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Q06593

- OPT2_YEAST

UniProt

Q06593 - OPT2_YEAST

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Protein

Oligopeptide transporter 2

Gene

OPT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Transports tetra- and pentapeptides. Does not transport glutathione.2 Publications

GO - Molecular functioni

  1. oligopeptide transporter activity Source: SGD

GO - Biological processi

  1. cell redox homeostasis Source: SGD
  2. oligopeptide transport Source: SGD
  3. protein transport Source: UniProtKB-KW
  4. transmembrane transport Source: InterPro
  5. vacuole fusion, non-autophagic Source: SGD
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34316-MONOMER.

Protein family/group databases

TCDBi2.A.67.1.4. the oligopeptide transporter (opt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Oligopeptide transporter 2
Gene namesi
Name:OPT2
Ordered Locus Names:YPR194C
ORF Names:P9677.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR194c.
SGDiS000006398. OPT2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 167167CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Topological domaini189 – 1891ExtracellularSequence Analysis
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Topological domaini211 – 24030CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST
Topological domaini262 – 27211ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321HelicalSequence AnalysisAdd
BLAST
Topological domaini294 – 33441CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei335 – 35521HelicalSequence AnalysisAdd
BLAST
Topological domaini356 – 37419ExtracellularSequence AnalysisAdd
BLAST
Transmembranei375 – 39521HelicalSequence AnalysisAdd
BLAST
Topological domaini396 – 4049CytoplasmicSequence Analysis
Transmembranei405 – 42521HelicalSequence AnalysisAdd
BLAST
Topological domaini426 – 48055ExtracellularSequence AnalysisAdd
BLAST
Transmembranei481 – 50121HelicalSequence AnalysisAdd
BLAST
Topological domaini502 – 55352CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei554 – 57421HelicalSequence AnalysisAdd
BLAST
Topological domaini575 – 5828ExtracellularSequence Analysis
Transmembranei583 – 60321HelicalSequence AnalysisAdd
BLAST
Topological domaini604 – 61411CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei615 – 63521HelicalSequence AnalysisAdd
BLAST
Topological domaini636 – 67136ExtracellularSequence AnalysisAdd
BLAST
Transmembranei672 – 69221HelicalSequence AnalysisAdd
BLAST
Topological domaini693 – 73038CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei731 – 75121HelicalSequence AnalysisAdd
BLAST
Topological domaini752 – 76615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei767 – 78923HelicalSequence AnalysisAdd
BLAST
Topological domaini790 – 81122CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei812 – 83221HelicalSequence AnalysisAdd
BLAST
Topological domaini833 – 87745ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: SGD
  2. peroxisome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 877877Oligopeptide transporter 2PRO_0000262733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi860 – 8601N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

GenevestigatoriQ06593.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ESS1P226961EBI-37672,EBI-6679
SET2P469951EBI-37672,EBI-16985

Protein-protein interaction databases

BioGridi36366. 19 interactions.
DIPiDIP-5482N.
IntActiQ06593. 2 interactions.
MINTiMINT-564157.
STRINGi4932.YPR194C.

Structurei

3D structure databases

ProteinModelPortaliQ06593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG327553.
GeneTreeiENSGT00530000068053.
HOGENOMiHOG000166970.
InParanoidiQ06593.
OMAiKIPPRAI.
OrthoDBiEOG70KGZ1.

Family and domain databases

InterProiIPR004648. Oligpept_transpt.
IPR004813. OPT.
[Graphical view]
PfamiPF03169. OPT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00727. ISP4_OPT. 1 hit.
TIGR00728. OPT_sfam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06593-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSETVKDKVI IDEKVSTKGT VDYAEGAEYS ERLSNHSSDF SQWYTDEQIL
60 70 80 90 100
HFMKKLGYEN RTLYDIPEDV AYILKKMPEL TLEDSFKILK DSIIYFKDDE
110 120 130 140 150
NIPHDQYEEW KRLVDLEDLD SKEGIDEYDS FDIRAFASAI KFHSPYQEVR
160 170 180 190 200
AVVDPEDDPT IPVETFRAYF LAIIWSVIGS GFNEFFSHRV VSISLNTPII
210 220 230 240 250
QMFLYICGKA WAKTIPCWTI TIRGRKYGIN IDKPWTQKEQ MFSTLLYAIC
260 270 280 290 300
QGAFYTHYNI LTQKLFYHSA FSFGYQFLLS LSVQFIGFGF AGILRKFVVY
310 320 330 340 350
PARALWPTVM PTIAINKALL GKEKHESGMS RYKFFFLTFF IMFIYNWFPT
360 370 380 390 400
YIINILNTFN WMTWIKPSNI NLANITGGVT GLGINPISSF DWNVISFNSP
410 420 430 440 450
LVYPFWSYLT QYLGCILAAL IVIAVYYSNY MSCQYLPIFT NSLYTNTGHS
460 470 480 490 500
FKVTEVLDSD NKLDVKKYQS YSPPYYSAGN LVSYGAFICA YPLMITWSFI
510 520 530 540 550
VHSKLLFNAF KDWALNLWAM RKLKSWVTMF KSDYRALDDY DDPHSNAMKN
560 570 580 590 600
YKEVPDWWYF AILIGSLVVG IAVVEHYPTN TPVWGLFVCL GFNFVFLIPT
610 620 630 640 650
TILQATTGYS FGLNLLIEMV MGYALPGNPI AIMILKAFGY NIDGQADNYV
660 670 680 690 700
SNLKIAHYCK IPPMALFRGQ CVIVFIQIFV NLGVLNWQIS NIKDFCTPHQ
710 720 730 740 750
NAKFTCPDAV TYYNASVVWG AIGPKRIFNY IYPIFKWCWL IGACIGIFFG
760 770 780 790 800
VWKRWGKFYP RYFDPMLFVG GMLNMSPPYN LMYYTSGMIV SYISQYYMKR
810 820 830 840 850
HHLNLWEKYN YVLSAGFSTG LVLSAIIIFF AVQYKDTAFN WWGNTVPYAG
860 870
ADGVGYPLKN ITDTANGYFG YAPGHYP
Length:877
Mass (Da):101,261
Last modified:November 1, 1996 - v1
Checksum:i3524D342E7EE4B50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25841 Genomic DNA. Translation: AAB64623.1.
BK006949 Genomic DNA. Translation: DAA11610.1.
PIRiS58824.
RefSeqiNP_015520.1. NM_001184291.1.

Genome annotation databases

EnsemblFungiiYPR194C; YPR194C; YPR194C.
GeneIDi856324.
KEGGisce:YPR194C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25841 Genomic DNA. Translation: AAB64623.1 .
BK006949 Genomic DNA. Translation: DAA11610.1 .
PIRi S58824.
RefSeqi NP_015520.1. NM_001184291.1.

3D structure databases

ProteinModelPortali Q06593.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36366. 19 interactions.
DIPi DIP-5482N.
IntActi Q06593. 2 interactions.
MINTi MINT-564157.
STRINGi 4932.YPR194C.

Protein family/group databases

TCDBi 2.A.67.1.4. the oligopeptide transporter (opt) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR194C ; YPR194C ; YPR194C .
GeneIDi 856324.
KEGGi sce:YPR194C.

Organism-specific databases

CYGDi YPR194c.
SGDi S000006398. OPT2.

Phylogenomic databases

eggNOGi NOG327553.
GeneTreei ENSGT00530000068053.
HOGENOMi HOG000166970.
InParanoidi Q06593.
OMAi KIPPRAI.
OrthoDBi EOG70KGZ1.

Enzyme and pathway databases

BioCyci YEAST:G3O-34316-MONOMER.

Miscellaneous databases

NextBioi 981724.

Gene expression databases

Genevestigatori Q06593.

Family and domain databases

InterProi IPR004648. Oligpept_transpt.
IPR004813. OPT.
[Graphical view ]
Pfami PF03169. OPT. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00727. ISP4_OPT. 1 hit.
TIGR00728. OPT_sfam. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Schizosaccharomyces pombe isp4 encodes a transporter representing a novel family of oligopeptide transporters."
    Lubkowitz M.A., Barnes D., Breslav M., Burchfield A., Naider F., Becker J.M.
    Mol. Microbiol. 28:729-741(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae."
    Bourbouloux A., Shahi P., Chakladar A., Delrot S., Bachhawat A.K.
    J. Biol. Chem. 275:13259-13265(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiOPT2_YEAST
AccessioniPrimary (citable) accession number: Q06593
Secondary accession number(s): D6W4J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3