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Protein

ABC1 family protein MCP2

Gene

MCP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression (PubMed:25683707). Involved in mitochondrial lipid homeostasis (PubMed:23781023).2 Publications

Miscellaneous

Present with 1600 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • lipid homeostasis Source: SGD
  • mitochondrion organization Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-32357-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ABC1 family protein MCP21 Publication
Alternative name(s):
MDM10-complementing protein 21 Publication
MIOREX complex component 131 Publication
Mitochondrial organization of gene expression protein 131 Publication
Gene namesi
Name:MCP21 Publication
Synonyms:MRX131 Publication
Ordered Locus Names:YLR253WImported
ORF Names:L9672.2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR253W
SGDiS000004243 MCP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 34Mitochondrial matrix1 PublicationAdd BLAST16
Transmembranei35 – 51HelicalSequence analysisAdd BLAST17
Topological domaini52 – 569Mitochondrial intermembrane1 PublicationAdd BLAST518

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 18MitochondrionSequence analysisAdd BLAST18
ChainiPRO_000020073719 – 569ABC1 family protein MCP2Add BLAST551

Proteomic databases

MaxQBiQ06567
PaxDbiQ06567
PRIDEiQ06567

Interactioni

Protein-protein interaction databases

BioGridi31520, 57 interactors
DIPiDIP-4782N
IntActiQ06567, 3 interactors
MINTiQ06567
STRINGi4932.YLR253W

Structurei

3D structure databases

ProteinModelPortaliQ06567
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074734
HOGENOMiHOG000188189
InParanoidiQ06567
KOiK08869
OMAiPYVKGNS
OrthoDBiEOG092C1H5E

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR004147 UbiB_dom
PfamiView protein in Pfam
PF03109 ABC1, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTKAFFNKL PFEVFRRYVR TGKSIPQRSP RTRKSLLVGG TIASAVVLYN
60 70 80 90 100
FNDTFHDSVK HTALTTKRIA VVTQATTRCF YHYKRALNKS YENKKEREVA
110 120 130 140 150
LNKCHKMCAL ITLHALRSNG GIYIKLGQHI GAMTYLLPKE WTDTMIPLQD
160 170 180 190 200
HCPESTYEEI DELFKEDLGT SIEDMFLEFN KTPIGVASLA QVHVAKLKNS
210 220 230 240 250
DGKGSSVAVK CQHPSLKEFI PLDVMLTRTV FELLDVFFPD YPLTWLGDEL
260 270 280 290 300
QSSIYVELNF TKEAENAEKT RHYFSKFKKQ TALKIPKVIE SHKRILIMEY
310 320 330 340 350
VGGKRLDDLE YIDSHGISRS EVSSCLSHIF NNMIFTPNVG IHCDPHGGNL
360 370 380 390 400
AIRSVKPAKD NGYHNFEIVL FDHGLYRYPS TRTRRLYAKF WLSLLFDKDQ
410 420 430 440 450
TKMKKYAKGF ANITDEQFPL LAAAITGRSI DAALNYDIST SRTQEEMDVM
460 470 480 490 500
ANGILEGTLL SDLMSILSRI PRVVLLILKT NDLTRHLDEC LQNPLGPERT
510 520 530 540 550
FLIMTQYCAK TVYDEKVERI NSEYARWSIK WMWENLTNWI VYERRINQLY
560
FYDFVLWWKK FIPKTWLSS
Length:569
Mass (Da):65,917
Last modified:November 1, 1996 - v1
Checksum:i7DC8EE15C09C26E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20865 Genomic DNA Translation: AAB67388.1
BK006945 Genomic DNA Translation: DAA09566.1
PIRiS59398
RefSeqiNP_013354.1, NM_001182140.1

Genome annotation databases

EnsemblFungiiYLR253W; YLR253W; YLR253W
GeneIDi850955
KEGGisce:YLR253W

Similar proteinsi

Entry informationi

Entry nameiMCP2_YEAST
AccessioniPrimary (citable) accession number: Q06567
Secondary accession number(s): D6VYQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health