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Q06644

- PMT7_YEAST

UniProt

Q06644 - PMT7_YEAST

Protein

Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7

Gene

PMT7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.By similarity

    Catalytic activityi

    Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

    GO - Molecular functioni

    1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29866-MONOMER.
    BRENDAi2.4.1.109. 984.

    Protein family/group databases

    CAZyiGT39. Glycosyltransferase Family 39.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7 (EC:2.4.1.109)
    Gene namesi
    Name:PMT7
    Ordered Locus Names:YDR307W
    ORF Names:D9740.4
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR307w.
    SGDiS000002715. PMT7.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 662662Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7PRO_0000121497Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ06644.
    PaxDbiQ06644.
    PeptideAtlasiQ06644.

    Expressioni

    Gene expression databases

    GenevestigatoriQ06644.

    Interactioni

    Protein-protein interaction databases

    BioGridi32360. 41 interactions.
    DIPiDIP-5150N.
    IntActiQ06644. 19 interactions.
    MINTiMINT-521790.
    STRINGi4932.YDR307W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06644.
    SMRiQ06644. Positions 289-383.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626LumenalSequence AnalysisAdd
    BLAST
    Topological domaini48 – 159112CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini181 – 19515LumenalSequence AnalysisAdd
    BLAST
    Topological domaini217 – 23519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 482226LumenalSequence AnalysisAdd
    BLAST
    Topological domaini504 – 56562CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini587 – 61731LumenalSequence AnalysisAdd
    BLAST
    Topological domaini639 – 66224CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei483 – 50321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei566 – 58621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei618 – 63821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini289 – 34456MIR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini359 – 41860MIR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini432 – 48857MIR 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyltransferase 39 family.Curated
    Contains 3 MIR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1928.
    GeneTreeiENSGT00740000116239.
    KOiK00728.
    OMAiITRRINC.
    OrthoDBiEOG7KDFKG.

    Family and domain databases

    InterProiIPR027005. GlyclTrfase_39_like.
    IPR016093. MIR_motif.
    [Graphical view]
    PANTHERiPTHR10050. PTHR10050. 1 hit.
    PfamiPF02815. MIR. 1 hit.
    [Graphical view]
    SMARTiSM00472. MIR. 3 hits.
    [Graphical view]
    SUPFAMiSSF82109. SSF82109. 1 hit.
    PROSITEiPS50919. MIR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06644-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDLRLQGPY RKYIPYNIFQ QCGIGHLKTL DYIFAFLIVI TNFTLIWKSH    50
    SSSFWNRPWD NNSEQELSQL IQFYLDKAFY IHELPPFTIQ FYSIIRRLKI 100
    AENLRYVSLF LNSSTLGFLF LITRRINCSR LISATGLLIL SNWETFRNEG 150
    TIISFDSLEW CLFSVVIYSF ISISIAKLGT TNWFANVITL SISLGLAISS 200
    KFIGIVTWAF VILSFVRQFD RLISDVKVTT IQIIKFVILC LLFVLIIPGS 250
    IFIISYSNLL SNFKTDTPQF SKYMSTYFKS YLRGPQVQPS RLYYGSTITL 300
    RHLDSMVGYL ASHDISYPSD VDEQLVALSF EEFAADNEWL IEHPTLNLSF 350
    SEVYHADQLI PVEFGQSIKL RHKSTGKLLR ASTAKPPISE QDYDFQISCT 400
    KDSNYEGGMD ERWDVLLIKD EINNDKKDNA DDKYIKPLQS EIRFYNNGQR 450
    CGLLGHDLRL PEWGRFEQEV LCMEYPVIPR TTFLIDSVQL PVDFQVPMIE 500
    YYIGKISSSA EFNHTLSWSQ FLYLFKEYIF KQYKYNYYIK YGKNKVTFED 550
    AFAVEKWPIT LDTDSPVWFN FAWYGSLLSM IIFMCVQCKR MISWNPWTTA 600
    EPSFSIKWEV YNEFGWECIV GWFLHFYIFT MSPHFNLGKK LYFQSFFFSV 650
    LCLLESLDCL AK 662
    Length:662
    Mass (Da):77,570
    Last modified:November 1, 1997 - v1
    Checksum:i9083D1DF765A3AE5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28374 Genomic DNA. Translation: AAB64743.1.
    BK006938 Genomic DNA. Translation: DAA12146.1.
    PIRiS61193.
    RefSeqiNP_010593.3. NM_001180615.3.

    Genome annotation databases

    EnsemblFungiiYDR307W; YDR307W; YDR307W.
    GeneIDi851902.
    KEGGisce:YDR307W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28374 Genomic DNA. Translation: AAB64743.1 .
    BK006938 Genomic DNA. Translation: DAA12146.1 .
    PIRi S61193.
    RefSeqi NP_010593.3. NM_001180615.3.

    3D structure databases

    ProteinModelPortali Q06644.
    SMRi Q06644. Positions 289-383.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32360. 41 interactions.
    DIPi DIP-5150N.
    IntActi Q06644. 19 interactions.
    MINTi MINT-521790.
    STRINGi 4932.YDR307W.

    Protein family/group databases

    CAZyi GT39. Glycosyltransferase Family 39.

    Proteomic databases

    MaxQBi Q06644.
    PaxDbi Q06644.
    PeptideAtlasi Q06644.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR307W ; YDR307W ; YDR307W .
    GeneIDi 851902.
    KEGGi sce:YDR307W.

    Organism-specific databases

    CYGDi YDR307w.
    SGDi S000002715. PMT7.

    Phylogenomic databases

    eggNOGi COG1928.
    GeneTreei ENSGT00740000116239.
    KOi K00728.
    OMAi ITRRINC.
    OrthoDBi EOG7KDFKG.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29866-MONOMER.
    BRENDAi 2.4.1.109. 984.

    Miscellaneous databases

    NextBioi 969909.

    Gene expression databases

    Genevestigatori Q06644.

    Family and domain databases

    InterProi IPR027005. GlyclTrfase_39_like.
    IPR016093. MIR_motif.
    [Graphical view ]
    PANTHERi PTHR10050. PTHR10050. 1 hit.
    Pfami PF02815. MIR. 1 hit.
    [Graphical view ]
    SMARTi SM00472. MIR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF82109. SSF82109. 1 hit.
    PROSITEi PS50919. MIR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiPMT7_YEAST
    AccessioniPrimary (citable) accession number: Q06644
    Secondary accession number(s): D6VST6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3