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Q06549

- CDD_YEAST

UniProt

Q06549 - CDD_YEAST

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Protein

Cytidine deaminase

Gene

CDD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

Catalytic activityi

Cytidine + H2O = uridine + NH3.
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Zinc; catalytic
Active sitei63 – 631Proton donorBy similarity
Metal bindingi96 – 961Zinc; catalytic
Metal bindingi99 – 991Zinc; catalytic

GO - Molecular functioni

  1. cytidine deaminase activity Source: SGD
  2. identical protein binding Source: IntAct
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. cytidine catabolic process Source: SGD
  2. deoxycytidine catabolic process Source: SGD
  3. pyrimidine-containing compound salvage Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:YLR245C-MONOMER.
YEAST:YLR245C-MONOMER.
ReactomeiREACT_250994. Pyrimidine salvage reactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine deaminase (EC:3.5.4.5)
Short name:
CDA
Alternative name(s):
Cytidine aminohydrolase
Gene namesi
Name:CDD1
Ordered Locus Names:YLR245C
ORF Names:L9672.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR245c.
SGDiS000004235. CDD1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Cytidine deaminasePRO_0000171685Add
BLAST

Proteomic databases

MaxQBiQ06549.
PaxDbiQ06549.
PeptideAtlasiQ06549.

Expressioni

Gene expression databases

GenevestigatoriQ06549.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-4455,EBI-4455

Protein-protein interaction databases

BioGridi31512. 17 interactions.
DIPiDIP-1252N.
IntActiQ06549. 10 interactions.
MINTiMINT-398236.
STRINGi4932.YLR245C.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 2114Combined sources
Helixi22 – 243Combined sources
Turni28 – 303Combined sources
Beta strandi34 – 396Combined sources
Beta strandi45 – 495Combined sources
Helixi56 – 583Combined sources
Helixi62 – 7211Combined sources
Beta strandi81 – 877Combined sources
Beta strandi89 – 913Combined sources
Helixi97 – 1048Combined sources
Beta strandi112 – 1165Combined sources
Beta strandi118 – 12710Combined sources
Helixi128 – 1314Combined sources
Helixi138 – 1403Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R5TX-ray2.00A/B/C/D1-142[»]
ProteinModelPortaliQ06549.
SMRiQ06549. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06549.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 114105CMP/dCMP deaminase zinc-bindingAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 523Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0295.
GeneTreeiENSGT00390000000911.
HOGENOMiHOG000014707.
InParanoidiQ06549.
KOiK01489.
OMAiENATYGL.
OrthoDBiEOG7NCVG0.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06549-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVGGIEDRQ LEALKRAALK ACELSYSPYS HFRVGCSILT NNDVIFTGAN
60 70 80 90 100
VENASYSNCI CAERSAMIQV LMAGHRSGWK CMVICGDSED QCVSPCGVCR
110 120 130 140
QFINEFVVKD FPIVMLNSTG SRSKVMTMGE LLPMAFGPSH LN
Length:142
Mass (Da):15,536
Last modified:November 1, 1996 - v1
Checksum:i962BD69CCB30D51F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080089 Genomic DNA. Translation: AAD04031.1.
U20865 Genomic DNA. Translation: AAB67399.1.
AY557930 Genomic DNA. Translation: AAS56256.1.
BK006945 Genomic DNA. Translation: DAA09559.1.
PIRiS59391.
RefSeqiNP_013346.1. NM_001182132.1.

Genome annotation databases

EnsemblFungiiYLR245C; YLR245C; YLR245C.
GeneIDi850946.
KEGGisce:YLR245C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080089 Genomic DNA. Translation: AAD04031.1 .
U20865 Genomic DNA. Translation: AAB67399.1 .
AY557930 Genomic DNA. Translation: AAS56256.1 .
BK006945 Genomic DNA. Translation: DAA09559.1 .
PIRi S59391.
RefSeqi NP_013346.1. NM_001182132.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1R5T X-ray 2.00 A/B/C/D 1-142 [» ]
ProteinModelPortali Q06549.
SMRi Q06549. Positions 2-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31512. 17 interactions.
DIPi DIP-1252N.
IntActi Q06549. 10 interactions.
MINTi MINT-398236.
STRINGi 4932.YLR245C.

Proteomic databases

MaxQBi Q06549.
PaxDbi Q06549.
PeptideAtlasi Q06549.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR245C ; YLR245C ; YLR245C .
GeneIDi 850946.
KEGGi sce:YLR245C.

Organism-specific databases

CYGDi YLR245c.
SGDi S000004235. CDD1.

Phylogenomic databases

eggNOGi COG0295.
GeneTreei ENSGT00390000000911.
HOGENOMi HOG000014707.
InParanoidi Q06549.
KOi K01489.
OMAi ENATYGL.
OrthoDBi EOG7NCVG0.

Enzyme and pathway databases

BioCyci MetaCyc:YLR245C-MONOMER.
YEAST:YLR245C-MONOMER.
Reactomei REACT_250994. Pyrimidine salvage reactions.

Miscellaneous databases

EvolutionaryTracei Q06549.
NextBioi 967405.
PROi Q06549.

Gene expression databases

Genevestigatori Q06549.

Family and domain databases

InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view ]
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR01354. cyt_deam_tetra. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism."
    Kurtz J.-E., Exinger F., Erbs P., Jund R.
    Curr. Genet. 36:130-136(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: ATCC 28383 / FL100 / VTT C-80102.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1."
    Xie K., Sowden M.P., Dance G.S., Torelli A.T., Smith H.C., Wedekind J.E.
    Proc. Natl. Acad. Sci. U.S.A. 101:8114-8119(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH ZINC IONS, SUBUNIT.

Entry informationi

Entry nameiCDD_YEAST
AccessioniPrimary (citable) accession number: Q06549
Secondary accession number(s): D6VYP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3120 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3