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Q06623 (HDA3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
HDA1 complex subunit 3
Alternative name(s):
Histone deacetylase complex 1 subunit 3
Gene names
Name:HDA3
Synonyms:PLO1
Ordered Locus Names:YPR179C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length655 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for activity of HDA1 histone deacetylase complex. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Ref.3 Ref.4

Subunit structure

Heterodimer with HDA2. Component of the HDA1 histone deacetylase complex composed of at least one HDA1 homodimer and one HDA2/HDA3 heterodimer. Interacts with HDA1 and HDA3. Ref.4

Subcellular location

Nucleus Ref.5.

Miscellaneous

Present with 1100 molecules/cell in log phase SD medium. Ref.6

Sequence similarities

Belongs to the HDA2/3 family. HDA3 subfamily.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HDA1P539737EBI-38663,EBI-8206
HDA2Q066295EBI-38663,EBI-32800

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 655655HDA1 complex subunit 3
PRO_0000083932

Regions

Coiled coil482 – 632151 Potential

Secondary structure

............................................... 655
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q06623 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CC8F8F73D6B78E45

FASTA65575,463
        10         20         30         40         50         60 
MDLLRILDTK PIPTIVDATT LGISGNTSGD YWLPTTMSLY QKELTDQIVS LHYSDILRYF 

        70         80         90        100        110        120 
ETSHYKEDVI LESMKTMCLN GSLVATHPYL LIDHYMPKSL ITRDVPAHLA ENSGKFSVLR 

       130        140        150        160        170        180 
DLINLVQEYE TETAIVCRPG RTMDLLEALL LGNKVHIKRY DGHSIKSKQK ANDFSCTVHL 

       190        200        210        220        230        240 
FSSEGINFTK YPIKSKARFD MLICLDTTVD TSQKDIQYLL QYKRERKGLE RYAPIVRLVA 

       250        260        270        280        290        300 
INSIDHCRLF FGKKFDKNSR EYLENVTAAM VILRDRLGTL PPDLRPIYSQ KLHYLVEWLE 

       310        320        330        340        350        360 
NPTVPWPLPD IYPLKQYTSM DVERSLLTEV HFKKSDDQLE DAFSNCSKKR GRHGANKAAS 

       370        380        390        400        410        420 
STVAGIEDNI TPSFYSTKRL KNDYYTNPLK QDMTQLTGIT TADNSSNVNY HLSSGIITHK 

       430        440        450        460        470        480 
LIQSMGEVYM DICVQKQELD DYSCLDDLQN DHLKFFSNED EKIIKEYETV LRTNNENLNR 

       490        500        510        520        530        540 
SHELEVENNL KFSQIETLEK DIETLKGSLM AQGETLSKLK DAFVKTDNVQ DEIEKEERVS 

       550        560        570        580        590        600 
VSRDTEKKYM EQEIKRAVDA IRENEEETHK LNEKQNGLES ELKLKFEKSE ISTKELNEKI 

       610        620        630        640        650 
GFLKKELKLE NDLNEELVGQ LSKTMDNLEN LTIPRVRTQN GNTKKKSRAK KPGNV 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed: 9169875] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex."
Carmen A.A., Rundlett S.E., Grunstein M.
J. Biol. Chem. 271:15837-15844(1996) [PubMed: 8663039] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE HDA1 HISTONE DEACETYLASE COMPLEX.
[4]"HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1."
Wu J., Carmen A.A., Kobayashi R., Suka N., Grunstein M.
Proc. Natl. Acad. Sci. U.S.A. 98:4391-4396(2001) [PubMed: 11287668] [Abstract]
Cited for: FUNCTION, INTERACTION WITH HDA1 AND HDA3.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U25842 Genomic DNA. Translation: AAB68112.1.
BK006949 Genomic DNA. Translation: DAA11595.1.
PIRS59836.
RefSeqNP_015505.1. NM_001184276.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3HGQX-ray3.00A/B/C/D6-333[»]
3HGTX-ray2.20A/B6-333[»]
ProteinModelPortalQ06623.
SMRQ06623. Positions 27-331.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4636N.
IntActQ06623. 7 interactions.
MINTMINT-563224.
STRINGQ06623.

Proteomic databases

PeptideAtlasQ06623.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPR179C; YPR179C; YPR179C.
GeneID856309.
KEGGsce:YPR179C.
NMPDRfig|4932.3.peg.6654.

Organism-specific databases

CYGDYPR179c.
SGDS000006383. HDA3.

Phylogenomic databases

eggNOGfuNOG04208.
GeneTreeEFGT00050000001913.
HOGENOMHBG204014.
OMAYQKELTD.
OrthoDBEOG418FX1.

Gene expression databases

ArrayExpressQ06623.
GenevestigatorQ06623.
GermOnlineYPR179C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR021006. HDA_complex_subunit-2/3.
[Graphical view]
PfamPF11496. HDA2-3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio981679.

Entry information

Entry nameHDA3_YEAST
AccessionPrimary (citable) accession number: Q06623
Secondary accession number(s): D6W4H9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: November 1, 1996
Last modified: December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families