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Protein

F-box protein YDR306C

Gene

YDR306C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-29865-MONOMER
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box protein YDR306C
Gene namesi
Ordered Locus Names:YDR306C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR306C
SGDiS000002714 YDR306C

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002538051 – 478F-box protein YDR306CAdd BLAST478

Post-translational modificationi

Autoubiquitinated by the E3 ubiquitin ligase complex in conjunction with the E2 enzyme CDC34.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ06640
PRIDEiQ06640

Interactioni

Subunit structurei

Interacts with SKP1. Component of the probable SCF(YDR306C) complex containing CDC53, SKP1, RBX1 and YDR306C.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32358, 61 interactors
DIPiDIP-5370N
IntActiQ06640, 33 interactors
MINTiQ06640
STRINGi4932.YDR306C

Structurei

3D structure databases

ProteinModelPortaliQ06640
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 173F-boxAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi81 – 90Poly-Ser10

Domaini

The F-box domain contains an unusual insert of 18 residues (131-148).

Phylogenomic databases

HOGENOMiHOG000246591
InParanoidiQ06640
OMAiTHLSFPR
OrthoDBiEOG092C2K6Z

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf

Sequencei

Sequence statusi: Complete.

Q06640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKSRPKKI KAPYRKYVAG EGFSSTRNDN KAKEFTITIP EDAELIETPQ
60 70 80 90 100
GSYYYDETND TIVKLTRLSN EKKDKKGRKQ SPSSSSTSSS KGEKNGKVIE
110 120 130 140 150
SEEARMHSVS VKMVLPWEIQ HRIIHYLDIP EKEEKLNKTA NGKKTTTGIN
160 170 180 190 200
MNYLLVCRNW YAMCLPKLYY APALTSKNFN GFVDTIIINK KKNLGHYVFE
210 220 230 240 250
LNLSTILQSG RNSFVSKLLR RCCSNLTKFI APQTSFGYAP LISLKSCHDL
260 270 280 290 300
KFLDLGLVSE TVKLKELFSA IKNFTKLTHL SFPRSSIDCQ GFQDIQWPQN
310 320 330 340 350
LRYLKLSGGI TNEFVIDTKW PTTITTLEFS YCPQITELSI YSLLSQIGDN
360 370 380 390 400
LKHLFFHYPM PSLAENSLDH VFTYCANLIS LQLMVDYCSK WCFSEFMLSK
410 420 430 440 450
LVEYDRPLKT LYLECSGSLG LASKIHPDDL TIAILESRLP CLKNICVSPK
460 470
LGWNMKSDEV ADLVVSLEDQ DGSLYLNY
Length:478
Mass (Da):54,437
Last modified:November 1, 1996 - v1
Checksum:iF0F69FBE96FD0155
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28374 Genomic DNA Translation: AAB64742.1
BK006938 Genomic DNA Translation: DAA12145.1
PIRiS61192
RefSeqiNP_010592.1, NM_001180614.1

Genome annotation databases

EnsemblFungiiYDR306C; YDR306C; YDR306C
GeneIDi851900
KEGGisce:YDR306C

Similar proteinsi

Entry informationi

Entry nameiYD306_YEAST
AccessioniPrimary (citable) accession number: Q06640
Secondary accession number(s): D6VST5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health