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Protein

ABC1 family protein MCP2

Gene

MCP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression (PubMed:25683707). Involved in mitochondrial lipid homeostasis (PubMed:23781023).2 Publications

GO - Biological processi

  • lipid homeostasis Source: SGD
  • mitochondrion organization Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32357-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC1 family protein MCP21 Publication
Alternative name(s):
MDM10-complementing protein 21 Publication
MIOREX complex component 131 Publication
Mitochondrial organization of gene expression protein 131 Publication
Gene namesi
Name:MCP21 Publication
Synonyms:MRX131 Publication
Ordered Locus Names:YLR253WImported
ORF Names:L9672.2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR253W.
SGDiS000004243. MCP2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 3416Mitochondrial matrix1 PublicationAdd
BLAST
Transmembranei35 – 5117HelicalSequence analysisAdd
BLAST
Topological domaini52 – 569518Mitochondrial intermembrane1 PublicationAdd
BLAST

GO - Cellular componenti

  • integral component of mitochondrial membrane Source: SGD
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1818MitochondrionSequence analysisAdd
BLAST
Chaini19 – 569551ABC1 family protein MCP2PRO_0000200737Add
BLAST

Proteomic databases

MaxQBiQ06567.

Interactioni

Protein-protein interaction databases

BioGridi31520. 26 interactions.
DIPiDIP-4782N.
IntActiQ06567. 2 interactions.
MINTiMINT-485659.

Structurei

3D structure databases

ProteinModelPortaliQ06567.
SMRiQ06567. Positions 158-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074734.
HOGENOMiHOG000188189.
InParanoidiQ06567.
KOiK08869.
OMAiRCFKLYK.
OrthoDBiEOG092C1H5E.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTKAFFNKL PFEVFRRYVR TGKSIPQRSP RTRKSLLVGG TIASAVVLYN
60 70 80 90 100
FNDTFHDSVK HTALTTKRIA VVTQATTRCF YHYKRALNKS YENKKEREVA
110 120 130 140 150
LNKCHKMCAL ITLHALRSNG GIYIKLGQHI GAMTYLLPKE WTDTMIPLQD
160 170 180 190 200
HCPESTYEEI DELFKEDLGT SIEDMFLEFN KTPIGVASLA QVHVAKLKNS
210 220 230 240 250
DGKGSSVAVK CQHPSLKEFI PLDVMLTRTV FELLDVFFPD YPLTWLGDEL
260 270 280 290 300
QSSIYVELNF TKEAENAEKT RHYFSKFKKQ TALKIPKVIE SHKRILIMEY
310 320 330 340 350
VGGKRLDDLE YIDSHGISRS EVSSCLSHIF NNMIFTPNVG IHCDPHGGNL
360 370 380 390 400
AIRSVKPAKD NGYHNFEIVL FDHGLYRYPS TRTRRLYAKF WLSLLFDKDQ
410 420 430 440 450
TKMKKYAKGF ANITDEQFPL LAAAITGRSI DAALNYDIST SRTQEEMDVM
460 470 480 490 500
ANGILEGTLL SDLMSILSRI PRVVLLILKT NDLTRHLDEC LQNPLGPERT
510 520 530 540 550
FLIMTQYCAK TVYDEKVERI NSEYARWSIK WMWENLTNWI VYERRINQLY
560
FYDFVLWWKK FIPKTWLSS
Length:569
Mass (Da):65,917
Last modified:November 1, 1996 - v1
Checksum:i7DC8EE15C09C26E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20865 Genomic DNA. Translation: AAB67388.1.
BK006945 Genomic DNA. Translation: DAA09566.1.
PIRiS59398.
RefSeqiNP_013354.1. NM_001182140.1.

Genome annotation databases

EnsemblFungiiYLR253W; YLR253W; YLR253W.
GeneIDi850955.
KEGGisce:YLR253W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20865 Genomic DNA. Translation: AAB67388.1.
BK006945 Genomic DNA. Translation: DAA09566.1.
PIRiS59398.
RefSeqiNP_013354.1. NM_001182140.1.

3D structure databases

ProteinModelPortaliQ06567.
SMRiQ06567. Positions 158-447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31520. 26 interactions.
DIPiDIP-4782N.
IntActiQ06567. 2 interactions.
MINTiMINT-485659.

Proteomic databases

MaxQBiQ06567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR253W; YLR253W; YLR253W.
GeneIDi850955.
KEGGisce:YLR253W.

Organism-specific databases

EuPathDBiFungiDB:YLR253W.
SGDiS000004243. MCP2.

Phylogenomic databases

GeneTreeiENSGT00550000074734.
HOGENOMiHOG000188189.
InParanoidiQ06567.
KOiK08869.
OMAiRCFKLYK.
OrthoDBiEOG092C1H5E.

Enzyme and pathway databases

BioCyciYEAST:G3O-32357-MONOMER.

Miscellaneous databases

PROiQ06567.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMCP2_YEAST
AccessioniPrimary (citable) accession number: Q06567
Secondary accession number(s): D6VYQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1600 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.