ID   ACR3_YEAST              Reviewed;         404 AA.
AC   Q06598;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 68.
DE   RecName: Full=Arsenical-resistance protein ACR3;
GN   Name=ACR3; Synonyms=ARR3; OrderedLocusNames=YPR201W; ORFNames=P9677.2;
OS   Saccharomyces cerevisiae (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=97377989; PubMed=9234670;
RX   DOI=10.1002/(SICI)1097-0061(199707)13:9<819::AID-YEA142>3.0.CO;2-Y;
RA   Bobrowicz P., Wysocki R., Owsianik G., Goffeau A., Ulaszewski S.;
RT   "Isolation of three contiguous genes, ACR1, ACR2 and ACR3, involved in
RT   resistance to arsenic compounds in the yeast Saccharomyces
RT   cerevisiae.";
RL   Yeast 13:819-828(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204511 / S288c / AB972;
RX   MEDLINE=97313271; PubMed=9169875;
RA   Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA   Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V.,
RA   Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M.,
RA   Chung E., Churcher C.M., Coster F., Davis K., Davis R.W.,
RA   Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A.,
RA   Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A.,
RA   Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W.,
RA   Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K.,
RA   Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J.,
RA   Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D.,
RA   Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA   Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA   Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA   Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA   Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V.,
RA   Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W.,
RA   Zollner A., Vo D.H., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL   Nature 387:103-105(1997).
CC   -!- FUNCTION: Involved in resistance to arsenic compounds.
CC   -!- INTERACTION:
CC       P02829:HSP82; NbExp=1; IntAct=EBI-2122, EBI-8659;
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the ACR3 family.
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DR   EMBL; U25841; AAB64629.1; -; Genomic_DNA.
DR   PIR; S58830; S58830.
DR   RefSeq; NP_015527.1; -.
DR   DIP; DIP:3797N; -.
DR   IntAct; Q06598; 3.
DR   TCDB; 2.A.59.1.1; arsenical resistance-3 (ACR3) family.
DR   Ensembl; YPR201W; Saccharomyces cerevisiae.
DR   GeneID; 856331; -.
DR   GenomeReviews; U00094_GR; YPR201W.
DR   KEGG; sce:YPR201W; -.
DR   NMPDR; fig|4932.3.peg.6676; -.
DR   CYGD; YPR201w; -.
DR   SGD; S000006405; ARR3.
DR   HOGENOM; Q06598; -.
DR   OMA; Q06598; SVYAYVF.
DR   NextBio; 981739; -.
DR   ArrayExpress; Q06598; -.
DR   GermOnline; YPR201W; Saccharomyces cerevisiae.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015105; F:arsenite transmembrane transporter activity; IGI:SGD.
DR   GO; GO:0008508; F:bile acid:sodium symporter activity; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0015700; P:arsenite transport; IGI:SGD.
DR   GO; GO:0046685; P:response to arsenic; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   InterPro; IPR004706; Arsenical-R_Acr3.
DR   InterPro; IPR002657; BilAc/Na_symport.
DR   PANTHER; PTHR10361; BilAc/Na_symport; 1.
DR   Pfam; PF01758; SBF; 1.
DR   PIRSF; PIRSF005508; Acr3; 1.
DR   TIGRFAMs; TIGR00832; acr3; 1.
PE   1: Evidence at protein level;
KW   Arsenical resistance; Complete proteome; Membrane; Transmembrane;
KW   Transport.
FT   CHAIN         1    404       Arsenical-resistance protein ACR3.
FT                                /FTId=PRO_0000064440.
FT   TRANSMEM     35     55       Potential.
FT   TRANSMEM     70     90       Potential.
FT   TRANSMEM    114    134       Potential.
FT   TRANSMEM    142    162       Potential.
FT   TRANSMEM    170    190       Potential.
FT   TRANSMEM    217    237       Potential.
FT   TRANSMEM    247    267       Potential.
FT   TRANSMEM    281    301       Potential.
FT   TRANSMEM    344    364       Potential.
FT   TRANSMEM    370    390       Potential.
SQ   SEQUENCE   404 AA;  45848 MW;  1BE290E26772B4CA CRC64;
     MSEDQKSENS VPSKVNMVNR TDILTTIKSL SWLDLMLPFT IILSIIIAVI ISVYVPSSRH
     TFDAEGHPNL MGVSIPLTVG MIVMMIPPIC KVSWESIHKY FYRSYIRKQL ALSLFLNWVI
     GPLLMTALAW MALFDYKEYR QGIIMIGVAR CIAMVLIWNQ IAGGDNDLCV VLVITNSLLQ
     MVLYAPLQIF YCYVISHDHL NTSNRVLFEE VAKSVGVFLG IPLGIGIIIR LGSLTIAGKS
     NYEKYILRFI SPWAMIGFHY TLFVIFISRG YQFIHEIGSA ILCFVPLVLY FFIAWFLTFA
     LMRYLSISRS DTQRECSCDQ ELLLKRVWGR KSCEASFSIT MTQCFTMASN NFELSLAIAI
     SLYGNNSKQA IAATFGPLLE VPILLILAIV ARILKPYYIW NNRN
//