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Protein

Myosin light chain 2

Gene

MLC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory light chain for the class II conventional myosin MYO1. May play a role in the disassembly of the MYO1 ring at the bud neck at the end of its contraction during cytokinesis.1 Publication

Miscellaneous

Present with 1127 molecules/cell in log phase SD medium.1 Publication
This chain binds calcium.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi28 – 39PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • myosin II binding Source: SGD

GO - Biological processi

  • actomyosin contractile ring contraction Source: SGD

Keywordsi

Molecular functionMotor protein, Myosin
Biological processCell cycle, Cell division
LigandCalcium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34311-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 2
Alternative name(s):
Calmodulin-like myosin light chain MLC2
MYO1 light chain 2
Myosin-1 light chain
Gene namesi
Name:MLC2
Ordered Locus Names:YPR188C
ORF Names:P9677.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR188C.
SGDiS000006392. MLC2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001987661 – 163Myosin light chain 2Add BLAST163

Proteomic databases

MaxQBiQ06580.
PRIDEiQ06580.

PTM databases

iPTMnetiQ06580.

Interactioni

Subunit structurei

Interacts with the IQ domain of MYO1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MYO1P089643EBI-10999,EBI-11650

GO - Molecular functioni

  • myosin II binding Source: SGD

Protein-protein interaction databases

BioGridi36360. 39 interactors.
DIPiDIP-2767N.
IntActiQ06580. 12 interactors.
MINTiMINT-514040.
STRINGi4932.YPR188C.

Structurei

3D structure databases

ProteinModelPortaliQ06580.
SMRiQ06580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 50EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini92 – 127EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000066016.
InParanoidiQ06580.
OMAiFMNTISE.
OrthoDBiEOG092C4XFN.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q06580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHSESLTFN QLTQDYINKL KDAFQMLDED EDGLISRGDL TKIYATLGKT
60 70 80 90 100
LTDEEWSKMV PDNDTSTAEV GEEGVSFPIF LSIMGKNLSQ FPEREELEES
110 120 130 140 150
LKAIGRGHDL NVPLNEVIDS LKEAGFENPE EEFAKLFKLF TTNQQATEER
160
TFRGKLFLDS ITD
Length:163
Mass (Da):18,521
Last modified:November 1, 1996 - v1
Checksum:i6BAE6EA0ADF66B9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25841 Genomic DNA. Translation: AAB64617.1.
AY558057 Genomic DNA. Translation: AAS56383.1.
BK006949 Genomic DNA. Translation: DAA11604.1.
PIRiS58818.
RefSeqiNP_015514.1. NM_001184285.1.

Genome annotation databases

EnsemblFungiiYPR188C; YPR188C; YPR188C.
GeneIDi856318.
KEGGisce:YPR188C.

Similar proteinsi

Entry informationi

Entry nameiMLC2_YEAST
AccessioniPrimary (citable) accession number: Q06580
Secondary accession number(s): D6W4I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names