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Q06628

- ATG13_YEAST

UniProt

Q06628 - ATG13_YEAST

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Protein

Autophagy-related protein 13

Gene

ATG13

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Required for autophosphorylation of ATG1 at 'Thr-226' and its dimerization. May also be involved in the regulation of autophagy through SNF1. Involved in ATG9 and ATG23 cycling through the pre-autophagosomal structure. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase.23 Publications

GO - Molecular functioni

  1. protein kinase regulator activity Source: SGD

GO - Biological processi

  1. activation of protein kinase activity Source: SGD
  2. autophagy Source: UniProtKB
  3. CVT pathway Source: SGD
  4. late nucleophagy Source: SGD
  5. macroautophagy Source: SGD
  6. mitochondrion degradation Source: SGD
  7. piecemeal microautophagy of nucleus Source: SGD
  8. protein localization to pre-autophagosomal structure Source: SGD
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34308-MONOMER.

Protein family/group databases

TCDBi9.A.15.1.1. the autophagy-related phagophore-formation transporter (apt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 13
Gene namesi
Name:ATG13
Synonyms:APG13
Ordered Locus Names:YPR185W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR185w.
SGDiS000006389. ATG13.

Subcellular locationi

GO - Cellular componenti

  1. ATG1/UKL1 signaling complex Source: SGD
  2. cytoplasm Source: UniProtKB-KW
  3. extrinsic component of membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi344 – 3441S → A: Decreases phosphorylation by PKA. 1 Publication
Mutagenesisi348 – 3481S → A: Leads to constitutive activation of autophagy; when associated with A-437; A-438; A-496; A-535; A-541; A-646 and A-649. 1 Publication
Mutagenesisi437 – 4371S → A: Decreases phosphorylation by PKA. Leads to constitutive activation of autophagy; when associated with A-348; A-438; A-496; A-535; A-541; A-646 and A-649. 2 Publications
Mutagenesisi438 – 4381S → A: Leads to constitutive activation of autophagy; when associated with A-348; A-437; A-496; A-535; A-541; A-646 and A-649. 1 Publication
Mutagenesisi468 – 4681F → A: Impairs binding to ATG1; when associated with A-469. 1 Publication
Mutagenesisi469 – 4691V → A: Impairs binding to ATG1; when associated with A-468. 1 Publication
Mutagenesisi496 – 4961S → A: Leads to constitutive activation of autophagy; when associated with A-348; A-437; A-438; A-535; A-541; A-646 and A-649. 1 Publication
Mutagenesisi535 – 5351S → A: Leads to constitutive activation of autophagy; when associated with A-348; A-437; A-438; A-496; A-541; A-646 and A-649. 1 Publication
Mutagenesisi541 – 5411S → A: Leads to constitutive activation of autophagy; when associated with A-348; A-437; A-438; A-496; A-535; A-646 and A-649. 1 Publication
Mutagenesisi581 – 5811S → A: Decreases phosphorylation by PKA. 1 Publication
Mutagenesisi646 – 6461S → A: Leads to constitutive activation of autophagy; when associated with A-348; A-437; A-438; A-496; A-535; A-541 and A-649. 1 Publication
Mutagenesisi649 – 6491S → A: Leads to constitutive activation of autophagy; when associated with A-348; A-437; A-438; A-496; A-535; A-541, and A-646. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738Autophagy-related protein 13PRO_0000157972Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei344 – 3441Phosphoserine; by PKA1 Publication
Modified residuei348 – 3481Phosphoserine; by TORC11 Publication
Modified residuei355 – 3551Phosphoserine3 Publications
Modified residuei360 – 3601Phosphoserine1 Publication
Modified residuei437 – 4371Phosphoserine; by TORC1 and PKA2 Publications
Modified residuei438 – 4381Phosphoserine; by TORC11 Publication
Modified residuei461 – 4611Phosphoserine2 Publications
Modified residuei496 – 4961Phosphoserine; by TORC11 Publication
Modified residuei535 – 5351Phosphoserine; by TORC11 Publication
Modified residuei541 – 5411Phosphoserine; by TORC11 Publication
Modified residuei554 – 5541Phosphoserine1 Publication
Modified residuei581 – 5811Phosphoserine; by PKA1 Publication
Modified residuei646 – 6461Phosphoserine; by TORC11 Publication
Modified residuei649 – 6491Phosphoserine; by TORC14 Publications

Post-translational modificationi

Phosphorylated; hyperphosphorylated by the TORC1 kinase complex to repress the induction of autophagy. Starvation and TOR inactivation results in ATG13 partial dephosphorylation leading to ATG1-binding. Rephosphorylated by ATG1 during prolonged nitrogen starvation. Also phosphorylated by PKA. PKA phosphorylation regulates the association of ATG13 with the PAS. Within this regulatory network, mitochondrial respiratory deficiency suppresses autophagic flux. Hyperphosphorylation in rich medium is impaired in the absence of VAC8.15 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06628.
PaxDbiQ06628.

Expressioni

Gene expression databases

GenevestigatoriQ06628.

Interactioni

Subunit structurei

Hypophosphorylated form interacts with ATG1 to form the ATG1-ATG13 kinase complex. The ATG1-ATG13 complex interacts with the ATG17-ATG29-ATG31 complex through direct interaction with ATG17. Interacts with VAC8.13 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG1P5310413EBI-36188,EBI-2657
VAC8P399685EBI-36188,EBI-20212

Protein-protein interaction databases

BioGridi36357. 77 interactions.
DIPiDIP-1191N.
IntActiQ06628. 8 interactions.
MINTiMINT-384768.
STRINGi4932.YPR185W.

Structurei

3D structure databases

ProteinModelPortaliQ06628.
SMRiQ06628. Positions 7-267, 463-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni432 – 52089Interaction with ATG1Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi306 – 33833Poly-GlnAdd
BLAST
Compositional biasi622 – 6254Poly-Asp
Compositional biasi699 – 70810Poly-Asn

Sequence similaritiesi

Belongs to the ATG13 fungi family.Curated

Phylogenomic databases

eggNOGiNOG318247.
HOGENOMiHOG000034130.
InParanoidiQ06628.
KOiK08331.
OMAiNIASHLE.
OrthoDBiEOG744TJK.

Family and domain databases

InterProiIPR018731. Autophagy-rel_p13.
[Graphical view]
PfamiPF10033. ATG13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06628-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAEEDIEKQ VLQLIDSFFL KTTLLICSTE SSRYQSSTEN IFLFDDTWFE
60 70 80 90 100
DHSELVSELP EIISKWSHYD GRKELPPLVV ETYLDLRQLN SSHLVRLKDH
110 120 130 140 150
EGHLWNVCKG TKKQEIVMER WLIELDNSSP TFKSYSEDET DVNELSKQLV
160 170 180 190 200
LLFRYLLTLI QLLPTTELYQ LLIKSYNGPQ NEGSSNPITS TGPLVSIRTC
210 220 230 240 250
VLDGSKPILS KGRIGLSKPI INTYSNALNE SNLPAHLDQK KITPVWTKFG
260 270 280 290 300
LLRVSVSYRR DWKFEINNTN DELFSARHAS VSHNSQGPQN QPEQEGQSDQ
310 320 330 340 350
DIGKRQPQFQ QQQQPQQQQQ QQQQQQRQHQ VQTQQQRQIP DRRSLSLSPC
360 370 380 390 400
TRANSFEPQS WQKKVYPISR PVQPFKVGSI GSQSASRNPS NSSFFNQPPV
410 420 430 440 450
HRPSMSSNYG PQMNIEGTSV GSTSKYSSSF GNIRRHSSVK TTENAEKVSK
460 470 480 490 500
AVKSPLQPQE SQEDLMDFVK LLEEKPDLTI KKTSGNNPPN INISDSLIRY
510 520 530 540 550
QNLKPSNDLL SEDLSVSLSM DPNHTYHRGR SDSHSPLPSI SPSMHYGSLN
560 570 580 590 600
SRMSQGANAS HLIARGGGNS STSALNSRRN SLDKSSNKQG MSGLPPIFGG
610 620 630 640 650
ESTSYHHDNK IQKYNQLGVE EDDDDENDRL LNQMGNSATK FKSSISPRSI
660 670 680 690 700
DSISSSFIKS RIPIRQPYHY SQPTTAPFQA QAKFHKPANK LIDNGNRSNS
710 720 730
NNNNHNGNDA VGVMHNDEDD QDDDLVFFMS DMNLSKEG
Length:738
Mass (Da):83,281
Last modified:November 1, 1996 - v1
Checksum:i45CD16F69B795E62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25842 Genomic DNA. Translation: AAB68118.1.
D88025 Genomic DNA. Translation: BAA21485.1.
BK006949 Genomic DNA. Translation: DAA11601.1.
PIRiS59842.
RefSeqiNP_015511.1. NM_001184282.1.

Genome annotation databases

EnsemblFungiiYPR185W; YPR185W; YPR185W.
GeneIDi856315.
KEGGisce:YPR185W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25842 Genomic DNA. Translation: AAB68118.1 .
D88025 Genomic DNA. Translation: BAA21485.1 .
BK006949 Genomic DNA. Translation: DAA11601.1 .
PIRi S59842.
RefSeqi NP_015511.1. NM_001184282.1.

3D structure databases

ProteinModelPortali Q06628.
SMRi Q06628. Positions 7-267, 463-517.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36357. 77 interactions.
DIPi DIP-1191N.
IntActi Q06628. 8 interactions.
MINTi MINT-384768.
STRINGi 4932.YPR185W.

Protein family/group databases

TCDBi 9.A.15.1.1. the autophagy-related phagophore-formation transporter (apt) family.

Proteomic databases

MaxQBi Q06628.
PaxDbi Q06628.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR185W ; YPR185W ; YPR185W .
GeneIDi 856315.
KEGGi sce:YPR185W.

Organism-specific databases

CYGDi YPR185w.
SGDi S000006389. ATG13.

Phylogenomic databases

eggNOGi NOG318247.
HOGENOMi HOG000034130.
InParanoidi Q06628.
KOi K08331.
OMAi NIASHLE.
OrthoDBi EOG744TJK.

Enzyme and pathway databases

BioCyci YEAST:G3O-34308-MONOMER.

Miscellaneous databases

NextBioi 981697.

Gene expression databases

Genevestigatori Q06628.

Family and domain databases

InterProi IPR018731. Autophagy-rel_p13.
[Graphical view ]
Pfami PF10033. ATG13. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae."
    Funakoshi T., Matsuura A., Noda T., Ohsumi Y.
    Gene 192:207-213(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae."
    Tsukada M., Ohsumi Y.
    FEBS Lett. 333:169-174(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting."
    Scott S.V., Nice D.C. III, Nau J.J., Weisman L.S., Kamada Y., Keizer-Gunnink I., Funakoshi T., Veenhuis M., Ohsumi Y., Klionsky D.J.
    J. Biol. Chem. 275:25840-25849(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH VAC8.
  6. "Dissection of autophagosome biogenesis into distinct nucleation and expansion steps."
    Abeliovich H., Dunn W.A. Jr., Kim J., Klionsky D.J.
    J. Cell Biol. 151:1025-1034(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Tor-mediated induction of autophagy via an Apg1 protein kinase complex."
    Kamada Y., Funakoshi T., Shintani T., Nagano K., Ohsumi M., Ohsumi Y.
    J. Cell Biol. 150:1507-1513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION, INTERACTION WITH ATG1.
  8. "Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p."
    Wang Z., Wilson W.A., Fujino M.A., Roach P.J.
    Mol. Cell. Biol. 21:5742-5752(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: NOMENCLATURE.
  10. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  11. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  12. "The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure."
    Reggiori F., Tucker K.A., Stromhaug P.E., Klionsky D.J.
    Dev. Cell 6:79-90(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy."
    Kabeya Y., Kamada Y., Baba M., Takikawa H., Sasaki M., Ohsumi Y.
    Mol. Biol. Cell 16:2544-2553(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ATG1 AND ATG17.
  14. Cited for: INTERACTION WITH ATG1 AND ATG17.
  15. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  16. "A cycling protein complex required for selective autophagy."
    Legakis J.E., Yen W.L., Klionsky D.J.
    Autophagy 3:422-432(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Hierarchy of Atg proteins in pre-autophagosomal structure organization."
    Suzuki K., Kubota Y., Sekito T., Ohsumi Y.
    Genes Cells 12:209-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.
  18. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355 AND SER-360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  19. "Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae."
    Yorimitsu T., Zaman S., Broach J.R., Klionsky D.J.
    Mol. Biol. Cell 18:4180-4189(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION.
  20. "The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae."
    Cheong H., Nair U., Geng J., Klionsky D.J.
    Mol. Biol. Cell 19:668-681(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  21. "Organization of the pre-autophagosomal structure responsible for autophagosome formation."
    Kawamata T., Kamada Y., Kabeya Y., Sekito T., Ohsumi Y.
    Mol. Biol. Cell 19:2039-2050(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE ATG1-ATG13 COMPLEX.
  22. "Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy."
    He C., Baba M., Cao Y., Klionsky D.J.
    Mol. Biol. Cell 19:5506-5516(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATG1.
  23. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355; SER-461; SER-554 AND SER-649, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  24. "Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae."
    Kabeya Y., Noda N.N., Fujioka Y., Suzuki K., Inagaki F., Ohsumi Y.
    Biochem. Biophys. Res. Commun. 389:612-615(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH THE ATG17-ATG29-ATG31 COMPLEX.
  25. "The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy."
    Stephan J.S., Yeh Y.Y., Ramachandran V., Deminoff S.J., Herman P.K.
    Proc. Natl. Acad. Sci. U.S.A. 106:17049-17054(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-344; SER-437 AND SER-581 BY PKA, MUTAGENESIS OF SER-344; SER-437 AND SER-581, FUNCTION, INTERACTION WITH ATG17.
  26. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355; SER-461 AND SER-649, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  27. "Induction of autophagic flux by amino acid deprivation is distinct from nitrogen starvation-induced macroautophagy."
    Ecker N., Mor A., Journo D., Abeliovich H.
    Autophagy 6:879-890(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  28. "Activation of Atg1 kinase in autophagy by regulated phosphorylation."
    Kijanska M., Dohnal I., Reiter W., Kaspar S., Stoffel I., Ammerer G., Kraft C., Peter M.
    Autophagy 6:1168-1178(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATG1.
  29. "Autophosphorylation within the Atg1 activation loop is required for both kinase activity and the induction of autophagy in Saccharomyces cerevisiae."
    Yeh Y.Y., Wrasman K., Herman P.K.
    Genetics 185:871-882(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ATG1.
  30. "An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis."
    Mari M., Griffith J., Rieter E., Krishnappa L., Klionsky D.J., Reggiori F.
    J. Cell Biol. 190:1005-1022(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  31. "Tor directly controls the Atg1 kinase complex to regulate autophagy."
    Kamada Y., Yoshino K., Kondo C., Kawamata T., Oshiro N., Yonezawa K., Ohsumi Y.
    Mol. Cell. Biol. 30:1049-1058(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-348; SER-437; SER-438; SER-496; SER-535; SER-541; SER-646 AND SER-649, MUTAGENESIS OF SER-348; SER-437; SER-438; SER-496; SER-535; SER-541; SER-646 AND SER-649, FUNCTION.
  32. "Bidirectional regulation between TORC1 and autophagy in Saccharomyces cerevisiae."
    Shin C.S., Huh W.K.
    Autophagy 7:854-862(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY ATG1.
  33. "Mitochondria regulate autophagy by conserved signalling pathways."
    Graef M., Nunnari J.
    EMBO J. 30:2101-2114(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION OF THE ATG1-ATG13 COMPLEX.
  34. "Antagonistic interactions between the cAMP-dependent protein kinase and Tor signaling pathways modulate cell growth in Saccharomyces cerevisiae."
    Ramachandran V., Herman P.K.
    Genetics 187:441-454(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION.
  35. "An Atg13 protein-mediated self-association of the Atg1 protein kinase is important for the induction of autophagy."
    Yeh Y.Y., Shah K.H., Herman P.K.
    J. Biol. Chem. 286:28931-28939(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ATG1.
  36. "Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation."
    Wu X., Tu B.P.
    Mol. Biol. Cell 22:4124-4133(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION.
  37. "Architecture of the Atg17 complex as a scaffold for autophagosome biogenesis."
    Ragusa M.J., Stanley R.E., Hurley J.H.
    Cell 151:1501-1512(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH THE ATG17-ATG29-ATG31 COMPLEX.
  38. Cited for: INTERACTION WITH ATG1, MUTAGENESIS OF PHE-468 AND VAL-469, FUNCTION.
  39. "Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway."
    Umekawa M., Klionsky D.J.
    J. Biol. Chem. 287:16300-16310(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION BY TORC1 COMPLEX.
  40. "The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation."
    Nakatogawa H., Ohbayashi S., Sakoh-Nakatogawa M., Kakuta S., Suzuki S.W., Kirisako H., Kondo-Kakuta C., Noda N.N., Yamamoto H., Ohsumi Y.
    J. Biol. Chem. 287:28503-28507(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ATG1.
  41. "The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling."
    Lisa-Santamaria P., Jimenez A., Revuelta J.L.
    J. Biol. Chem. 287:29636-29647(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION.
  42. "Transient sequestration of TORC1 into stress granules during heat stress."
    Takahara T., Maeda T.
    Mol. Cell 47:242-252(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.

Entry informationi

Entry nameiATG13_YEAST
AccessioniPrimary (citable) accession number: Q06628
Secondary accession number(s): D6W4I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3