Q06598 (ARR3_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 29, 2013.
Version 102.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Arsenical-resistance protein 3 | ||||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome] | ||||||||
| Taxonomic identifier | 559292 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › ![]() |
Protein attributes
| Sequence length | 404 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Involved in resistance to arsenic compounds. Ref.1 |
| Subcellular location | Membrane; Multi-pass membrane protein Potential. |
| Sequence similarities | Belongs to the ACR3 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Arsenical resistance Transport |
| Cellular component | Membrane |
| Domain | Transmembrane Transmembrane helix |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | arsenite transport Inferred from genetic interaction PubMed 9374482. Source: SGD response to arsenic-containing substanceInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD plasma membraneInferred from direct assay PubMed 20655873. Source: SGD |
| Molecular_function | antimonite transmembrane transporter activity Inferred from mutant phenotype PubMed 20655873. Source: SGD antiporter activityInferred from mutant phenotype PubMed 21447319. Source: SGD arsenite transmembrane transporter activityInferred from genetic interaction PubMed 9374482. Source: SGD bile acid:sodium symporter activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| HSP82 | P02829 | 2 | EBI-2122,EBI-8659 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 404 | 404 | Arsenical-resistance protein 3 | PRO_0000064440 | |||||
Regions | |||||||||
| Transmembrane | 35 – 55 | 21 | Helical; Potential | ||||||
| Transmembrane | 70 – 90 | 21 | Helical; Potential | ||||||
| Transmembrane | 114 – 134 | 21 | Helical; Potential | ||||||
| Transmembrane | 142 – 162 | 21 | Helical; Potential | ||||||
| Transmembrane | 170 – 190 | 21 | Helical; Potential | ||||||
| Transmembrane | 217 – 237 | 21 | Helical; Potential | ||||||
| Transmembrane | 247 – 267 | 21 | Helical; Potential | ||||||
| Transmembrane | 281 – 301 | 21 | Helical; Potential | ||||||
| Transmembrane | 344 – 364 | 21 | Helical; Potential | ||||||
| Transmembrane | 370 – 390 | 21 | Helical; Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation of three contiguous genes, ACR1, ACR2 and ACR3, involved in resistance to arsenic compounds in the yeast Saccharomyces cerevisiae." Bobrowicz P., Wysocki R., Owsianik G., Goffeau A., Ulaszewski S. Yeast 13:819-828(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. |
| [2] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. Hani J.Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972. |
| [3] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U25841 Genomic DNA. Translation: AAB64629.1. BK006949 Genomic DNA. Translation: DAA11615.1. |
| PIR | S58830. |
| RefSeq | NP_015527.1. NM_001184298.1. |
3D structure databases | |
| ProteinModelPortal | Q06598. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-3797N. |
| IntAct | Q06598. 2 interactions. |
| MINT | MINT-560243. |
| STRING | 4932.YPR201W. |
Protein family/group databases | |
| TCDB | 2.A.59.1.1. arsenical resistance-3 (ACR3) family. |
Proteomic databases | |
| PaxDb | Q06598. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YPR201W; YPR201W; YPR201W. |
| GeneID | 856331. |
| KEGG | sce:YPR201W. |
Organism-specific databases | |
| CYGD | YPR201w. |
| SGD | S000006405. ARR3. |
Phylogenomic databases | |
| eggNOG | COG0798. |
| KO | K03325. |
| OMA | YPEYMVG. |
| OrthoDB | EOG4NKG4T. |
Enzyme and pathway databases | |
| BioCyc | YEAST:G3O-34321-MONOMER. |
Gene expression databases | |
| Genevestigator | Q06598. |
| GermOnline | YPR201W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR004706. Arsenical-R_Acr3. IPR002657. BilAc/Na_symport. [Graphical view] |
| PANTHER | PTHR10361. PTHR10361. 1 hit. |
| Pfam | PF01758. SBF. 1 hit. [Graphical view] |
| PIRSF | PIRSF005508. Acr3. 1 hit. |
| TIGRFAMs | TIGR00832. acr3. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 981739. |
Entry information
| Entry name | ARR3_YEAST | ||||||||
| Accession | Primary (citable) accession number: Q06598 Secondary accession number(s): D6W4J9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XVI Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with
