Reviewed, UniProtKB/Swiss-Prot Q06598 (ACR3_YEAST)

Names and origin

Protein names

Recommended name:
    Arsenical-resistance protein ACR3

Gene names

Name:	ACR3
Synonyms:	ARR3
Ordered Locus Names:	YPR201W
ORF Names:	P9677.2

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in resistance to arsenic compounds.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ACR3 family.

Ontologies

Keywords
Biological process	Arsenical resistance Transport
Cellular component	Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arsenite transport Inferred from genetic interaction. Source: SGD response to arsenic Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arsenite transmembrane transporter activity Inferred from genetic interaction. Source: SGD bile acid:sodium symporter activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HSP82	P02829	1	EBI-2122,EBI-8659

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Arsenical-resistance protein ACR3		PRO_0000064440
Regions
	Transmembrane	35 – 55	21	Potential
	Transmembrane	70 – 90	21	Potential
	Transmembrane	114 – 134	21	Potential
	Transmembrane	142 – 162	21	Potential
	Transmembrane	170 – 190	21	Potential
	Transmembrane	217 – 237	21	Potential
	Transmembrane	247 – 267	21	Potential
	Transmembrane	281 – 301	21	Potential
	Transmembrane	344 – 364	21	Potential
	Transmembrane	370 – 390	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q06598-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1BE290E26772B4CA	FASTA	404	45,848
	10 20 30 40 50 60 MSEDQKSENS VPSKVNMVNR TDILTTIKSL SWLDLMLPFT IILSIIIAVI ISVYVPSSRH 70 80 90 100 110 120 TFDAEGHPNL MGVSIPLTVG MIVMMIPPIC KVSWESIHKY FYRSYIRKQL ALSLFLNWVI 130 140 150 160 170 180 GPLLMTALAW MALFDYKEYR QGIIMIGVAR CIAMVLIWNQ IAGGDNDLCV VLVITNSLLQ 190 200 210 220 230 240 MVLYAPLQIF YCYVISHDHL NTSNRVLFEE VAKSVGVFLG IPLGIGIIIR LGSLTIAGKS 250 260 270 280 290 300 NYEKYILRFI SPWAMIGFHY TLFVIFISRG YQFIHEIGSA ILCFVPLVLY FFIAWFLTFA 310 320 330 340 350 360 LMRYLSISRS DTQRECSCDQ ELLLKRVWGR KSCEASFSIT MTQCFTMASN NFELSLAIAI 370 380 390 400 SLYGNNSKQA IAATFGPLLE VPILLILAIV ARILKPYYIW NNRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of three contiguous genes, ACR1, ACR2 and ACR3, involved in resistance to arsenic compounds in the yeast Saccharomyces cerevisiae." Bobrowicz P., Wysocki R., Owsianik G., Goffeau A., Ulaszewski S. Yeast 13:819-828(1997) [PubMed: 9234670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J. Nature 387:103-105(1997) [PubMed: 9169875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U25841 Genomic DNA. Translation: AAB64629.1.
PIR	S58830.
RefSeq	NP_015527.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:3797N.
IntAct	Q06598. 3 interactions.
STRING	Q06598.
Protein family/group databases
TCDB	2.A.59.1.1. arsenical resistance-3 (ACR3) family.
Genome annotation databases
Ensembl	YPR201W; YPR201W; YPR201W; Saccharomyces cerevisiae. [Genome view]
GeneID	856331.
KEGG	sce:YPR201W.
NMPDR	fig|4932.3.peg.6676.
Organism-specific databases
CYGD	YPR201w.
SGD	S000006405. ARR3.
Phylogenomic databases
HOGENOM	Q06598.
OMA	SVYAYVF
OrthoDB	EOG937SX5
Gene expression databases
ArrayExpress	Q06598.
Genevestigator	Q06598.
GermOnline	YPR201W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR004706. Arsenical-R_Acr3. IPR002657. BilAc/Na_symport. [Graphical view]
PANTHER	PTHR10361. BilAc/Na_symport. 1 hit.
Pfam	PF01758. SBF. 1 hit. [Graphical view]
PIRSF	PIRSF005508. Acr3. 1 hit.
TIGRFAMs	TIGR00832. acr3. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	981739.

Entry information

Entry name

ACR3_YEAST

Accession

Primary (citable) accession number: Q06598

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 24, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)