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Q06593 (OPT2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oligopeptide transporter 2
Gene names
Name:OPT2
Ordered Locus Names:YPR194C
ORF Names:P9677.13
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length877 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transports tetra- and pentapeptides. Does not transport glutathione. Ref.3 Ref.4

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the oligopeptide OPT transporter family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ESS1P226961EBI-37672,EBI-6679
SET2P469951EBI-37672,EBI-16985

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 877877Oligopeptide transporter 2
PRO_0000262733

Regions

Topological domain1 – 167167Cytoplasmic Potential
Transmembrane168 – 18821Helical; Potential
Topological domain1891Extracellular Potential
Transmembrane190 – 21021Helical; Potential
Topological domain211 – 24030Cytoplasmic Potential
Transmembrane241 – 26121Helical; Potential
Topological domain262 – 27211Extracellular Potential
Transmembrane273 – 29321Helical; Potential
Topological domain294 – 33441Cytoplasmic Potential
Transmembrane335 – 35521Helical; Potential
Topological domain356 – 37419Extracellular Potential
Transmembrane375 – 39521Helical; Potential
Topological domain396 – 4049Cytoplasmic Potential
Transmembrane405 – 42521Helical; Potential
Topological domain426 – 48055Extracellular Potential
Transmembrane481 – 50121Helical; Potential
Topological domain502 – 55352Cytoplasmic Potential
Transmembrane554 – 57421Helical; Potential
Topological domain575 – 5828Extracellular Potential
Transmembrane583 – 60321Helical; Potential
Topological domain604 – 61411Cytoplasmic Potential
Transmembrane615 – 63521Helical; Potential
Topological domain636 – 67136Extracellular Potential
Transmembrane672 – 69221Helical; Potential
Topological domain693 – 73038Cytoplasmic Potential
Transmembrane731 – 75121Helical; Potential
Topological domain752 – 76615Extracellular Potential
Transmembrane767 – 78923Helical; Potential
Topological domain790 – 81122Cytoplasmic Potential
Transmembrane812 – 83221Helical; Potential
Topological domain833 – 87745Extracellular Potential

Amino acid modifications

Glycosylation3741N-linked (GlcNAc...) Potential
Glycosylation8601N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q06593 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 3524D342E7EE4B50

FASTA877101,261
        10         20         30         40         50         60 
MSETVKDKVI IDEKVSTKGT VDYAEGAEYS ERLSNHSSDF SQWYTDEQIL HFMKKLGYEN 

        70         80         90        100        110        120 
RTLYDIPEDV AYILKKMPEL TLEDSFKILK DSIIYFKDDE NIPHDQYEEW KRLVDLEDLD 

       130        140        150        160        170        180 
SKEGIDEYDS FDIRAFASAI KFHSPYQEVR AVVDPEDDPT IPVETFRAYF LAIIWSVIGS 

       190        200        210        220        230        240 
GFNEFFSHRV VSISLNTPII QMFLYICGKA WAKTIPCWTI TIRGRKYGIN IDKPWTQKEQ 

       250        260        270        280        290        300 
MFSTLLYAIC QGAFYTHYNI LTQKLFYHSA FSFGYQFLLS LSVQFIGFGF AGILRKFVVY 

       310        320        330        340        350        360 
PARALWPTVM PTIAINKALL GKEKHESGMS RYKFFFLTFF IMFIYNWFPT YIINILNTFN 

       370        380        390        400        410        420 
WMTWIKPSNI NLANITGGVT GLGINPISSF DWNVISFNSP LVYPFWSYLT QYLGCILAAL 

       430        440        450        460        470        480 
IVIAVYYSNY MSCQYLPIFT NSLYTNTGHS FKVTEVLDSD NKLDVKKYQS YSPPYYSAGN 

       490        500        510        520        530        540 
LVSYGAFICA YPLMITWSFI VHSKLLFNAF KDWALNLWAM RKLKSWVTMF KSDYRALDDY 

       550        560        570        580        590        600 
DDPHSNAMKN YKEVPDWWYF AILIGSLVVG IAVVEHYPTN TPVWGLFVCL GFNFVFLIPT 

       610        620        630        640        650        660 
TILQATTGYS FGLNLLIEMV MGYALPGNPI AIMILKAFGY NIDGQADNYV SNLKIAHYCK 

       670        680        690        700        710        720 
IPPMALFRGQ CVIVFIQIFV NLGVLNWQIS NIKDFCTPHQ NAKFTCPDAV TYYNASVVWG 

       730        740        750        760        770        780 
AIGPKRIFNY IYPIFKWCWL IGACIGIFFG VWKRWGKFYP RYFDPMLFVG GMLNMSPPYN 

       790        800        810        820        830        840 
LMYYTSGMIV SYISQYYMKR HHLNLWEKYN YVLSAGFSTG LVLSAIIIFF AVQYKDTAFN 

       850        860        870 
WWGNTVPYAG ADGVGYPLKN ITDTANGYFG YAPGHYP 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Schizosaccharomyces pombe isp4 encodes a transporter representing a novel family of oligopeptide transporters."
Lubkowitz M.A., Barnes D., Breslav M., Burchfield A., Naider F., Becker J.M.
Mol. Microbiol. 28:729-741(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae."
Bourbouloux A., Shahi P., Chakladar A., Delrot S., Bachhawat A.K.
J. Biol. Chem. 275:13259-13265(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U25841 Genomic DNA. Translation: AAB64623.1.
BK006949 Genomic DNA. Translation: DAA11610.1.
PIRS58824.
RefSeqNP_015520.1. NM_001184291.1.

3D structure databases

ProteinModelPortalQ06593.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36366. 19 interactions.
DIPDIP-5482N.
IntActQ06593. 2 interactions.
MINTMINT-564157.
STRING4932.YPR194C.

Protein family/group databases

TCDB2.A.67.1.4. the oligopeptide transporter (opt) family.
2.A.67.1.7. the oligopeptide transporter (opt) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPR194C; YPR194C; YPR194C.
GeneID856324.
KEGGsce:YPR194C.

Organism-specific databases

CYGDYPR194c.
SGDS000006398. OPT2.

Phylogenomic databases

eggNOGNOG327553.
GeneTreeENSGT00530000068053.
HOGENOMHOG000166970.
OMAFTIAINF.
OrthoDBEOG70KGZ1.

Enzyme and pathway databases

BioCycYEAST:G3O-34316-MONOMER.

Gene expression databases

GenevestigatorQ06593.

Family and domain databases

InterProIPR004648. Oligpept_transpt.
IPR004813. OPT.
[Graphical view]
PfamPF03169. OPT. 1 hit.
[Graphical view]
TIGRFAMsTIGR00727. ISP4_OPT. 1 hit.
TIGR00728. OPT_sfam. 1 hit.
ProtoNetSearch...

Other

NextBio981724.

Entry information

Entry nameOPT2_YEAST
AccessionPrimary (citable) accession number: Q06593
Secondary accession number(s): D6W4J4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families