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Protein

Homeobox protein notochord

Gene

noto

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Plays a fundamental role in notochord formation, acting within the mesodermal region.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi138 – 19760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • notochord formation Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein notochord
Short name:
Xnot
Gene namesi
Name:noto
Synonyms:not
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865187. not.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Homeobox protein notochordPRO_0000274813Add
BLAST

Expressioni

Tissue specificityi

Expressed throughout the embryo during pre-gastrula stages. Localized to the dorsal lip of the blastopore (Spemann organizer) during early gastrulation, after which expression continues in tissues derived from the organizer. Expressed in the notochord during mid-gastrulation. During neurulation, expressed in the notochord, archenteron roof and the prospective floor plate. Also expressed in the region that will become the epiphysis, the pineal body precursor. By the early tailbud stages, expression is limited to posterior notochord and floor plate before becoming restricted to the tip of the tail in the tadpole.1 Publication

Developmental stagei

Expressed both maternally and zygotically. Expression increases markedly at the mid-blastula transition (MBT) and peaks at the onset of gastrulation before declining rapidly during the gastrula stages. Another decrease in expression levels occurs towards the end of the neurula stages, although expression is retained into the late tailbud stages.1 Publication

Inductioni

By activin, derriere, fgf2/bFGF and wnt8. Repressed by bmp4/dvr-4.2 Publications

Structurei

3D structure databases

ProteinModelPortaliQ06615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG082047.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHSPVFPAF GHHLAQHPAM PLAMELPRTP KASFNIDSIL SRTDRPASKL
60 70 80 90 100
SMEMPSWQPP SPPSMPYRYS YGMMPYPPVW LIKPTVGYPN MAQQQPMRMP
110 120 130 140 150
RGECLCPDPT CKERVLPFSH CPNGAMNPLS WRTGPCKMKR IRTVFTPEQL
160 170 180 190 200
EKLEKEFLKQ QYMVGTERVD LASTLNLTET QVKVWFQNRR IKWRKQSLEQ
210 220 230
KKAKLSQFGV IPADSSDHTD DSRETEEDED DLDVEL
Length:236
Mass (Da):27,215
Last modified:November 1, 1996 - v1
Checksum:i538FF7C9FD87CAD3
GO

Sequence cautioni

The sequence AAI23238 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19577 mRNA. Translation: CAA79629.1.
BC123237 mRNA. Translation: AAI23238.1. Different initiation.
PIRiA46305.
RefSeqiNP_001081625.1. NM_001088156.1.
UniGeneiXl.35.

Genome annotation databases

GeneIDi397961.
KEGGixla:397961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19577 mRNA. Translation: CAA79629.1.
BC123237 mRNA. Translation: AAI23238.1. Different initiation.
PIRiA46305.
RefSeqiNP_001081625.1. NM_001088156.1.
UniGeneiXl.35.

3D structure databases

ProteinModelPortaliQ06615.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397961.
KEGGixla:397961.

Organism-specific databases

CTDi397961.
XenbaseiXB-GENE-865187. not.

Phylogenomic databases

HOVERGENiHBG082047.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOTO_XENLA
AccessioniPrimary (citable) accession number: Q06615
Secondary accession number(s): Q0IHA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.