
Last modified:November 1, 1997 - v1
Checksum:i9083D1DF765A3AE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28374 Genomic DNA. Translation: AAB64743.1.
BK006938 Genomic DNA. Translation: DAA12146.1.
PIRiS61193.
RefSeqiNP_010593.3. NM_001180615.3.

Genome annotation databases

EnsemblFungiiYDR307W; YDR307W; YDR307W.
GeneIDi851902.
KEGGisce:YDR307W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28374 Genomic DNA. Translation: AAB64743.1.
BK006938 Genomic DNA. Translation: DAA12146.1.
PIRiS61193.
RefSeqiNP_010593.3. NM_001180615.3.

3D structure databases

ProteinModelPortaliQ06644.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32360. 41 interactors.
DIPiDIP-5150N.
IntActiQ06644. 19 interactors.
MINTiMINT-521790.

Protein family/group databases

CAZyiGT39. Glycosyltransferase Family 39.

Proteomic databases

MaxQBiQ06644.
PRIDEiQ06644.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR307W; YDR307W; YDR307W.
GeneIDi851902.
KEGGisce:YDR307W.

Organism-specific databases

EuPathDBiFungiDB:YDR307W.
SGDiS000002715. PMT7.

Phylogenomic databases

InParanoidiQ06644.
KOiK00728.
OMAiQEVLCVD.
OrthoDBiEOG092C120U.

Enzyme and pathway databases

UniPathwayiUPA00378.
BioCyciYEAST:G3O-29866-MONOMER.
BRENDAi2.4.1.109. 984.

Miscellaneous databases

PROiQ06644.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39-like.
IPR003342. Glyco_trans_39/83.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPMT7_YEAST
AccessioniPrimary (citable) accession number: Q06644
Secondary accession number(s): D6VST6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.