ID   ACR2_YEAST              Reviewed;         130 AA.
AC   Q06597;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 66.
DE   RecName: Full=Arsenical-resistance protein ACR2;
GN   Name=ACR2; Synonyms=ARR2; OrderedLocusNames=YPR200C;
GN   ORFNames=P9677.16;
OS   Saccharomyces cerevisiae (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=97377989; PubMed=9234670;
RX   DOI=10.1002/(SICI)1097-0061(199707)13:9<819::AID-YEA142>3.0.CO;2-Y;
RA   Bobrowicz P., Wysocki R., Owsianik G., Goffeau A., Ulaszewski S.;
RT   "Isolation of three contiguous genes, ACR1, ACR2 and ACR3, involved in
RT   resistance to arsenic compounds in the yeast Saccharomyces
RT   cerevisiae.";
RL   Yeast 13:819-828(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204511 / S288c / AB972;
RX   MEDLINE=97313271; PubMed=9169875;
RA   Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA   Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V.,
RA   Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M.,
RA   Chung E., Churcher C.M., Coster F., Davis K., Davis R.W.,
RA   Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A.,
RA   Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A.,
RA   Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W.,
RA   Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K.,
RA   Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J.,
RA   Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D.,
RA   Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA   Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA   Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA   Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA   Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V.,
RA   Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W.,
RA   Zollner A., Vo D.H., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL   Nature 387:103-105(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
RA   Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
RA   Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
RA   Kolodner R.D., LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-
RT   encoding clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
CC   -!- FUNCTION: Involved in resistance to arsenic compounds.
CC   -!- INTERACTION:
CC       P22696:ESS1; NbExp=1; IntAct=EBI-2117, EBI-6679;
CC       P33203:PRP40; NbExp=1; IntAct=EBI-2117, EBI-701;
CC       P46995:SET2; NbExp=1; IntAct=EBI-2117, EBI-16985;
CC   -!- SIMILARITY: Contains 1 rhodanese domain.
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DR   EMBL; U25841; AAB64628.1; -; Genomic_DNA.
DR   EMBL; AY558053; AAS56379.1; -; Genomic_DNA.
DR   PIR; S58829; S58829.
DR   RefSeq; NP_015526.1; -.
DR   IntAct; Q06597; 3.
DR   Ensembl; YPR200C; Saccharomyces cerevisiae.
DR   GeneID; 856330; -.
DR   GenomeReviews; U00094_GR; YPR200C.
DR   KEGG; sce:YPR200C; -.
DR   NMPDR; fig|4932.3.peg.6675; -.
DR   CYGD; YPR200c; -.
DR   SGD; S000006404; ARR2.
DR   HOGENOM; Q06597; -.
DR   OMA; Q06597; ETHCRES.
DR   BioCyc; MetaCyc:MON-10864; -.
DR   NextBio; 981736; -.
DR   ArrayExpress; Q06597; -.
DR   GermOnline; YPR200C; Saccharomyces cerevisiae.
DR   GO; GO:0030611; F:arsenate reductase activity; IDA:SGD.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0046685; P:response to arsenic; TAS:SGD.
DR   InterPro; IPR001763; Rhodanese-like.
DR   Gene3D; G3DSA:3.40.250.10; Rhodanese-like; 1.
DR   SMART; SM00450; RHOD; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
PE   1: Evidence at protein level;
KW   Arsenical resistance; Complete proteome.
FT   CHAIN         1    130       Arsenical-resistance protein ACR2.
FT                                /FTId=PRO_0000064439.
FT   DOMAIN       17    124       Rhodanese.
SQ   SEQUENCE   130 AA;  14883 MW;  3B32697BD503330F CRC64;
     MVSFITSRQL KGLIENQRKD FQVVDLRRED FARDHITNAW HVPVTAQITE KQLNQLIKGL
     SDTFSSSQFV KVIFHCTGSK NRGPKVAAKF ETYLQEEDIT SKFESCILVG GFYAWETHCR
     ESNLKLIVSG
//