Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GA-binding protein alpha chain

Gene

GABPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi320 – 40081ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: Ensembl
  • DNA binding Source: ProtInc
  • protein heterodimerization activity Source: MGI
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
  • sequence-specific DNA binding transcription factor activity Source: ProtInc
  • transcription coactivator activity Source: ProtInc
  • transcription regulatory region DNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_264212. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
GA-binding protein alpha chain
Short name:
GABP subunit alpha
Alternative name(s):
Nuclear respiratory factor 2 subunit alpha
Transcription factor E4TF1-60
Gene namesi
Name:GABPA
Synonyms:E4TF1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:4071. GABPA.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: BHF-UCL
  • nucleoplasm Source: HPA
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28485.

Polymorphism and mutation databases

BioMutaiGABPA.
DMDMi729553.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454GA-binding protein alpha chainPRO_0000204127Add
BLAST

Proteomic databases

MaxQBiQ06546.
PaxDbiQ06546.
PeptideAtlasiQ06546.
PRIDEiQ06546.

PTM databases

PhosphoSiteiQ06546.

Expressioni

Gene expression databases

BgeeiQ06546.
CleanExiHS_GABPA.
ExpressionAtlasiQ06546. baseline and differential.
GenevestigatoriQ06546.

Organism-specific databases

HPAiCAB004411.
HPA003258.
HPA028791.

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
HCFC1P516102EBI-638925,EBI-396176

Protein-protein interaction databases

BioGridi108826. 25 interactions.
DIPiDIP-33980N.
IntActiQ06546. 3 interactions.
MINTiMINT-189695.
STRINGi9606.ENSP00000346886.

Structurei

3D structure databases

ProteinModelPortaliQ06546.
SMRiQ06546. Positions 35-121, 168-254, 320-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 25184PNTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG252121.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000285952.
HOVERGENiHBG051687.
InParanoidiQ06546.
KOiK09441.
OMAiGIPYDPV.
OrthoDBiEOG7TXKGT.
PhylomeDBiQ06546.
TreeFamiTF350537.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR024668. GABP_asu_N.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016312. TF_GA-bd_asu.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF11620. GABP-alpha. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF001703. GABP_alpha. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN
60 70 80 90 100
LKKLLEPRLQ CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS
110 120 130 140 150
YQGIEPKLNI LEIVKPADTV EVVIDPDAHH AESEAHLVEE AQVITLDGTK
160 170 180 190 200
HITTISDETS EQVTRWAAAL EGYRKEQERL GIPYDPIQWS TDQVLHWVVW
210 220 230 240 250
VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL WSHLELLRKY
260 270 280 290 300
VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP
310 320 330 340 350
RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL
360 370 380 390 400
NQPELVAQKW GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV
410 420 430 440 450
CDLKTLIGYS AAELNRLVTE CEQKKLAKMQ LHGIAQPVTA VALATASLQT

EKDN
Length:454
Mass (Da):51,295
Last modified:February 1, 1995 - v1
Checksum:i1AF2ABBBC79191DD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti289 – 2902SS → RC in AAA65706 (PubMed:7799916).Curated
Sequence conflicti440 – 4401A → V in AAA65706 (PubMed:7799916).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti291 – 2911A → V.
Corresponds to variant rs2829897 [ dbSNP | Ensembl ].
VAR_020315
Natural varianti345 – 3451E → K.
Corresponds to variant rs2829900 [ dbSNP | Ensembl ].
VAR_020316

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13318 mRNA. Translation: BAA02575.1.
U13044 mRNA. Translation: AAA65706.1.
CCDSiCCDS13575.1.
PIRiA48146.
I38739.
RefSeqiNP_001184226.1. NM_001197297.1.
NP_002031.2. NM_002040.3.
XP_005260995.1. XM_005260938.3.
UniGeneiHs.473470.

Genome annotation databases

EnsembliENST00000354828; ENSP00000346886; ENSG00000154727.
ENST00000400075; ENSP00000382948; ENSG00000154727.
GeneIDi2551.
KEGGihsa:2551.
UCSCiuc002ylx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13318 mRNA. Translation: BAA02575.1.
U13044 mRNA. Translation: AAA65706.1.
CCDSiCCDS13575.1.
PIRiA48146.
I38739.
RefSeqiNP_001184226.1. NM_001197297.1.
NP_002031.2. NM_002040.3.
XP_005260995.1. XM_005260938.3.
UniGeneiHs.473470.

3D structure databases

ProteinModelPortaliQ06546.
SMRiQ06546. Positions 35-121, 168-254, 320-429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108826. 25 interactions.
DIPiDIP-33980N.
IntActiQ06546. 3 interactions.
MINTiMINT-189695.
STRINGi9606.ENSP00000346886.

PTM databases

PhosphoSiteiQ06546.

Polymorphism and mutation databases

BioMutaiGABPA.
DMDMi729553.

Proteomic databases

MaxQBiQ06546.
PaxDbiQ06546.
PeptideAtlasiQ06546.
PRIDEiQ06546.

Protocols and materials databases

DNASUi2551.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354828; ENSP00000346886; ENSG00000154727.
ENST00000400075; ENSP00000382948; ENSG00000154727.
GeneIDi2551.
KEGGihsa:2551.
UCSCiuc002ylx.4. human.

Organism-specific databases

CTDi2551.
GeneCardsiGC21P027106.
HGNCiHGNC:4071. GABPA.
HPAiCAB004411.
HPA003258.
HPA028791.
MIMi600609. gene.
neXtProtiNX_Q06546.
PharmGKBiPA28485.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG252121.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000285952.
HOVERGENiHBG051687.
InParanoidiQ06546.
KOiK09441.
OMAiGIPYDPV.
OrthoDBiEOG7TXKGT.
PhylomeDBiQ06546.
TreeFamiTF350537.

Enzyme and pathway databases

ReactomeiREACT_264212. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

ChiTaRSiGABPA. human.
GeneWikiiGABPA.
GenomeRNAii2551.
NextBioi10071.
PROiQ06546.
SOURCEiSearch...

Gene expression databases

BgeeiQ06546.
CleanExiHS_GABPA.
ExpressionAtlasiQ06546. baseline and differential.
GenevestigatoriQ06546.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR024668. GABP_asu_N.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016312. TF_GA-bd_asu.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF11620. GABP-alpha. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF001703. GABP_alpha. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs."
    Watanabe H., Sawada J., Yano K., Yamaguchi K., Goto M., Handa H.
    Mol. Cell. Biol. 13:1385-1391(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain."
    Gugneja S., Virbasius J.V., Scarpulla R.C.
    Mol. Cell. Biol. 15:102-111(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGABPA_HUMAN
AccessioniPrimary (citable) accession number: Q06546
Secondary accession number(s): Q12939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 29, 2015
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.