Q06597 (ARR2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arsenical-resistance protein 2

Gene names

Name:	ARR2
Synonyms:	ACR2
Ordered Locus Names:	YPR200C
ORF Names:	P9677.16

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in resistance to arsenic compounds. Ref.1
Sequence similarities	Contains 1 rhodanese domain.

Ontologies

Keywords
Biological process	Arsenical resistance
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to arsenic-containing substance Traceable author statement. Source: SGD
Molecular function	arsenate reductase activity Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 130	130	Arsenical-resistance protein 2		PRO_0000064439
Regions
	Domain	17 – 124	108	Rhodanese

Sequences

	Sequence		Length	Mass (Da)
	Q06597 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3B32697BD503330F	FASTA	130	14,883
	10 20 30 40 50 60 MVSFITSRQL KGLIENQRKD FQVVDLRRED FARDHITNAW HVPVTAQITE KQLNQLIKGL 70 80 90 100 110 120 SDTFSSSQFV KVIFHCTGSK NRGPKVAAKF ETYLQEEDIT SKFESCILVG GFYAWETHCR 130 ESNLKLIVSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of three contiguous genes, ACR1, ACR2 and ACR3, involved in resistance to arsenic compounds in the yeast Saccharomyces cerevisiae." Bobrowicz P., Wysocki R., Owsianik G., Goffeau A., Ulaszewski S. Yeast 13:819-828(1997) [PubMed: 9234670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J. Nature 387:103-105(1997) [PubMed: 9169875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U25841 Genomic DNA. Translation: AAB64628.1. AY558053 Genomic DNA. Translation: AAS56379.1. BK006949 Genomic DNA. Translation: DAA11614.1.
PIR	S58829.
RefSeq	NP_015526.1. NM_001184297.1.
3D structure databases
ProteinModelPortal	Q06597.
SMR	Q06597. Positions 2-128.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q06597. 3 interactions.
MINT	MINT-4084004.
STRING	Q06597.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YPR200C; YPR200C; YPR200C.
GeneID	856330.
KEGG	sce:YPR200C.
NMPDR	fig|4932.3.peg.6675.
Organism-specific databases
CYGD	YPR200c.
SGD	S000006404. ARR2.
Phylogenomic databases
eggNOG	fuNOG15563.
HOGENOM	HBG204019.
OMA	ETHCRES.
OrthoDB	EOG49GPS2.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-10864.
Gene expression databases
ArrayExpress	Q06597.
Genevestigator	Q06597.
GermOnline	YPR200C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001763. Rhodanese-like. [Graphical view]
Gene3D	G3DSA:3.40.250.10. Rhodanese-like. 1 hit.
Pfam	PF00581. Rhodanese. 1 hit. [Graphical view]
SMART	SM00450. RHOD. 1 hit. [Graphical view]
SUPFAM	SSF52821. Rhodanese-like. 1 hit.
PROSITE	PS50206. RHODANESE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	981736.

Entry information

Entry name

ARR2_YEAST

Accession

Primary (citable) accession number: Q06597
Secondary accession number(s): D6W4J8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program