GA-binding protein alpha chain - Homo sapiens (Human)

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Q06546 (GABPA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 134. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
GA-binding protein alpha chain
Short name=GABP subunit alpha

Alternative name(s):
Nuclear respiratory factor 2 subunit alpha
Transcription factor E4TF1-60

Gene names

Name:	GABPA
Synonyms:	E4TF1A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.
Subunit structure	Heterotetramer of two alpha and two beta subunits.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	in utero embryonic development Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara
Cellular_component	nuclear chromatin Inferred from direct assay PubMed 22306510. Source: BHF-UCL
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding Inferred from direct assay PubMed 22306510. Source: BHF-UCL RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from direct assay PubMed 22306510. Source: BHF-UCL protein heterodimerization activity Inferred from direct assay PubMed 9857059. Source: MGI transcription coactivator activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HCFC1	P51610	2	EBI-638925,EBI-396176

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 454

454

GA-binding protein alpha chain

PRO_0000204127

Regions

Domain

168 – 251

PNT

DNA binding

320 – 400

ETS

Natural variations

Natural variant

291

A → V.
Corresponds to variant rs2829897 [ dbSNP | Ensembl ].

VAR_020315

Natural variant

345

E → K.
Corresponds to variant rs2829900 [ dbSNP | Ensembl ].

VAR_020316

Experimental info

Sequence conflict

289 – 290

SS → RC in AAA65706. Ref.2

Sequence conflict

440

A → V in AAA65706. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q06546 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 1AF2ABBBC79191DD
Show »

FASTA

454

51,295

        10         20         30         40         50         60 
MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN LKKLLEPRLQ 

        70         80         90        100        110        120 
CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS YQGIEPKLNI LEIVKPADTV 

       130        140        150        160        170        180 
EVVIDPDAHH AESEAHLVEE AQVITLDGTK HITTISDETS EQVTRWAAAL EGYRKEQERL 

       190        200        210        220        230        240 
GIPYDPIQWS TDQVLHWVVW VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL 

       250        260        270        280        290        300 
WSHLELLRKY VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP 

       310        320        330        340        350        360 
RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL NQPELVAQKW 

       370        380        390        400        410        420 
GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV CDLKTLIGYS AAELNRLVTE 

       430        440        450 
CEQKKLAKMQ LHGIAQPVTA VALATASLQT EKDN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs." Watanabe H., Sawada J., Yano K., Yamaguchi K., Goto M., Handa H. Mol. Cell. Biol. 13:1385-1391(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain." Gugneja S., Virbasius J.V., Scarpulla R.C. Mol. Cell. Biol. 15:102-111(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13318 mRNA. Translation: BAA02575.1. U13044 mRNA. Translation: AAA65706.1.
IPI	IPI00299413.
PIR	A48146. I38739.
RefSeq	NP_001184226.1. NM_001197297.1. NP_002031.2. NM_002040.3.
UniGene	Hs.246310. Hs.473470.
3D structure databases
ProteinModelPortal	Q06546.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q06546. 2 interactions.
MINT	MINT-189695.
STRING	9606.ENSP00000346886.
PTM databases
PhosphoSite	Q06546.
Polymorphism databases
DMDM	729553.
Proteomic databases
PaxDb	Q06546.
PeptideAtlas	Q06546.
PRIDE	Q06546.
Protocols and materials databases
DNASU	2551.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354828; ENSP00000346886; ENSG00000154727. ENST00000400075; ENSP00000382948; ENSG00000154727.
GeneID	2551.
KEGG	hsa:2551.
UCSC	uc002ylx.4. human.
Organism-specific databases
CTD	2551.
GeneCards	GC21P027106.
HGNC	HGNC:4071. GABPA.
HPA	CAB004411. HPA003258. HPA028791.
MIM	600609. gene.
neXtProt	NX_Q06546.
PharmGKB	PA28485.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG252121.
HOGENOM	HOG000285952.
HOVERGEN	HBG051687.
InParanoid	Q06546.
KO	K09441.
OMA	GIPYDPV.
OrthoDB	EOG41NTKX.
PhylomeDB	Q06546.
Gene expression databases
ArrayExpress	Q06546.
Bgee	Q06546.
CleanEx	HS_GABPA.
Genevestigator	Q06546.
GermOnline	ENSG00000154727. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 1.10.150.50. 1 hit.
InterPro	IPR000418. Ets_dom. IPR024668. GABP_asu_N. IPR003118. Pointed_dom. IPR013761. SAM/pointed. IPR016312. TF_GA-bd_asu. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00178. Ets. 1 hit. PF11620. GABP-alpha. 1 hit. PF02198. SAM_PNT. 1 hit. [Graphical view]
PIRSF	PIRSF001703. GABP_alpha. 1 hit.
PRINTS	PR00454. ETSDOMAIN.
SMART	SM00413. ETS. 1 hit. SM00251. SAM_PNT. 1 hit. [Graphical view]
SUPFAM	SSF47769. SAM_homology. 1 hit.
PROSITE	PS00345. ETS_DOMAIN_1. 1 hit. PS00346. ETS_DOMAIN_2. 1 hit. PS50061. ETS_DOMAIN_3. 1 hit. PS51433. PNT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GABPA. human.
GenomeRNAi	2551.
NextBio	10071.
SOURCE	Search...

Entry information

Entry name

GABPA_HUMAN

Accession

Primary (citable) accession number: Q06546
Secondary accession number(s): Q12939

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 134 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents