Reviewed, UniProtKB/Swiss-Prot Q06597 (ACR2_YEAST)

Names and origin

Protein names

Recommended name:
    Arsenical-resistance protein ACR2

Gene names

Name:	ACR2
Synonyms:	ARR2
Ordered Locus Names:	YPR200C
ORF Names:	P9677.16

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in resistance to arsenic compounds.
Sequence similarities	Contains 1 rhodanese domain.

Ontologies

Keywords
Biological process	Arsenical resistance
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	response to arsenic Traceable author statement. Source: SGD
Molecular function	arsenate reductase activity Inferred from direct assay. Source: SGD protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ESS1	P22696	1	EBI-2117,EBI-6679
PRP40	P33203	1	EBI-2117,EBI-701
SET2	P46995	1	EBI-2117,EBI-16985

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 130	130	Arsenical-resistance protein ACR2		PRO_0000064439
Regions
	Domain	17 – 124	108	Rhodanese

Sequences

	Sequence		Length	Mass (Da)
	Q06597-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3B32697BD503330F	FASTA	130	14,883
	10 20 30 40 50 60 MVSFITSRQL KGLIENQRKD FQVVDLRRED FARDHITNAW HVPVTAQITE KQLNQLIKGL 70 80 90 100 110 120 SDTFSSSQFV KVIFHCTGSK NRGPKVAAKF ETYLQEEDIT SKFESCILVG GFYAWETHCR 130 ESNLKLIVSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of three contiguous genes, ACR1, ACR2 and ACR3, involved in resistance to arsenic compounds in the yeast Saccharomyces cerevisiae." Bobrowicz P., Wysocki R., Owsianik G., Goffeau A., Ulaszewski S. Yeast 13:819-828(1997) [PubMed: 9234670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J. Nature 387:103-105(1997) [PubMed: 9169875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U25841 Genomic DNA. Translation: AAB64628.1. AY558053 Genomic DNA. Translation: AAS56379.1.
PIR	S58829.
RefSeq	NP_015526.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q06597. 3 interactions.
Genome annotation databases
Ensembl	YPR200C. Saccharomyces cerevisiae. [Contig view]
GeneID	856330.
GenomeReviews	Gene locus YPR200C in contig U00094_GR.
KEGG	sce:YPR200C.
NMPDR	fig|4932.3.peg.6675.
Organism-specific databases
CYGD	YPR200c.
SGD	S000006404. ARR2.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	Q06597.
OMA	Q06597. ETHCRES.
Enzyme and pathway databases
BioCyc	MetaCyc:MON-10864.
Gene expression databases
ArrayExpress	Q06597.
GermOnline	YPR200C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001763. Rhodanese-like. [Graphical view]
Gene3D	G3DSA:3.40.250.10. Rhodanese-like. 1 hit.
SMART	SM00450. RHOD. 1 hit. [Graphical view]
PROSITE	PS50206. RHODANESE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	981736.

Entry information

Entry name

ACR2_YEAST

Accession

Primary (citable) accession number: Q06597

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)