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Protein

Oligopeptide transporter 2

Gene

OPT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports tetra- and pentapeptides. Does not transport glutathione.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: SGD
  • oligopeptide transport Source: SGD
  • positive regulation of monopolar cell growth Source: SGD
  • protein transport Source: UniProtKB-KW
  • regulation of phospholipid translocation Source: SGD
  • regulation of vacuole organization Source: SGD
  • vacuole fusion, non-autophagic Source: SGD
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34316-MONOMER.

Protein family/group databases

TCDBi2.A.67.1.4. the oligopeptide transporter (opt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Oligopeptide transporter 2
Gene namesi
Name:OPT2
Ordered Locus Names:YPR194C
ORF Names:P9677.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR194C.
SGDiS000006398. OPT2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 167CytoplasmicSequence analysisAdd BLAST167
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189ExtracellularSequence analysis1
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 240CytoplasmicSequence analysisAdd BLAST30
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 272ExtracellularSequence analysisAdd BLAST11
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Topological domaini294 – 334CytoplasmicSequence analysisAdd BLAST41
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 374ExtracellularSequence analysisAdd BLAST19
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 404CytoplasmicSequence analysis9
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 480ExtracellularSequence analysisAdd BLAST55
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Topological domaini502 – 553CytoplasmicSequence analysisAdd BLAST52
Transmembranei554 – 574HelicalSequence analysisAdd BLAST21
Topological domaini575 – 582ExtracellularSequence analysis8
Transmembranei583 – 603HelicalSequence analysisAdd BLAST21
Topological domaini604 – 614CytoplasmicSequence analysisAdd BLAST11
Transmembranei615 – 635HelicalSequence analysisAdd BLAST21
Topological domaini636 – 671ExtracellularSequence analysisAdd BLAST36
Transmembranei672 – 692HelicalSequence analysisAdd BLAST21
Topological domaini693 – 730CytoplasmicSequence analysisAdd BLAST38
Transmembranei731 – 751HelicalSequence analysisAdd BLAST21
Topological domaini752 – 766ExtracellularSequence analysisAdd BLAST15
Transmembranei767 – 789HelicalSequence analysisAdd BLAST23
Topological domaini790 – 811CytoplasmicSequence analysisAdd BLAST22
Transmembranei812 – 832HelicalSequence analysisAdd BLAST21
Topological domaini833 – 877ExtracellularSequence analysisAdd BLAST45

GO - Cellular componenti

  • Golgi trans cisterna Source: SGD
  • integral component of plasma membrane Source: SGD
  • peroxisome Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002627331 – 877Oligopeptide transporter 2Add BLAST877

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi374N-linked (GlcNAc...)Sequence analysis1
Glycosylationi860N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ06593.

Interactioni

Protein-protein interaction databases

BioGridi36366. 52 interactors.
DIPiDIP-5482N.
IntActiQ06593. 2 interactors.
MINTiMINT-564157.

Structurei

3D structure databases

ProteinModelPortaliQ06593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000068053.
HOGENOMiHOG000166970.
InParanoidiQ06593.
OMAiNTWITAG.
OrthoDBiEOG092C0W76.

Family and domain databases

InterProiIPR004648. Oligpept_transpt.
IPR004813. OPT.
[Graphical view]
PfamiPF03169. OPT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00727. ISP4_OPT. 1 hit.
TIGR00728. OPT_sfam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETVKDKVI IDEKVSTKGT VDYAEGAEYS ERLSNHSSDF SQWYTDEQIL
60 70 80 90 100
HFMKKLGYEN RTLYDIPEDV AYILKKMPEL TLEDSFKILK DSIIYFKDDE
110 120 130 140 150
NIPHDQYEEW KRLVDLEDLD SKEGIDEYDS FDIRAFASAI KFHSPYQEVR
160 170 180 190 200
AVVDPEDDPT IPVETFRAYF LAIIWSVIGS GFNEFFSHRV VSISLNTPII
210 220 230 240 250
QMFLYICGKA WAKTIPCWTI TIRGRKYGIN IDKPWTQKEQ MFSTLLYAIC
260 270 280 290 300
QGAFYTHYNI LTQKLFYHSA FSFGYQFLLS LSVQFIGFGF AGILRKFVVY
310 320 330 340 350
PARALWPTVM PTIAINKALL GKEKHESGMS RYKFFFLTFF IMFIYNWFPT
360 370 380 390 400
YIINILNTFN WMTWIKPSNI NLANITGGVT GLGINPISSF DWNVISFNSP
410 420 430 440 450
LVYPFWSYLT QYLGCILAAL IVIAVYYSNY MSCQYLPIFT NSLYTNTGHS
460 470 480 490 500
FKVTEVLDSD NKLDVKKYQS YSPPYYSAGN LVSYGAFICA YPLMITWSFI
510 520 530 540 550
VHSKLLFNAF KDWALNLWAM RKLKSWVTMF KSDYRALDDY DDPHSNAMKN
560 570 580 590 600
YKEVPDWWYF AILIGSLVVG IAVVEHYPTN TPVWGLFVCL GFNFVFLIPT
610 620 630 640 650
TILQATTGYS FGLNLLIEMV MGYALPGNPI AIMILKAFGY NIDGQADNYV
660 670 680 690 700
SNLKIAHYCK IPPMALFRGQ CVIVFIQIFV NLGVLNWQIS NIKDFCTPHQ
710 720 730 740 750
NAKFTCPDAV TYYNASVVWG AIGPKRIFNY IYPIFKWCWL IGACIGIFFG
760 770 780 790 800
VWKRWGKFYP RYFDPMLFVG GMLNMSPPYN LMYYTSGMIV SYISQYYMKR
810 820 830 840 850
HHLNLWEKYN YVLSAGFSTG LVLSAIIIFF AVQYKDTAFN WWGNTVPYAG
860 870
ADGVGYPLKN ITDTANGYFG YAPGHYP
Length:877
Mass (Da):101,261
Last modified:November 1, 1996 - v1
Checksum:i3524D342E7EE4B50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25841 Genomic DNA. Translation: AAB64623.1.
BK006949 Genomic DNA. Translation: DAA11610.1.
PIRiS58824.
RefSeqiNP_015520.1. NM_001184291.1.

Genome annotation databases

EnsemblFungiiYPR194C; YPR194C; YPR194C.
GeneIDi856324.
KEGGisce:YPR194C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25841 Genomic DNA. Translation: AAB64623.1.
BK006949 Genomic DNA. Translation: DAA11610.1.
PIRiS58824.
RefSeqiNP_015520.1. NM_001184291.1.

3D structure databases

ProteinModelPortaliQ06593.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36366. 52 interactors.
DIPiDIP-5482N.
IntActiQ06593. 2 interactors.
MINTiMINT-564157.

Protein family/group databases

TCDBi2.A.67.1.4. the oligopeptide transporter (opt) family.

Proteomic databases

PRIDEiQ06593.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR194C; YPR194C; YPR194C.
GeneIDi856324.
KEGGisce:YPR194C.

Organism-specific databases

EuPathDBiFungiDB:YPR194C.
SGDiS000006398. OPT2.

Phylogenomic databases

GeneTreeiENSGT00530000068053.
HOGENOMiHOG000166970.
InParanoidiQ06593.
OMAiNTWITAG.
OrthoDBiEOG092C0W76.

Enzyme and pathway databases

BioCyciYEAST:G3O-34316-MONOMER.

Miscellaneous databases

PROiQ06593.

Family and domain databases

InterProiIPR004648. Oligpept_transpt.
IPR004813. OPT.
[Graphical view]
PfamiPF03169. OPT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00727. ISP4_OPT. 1 hit.
TIGR00728. OPT_sfam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOPT2_YEAST
AccessioniPrimary (citable) accession number: Q06593
Secondary accession number(s): D6W4J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.