UniProtKB - Q06593 (OPT2_YEAST)
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Protein
Oligopeptide transporter 2
Gene
OPT2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Transports tetra- and pentapeptides. Does not transport glutathione.2 Publications
GO - Molecular functioni
- oligopeptide transmembrane transporter activity Source: SGD
GO - Biological processi
- cell redox homeostasis Source: SGD
- oligopeptide transport Source: SGD
- positive regulation of monopolar cell growth Source: SGD
- protein transport Source: UniProtKB-KW
- regulation of phospholipid translocation Source: SGD
- regulation of vacuole organization Source: SGD
- vacuole fusion, non-autophagic Source: SGD
Keywordsi
Biological process | Peptide transport, Protein transport, Transport |
Enzyme and pathway databases
BioCyci | YEAST:G3O-34316-MONOMER. |
Protein family/group databases
TCDBi | 2.A.67.1.4. the oligopeptide transporter (opt) family. |
Names & Taxonomyi
Protein namesi | Recommended name: Oligopeptide transporter 2 |
Gene namesi | Name:OPT2 Ordered Locus Names:YPR194C ORF Names:P9677.13 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YPR194C. |
SGDi | S000006398. OPT2. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 167 | CytoplasmicSequence analysisAdd BLAST | 167 | |
Transmembranei | 168 – 188 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 189 | ExtracellularSequence analysis | 1 | |
Transmembranei | 190 – 210 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 211 – 240 | CytoplasmicSequence analysisAdd BLAST | 30 | |
Transmembranei | 241 – 261 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 262 – 272 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 273 – 293 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 294 – 334 | CytoplasmicSequence analysisAdd BLAST | 41 | |
Transmembranei | 335 – 355 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 356 – 374 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 375 – 395 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 396 – 404 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 405 – 425 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 426 – 480 | ExtracellularSequence analysisAdd BLAST | 55 | |
Transmembranei | 481 – 501 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 502 – 553 | CytoplasmicSequence analysisAdd BLAST | 52 | |
Transmembranei | 554 – 574 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 575 – 582 | ExtracellularSequence analysis | 8 | |
Transmembranei | 583 – 603 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 604 – 614 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 615 – 635 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 636 – 671 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 672 – 692 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 693 – 730 | CytoplasmicSequence analysisAdd BLAST | 38 | |
Transmembranei | 731 – 751 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 752 – 766 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 767 – 789 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 790 – 811 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 812 – 832 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 833 – 877 | ExtracellularSequence analysisAdd BLAST | 45 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000262733 | 1 – 877 | Oligopeptide transporter 2Add BLAST | 877 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 374 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 860 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q06593. |
PRIDEi | Q06593. |
Interactioni
Protein-protein interaction databases
BioGridi | 36366. 104 interactors. |
DIPi | DIP-5482N. |
IntActi | Q06593. 2 interactors. |
STRINGi | 4932.YPR194C. |
Structurei
3D structure databases
ProteinModelPortali | Q06593. |
SMRi | Q06593. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the oligopeptide OPT transporter family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00530000068053. |
HOGENOMi | HOG000166970. |
InParanoidi | Q06593. |
OMAi | LLVINWE. |
OrthoDBi | EOG092C0W76. |
Family and domain databases
InterProi | View protein in InterPro IPR004648. Oligpept_transpt. IPR004813. OPT. |
Pfami | View protein in Pfam PF03169. OPT. 1 hit. |
TIGRFAMsi | TIGR00727. ISP4_OPT. 1 hit. TIGR00728. OPT_sfam. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q06593-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSETVKDKVI IDEKVSTKGT VDYAEGAEYS ERLSNHSSDF SQWYTDEQIL
60 70 80 90 100
HFMKKLGYEN RTLYDIPEDV AYILKKMPEL TLEDSFKILK DSIIYFKDDE
110 120 130 140 150
NIPHDQYEEW KRLVDLEDLD SKEGIDEYDS FDIRAFASAI KFHSPYQEVR
160 170 180 190 200
AVVDPEDDPT IPVETFRAYF LAIIWSVIGS GFNEFFSHRV VSISLNTPII
210 220 230 240 250
QMFLYICGKA WAKTIPCWTI TIRGRKYGIN IDKPWTQKEQ MFSTLLYAIC
260 270 280 290 300
QGAFYTHYNI LTQKLFYHSA FSFGYQFLLS LSVQFIGFGF AGILRKFVVY
310 320 330 340 350
PARALWPTVM PTIAINKALL GKEKHESGMS RYKFFFLTFF IMFIYNWFPT
360 370 380 390 400
YIINILNTFN WMTWIKPSNI NLANITGGVT GLGINPISSF DWNVISFNSP
410 420 430 440 450
LVYPFWSYLT QYLGCILAAL IVIAVYYSNY MSCQYLPIFT NSLYTNTGHS
460 470 480 490 500
FKVTEVLDSD NKLDVKKYQS YSPPYYSAGN LVSYGAFICA YPLMITWSFI
510 520 530 540 550
VHSKLLFNAF KDWALNLWAM RKLKSWVTMF KSDYRALDDY DDPHSNAMKN
560 570 580 590 600
YKEVPDWWYF AILIGSLVVG IAVVEHYPTN TPVWGLFVCL GFNFVFLIPT
610 620 630 640 650
TILQATTGYS FGLNLLIEMV MGYALPGNPI AIMILKAFGY NIDGQADNYV
660 670 680 690 700
SNLKIAHYCK IPPMALFRGQ CVIVFIQIFV NLGVLNWQIS NIKDFCTPHQ
710 720 730 740 750
NAKFTCPDAV TYYNASVVWG AIGPKRIFNY IYPIFKWCWL IGACIGIFFG
760 770 780 790 800
VWKRWGKFYP RYFDPMLFVG GMLNMSPPYN LMYYTSGMIV SYISQYYMKR
810 820 830 840 850
HHLNLWEKYN YVLSAGFSTG LVLSAIIIFF AVQYKDTAFN WWGNTVPYAG
860 870
ADGVGYPLKN ITDTANGYFG YAPGHYP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U25841 Genomic DNA. Translation: AAB64623.1. BK006949 Genomic DNA. Translation: DAA11610.1. |
PIRi | S58824. |
RefSeqi | NP_015520.1. NM_001184291.1. |
Genome annotation databases
EnsemblFungii | YPR194C; YPR194C; YPR194C. |
GeneIDi | 856324. |
KEGGi | sce:YPR194C. |
Similar proteinsi
Entry informationi
Entry namei | OPT2_YEAST | |
Accessioni | Q06593Primary (citable) accession number: Q06593 Secondary accession number(s): D6W4J4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |