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Q06580

- MLC2_YEAST

UniProt

Q06580 - MLC2_YEAST

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Protein

Myosin light chain 2

Gene

MLC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Regulatory light chain for the class II conventional myosin MYO1. May play a role in the disassembly of the MYO1 ring at the bud neck at the end of its contraction during cytokinesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi28 – 3912PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. myosin II binding Source: SGD

GO - Biological processi

  1. actomyosin contractile ring contraction Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34311-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 2
Alternative name(s):
Calmodulin-like myosin light chain MLC2
MYO1 light chain 2
Myosin-1 light chain
Gene namesi
Name:MLC2
Ordered Locus Names:YPR188C
ORF Names:P9677.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR188c.
SGDiS000006392. MLC2.

Subcellular locationi

Bud neck 2 Publications
Note: Forms a ring at the bud neck in a MYO1-dependent manner.

GO - Cellular componenti

  1. cellular bud neck contractile ring Source: SGD
  2. myosin II complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Myosin light chain 2PRO_0000198766Add
BLAST

Proteomic databases

MaxQBiQ06580.
PaxDbiQ06580.

Expressioni

Gene expression databases

GenevestigatoriQ06580.

Interactioni

Subunit structurei

Interacts with the IQ domain of MYO1.1 Publication

Protein-protein interaction databases

BioGridi36360. 23 interactions.
DIPiDIP-2767N.
IntActiQ06580. 7 interactions.
MINTiMINT-514040.
STRINGi4932.YPR188C.

Structurei

3D structure databases

ProteinModelPortaliQ06580.
SMRiQ06580. Positions 7-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 5036EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini92 – 12736EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
HOGENOMiHOG000066016.
InParanoidiQ06580.
OMAiQATEERT.
OrthoDBiEOG73FR0X.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06580-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDHSESLTFN QLTQDYINKL KDAFQMLDED EDGLISRGDL TKIYATLGKT
60 70 80 90 100
LTDEEWSKMV PDNDTSTAEV GEEGVSFPIF LSIMGKNLSQ FPEREELEES
110 120 130 140 150
LKAIGRGHDL NVPLNEVIDS LKEAGFENPE EEFAKLFKLF TTNQQATEER
160
TFRGKLFLDS ITD
Length:163
Mass (Da):18,521
Last modified:November 1, 1996 - v1
Checksum:i6BAE6EA0ADF66B9B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25841 Genomic DNA. Translation: AAB64617.1.
AY558057 Genomic DNA. Translation: AAS56383.1.
BK006949 Genomic DNA. Translation: DAA11604.1.
PIRiS58818.
RefSeqiNP_015514.1. NM_001184285.1.

Genome annotation databases

EnsemblFungiiYPR188C; YPR188C; YPR188C.
GeneIDi856318.
KEGGisce:YPR188C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25841 Genomic DNA. Translation: AAB64617.1 .
AY558057 Genomic DNA. Translation: AAS56383.1 .
BK006949 Genomic DNA. Translation: DAA11604.1 .
PIRi S58818.
RefSeqi NP_015514.1. NM_001184285.1.

3D structure databases

ProteinModelPortali Q06580.
SMRi Q06580. Positions 7-123.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36360. 23 interactions.
DIPi DIP-2767N.
IntActi Q06580. 7 interactions.
MINTi MINT-514040.
STRINGi 4932.YPR188C.

Proteomic databases

MaxQBi Q06580.
PaxDbi Q06580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR188C ; YPR188C ; YPR188C .
GeneIDi 856318.
KEGGi sce:YPR188C.

Organism-specific databases

CYGDi YPR188c.
SGDi S000006392. MLC2.

Phylogenomic databases

eggNOGi COG5126.
HOGENOMi HOG000066016.
InParanoidi Q06580.
OMAi QATEERT.
OrthoDBi EOG73FR0X.

Enzyme and pathway databases

BioCyci YEAST:G3O-34311-MONOMER.

Miscellaneous databases

NextBioi 981706.

Gene expression databases

Genevestigatori Q06580.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Identification and functional analysis of the essential and regulatory light chains of the only type II myosin Myo1p in Saccharomyces cerevisiae."
    Luo J., Vallen E.A., Dravis C., Tcheperegine S.E., Drees B., Bi E.
    J. Cell Biol. 165:843-855(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MYO1.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMLC2_YEAST
AccessioniPrimary (citable) accession number: Q06580
Secondary accession number(s): D6W4I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1127 molecules/cell in log phase SD medium.1 Publication
This chain binds calcium.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3