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Protein

E3 ubiquitin-protein ligase RING1

Gene

RING1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri48 – 88RING-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Ligase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112477-MONOMER.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.
R-HSA-4570464. SUMOylation of RNA binding proteins.
SIGNORiQ06587.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RING1 (EC:6.3.2.-)
Alternative name(s):
Polycomb complex protein RING1
RING finger protein 1
Really interesting new gene 1 protein
Gene namesi
Name:RING1
Synonyms:RNF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:10018. RING1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nuclear speck Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • PcG protein complex Source: UniProtKB
  • PRC1 complex Source: UniProtKB
  • sex chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6015.
OpenTargetsiENSG00000204227.
ENSG00000206287.
ENSG00000226788.
ENSG00000228520.
ENSG00000231115.
ENSG00000235107.
PharmGKBiPA34393.

Polymorphism and mutation databases

BioMutaiRING1.
DMDMi90110053.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000563841 – 406E3 ubiquitin-protein ligase RING1Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphothreonineCombined sources1
Modified residuei38PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei215PhosphothreonineCombined sources1
Modified residuei220PhosphothreonineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ06587.
MaxQBiQ06587.
PaxDbiQ06587.
PeptideAtlasiQ06587.
PRIDEiQ06587.
TopDownProteomicsiQ06587-1. [Q06587-1]
Q06587-2. [Q06587-2]

PTM databases

iPTMnetiQ06587.
PhosphoSitePlusiQ06587.

Expressioni

Gene expression databases

BgeeiENSG00000204227.
CleanExiHS_RING1.
GenevisibleiQ06587. HS.

Organism-specific databases

HPAiHPA008701.

Interactioni

Subunit structurei

Component of chromatin-associated Polycomb (PcG) complexes. Interacts with BMI1 (By similarity). Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2 MBLR, L3MBTL2 and YAF2. Interacts with CBX2 and PCGF6. Component of a PRC1-like complex. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RNF2/RING2. Interacts with PCGF2, RNF2; CBX6, CBX7 and CBX8. Interacts with PHC2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BMI1P3522616EBI-752313,EBI-2341576
CBX6O955035EBI-752313,EBI-3951758
CBX7O959315EBI-752313,EBI-3923843
CBX8Q9HC5211EBI-752313,EBI-712912
PCGF1Q9BSM17EBI-752313,EBI-749901
PCGF2P352277EBI-752313,EBI-2129767
PCGF3Q3KNV84EBI-752313,EBI-2339807
PCGF5Q86SE94EBI-752313,EBI-2827999
PCGF6Q9BYE73EBI-752313,EBI-1048026
RNF2Q994965EBI-752313,EBI-722416
RYBPQ8N48814EBI-752313,EBI-752324
USP11P517844EBI-752313,EBI-306876
USP7Q930095EBI-752313,EBI-302474
YAF2Q8IY576EBI-752313,EBI-2842031

Protein-protein interaction databases

BioGridi111947. 72 interactors.
DIPiDIP-42043N.
IntActiQ06587. 66 interactors.
MINTiMINT-1327105.
STRINGi9606.ENSP00000363787.

Structurei

3D structure databases

ProteinModelPortaliQ06587.
SMRiQ06587.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 234Necessary for transcriptional repressionBy similarityAdd BLAST205
Regioni230 – 406Necessary for interaction with CBX2By similarityAdd BLAST177

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi201 – 204Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi205 – 260Gly-richAdd BLAST56
Compositional biasi314 – 377Gly-richAdd BLAST64

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri48 – 88RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0311. Eukaryota.
ENOG410XQ5G. LUCA.
GeneTreeiENSGT00390000016977.
HOGENOMiHOG000273917.
HOVERGENiHBG079942.
InParanoidiQ06587.
KOiK10695.
OMAiQSASKTW.
OrthoDBiEOG091G06VO.
PhylomeDBiQ06587.
TreeFamiTF105501.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF16207. RAWUL. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q06587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTPANAQNA SKTWELSLYE LHRTPQEAIM DGTEIAVSPR SLHSELMCPI
60 70 80 90 100
CLDMLKNTMT TKECLHRFCS DCIVTALRSG NKECPTCRKK LVSKRSLRPD
110 120 130 140 150
PNFDALISKI YPSREEYEAH QDRVLIRLSR LHNQQALSSS IEEGLRMQAM
160 170 180 190 200
HRAQRVRRPI PGSDQTTTMS GGEGEPGEGE GDGEDVSSDS APDSAPGPAP
210 220 230 240 250
KRPRGGGAGG SSVGTGGGGT GGVGGGAGSE DSGDRGGTLG GGTLGPPSPP
260 270 280 290 300
GAPSPPEPGG EIELVFRPHP LLVEKGEYCQ TRYVKTTGNA TVDHLSKYLA
310 320 330 340 350
LRIALERRQQ QEAGEPGGPG GGASDTGGPD GCGGEGGGAG GGDGPEEPAL
360 370 380 390 400
PSLEGVSEKQ YTIYIAPGGG AFTTLNGSLT LELVNEKFWK VSRPLELCYA

PTKDPK
Length:406
Mass (Da):42,429
Last modified:March 21, 2006 - v2
Checksum:i6959787479DE9DAB
GO
Isoform 2 (identifier: Q06587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:377
Mass (Da):39,146
Checksum:iF406E93593E0CF69
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07661895R → Q.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0176941 – 29Missing in isoform 2. 2 PublicationsAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14000 mRNA. Translation: CAA78389.1.
BT007352 mRNA. Translation: AAP36016.1.
AK289355 mRNA. Translation: BAF82044.1.
AL031228 Genomic DNA. Translation: CAA20235.1.
AL031228 Genomic DNA. Translation: CAI95620.1.
AL713971 Genomic DNA. Translation: CAI17650.1.
AL645940 Genomic DNA. Translation: CAI18069.1.
AL844527 Genomic DNA. Translation: CAI41841.1.
CR759786 Genomic DNA. Translation: CAQ08246.1.
CR759733 Genomic DNA. Translation: CAQ10303.1.
CR847841, CR547129 Genomic DNA. Translation: CAQ10314.1.
CR547129, CR847841 Genomic DNA. Translation: CAQ10355.1.
BC002922 mRNA. Translation: AAH02922.2.
BC051866 mRNA. Translation: AAH51866.1.
CCDSiCCDS34424.1. [Q06587-1]
PIRiA47380.
RefSeqiNP_002922.2. NM_002931.3. [Q06587-1]
UniGeneiHs.631989.

Genome annotation databases

EnsembliENST00000374656; ENSP00000363787; ENSG00000204227. [Q06587-1]
ENST00000383212; ENSP00000372699; ENSG00000206287. [Q06587-1]
ENST00000415941; ENSP00000412190; ENSG00000226788. [Q06587-1]
ENST00000427374; ENSP00000400572; ENSG00000231115. [Q06587-1]
ENST00000430233; ENSP00000396271; ENSG00000228520. [Q06587-1]
ENST00000436128; ENSP00000396439; ENSG00000235107. [Q06587-1]
GeneIDi6015.
KEGGihsa:6015.
UCSCiuc003odk.4. human. [Q06587-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14000 mRNA. Translation: CAA78389.1.
BT007352 mRNA. Translation: AAP36016.1.
AK289355 mRNA. Translation: BAF82044.1.
AL031228 Genomic DNA. Translation: CAA20235.1.
AL031228 Genomic DNA. Translation: CAI95620.1.
AL713971 Genomic DNA. Translation: CAI17650.1.
AL645940 Genomic DNA. Translation: CAI18069.1.
AL844527 Genomic DNA. Translation: CAI41841.1.
CR759786 Genomic DNA. Translation: CAQ08246.1.
CR759733 Genomic DNA. Translation: CAQ10303.1.
CR847841, CR547129 Genomic DNA. Translation: CAQ10314.1.
CR547129, CR847841 Genomic DNA. Translation: CAQ10355.1.
BC002922 mRNA. Translation: AAH02922.2.
BC051866 mRNA. Translation: AAH51866.1.
CCDSiCCDS34424.1. [Q06587-1]
PIRiA47380.
RefSeqiNP_002922.2. NM_002931.3. [Q06587-1]
UniGeneiHs.631989.

3D structure databases

ProteinModelPortaliQ06587.
SMRiQ06587.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111947. 72 interactors.
DIPiDIP-42043N.
IntActiQ06587. 66 interactors.
MINTiMINT-1327105.
STRINGi9606.ENSP00000363787.

PTM databases

iPTMnetiQ06587.
PhosphoSitePlusiQ06587.

Polymorphism and mutation databases

BioMutaiRING1.
DMDMi90110053.

Proteomic databases

EPDiQ06587.
MaxQBiQ06587.
PaxDbiQ06587.
PeptideAtlasiQ06587.
PRIDEiQ06587.
TopDownProteomicsiQ06587-1. [Q06587-1]
Q06587-2. [Q06587-2]

Protocols and materials databases

DNASUi6015.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374656; ENSP00000363787; ENSG00000204227. [Q06587-1]
ENST00000383212; ENSP00000372699; ENSG00000206287. [Q06587-1]
ENST00000415941; ENSP00000412190; ENSG00000226788. [Q06587-1]
ENST00000427374; ENSP00000400572; ENSG00000231115. [Q06587-1]
ENST00000430233; ENSP00000396271; ENSG00000228520. [Q06587-1]
ENST00000436128; ENSP00000396439; ENSG00000235107. [Q06587-1]
GeneIDi6015.
KEGGihsa:6015.
UCSCiuc003odk.4. human. [Q06587-1]

Organism-specific databases

CTDi6015.
DisGeNETi6015.
GeneCardsiRING1.
HGNCiHGNC:10018. RING1.
HPAiHPA008701.
MIMi602045. gene.
neXtProtiNX_Q06587.
OpenTargetsiENSG00000204227.
ENSG00000206287.
ENSG00000226788.
ENSG00000228520.
ENSG00000231115.
ENSG00000235107.
PharmGKBiPA34393.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0311. Eukaryota.
ENOG410XQ5G. LUCA.
GeneTreeiENSGT00390000016977.
HOGENOMiHOG000273917.
HOVERGENiHBG079942.
InParanoidiQ06587.
KOiK10695.
OMAiQSASKTW.
OrthoDBiEOG091G06VO.
PhylomeDBiQ06587.
TreeFamiTF105501.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:ENSG00000112477-MONOMER.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.
R-HSA-4570464. SUMOylation of RNA binding proteins.
SIGNORiQ06587.

Miscellaneous databases

ChiTaRSiRING1. human.
GeneWikiiRING1.
GenomeRNAii6015.
PROiQ06587.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204227.
CleanExiHS_RING1.
GenevisibleiQ06587. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF16207. RAWUL. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRING1_HUMAN
AccessioniPrimary (citable) accession number: Q06587
Secondary accession number(s): A8JZZ0
, Q5JP96, Q5SQW2, Q86V19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 21, 2006
Last modified: November 30, 2016
This is version 169 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.