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Protein

Myosin light chain 2

Gene

MLC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory light chain for the class II conventional myosin MYO1. May play a role in the disassembly of the MYO1 ring at the bud neck at the end of its contraction during cytokinesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi28 – 3912PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • myosin II binding Source: SGD

GO - Biological processi

  • actomyosin contractile ring contraction Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34311-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 2
Alternative name(s):
Calmodulin-like myosin light chain MLC2
MYO1 light chain 2
Myosin-1 light chain
Gene namesi
Name:MLC2
Ordered Locus Names:YPR188C
ORF Names:P9677.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR188C.
SGDiS000006392. MLC2.

Subcellular locationi

GO - Cellular componenti

  • cellular bud neck contractile ring Source: SGD
  • myosin II complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Myosin light chain 2PRO_0000198766Add
BLAST

Proteomic databases

MaxQBiQ06580.

PTM databases

iPTMnetiQ06580.

Interactioni

Subunit structurei

Interacts with the IQ domain of MYO1.1 Publication

GO - Molecular functioni

  • myosin II binding Source: SGD

Protein-protein interaction databases

BioGridi36360. 22 interactions.
DIPiDIP-2767N.
IntActiQ06580. 7 interactions.
MINTiMINT-514040.

Structurei

3D structure databases

ProteinModelPortaliQ06580.
SMRiQ06580. Positions 7-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 5036EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini92 – 12736EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000066016.
InParanoidiQ06580.
OMAiFMNTISE.
OrthoDBiEOG092C4XFN.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHSESLTFN QLTQDYINKL KDAFQMLDED EDGLISRGDL TKIYATLGKT
60 70 80 90 100
LTDEEWSKMV PDNDTSTAEV GEEGVSFPIF LSIMGKNLSQ FPEREELEES
110 120 130 140 150
LKAIGRGHDL NVPLNEVIDS LKEAGFENPE EEFAKLFKLF TTNQQATEER
160
TFRGKLFLDS ITD
Length:163
Mass (Da):18,521
Last modified:November 1, 1996 - v1
Checksum:i6BAE6EA0ADF66B9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25841 Genomic DNA. Translation: AAB64617.1.
AY558057 Genomic DNA. Translation: AAS56383.1.
BK006949 Genomic DNA. Translation: DAA11604.1.
PIRiS58818.
RefSeqiNP_015514.1. NM_001184285.1.

Genome annotation databases

EnsemblFungiiYPR188C; YPR188C; YPR188C.
GeneIDi856318.
KEGGisce:YPR188C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25841 Genomic DNA. Translation: AAB64617.1.
AY558057 Genomic DNA. Translation: AAS56383.1.
BK006949 Genomic DNA. Translation: DAA11604.1.
PIRiS58818.
RefSeqiNP_015514.1. NM_001184285.1.

3D structure databases

ProteinModelPortaliQ06580.
SMRiQ06580. Positions 7-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36360. 22 interactions.
DIPiDIP-2767N.
IntActiQ06580. 7 interactions.
MINTiMINT-514040.

PTM databases

iPTMnetiQ06580.

Proteomic databases

MaxQBiQ06580.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR188C; YPR188C; YPR188C.
GeneIDi856318.
KEGGisce:YPR188C.

Organism-specific databases

EuPathDBiFungiDB:YPR188C.
SGDiS000006392. MLC2.

Phylogenomic databases

HOGENOMiHOG000066016.
InParanoidiQ06580.
OMAiFMNTISE.
OrthoDBiEOG092C4XFN.

Enzyme and pathway databases

BioCyciYEAST:G3O-34311-MONOMER.

Miscellaneous databases

PROiQ06580.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMLC2_YEAST
AccessioniPrimary (citable) accession number: Q06580
Secondary accession number(s): D6W4I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1127 molecules/cell in log phase SD medium.1 Publication
This chain binds calcium.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.