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Q06546

- GABPA_HUMAN

UniProt

Q06546 - GABPA_HUMAN

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Protein
GA-binding protein alpha chain
Gene
GABPA, E4TF1A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi320 – 40081ETS
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: BHF-UCL
  3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
  4. chromatin binding Source: Ensembl
  5. protein binding Source: IntAct
  6. protein heterodimerization activity Source: MGI
  7. sequence-specific DNA binding transcription factor activity Source: ProtInc
  8. transcription coactivator activity Source: ProtInc
  9. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. cell differentiation Source: RefGenome
  2. in utero embryonic development Source: Ensembl
  3. negative regulation of megakaryocyte differentiation Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  6. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_200608. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
GA-binding protein alpha chain
Short name:
GABP subunit alpha
Alternative name(s):
Nuclear respiratory factor 2 subunit alpha
Transcription factor E4TF1-60
Gene namesi
Name:GABPA
Synonyms:E4TF1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:4071. GABPA.

Subcellular locationi

GO - Cellular componenti

  1. nuclear chromatin Source: BHF-UCL
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28485.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454GA-binding protein alpha chain
PRO_0000204127Add
BLAST

Proteomic databases

MaxQBiQ06546.
PaxDbiQ06546.
PeptideAtlasiQ06546.
PRIDEiQ06546.

PTM databases

PhosphoSiteiQ06546.

Expressioni

Gene expression databases

ArrayExpressiQ06546.
BgeeiQ06546.
CleanExiHS_GABPA.
GenevestigatoriQ06546.

Organism-specific databases

HPAiCAB004411.
HPA003258.
HPA028791.

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
HCFC1P516102EBI-638925,EBI-396176

Protein-protein interaction databases

BioGridi108826. 24 interactions.
IntActiQ06546. 3 interactions.
MINTiMINT-189695.
STRINGi9606.ENSP00000346886.

Structurei

3D structure databases

ProteinModelPortaliQ06546.
SMRiQ06546. Positions 35-121, 168-254, 320-429.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 25184PNT
Add
BLAST

Sequence similaritiesi

Belongs to the ETS family.

Phylogenomic databases

eggNOGiNOG252121.
HOGENOMiHOG000285952.
HOVERGENiHBG051687.
InParanoidiQ06546.
KOiK09441.
OMAiGIPYDPV.
OrthoDBiEOG7TXKGT.
PhylomeDBiQ06546.
TreeFamiTF350537.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR024668. GABP_asu_N.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016312. TF_GA-bd_asu.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF11620. GABP-alpha. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF001703. GABP_alpha. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06546-1 [UniParc]FASTAAdd to Basket

« Hide

MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN    50
LKKLLEPRLQ CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS 100
YQGIEPKLNI LEIVKPADTV EVVIDPDAHH AESEAHLVEE AQVITLDGTK 150
HITTISDETS EQVTRWAAAL EGYRKEQERL GIPYDPIQWS TDQVLHWVVW 200
VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL WSHLELLRKY 250
VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP 300
RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL 350
NQPELVAQKW GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV 400
CDLKTLIGYS AAELNRLVTE CEQKKLAKMQ LHGIAQPVTA VALATASLQT 450
EKDN 454
Length:454
Mass (Da):51,295
Last modified:February 1, 1995 - v1
Checksum:i1AF2ABBBC79191DD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti291 – 2911A → V.
Corresponds to variant rs2829897 [ dbSNP | Ensembl ].
VAR_020315
Natural varianti345 – 3451E → K.
Corresponds to variant rs2829900 [ dbSNP | Ensembl ].
VAR_020316

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti289 – 2902SS → RC in AAA65706. 1 Publication
Sequence conflicti440 – 4401A → V in AAA65706. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13318 mRNA. Translation: BAA02575.1.
U13044 mRNA. Translation: AAA65706.1.
CCDSiCCDS13575.1.
PIRiA48146.
I38739.
RefSeqiNP_001184226.1. NM_001197297.1.
NP_002031.2. NM_002040.3.
XP_005260995.1. XM_005260938.2.
XP_005260996.1. XM_005260939.2.
UniGeneiHs.473470.

Genome annotation databases

EnsembliENST00000354828; ENSP00000346886; ENSG00000154727.
ENST00000400075; ENSP00000382948; ENSG00000154727.
GeneIDi2551.
KEGGihsa:2551.
UCSCiuc002ylx.4. human.

Polymorphism databases

DMDMi729553.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13318 mRNA. Translation: BAA02575.1 .
U13044 mRNA. Translation: AAA65706.1 .
CCDSi CCDS13575.1.
PIRi A48146.
I38739.
RefSeqi NP_001184226.1. NM_001197297.1.
NP_002031.2. NM_002040.3.
XP_005260995.1. XM_005260938.2.
XP_005260996.1. XM_005260939.2.
UniGenei Hs.473470.

3D structure databases

ProteinModelPortali Q06546.
SMRi Q06546. Positions 35-121, 168-254, 320-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108826. 24 interactions.
IntActi Q06546. 3 interactions.
MINTi MINT-189695.
STRINGi 9606.ENSP00000346886.

PTM databases

PhosphoSitei Q06546.

Polymorphism databases

DMDMi 729553.

Proteomic databases

MaxQBi Q06546.
PaxDbi Q06546.
PeptideAtlasi Q06546.
PRIDEi Q06546.

Protocols and materials databases

DNASUi 2551.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354828 ; ENSP00000346886 ; ENSG00000154727 .
ENST00000400075 ; ENSP00000382948 ; ENSG00000154727 .
GeneIDi 2551.
KEGGi hsa:2551.
UCSCi uc002ylx.4. human.

Organism-specific databases

CTDi 2551.
GeneCardsi GC21P027106.
HGNCi HGNC:4071. GABPA.
HPAi CAB004411.
HPA003258.
HPA028791.
MIMi 600609. gene.
neXtProti NX_Q06546.
PharmGKBi PA28485.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG252121.
HOGENOMi HOG000285952.
HOVERGENi HBG051687.
InParanoidi Q06546.
KOi K09441.
OMAi GIPYDPV.
OrthoDBi EOG7TXKGT.
PhylomeDBi Q06546.
TreeFami TF350537.

Enzyme and pathway databases

Reactomei REACT_200608. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

ChiTaRSi GABPA. human.
GeneWikii GABPA.
GenomeRNAii 2551.
NextBioi 10071.
PROi Q06546.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q06546.
Bgeei Q06546.
CleanExi HS_GABPA.
Genevestigatori Q06546.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProi IPR000418. Ets_dom.
IPR024668. GABP_asu_N.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016312. TF_GA-bd_asu.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF11620. GABP-alpha. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view ]
PIRSFi PIRSF001703. GABP_alpha. 1 hit.
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs."
    Watanabe H., Sawada J., Yano K., Yamaguchi K., Goto M., Handa H.
    Mol. Cell. Biol. 13:1385-1391(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain."
    Gugneja S., Virbasius J.V., Scarpulla R.C.
    Mol. Cell. Biol. 15:102-111(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGABPA_HUMAN
AccessioniPrimary (citable) accession number: Q06546
Secondary accession number(s): Q12939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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