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Protein

Protein BFR2

Gene

BFR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in endoplasmic reticulum to Golgi transport. Involved in a protein-transport step blocked by brefeldin A, which disrupts the Golgi apparatus and its incoming protein flux. May also be involved for mass growth or cell proliferation.1 Publication

Miscellaneous

Present with 15400 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • protein transport Source: UniProtKB-KW
  • rRNA processing Source: SGD
  • vesicle-mediated transport Source: UniProtKB-KW

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29860-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BFR2
Alternative name(s):
Brefeldin A resistance protein 2
Gene namesi
Name:BFR2
Ordered Locus Names:YDR299W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR299W
SGDiS000002707 BFR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566341 – 534Protein BFR2Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei366PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei379PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06631
PaxDbiQ06631
PRIDEiQ06631

PTM databases

iPTMnetiQ06631

Expressioni

Inductioni

Up-regulated during cold stress and following nutrient replenishment by dilution of cells fron exhausted to fresh minimal medium.1 Publication

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32351, 114 interactors
DIPiDIP-1411N
IntActiQ06631, 22 interactors
MINTiQ06631
STRINGi4932.YDR299W

Structurei

3D structure databases

ProteinModelPortaliQ06631
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili86 – 161Sequence analysisAdd BLAST76

Sequence similaritiesi

Belongs to the AATF family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000000288
HOGENOMiHOG000065940
InParanoidiQ06631
KOiK14782
OMAiEVLLKWD
OrthoDBiEOG092C2YQ5

Family and domain databases

InterProiView protein in InterPro
IPR025160 AATF
IPR012617 AATF_C
PfamiView protein in Pfam
PF13339 AATF-Che1, 1 hit
PF08164 TRAUB, 1 hit

Sequencei

Sequence statusi: Complete.

Q06631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKSLADQIS DIAIKPVNKD FDIEDEENAS LFQHNEKNGE SDLSDYGNSN
60 70 80 90 100
TEETKKAHYL EVEKSKLRAE KGLELNDPKY TGVKGSRQAL YEEVSENEDE
110 120 130 140 150
EEEEEEEEEK EEDALSFRTD SEDEEVEIDE EESDADGGET EEAQQKRHAL
160 170 180 190 200
SKLIQQETKQ AINKLSQSVQ RDASKGYSIL QQTKLFDNII DLRIKLQKAV
210 220 230 240 250
IAANKLPLTT ESWEEAKMDD SEETKRLLKE NEKLFNNLFN RLINFRIKFQ
260 270 280 290 300
LGDHITQNEE VAKHKLSKKR SLKELYQETN SLDSELKEYR TAVLNKWSTK
310 320 330 340 350
VSSASGNAAL SSNKFKAINL PADVQVENQL SDMSRLMKRT KLNRRNITPL
360 370 380 390 400
YFQKDCANGR LPELISPVVK DSVDDNENSD DGLDIPKNYD PRRKDNNAID
410 420 430 440 450
ITENPYVFDD EDFYRVLLND LIDKKISNAH NSESAAITIT STNARSNNKL
460 470 480 490 500
KKNIDTKASK GRKLNYSVQD PIANYEAPIT SGYKWSDDQI DEFFAGLLGQ
510 520 530
RVNFNENEDE EQHARIENDE ELEAVKNDDI QIFG
Length:534
Mass (Da):61,203
Last modified:November 1, 1996 - v1
Checksum:iAE84AD597C2BBD8B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti451K → R in AAU09706 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28374 Genomic DNA Translation: AAB64735.1
AY723789 Genomic DNA Translation: AAU09706.1
BK006938 Genomic DNA Translation: DAA12138.1
PIRiS61185
RefSeqiNP_010585.3, NM_001180607.3

Genome annotation databases

EnsemblFungiiYDR299W; YDR299W; YDR299W
GeneIDi851893
KEGGisce:YDR299W

Similar proteinsi

Entry informationi

Entry nameiBFR2_YEAST
AccessioniPrimary (citable) accession number: Q06631
Secondary accession number(s): D6VSS8, Q66RD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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