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Q06593

- OPT2_YEAST

UniProt

Q06593 - OPT2_YEAST

Protein

Oligopeptide transporter 2

Gene

OPT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transports tetra- and pentapeptides. Does not transport glutathione.2 Publications

    GO - Molecular functioni

    1. oligopeptide transporter activity Source: SGD

    GO - Biological processi

    1. oligopeptide transport Source: SGD
    2. protein transport Source: UniProtKB-KW
    3. transmembrane transport Source: InterPro
    4. vacuole fusion, non-autophagic Source: SGD

    Keywords - Biological processi

    Peptide transport, Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34316-MONOMER.

    Protein family/group databases

    TCDBi2.A.67.1.4. the oligopeptide transporter (opt) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oligopeptide transporter 2
    Gene namesi
    Name:OPT2
    Ordered Locus Names:YPR194C
    ORF Names:P9677.13
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPR194c.
    SGDiS000006398. OPT2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 877877Oligopeptide transporter 2PRO_0000262733Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi860 – 8601N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriQ06593.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ESS1P226961EBI-37672,EBI-6679
    SET2P469951EBI-37672,EBI-16985

    Protein-protein interaction databases

    BioGridi36366. 19 interactions.
    DIPiDIP-5482N.
    IntActiQ06593. 2 interactions.
    MINTiMINT-564157.
    STRINGi4932.YPR194C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06593.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 167167CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini189 – 1891ExtracellularSequence Analysis
    Topological domaini211 – 24030CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 27211ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 33441CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini356 – 37419ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini396 – 4049CytoplasmicSequence Analysis
    Topological domaini426 – 48055ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini502 – 55352CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini575 – 5828ExtracellularSequence Analysis
    Topological domaini604 – 61411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini636 – 67136ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini693 – 73038CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini752 – 76615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini790 – 81122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini833 – 87745ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei335 – 35521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei375 – 39521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei405 – 42521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei481 – 50121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei554 – 57421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei583 – 60321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei615 – 63521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei672 – 69221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei731 – 75121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei767 – 78923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei812 – 83221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG327553.
    GeneTreeiENSGT00530000068053.
    HOGENOMiHOG000166970.
    OMAiKIPPRAI.
    OrthoDBiEOG70KGZ1.

    Family and domain databases

    InterProiIPR004648. Oligpept_transpt.
    IPR004813. OPT.
    [Graphical view]
    PfamiPF03169. OPT. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00727. ISP4_OPT. 1 hit.
    TIGR00728. OPT_sfam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q06593-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSETVKDKVI IDEKVSTKGT VDYAEGAEYS ERLSNHSSDF SQWYTDEQIL    50
    HFMKKLGYEN RTLYDIPEDV AYILKKMPEL TLEDSFKILK DSIIYFKDDE 100
    NIPHDQYEEW KRLVDLEDLD SKEGIDEYDS FDIRAFASAI KFHSPYQEVR 150
    AVVDPEDDPT IPVETFRAYF LAIIWSVIGS GFNEFFSHRV VSISLNTPII 200
    QMFLYICGKA WAKTIPCWTI TIRGRKYGIN IDKPWTQKEQ MFSTLLYAIC 250
    QGAFYTHYNI LTQKLFYHSA FSFGYQFLLS LSVQFIGFGF AGILRKFVVY 300
    PARALWPTVM PTIAINKALL GKEKHESGMS RYKFFFLTFF IMFIYNWFPT 350
    YIINILNTFN WMTWIKPSNI NLANITGGVT GLGINPISSF DWNVISFNSP 400
    LVYPFWSYLT QYLGCILAAL IVIAVYYSNY MSCQYLPIFT NSLYTNTGHS 450
    FKVTEVLDSD NKLDVKKYQS YSPPYYSAGN LVSYGAFICA YPLMITWSFI 500
    VHSKLLFNAF KDWALNLWAM RKLKSWVTMF KSDYRALDDY DDPHSNAMKN 550
    YKEVPDWWYF AILIGSLVVG IAVVEHYPTN TPVWGLFVCL GFNFVFLIPT 600
    TILQATTGYS FGLNLLIEMV MGYALPGNPI AIMILKAFGY NIDGQADNYV 650
    SNLKIAHYCK IPPMALFRGQ CVIVFIQIFV NLGVLNWQIS NIKDFCTPHQ 700
    NAKFTCPDAV TYYNASVVWG AIGPKRIFNY IYPIFKWCWL IGACIGIFFG 750
    VWKRWGKFYP RYFDPMLFVG GMLNMSPPYN LMYYTSGMIV SYISQYYMKR 800
    HHLNLWEKYN YVLSAGFSTG LVLSAIIIFF AVQYKDTAFN WWGNTVPYAG 850
    ADGVGYPLKN ITDTANGYFG YAPGHYP 877
    Length:877
    Mass (Da):101,261
    Last modified:November 1, 1996 - v1
    Checksum:i3524D342E7EE4B50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25841 Genomic DNA. Translation: AAB64623.1.
    BK006949 Genomic DNA. Translation: DAA11610.1.
    PIRiS58824.
    RefSeqiNP_015520.1. NM_001184291.1.

    Genome annotation databases

    EnsemblFungiiYPR194C; YPR194C; YPR194C.
    GeneIDi856324.
    KEGGisce:YPR194C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25841 Genomic DNA. Translation: AAB64623.1 .
    BK006949 Genomic DNA. Translation: DAA11610.1 .
    PIRi S58824.
    RefSeqi NP_015520.1. NM_001184291.1.

    3D structure databases

    ProteinModelPortali Q06593.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36366. 19 interactions.
    DIPi DIP-5482N.
    IntActi Q06593. 2 interactions.
    MINTi MINT-564157.
    STRINGi 4932.YPR194C.

    Protein family/group databases

    TCDBi 2.A.67.1.4. the oligopeptide transporter (opt) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPR194C ; YPR194C ; YPR194C .
    GeneIDi 856324.
    KEGGi sce:YPR194C.

    Organism-specific databases

    CYGDi YPR194c.
    SGDi S000006398. OPT2.

    Phylogenomic databases

    eggNOGi NOG327553.
    GeneTreei ENSGT00530000068053.
    HOGENOMi HOG000166970.
    OMAi KIPPRAI.
    OrthoDBi EOG70KGZ1.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34316-MONOMER.

    Miscellaneous databases

    NextBioi 981724.

    Gene expression databases

    Genevestigatori Q06593.

    Family and domain databases

    InterProi IPR004648. Oligpept_transpt.
    IPR004813. OPT.
    [Graphical view ]
    Pfami PF03169. OPT. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00727. ISP4_OPT. 1 hit.
    TIGR00728. OPT_sfam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Schizosaccharomyces pombe isp4 encodes a transporter representing a novel family of oligopeptide transporters."
      Lubkowitz M.A., Barnes D., Breslav M., Burchfield A., Naider F., Becker J.M.
      Mol. Microbiol. 28:729-741(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae."
      Bourbouloux A., Shahi P., Chakladar A., Delrot S., Bachhawat A.K.
      J. Biol. Chem. 275:13259-13265(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiOPT2_YEAST
    AccessioniPrimary (citable) accession number: Q06593
    Secondary accession number(s): D6W4J4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3