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Protein

Uncharacterized ATP-dependent helicase IRC20

Gene

IRC20

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Is probably involved in a pathway contributing to genomic integrity.

Miscellaneous

Present with 143 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi391 – 398ATPPROSITE-ProRule annotation8
Zinc fingeri1239 – 1277RING-typePROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • helicase activity Source: SGD
  • metal ion binding Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: SGD

GO - Biological processi

  • double-strand break repair via nonhomologous end joining Source: SGD
  • double-strand break repair via synthesis-dependent strand annealing Source: SGD

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processStress response
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32352-MONOMER
ReactomeiR-SCE-8866654 E3 ubiquitin ligases ubiquitinate target proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized ATP-dependent helicase IRC20 (EC:3.6.1.-)
Alternative name(s):
Increased recombination centers protein 20
Gene namesi
Name:IRC20
Ordered Locus Names:YLR247C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR247C
SGDiS000004237 IRC20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002681812 – 1556Uncharacterized ATP-dependent helicase IRC20Add BLAST1555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei810PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ06554
PaxDbiQ06554
PRIDEiQ06554

PTM databases

iPTMnetiQ06554

Expressioni

Inductioni

By heat shock and UV radiation.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi31515, 98 interactors
DIPiDIP-6373N
IntActiQ06554, 10 interactors
MINTiQ06554
STRINGi4932.YLR247C

Structurei

3D structure databases

ProteinModelPortaliQ06554
SMRiQ06554
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini378 – 583Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST206
Domaini1363 – 1531Helicase C-terminalPROSITE-ProRule annotationAdd BLAST169

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1239 – 1277RING-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00730000111123
InParanoidiQ06554
KOiK15710
OMAiIEATHVF
OrthoDBiEOG092C0ORB

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.30.40.10, 1 hit
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF52540 SSF52540, 4 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVGALLAR EYNVTAEKCD FFLENGSFDS VIAALPALNQ EQETVTQKVS
60 70 80 90 100
KNGKELINVA SVNIEIPERI SLSNNGRQLF KFIVDIEILP CENDNEATLV
110 120 130 140 150
VSSDSVSLFQ IGFKMENNSK IAVDKQLPLI LDICAHKNQE RALRNQLENR
160 170 180 190 200
KSLERKPSRK RRKKNSNVND PEKLLKSRIH ELSLSYKDFE CSPVVFRYND
210 220 230 240 250
SSLTWVLSFN LKLKFLNNKF NRFSVEANQI LDLTFSNRDE NEFERYHKHS
260 270 280 290 300
HIHSNFIQKQ FISQILEYSK DRLSKIKPFL PQSIPDLKVN LLPFQRESVE
310 320 330 340 350
WMLIKEGHGN SLSDTPTVID EVGLIDFMNE YYAYGYELIA RSPDEVGPSL
360 370 380 390 400
LWNKLTGYIL TTEDAAHLYN QYRKERLSGD YPVCAKGVLA EEMGLGKTIE
410 420 430 440 450
ILSLILLNRR KLKDSEATFI DDENRTITKT KTTLIICPNA ILKQWLEEIE
460 470 480 490 500
LHANSLKWYT YRGYNEIMKD CKTVDEAVQQ LCQYDIIVTS YNIIATEVHH
510 520 530 540 550
AEFNRSIRSR RLKSPKYDYS SPLALMQFYR IILDEVQMLR SSSTYSAKCT
560 570 580 590 600
SLLHRIHTWG VSGTPIQNIY NFRMIMSYLK LHPFCDEVDF IRTLQEEIKL
610 620 630 640 650
RNEAKDYTSN DFVCQLKGVR FSIKDCMNIF YRYDLCIRHS KANVASQIHI
660 670 680 690 700
PRQHNFIIPL EFAPIEWDNY LNLWNNFLEL SGYNSDGSGS PRVSNAFLNE
710 720 730 740 750
WLSRLRYICC HALFPEILST RQKRLHGHLS RISNIDDILI SMRMDAFDSL
760 770 780 790 800
IGYYRERFHL SIKQAQYELE ISNTPAKALE SFIKIRDDLM IHIRQKFNVE
810 820 830 840 850
DPFDKSLNLS EDEDEHMDER FGEKETSSGD ESDREINGAK NHDNHNNDGM
860 870 880 890 900
LSNHLKKKGL RAMMNLLHDC YFFLGSVYYN LGTRKLEEAD DKHRKEKTEE
910 920 930 940 950
VVYSDVFPKN ELEEIEENRL LEQENYANAE ILRKSILSSE ARKVDMTIKM
960 970 980 990 1000
ARTKFAPMTS NIPLRLINIE FDHKNDYSSN LAVSRCFKSL SKLIEGLNEQ
1010 1020 1030 1040 1050
TKNFNELLDE LLIIIYEPVH RTEDDDSTNK IIGNEEYSTS IDSQDKIFSL
1060 1070 1080 1090 1100
LGCLEIILQN RDNILTSESE VKIPKHLVPE GSIISKYQKQ LLNSLRLISG
1110 1120 1130 1140 1150
TPLRTVFDEL KNSRIVRRIS SSNESESTIQ NFEDYLLQYE VESKSLFKYN
1160 1170 1180 1190 1200
KQVRESLKIL GSIYNAKTEY YSQLQRISDS LVSLHSLSAP QLSHLIRTIN
1210 1220 1230 1240 1250
KSLGGTLDAK INNIESRLIY LKNLSRLKDT LNDNQILSCS ICLGEVEIGA
1260 1270 1280 1290 1300
IIKCGHYFCK SCILTWLRAH SKCPICKGFC SISEVYNFKF KNSTEKREKE
1310 1320 1330 1340 1350
IQEPRREGAD SSQDNSNENS IISNMSEVEK LFGNKYEQFH QINEVHQIHI
1360 1370 1380 1390 1400
KESFGAKIDF VIKLISYLRL KSEQENADPP QVILYSQKTE YLKVIGKVLK
1410 1420 1430 1440 1450
LYHIEHLACL SNTANVGETI NNFKRQPSVT CLLLNVKTLG AGLNLINAKH
1460 1470 1480 1490 1500
IFLLDPILNN SDELQAMGRN NRIGQDEETF VWNFMIRNTV EENILRYKCI
1510 1520 1530 1540 1550
LEERKRKEKS KKGDKYDEAQ DETDNEESDD AKFEISVVDQ EVSNEHLWNC

FFHGSD
Length:1,556
Mass (Da):180,344
Last modified:November 1, 1996 - v1
Checksum:i6258491CE361EAC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20865 Genomic DNA Translation: AAB67400.1
BK006945 Genomic DNA Translation: DAA09561.1
PIRiS59393
RefSeqiNP_013348.1, NM_001182134.1

Genome annotation databases

EnsemblFungiiYLR247C; YLR247C; YLR247C
GeneIDi850949
KEGGisce:YLR247C

Similar proteinsi

Entry informationi

Entry nameiIRC20_YEAST
AccessioniPrimary (citable) accession number: Q06554
Secondary accession number(s): D6VYP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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