Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q06623 (HDA3_YEAST)

Last modified June 16, 2009. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    HDA1 complex subunit 3
Alternative name(s):
    Histone deacetylase complex 1 subunit 3
Gene names
Name: HDA3
Synonyms: PLO1
Ordered Locus Names: YPR179C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length655 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Required for activity of HDA1 histone deacetylase complex. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Ref.2 Ref.3

Subunit structure

Heterodimer with HDA2. Component of the HDA1 histone deacetylase complex composed of at least one HDA1 homodimer and one HDA2/HDA3 heterodimer. Interacts with HDA1 and HDA3. Ref.3

Subcellular location

Nucleus. Ref.4

Miscellaneous

Present with 1100 molecules/cell in log phase SD medium. Ref.5

Sequence similarities

Belongs to the HDA2/3 family. HDA3 subfamily.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TUP1P166491EBI-38663,EBI-19654
YCL021W-AQ96VH31EBI-38663,EBI-2044941

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 655655HDA1 complex subunit 3
PRO_0000083932

Regions

Coiled coil482 – 632151 Potential

Sequences

Sequence LengthMass (Da)Tools
Q06623-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CC8F8F73D6B78E45

FASTA65575,463
        10         20         30         40         50         60 
MDLLRILDTK PIPTIVDATT LGISGNTSGD YWLPTTMSLY QKELTDQIVS LHYSDILRYF 

        70         80         90        100        110        120 
ETSHYKEDVI LESMKTMCLN GSLVATHPYL LIDHYMPKSL ITRDVPAHLA ENSGKFSVLR 

       130        140        150        160        170        180 
DLINLVQEYE TETAIVCRPG RTMDLLEALL LGNKVHIKRY DGHSIKSKQK ANDFSCTVHL 

       190        200        210        220        230        240 
FSSEGINFTK YPIKSKARFD MLICLDTTVD TSQKDIQYLL QYKRERKGLE RYAPIVRLVA 

       250        260        270        280        290        300 
INSIDHCRLF FGKKFDKNSR EYLENVTAAM VILRDRLGTL PPDLRPIYSQ KLHYLVEWLE 

       310        320        330        340        350        360 
NPTVPWPLPD IYPLKQYTSM DVERSLLTEV HFKKSDDQLE DAFSNCSKKR GRHGANKAAS 

       370        380        390        400        410        420 
STVAGIEDNI TPSFYSTKRL KNDYYTNPLK QDMTQLTGIT TADNSSNVNY HLSSGIITHK 

       430        440        450        460        470        480 
LIQSMGEVYM DICVQKQELD DYSCLDDLQN DHLKFFSNED EKIIKEYETV LRTNNENLNR 

       490        500        510        520        530        540 
SHELEVENNL KFSQIETLEK DIETLKGSLM AQGETLSKLK DAFVKTDNVQ DEIEKEERVS 

       550        560        570        580        590        600 
VSRDTEKKYM EQEIKRAVDA IRENEEETHK LNEKQNGLES ELKLKFEKSE ISTKELNEKI 

       610        620        630        640        650 
GFLKKELKLE NDLNEELVGQ LSKTMDNLEN LTIPRVRTQN GNTKKKSRAK KPGNV 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed: 9169875] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex."
Carmen A.A., Rundlett S.E., Grunstein M.
J. Biol. Chem. 271:15837-15844(1996) [PubMed: 8663039] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE HDA1 HISTONE DEACETYLASE COMPLEX.
[3]"HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1."
Wu J., Carmen A.A., Kobayashi R., Suka N., Grunstein M.
Proc. Natl. Acad. Sci. U.S.A. 98:4391-4396(2001) [PubMed: 11287668] [Abstract]
Cited for: FUNCTION, INTERACTION WITH HDA1 AND HDA3.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

U25842 Genomic DNA. Translation: AAB68112.1.
PIRS59836.
RefSeqNP_015505.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:4636N.
IntActQ06623. 13 interactions.

Proteomic databases

PeptideAtlasQ06623.

Genome annotation databases

EnsemblYPR179C. Saccharomyces cerevisiae. [Contig view]
GeneID856309.
GenomeReviewsGene locus YPR179C in contig U00094_GR.
KEGGsce:YPR179C.
NMPDRfig|4932.3.peg.6654.

Organism-specific databases

CYGDYPR179c.
SGDS000006383. HDA3.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMQ06623.
OMAQ06623. YQKELTD.

Gene expression databases

ArrayExpressQ06623.
GermOnlineYPR179C. Saccharomyces cerevisiae.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio981679.

Entry information

Entry nameHDA3_YEAST
AccessionPrimary (citable) accession number: Q06623
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents