Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q06628

- ATG13_YEAST

UniProt

Q06628 - ATG13_YEAST

Protein

Autophagy-related protein 13

Gene

ATG13

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Required for autophosphorylation of ATG1 at 'Thr-226' and its dimerization. May also be involved in the regulation of autophagy through SNF1. Involved in ATG9 and ATG23 cycling through the pre-autophagosomal structure. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase.23 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein kinase regulator activity Source: SGD

    GO - Biological processi

    1. activation of protein kinase activity Source: SGD
    2. autophagy Source: UniProtKB
    3. CVT pathway Source: SGD
    4. late nucleophagy Source: SGD
    5. macroautophagy Source: SGD
    6. mitochondrion degradation Source: SGD
    7. piecemeal microautophagy of nucleus Source: SGD
    8. protein localization to pre-autophagosomal structure Source: SGD

    Keywords - Biological processi

    Autophagy, Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34308-MONOMER.

    Protein family/group databases

    TCDBi9.A.15.1.1. the autophagy-related phagophore-formation transporter (apt) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autophagy-related protein 13
    Gene namesi
    Name:ATG13
    Synonyms:APG13
    Ordered Locus Names:YPR185W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPR185w.
    SGDiS000006389. ATG13.

    Subcellular locationi

    GO - Cellular componenti

    1. ATG1/UKL1 signaling complex Source: SGD
    2. extrinsic component of membrane Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi344 – 3441S → A: Decreases phosphorylation by PKA. 1 Publication
    Mutagenesisi348 – 3481S → A: Leads to constitutive activation of autophagy; when associated with A-437; A-438; A-496; A-535; A-541; A-646 and A-649. 1 Publication
    Mutagenesisi437 – 4371S → A: Decreases phosphorylation by PKA. Leads to constitutive activation of autophagy; when associated with A-348; A-438; A-496; A-535; A-541; A-646 and A-649. 2 Publications
    Mutagenesisi438 – 4381S → A: Leads to constitutive activation of autophagy; when associated with A-348; A-437; A-496; A-535; A-541; A-646 and A-649. 1 Publication
    Mutagenesisi468 – 4681F → A: Impairs binding to ATG1; when associated with A-469. 1 Publication
    Mutagenesisi469 – 4691V → A: Impairs binding to ATG1; when associated with A-468. 1 Publication
    Mutagenesisi496 – 4961S → A: Leads to constitutive activation of autophagy; when associated with A-348; A-437; A-438; A-535; A-541; A-646 and A-649. 1 Publication
    Mutagenesisi535 – 5351S → A: Leads to constitutive activation of autophagy; when associated with A-348; A-437; A-438; A-496; A-541; A-646 and A-649. 1 Publication
    Mutagenesisi541 – 5411S → A: Leads to constitutive activation of autophagy; when associated with A-348; A-437; A-438; A-496; A-535; A-646 and A-649. 1 Publication
    Mutagenesisi581 – 5811S → A: Decreases phosphorylation by PKA. 1 Publication
    Mutagenesisi646 – 6461S → A: Leads to constitutive activation of autophagy; when associated with A-348; A-437; A-438; A-496; A-535; A-541 and A-649. 1 Publication
    Mutagenesisi649 – 6491S → A: Leads to constitutive activation of autophagy; when associated with A-348; A-437; A-438; A-496; A-535; A-541, and A-646. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 738738Autophagy-related protein 13PRO_0000157972Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei344 – 3441Phosphoserine; by PKA1 Publication
    Modified residuei348 – 3481Phosphoserine; by TORC11 Publication
    Modified residuei355 – 3551Phosphoserine3 Publications
    Modified residuei360 – 3601Phosphoserine1 Publication
    Modified residuei437 – 4371Phosphoserine; by TORC1 and PKA2 Publications
    Modified residuei438 – 4381Phosphoserine; by TORC11 Publication
    Modified residuei461 – 4611Phosphoserine2 Publications
    Modified residuei496 – 4961Phosphoserine; by TORC11 Publication
    Modified residuei535 – 5351Phosphoserine; by TORC11 Publication
    Modified residuei541 – 5411Phosphoserine; by TORC11 Publication
    Modified residuei554 – 5541Phosphoserine1 Publication
    Modified residuei581 – 5811Phosphoserine; by PKA1 Publication
    Modified residuei646 – 6461Phosphoserine; by TORC11 Publication
    Modified residuei649 – 6491Phosphoserine; by TORC14 Publications

    Post-translational modificationi

    Phosphorylated; hyperphosphorylated by the TORC1 kinase complex to repress the induction of autophagy. Starvation and TOR inactivation results in ATG13 partial dephosphorylation leading to ATG1-binding. Rephosphorylated by ATG1 during prolonged nitrogen starvation. Also phosphorylated by PKA. PKA phosphorylation regulates the association of ATG13 with the PAS. Within this regulatory network, mitochondrial respiratory deficiency suppresses autophagic flux. Hyperphosphorylation in rich medium is impaired in the absence of VAC8.15 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ06628.
    PaxDbiQ06628.

    Expressioni

    Gene expression databases

    GenevestigatoriQ06628.

    Interactioni

    Subunit structurei

    Hypophosphorylated form interacts with ATG1 to form the ATG1-ATG13 kinase complex. The ATG1-ATG13 complex interacts with the ATG17-ATG29-ATG31 complex through direct interaction with ATG17. Interacts with VAC8.13 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATG1P5310413EBI-36188,EBI-2657
    VAC8P399685EBI-36188,EBI-20212

    Protein-protein interaction databases

    BioGridi36357. 77 interactions.
    DIPiDIP-1191N.
    IntActiQ06628. 8 interactions.
    MINTiMINT-384768.
    STRINGi4932.YPR185W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06628.
    SMRiQ06628. Positions 7-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni432 – 52089Interaction with ATG1Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi306 – 33833Poly-GlnAdd
    BLAST
    Compositional biasi622 – 6254Poly-Asp
    Compositional biasi699 – 70810Poly-Asn

    Sequence similaritiesi

    Belongs to the ATG13 fungi family.Curated

    Phylogenomic databases

    eggNOGiNOG318247.
    HOGENOMiHOG000034130.
    KOiK08331.
    OMAiNIASHLE.
    OrthoDBiEOG744TJK.

    Family and domain databases

    InterProiIPR018731. Autophagy-rel_p13.
    [Graphical view]
    PfamiPF10033. ATG13. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06628-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAEEDIEKQ VLQLIDSFFL KTTLLICSTE SSRYQSSTEN IFLFDDTWFE    50
    DHSELVSELP EIISKWSHYD GRKELPPLVV ETYLDLRQLN SSHLVRLKDH 100
    EGHLWNVCKG TKKQEIVMER WLIELDNSSP TFKSYSEDET DVNELSKQLV 150
    LLFRYLLTLI QLLPTTELYQ LLIKSYNGPQ NEGSSNPITS TGPLVSIRTC 200
    VLDGSKPILS KGRIGLSKPI INTYSNALNE SNLPAHLDQK KITPVWTKFG 250
    LLRVSVSYRR DWKFEINNTN DELFSARHAS VSHNSQGPQN QPEQEGQSDQ 300
    DIGKRQPQFQ QQQQPQQQQQ QQQQQQRQHQ VQTQQQRQIP DRRSLSLSPC 350
    TRANSFEPQS WQKKVYPISR PVQPFKVGSI GSQSASRNPS NSSFFNQPPV 400
    HRPSMSSNYG PQMNIEGTSV GSTSKYSSSF GNIRRHSSVK TTENAEKVSK 450
    AVKSPLQPQE SQEDLMDFVK LLEEKPDLTI KKTSGNNPPN INISDSLIRY 500
    QNLKPSNDLL SEDLSVSLSM DPNHTYHRGR SDSHSPLPSI SPSMHYGSLN 550
    SRMSQGANAS HLIARGGGNS STSALNSRRN SLDKSSNKQG MSGLPPIFGG 600
    ESTSYHHDNK IQKYNQLGVE EDDDDENDRL LNQMGNSATK FKSSISPRSI 650
    DSISSSFIKS RIPIRQPYHY SQPTTAPFQA QAKFHKPANK LIDNGNRSNS 700
    NNNNHNGNDA VGVMHNDEDD QDDDLVFFMS DMNLSKEG 738
    Length:738
    Mass (Da):83,281
    Last modified:November 1, 1996 - v1
    Checksum:i45CD16F69B795E62
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25842 Genomic DNA. Translation: AAB68118.1.
    D88025 Genomic DNA. Translation: BAA21485.1.
    BK006949 Genomic DNA. Translation: DAA11601.1.
    PIRiS59842.
    RefSeqiNP_015511.1. NM_001184282.1.

    Genome annotation databases

    EnsemblFungiiYPR185W; YPR185W; YPR185W.
    GeneIDi856315.
    KEGGisce:YPR185W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25842 Genomic DNA. Translation: AAB68118.1 .
    D88025 Genomic DNA. Translation: BAA21485.1 .
    BK006949 Genomic DNA. Translation: DAA11601.1 .
    PIRi S59842.
    RefSeqi NP_015511.1. NM_001184282.1.

    3D structure databases

    ProteinModelPortali Q06628.
    SMRi Q06628. Positions 7-267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36357. 77 interactions.
    DIPi DIP-1191N.
    IntActi Q06628. 8 interactions.
    MINTi MINT-384768.
    STRINGi 4932.YPR185W.

    Protein family/group databases

    TCDBi 9.A.15.1.1. the autophagy-related phagophore-formation transporter (apt) family.

    Proteomic databases

    MaxQBi Q06628.
    PaxDbi Q06628.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPR185W ; YPR185W ; YPR185W .
    GeneIDi 856315.
    KEGGi sce:YPR185W.

    Organism-specific databases

    CYGDi YPR185w.
    SGDi S000006389. ATG13.

    Phylogenomic databases

    eggNOGi NOG318247.
    HOGENOMi HOG000034130.
    KOi K08331.
    OMAi NIASHLE.
    OrthoDBi EOG744TJK.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34308-MONOMER.

    Miscellaneous databases

    NextBioi 981697.

    Gene expression databases

    Genevestigatori Q06628.

    Family and domain databases

    InterProi IPR018731. Autophagy-rel_p13.
    [Graphical view ]
    Pfami PF10033. ATG13. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae."
      Funakoshi T., Matsuura A., Noda T., Ohsumi Y.
      Gene 192:207-213(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae."
      Tsukada M., Ohsumi Y.
      FEBS Lett. 333:169-174(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting."
      Scott S.V., Nice D.C. III, Nau J.J., Weisman L.S., Kamada Y., Keizer-Gunnink I., Funakoshi T., Veenhuis M., Ohsumi Y., Klionsky D.J.
      J. Biol. Chem. 275:25840-25849(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH VAC8.
    6. "Dissection of autophagosome biogenesis into distinct nucleation and expansion steps."
      Abeliovich H., Dunn W.A. Jr., Kim J., Klionsky D.J.
      J. Cell Biol. 151:1025-1034(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Tor-mediated induction of autophagy via an Apg1 protein kinase complex."
      Kamada Y., Funakoshi T., Shintani T., Nagano K., Ohsumi M., Ohsumi Y.
      J. Cell Biol. 150:1507-1513(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION, INTERACTION WITH ATG1.
    8. "Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p."
      Wang Z., Wilson W.A., Fujino M.A., Roach P.J.
      Mol. Cell. Biol. 21:5742-5752(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. Cited for: NOMENCLATURE.
    10. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    11. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    12. "The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure."
      Reggiori F., Tucker K.A., Stromhaug P.E., Klionsky D.J.
      Dev. Cell 6:79-90(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy."
      Kabeya Y., Kamada Y., Baba M., Takikawa H., Sasaki M., Ohsumi Y.
      Mol. Biol. Cell 16:2544-2553(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ATG1 AND ATG17.
    14. Cited for: INTERACTION WITH ATG1 AND ATG17.
    15. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
      Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
      Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: YAL6B.
    16. "A cycling protein complex required for selective autophagy."
      Legakis J.E., Yen W.L., Klionsky D.J.
      Autophagy 3:422-432(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    17. "Hierarchy of Atg proteins in pre-autophagosomal structure organization."
      Suzuki K., Kubota Y., Sekito T., Ohsumi Y.
      Genes Cells 12:209-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION.
    18. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355 AND SER-360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    19. "Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae."
      Yorimitsu T., Zaman S., Broach J.R., Klionsky D.J.
      Mol. Biol. Cell 18:4180-4189(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION.
    20. "The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae."
      Cheong H., Nair U., Geng J., Klionsky D.J.
      Mol. Biol. Cell 19:668-681(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    21. "Organization of the pre-autophagosomal structure responsible for autophagosome formation."
      Kawamata T., Kamada Y., Kabeya Y., Sekito T., Ohsumi Y.
      Mol. Biol. Cell 19:2039-2050(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE ATG1-ATG13 COMPLEX.
    22. "Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy."
      He C., Baba M., Cao Y., Klionsky D.J.
      Mol. Biol. Cell 19:5506-5516(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATG1.
    23. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355; SER-461; SER-554 AND SER-649, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    24. "Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae."
      Kabeya Y., Noda N.N., Fujioka Y., Suzuki K., Inagaki F., Ohsumi Y.
      Biochem. Biophys. Res. Commun. 389:612-615(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH THE ATG17-ATG29-ATG31 COMPLEX.
    25. "The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy."
      Stephan J.S., Yeh Y.Y., Ramachandran V., Deminoff S.J., Herman P.K.
      Proc. Natl. Acad. Sci. U.S.A. 106:17049-17054(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-344; SER-437 AND SER-581 BY PKA, MUTAGENESIS OF SER-344; SER-437 AND SER-581, FUNCTION, INTERACTION WITH ATG17.
    26. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355; SER-461 AND SER-649, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    27. "Induction of autophagic flux by amino acid deprivation is distinct from nitrogen starvation-induced macroautophagy."
      Ecker N., Mor A., Journo D., Abeliovich H.
      Autophagy 6:879-890(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    28. "Activation of Atg1 kinase in autophagy by regulated phosphorylation."
      Kijanska M., Dohnal I., Reiter W., Kaspar S., Stoffel I., Ammerer G., Kraft C., Peter M.
      Autophagy 6:1168-1178(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATG1.
    29. "Autophosphorylation within the Atg1 activation loop is required for both kinase activity and the induction of autophagy in Saccharomyces cerevisiae."
      Yeh Y.Y., Wrasman K., Herman P.K.
      Genetics 185:871-882(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ATG1.
    30. "An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis."
      Mari M., Griffith J., Rieter E., Krishnappa L., Klionsky D.J., Reggiori F.
      J. Cell Biol. 190:1005-1022(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    31. "Tor directly controls the Atg1 kinase complex to regulate autophagy."
      Kamada Y., Yoshino K., Kondo C., Kawamata T., Oshiro N., Yonezawa K., Ohsumi Y.
      Mol. Cell. Biol. 30:1049-1058(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-348; SER-437; SER-438; SER-496; SER-535; SER-541; SER-646 AND SER-649, MUTAGENESIS OF SER-348; SER-437; SER-438; SER-496; SER-535; SER-541; SER-646 AND SER-649, FUNCTION.
    32. "Bidirectional regulation between TORC1 and autophagy in Saccharomyces cerevisiae."
      Shin C.S., Huh W.K.
      Autophagy 7:854-862(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY ATG1.
    33. "Mitochondria regulate autophagy by conserved signalling pathways."
      Graef M., Nunnari J.
      EMBO J. 30:2101-2114(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION OF THE ATG1-ATG13 COMPLEX.
    34. "Antagonistic interactions between the cAMP-dependent protein kinase and Tor signaling pathways modulate cell growth in Saccharomyces cerevisiae."
      Ramachandran V., Herman P.K.
      Genetics 187:441-454(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION.
    35. "An Atg13 protein-mediated self-association of the Atg1 protein kinase is important for the induction of autophagy."
      Yeh Y.Y., Shah K.H., Herman P.K.
      J. Biol. Chem. 286:28931-28939(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ATG1.
    36. "Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation."
      Wu X., Tu B.P.
      Mol. Biol. Cell 22:4124-4133(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION.
    37. "Architecture of the Atg17 complex as a scaffold for autophagosome biogenesis."
      Ragusa M.J., Stanley R.E., Hurley J.H.
      Cell 151:1501-1512(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH THE ATG17-ATG29-ATG31 COMPLEX.
    38. Cited for: INTERACTION WITH ATG1, MUTAGENESIS OF PHE-468 AND VAL-469, FUNCTION.
    39. "Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway."
      Umekawa M., Klionsky D.J.
      J. Biol. Chem. 287:16300-16310(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION BY TORC1 COMPLEX.
    40. "The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation."
      Nakatogawa H., Ohbayashi S., Sakoh-Nakatogawa M., Kakuta S., Suzuki S.W., Kirisako H., Kondo-Kakuta C., Noda N.N., Yamamoto H., Ohsumi Y.
      J. Biol. Chem. 287:28503-28507(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ATG1.
    41. "The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling."
      Lisa-Santamaria P., Jimenez A., Revuelta J.L.
      J. Biol. Chem. 287:29636-29647(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION.
    42. "Transient sequestration of TORC1 into stress granules during heat stress."
      Takahara T., Maeda T.
      Mol. Cell 47:242-252(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.

    Entry informationi

    Entry nameiATG13_YEAST
    AccessioniPrimary (citable) accession number: Q06628
    Secondary accession number(s): D6W4I5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 149 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3