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Protein

F-box protein YDR306C

Gene

YDR306C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-29865-MONOMER.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box protein YDR306C
Gene namesi
Ordered Locus Names:YDR306C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR306C.
SGDiS000002714. YDR306C.

Subcellular locationi

GO - Cellular componenti

  • SCF ubiquitin ligase complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478F-box protein YDR306CPRO_0000253805Add
BLAST

Post-translational modificationi

Autoubiquitinated by the E3 ubiquitin ligase complex in conjunction with the E2 enzyme CDC34.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ06640.

Interactioni

Subunit structurei

Interacts with SKP1. Component of the probable SCF(YDR306C) complex containing CDC53, SKP1, RBX1 and YDR306C.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32358. 22 interactions.
DIPiDIP-5370N.
IntActiQ06640. 3 interactions.
MINTiMINT-557495.

Structurei

3D structure databases

ProteinModelPortaliQ06640.
SMRiQ06640. Positions 243-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 17362F-boxAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi81 – 9010Poly-Ser

Domaini

The F-box domain contains an unusual insert of 18 residues (131-148).

Sequence similaritiesi

Contains 1 F-box domain.Curated

Phylogenomic databases

HOGENOMiHOG000246591.
InParanoidiQ06640.
OMAiTHLSFPR.
OrthoDBiEOG7673MB.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKSRPKKI KAPYRKYVAG EGFSSTRNDN KAKEFTITIP EDAELIETPQ
60 70 80 90 100
GSYYYDETND TIVKLTRLSN EKKDKKGRKQ SPSSSSTSSS KGEKNGKVIE
110 120 130 140 150
SEEARMHSVS VKMVLPWEIQ HRIIHYLDIP EKEEKLNKTA NGKKTTTGIN
160 170 180 190 200
MNYLLVCRNW YAMCLPKLYY APALTSKNFN GFVDTIIINK KKNLGHYVFE
210 220 230 240 250
LNLSTILQSG RNSFVSKLLR RCCSNLTKFI APQTSFGYAP LISLKSCHDL
260 270 280 290 300
KFLDLGLVSE TVKLKELFSA IKNFTKLTHL SFPRSSIDCQ GFQDIQWPQN
310 320 330 340 350
LRYLKLSGGI TNEFVIDTKW PTTITTLEFS YCPQITELSI YSLLSQIGDN
360 370 380 390 400
LKHLFFHYPM PSLAENSLDH VFTYCANLIS LQLMVDYCSK WCFSEFMLSK
410 420 430 440 450
LVEYDRPLKT LYLECSGSLG LASKIHPDDL TIAILESRLP CLKNICVSPK
460 470
LGWNMKSDEV ADLVVSLEDQ DGSLYLNY
Length:478
Mass (Da):54,437
Last modified:November 1, 1996 - v1
Checksum:iF0F69FBE96FD0155
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28374 Genomic DNA. Translation: AAB64742.1.
BK006938 Genomic DNA. Translation: DAA12145.1.
PIRiS61192.
RefSeqiNP_010592.1. NM_001180614.1.

Genome annotation databases

EnsemblFungiiYDR306C; YDR306C; YDR306C.
GeneIDi851900.
KEGGisce:YDR306C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28374 Genomic DNA. Translation: AAB64742.1.
BK006938 Genomic DNA. Translation: DAA12145.1.
PIRiS61192.
RefSeqiNP_010592.1. NM_001180614.1.

3D structure databases

ProteinModelPortaliQ06640.
SMRiQ06640. Positions 243-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32358. 22 interactions.
DIPiDIP-5370N.
IntActiQ06640. 3 interactions.
MINTiMINT-557495.

Proteomic databases

PRIDEiQ06640.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR306C; YDR306C; YDR306C.
GeneIDi851900.
KEGGisce:YDR306C.

Organism-specific databases

EuPathDBiFungiDB:YDR306C.
SGDiS000002714. YDR306C.

Phylogenomic databases

HOGENOMiHOG000246591.
InParanoidiQ06640.
OMAiTHLSFPR.
OrthoDBiEOG7673MB.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciYEAST:G3O-29865-MONOMER.

Miscellaneous databases

PROiQ06640.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro."
    Kus B.M., Caldon C.E., Andorn-Broza R., Edwards A.M.
    Proteins 54:455-467(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SKP1, RECONSTITUTION OF THE SCF(YDR306C) COMPLEX, UBIQUITINATION.

Entry informationi

Entry nameiYD306_YEAST
AccessioniPrimary (citable) accession number: Q06640
Secondary accession number(s): D6VST5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.