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Q06592 (HPA2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase HPA2

EC=2.3.1.48
Gene names
Name:HPA2
Ordered Locus Names:YPR193C
ORF Names:P9677.12
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length156 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

In vitro, acetylates histone H3 'Lys-4' and 'Lys-14' and histone H4 'Lys-5' and 'Lys-12'.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Forms homodimers in the absence, and homotetramers in the presence of acetyl-CoA.

Post-translational modification

Autoacetylates in an intermolecular reaction.

Sequence similarities

Belongs to the acetyltransferase family. GNAT subfamily.

Contains 1 N-acetyltransferase domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself3EBI-34205,EBI-34205

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 156156Histone acetyltransferase HPA2
PRO_0000074633

Regions

Domain9 – 156148N-acetyltransferase
Region93 – 10614Acetyl-CoA binding

Sites

Site1391Important for catalytic activity

Secondary structure

............................ 156
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q06592 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 707C6EA8B8ED73A7

FASTA15618,334
        10         20         30         40         50         60 
MSNTSEDNIT VRFVTENDKE GWQRLWKSYQ DFYEVSFPDD LDDFNFGRFL DPNIKMWAAV 

        70         80         90        100        110        120 
AVESSSEKII GMINFFNHMT TWDFKDKIYI NDLYVDENSR VKGAGGKLIQ FVYDEADKLG 

       130        140        150 
TPSVYWCTDE SNHRAQLLYV KVGYKAPKIL YKRKGY 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Crystal structure of the histone acetyltransferase Hpa2: a tetrameric member of the Gcn5-related N-acetyltransferase superfamily."
Angus-Hill M.L., Dutnall R.N., Tafrov S.T., Sternglanz R., Ramakrishnan V.
J. Mol. Biol. 294:1311-1325(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 7-156 WITH ACETYL-COA.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U25841 Genomic DNA. Translation: AAB64622.1.
AY558056 Genomic DNA. Translation: AAS56382.1.
BK006949 Genomic DNA. Translation: DAA11609.1.
PIRS58823.
RefSeqNP_015519.1. NM_001184290.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1QSMX-ray2.40A/B/C/D5-156[»]
1QSOX-ray2.90A/B/C/D8-156[»]
ProteinModelPortalQ06592.
SMRQ06592. Positions 5-156.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36365. 49 interactions.
DIPDIP-2953N.
IntActQ06592. 4 interactions.
MINTMINT-514906.
STRING4932.YPR193C.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPR193C; YPR193C; YPR193C.
GeneID856323.
KEGGsce:YPR193C.

Organism-specific databases

CYGDYPR193c.
SGDS000006397. HPA2.

Phylogenomic databases

eggNOGCOG0454.
GeneTreeENSGT00390000015620.
HOGENOMHOG000078521.
OMALPLWQAY.
OrthoDBEOG7X3R3Q.

Enzyme and pathway databases

BioCycYEAST:G3O-34315-MONOMER.

Gene expression databases

GenevestigatorQ06592.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ06592.
NextBio981721.

Entry information

Entry nameHPA2_YEAST
AccessionPrimary (citable) accession number: Q06592
Secondary accession number(s): D6W4J3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references