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Protein

Histone acetyltransferase HPA2

Gene

HPA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

N-acetyltransferase that acetylates histone H3 at 'Lys-14' and histone H4 at 'Lys-5' and 'Lys-12'. Also acetylates polyamines like putrescine, spermidine and spermine, and certain other small basic proteins like nuclear HMG proteins.1 Publication

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei139Important for catalytic activity1 Publication1

GO - Molecular functioni

  • histone acetyltransferase activity Source: UniProtKB-EC
  • identical protein binding Source: IntAct
  • N-acetyltransferase activity Source: SGD

GO - Biological processi

  • protein acetylation Source: SGD

Keywordsi

Molecular functionAcyltransferase, Chromatin regulator, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-34315-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase HPA21 Publication (EC:2.3.1.482 Publications)
Gene namesi
Name:HPA21 Publication
Ordered Locus Names:YPR193CImported
ORF Names:P9677.12
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR193C
SGDiS000006397 HPA2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000746331 – 156Histone acetyltransferase HPA2Add BLAST156

Post-translational modificationi

Autoacetylates in an intermolecular reaction.1 Publication

Proteomic databases

PaxDbiQ06592
PRIDEiQ06592

Interactioni

Subunit structurei

Forms homodimers in the absence, and homotetramers in the presence of acetyl-CoA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-34205,EBI-34205

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi36365, 79 interactors
DIPiDIP-2953N
IntActiQ06592, 4 interactors
MINTiQ06592
STRINGi4932.YPR193C

Structurei

Secondary structure

1156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 13Combined sources5
Helixi16 – 18Combined sources3
Helixi19 – 32Combined sources14
Helixi39 – 50Combined sources12
Turni52 – 54Combined sources3
Beta strandi56 – 66Combined sources11
Beta strandi69 – 78Combined sources10
Beta strandi87 – 95Combined sources9
Helixi97 – 99Combined sources3
Beta strandi101 – 103Combined sources3
Helixi104 – 118Combined sources15
Beta strandi124 – 129Combined sources6
Helixi133 – 142Combined sources10
Beta strandi143 – 145Combined sources3
Beta strandi147 – 153Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QSMX-ray2.40A/B/C/D5-156[»]
1QSOX-ray2.90A/B/C/D8-156[»]
ProteinModelPortaliQ06592
SMRiQ06592
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06592

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 156N-acetyltransferasePROSITE-ProRule annotationAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 106Acetyl-CoA binding1 PublicationAdd BLAST14

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000015620
HOGENOMiHOG000078521
InParanoidiQ06592
KOiK18852
OMAiDGHIRYR
OrthoDBiEOG092C4ZYL

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR032962 HPA2/HPA3
PANTHERiPTHR10545:SF42 PTHR10545:SF42, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q06592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTSEDNIT VRFVTENDKE GWQRLWKSYQ DFYEVSFPDD LDDFNFGRFL
60 70 80 90 100
DPNIKMWAAV AVESSSEKII GMINFFNHMT TWDFKDKIYI NDLYVDENSR
110 120 130 140 150
VKGAGGKLIQ FVYDEADKLG TPSVYWCTDE SNHRAQLLYV KVGYKAPKIL

YKRKGY
Length:156
Mass (Da):18,334
Last modified:November 1, 1996 - v1
Checksum:i707C6EA8B8ED73A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25841 Genomic DNA Translation: AAB64622.1
AY558056 Genomic DNA Translation: AAS56382.1
BK006949 Genomic DNA Translation: DAA11609.1
PIRiS58823
RefSeqiNP_015519.1, NM_001184290.1

Genome annotation databases

EnsemblFungiiYPR193C; YPR193C; YPR193C
GeneIDi856323
KEGGisce:YPR193C

Similar proteinsi

Entry informationi

Entry nameiHPA2_YEAST
AccessioniPrimary (citable) accession number: Q06592
Secondary accession number(s): D6W4J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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