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Q06604

- BSP1_YEAST

UniProt

Q06604 - BSP1_YEAST

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Protein
Protein BSP1
Gene
BSP1, YPR171W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cortical patch protein involved in endocytosis. May serve as an adapter to link INP52 and INP53 to the cortical actin cytoskeleton.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein binding, bridging Source: SGD

GO - Biological processi

  1. actin cortical patch localization Source: SGD
  2. endocytosis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Enzyme and pathway databases

BioCyciYEAST:G3O-34298-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BSP1
Alternative name(s):
Binding of synaptojanin polyphosphoinositide phosphatase domain protein 1
Gene namesi
Name:BSP1
Ordered Locus Names:YPR171W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR171w.
SGDiS000006375. BSP1.

Subcellular locationi

Cell membrane; Peripheral membrane protein. Cytoplasmcytoskeletonactin patch
Note: Peripheral membrane protein in a PtdIns4P and PtdIns(4,5)P2 manner.3 Publications

GO - Cellular componenti

  1. actin cortical patch Source: SGD
  2. cellular bud neck Source: SGD
  3. cellular bud tip Source: SGD
  4. membrane Source: SGD
  5. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Protein BSP1
PRO_0000228137Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461Phosphoserine1 Publication
Modified residuei79 – 791Phosphoserine1 Publication
Modified residuei88 – 881Phosphoserine1 Publication
Modified residuei185 – 1851Phosphoserine1 Publication
Modified residuei220 – 2201Phosphoserine1 Publication
Modified residuei309 – 3091Phosphoserine1 Publication
Modified residuei320 – 3201Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by CDC28.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06604.
PaxDbiQ06604.

Expressioni

Gene expression databases

GenevestigatoriQ06604.

Interactioni

Subunit structurei

Interacts with CAP1, RVS167, SLA1, INP52 and INP53. The INP52 and INP53 C-terminal Sac1 domains are required for the binding with BSP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABP1P158912EBI-37047,EBI-2036
INP52P509424EBI-37047,EBI-28834
LSB3P436037EBI-37047,EBI-22980
RVS167P397435EBI-37047,EBI-14500
SDC25P0CF342EBI-37047,EBI-6315249
SLA1P327906EBI-37047,EBI-17313
YSC84P327936EBI-37047,EBI-24460

Protein-protein interaction databases

BioGridi36344. 69 interactions.
DIPiDIP-2756N.
IntActiQ06604. 21 interactions.
MINTiMINT-547483.
STRINGi4932.YPR171W.

Structurei

3D structure databases

ProteinModelPortaliQ06604.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG12793.
OMAiTRRISKF.
OrthoDBiEOG7FFN3X.

Sequencei

Sequence statusi: Complete.

Q06604-1 [UniParc]FASTAAdd to Basket

« Hide

MTKYERDPEL VNFLSKVEDL NSKRYSNIPS SKPAGEALSP VRSHNSGEYR    50
RADMMTGKNV EGCDNLAYRS AYNYEMTFSP KKTHYSLSEL NLERITPRPD 100
LEGSASQKEK KFLISEEDYL LLQKLKASQT YNDSNADKNL PSFEKGPRMP 150
SRGRPRPREK EIITIQYDFE LPGRADIPSS SSSSSPPPLP TRRDHIKITD 200
GNEEKPLLPT RPNKAEVTES PSSRSIKPDA VVPERVKPAP PVSRSTKPAS 250
FLSSLEDNKL TKAKSYNSEM ETPKTTVKSS HIDYLDSIQL KPTTLSPTMK 300
NKPKPTPPSP PAKRIPRSES FIKSMLNSNL TTTSKPSLPE KPQKLRNANL 350
AAHKTKPSIP PKKVELNIVL PELRPVETSP TKQNFENSID LPKLRSSNRN 400
IKKEEEDSIP EAIKGIQNLK KTKQQKPAIP QKKSFLTNNS KNTTLKNGDD 450
INKLNDEIEA LSLRNNLKKR PPTAPQRKIS LPEALRKVEL MKKSKTEPVL 500
ESSNELSINA KLDAIIASRN LRASNTLPEL SGVNTNIATS DKYTTSRDET 550
VKETKPLVHP NKNRTRGPRR KLPTRV 576
Length:576
Mass (Da):64,666
Last modified:November 1, 1996 - v1
Checksum:i7A33A775FCA1F3CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25842 Genomic DNA. Translation: AAB68105.1.
BK006949 Genomic DNA. Translation: DAA11588.1.
PIRiS59829.
RefSeqiNP_015497.1. NM_001184268.1.

Genome annotation databases

EnsemblFungiiYPR171W; YPR171W; YPR171W.
GeneIDi856301.
KEGGisce:YPR171W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25842 Genomic DNA. Translation: AAB68105.1 .
BK006949 Genomic DNA. Translation: DAA11588.1 .
PIRi S59829.
RefSeqi NP_015497.1. NM_001184268.1.

3D structure databases

ProteinModelPortali Q06604.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36344. 69 interactions.
DIPi DIP-2756N.
IntActi Q06604. 21 interactions.
MINTi MINT-547483.
STRINGi 4932.YPR171W.

Proteomic databases

MaxQBi Q06604.
PaxDbi Q06604.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR171W ; YPR171W ; YPR171W .
GeneIDi 856301.
KEGGi sce:YPR171W.

Organism-specific databases

CYGDi YPR171w.
SGDi S000006375. BSP1.

Phylogenomic databases

eggNOGi NOG12793.
OMAi TRRISKF.
OrthoDBi EOG7FFN3X.

Enzyme and pathway databases

BioCyci YEAST:G3O-34298-MONOMER.

Miscellaneous databases

NextBioi 981658.

Gene expression databases

Genevestigatori Q06604.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: INTERACTION WITH CAP1; RVS167 AND SLA1, SUBCELLULAR LOCATION.
  4. "Bsp1p/Ypr171p is an adapter that directly links some synaptojanin family members to the cortical actin cytoskeleton in yeast."
    Wicky S., Frischmuth S., Singer-Krueger B.
    FEBS Lett. 537:35-41(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH INP52 AND INP53, SUBCELLULAR LOCATION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: PHOSPHORYLATION BY CDC28.
  8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  9. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-309 AND SER-320, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79; SER-88 AND SER-185, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBSP1_YEAST
AccessioniPrimary (citable) accession number: Q06604
Secondary accession number(s): D6W4H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 704 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

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