Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GA-binding protein alpha chain

Gene

GABPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi320 – 400ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

  • activating transcription factor binding Source: UniProtKB
  • chromatin binding Source: Ensembl
  • DNA binding Source: ProtInc
  • DNA binding transcription factor activity Source: ProtInc
  • protein heterodimerization activity Source: MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: BHF-UCL
  • transcription coactivator activity Source: ProtInc
  • transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  • cell differentiation Source: GO_Central
  • cellular response to dopamine Source: CAFA
  • in utero embryonic development Source: Ensembl
  • mitochondrion organization Source: Reactome
  • negative regulation of megakaryocyte differentiation Source: Ensembl
  • negative regulation of transcription by RNA polymerase II Source: Ensembl
  • positive regulation of gene expression Source: CAFA
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • transcription by RNA polymerase II Source: ProtInc

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-2151201 Transcriptional activation of mitochondrial biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
GA-binding protein alpha chain
Short name:
GABP subunit alpha
Alternative name(s):
Nuclear respiratory factor 2 subunit alpha
Transcription factor E4TF1-60
Gene namesi
Name:GABPA
Synonyms:E4TF1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000154727.10
HGNCiHGNC:4071 GABPA
MIMi600609 gene
neXtProtiNX_Q06546

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2551
OpenTargetsiENSG00000154727
PharmGKBiPA28485

Polymorphism and mutation databases

BioMutaiGABPA
DMDMi729553

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041271 – 454GA-binding protein alpha chainAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei303PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ06546
MaxQBiQ06546
PaxDbiQ06546
PeptideAtlasiQ06546
PRIDEiQ06546

PTM databases

iPTMnetiQ06546
PhosphoSitePlusiQ06546

Expressioni

Gene expression databases

BgeeiENSG00000154727
CleanExiHS_GABPA
ExpressionAtlasiQ06546 baseline and differential
GenevisibleiQ06546 HS

Organism-specific databases

HPAiCAB004411
HPA003258
HPA028791

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.

Binary interactionsi

Show more details

GO - Molecular functioni

  • activating transcription factor binding Source: UniProtKB
  • protein heterodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi10882626 interactors.
DIPiDIP-33980N
IntActiQ06546 9 interactors.
MINTiQ06546
STRINGi9606.ENSP00000346886

Structurei

3D structure databases

ProteinModelPortaliQ06546
SMRiQ06546
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 251PNTPROSITE-ProRule annotationAdd BLAST84

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000285952
HOVERGENiHBG051687
InParanoidiQ06546
KOiK09441
OMAiNVFWTHL
OrthoDBiEOG091G0EXE
PhylomeDBiQ06546
TreeFamiTF350537

Family and domain databases

Gene3Di1.10.10.101 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR024668 GABP_asu_N
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR016312 TF_GA-bd_asu
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF11620 GABP-alpha, 1 hit
PF02198 SAM_PNT, 1 hit
PIRSFiPIRSF001703 GABP_alpha, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequencei

Sequence statusi: Complete.

Q06546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN
60 70 80 90 100
LKKLLEPRLQ CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS
110 120 130 140 150
YQGIEPKLNI LEIVKPADTV EVVIDPDAHH AESEAHLVEE AQVITLDGTK
160 170 180 190 200
HITTISDETS EQVTRWAAAL EGYRKEQERL GIPYDPIQWS TDQVLHWVVW
210 220 230 240 250
VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL WSHLELLRKY
260 270 280 290 300
VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP
310 320 330 340 350
RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL
360 370 380 390 400
NQPELVAQKW GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV
410 420 430 440 450
CDLKTLIGYS AAELNRLVTE CEQKKLAKMQ LHGIAQPVTA VALATASLQT

EKDN
Length:454
Mass (Da):51,295
Last modified:February 1, 1995 - v1
Checksum:i1AF2ABBBC79191DD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289 – 290SS → RC in AAA65706 (PubMed:7799916).Curated2
Sequence conflicti440A → V in AAA65706 (PubMed:7799916).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020315291A → V. Corresponds to variant dbSNP:rs2829897Ensembl.1
Natural variantiVAR_020316345E → K. Corresponds to variant dbSNP:rs2829900Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13318 mRNA Translation: BAA02575.1
U13044 mRNA Translation: AAA65706.1
CCDSiCCDS13575.1
PIRiA48146
I38739
RefSeqiNP_001184226.1, NM_001197297.1
NP_002031.2, NM_002040.3
XP_005260995.1, XM_005260938.4
XP_011527822.1, XM_011529520.2
XP_011527823.1, XM_011529521.2
XP_016883802.1, XM_017028313.1
UniGeneiHs.473470

Genome annotation databases

EnsembliENST00000354828; ENSP00000346886; ENSG00000154727
ENST00000400075; ENSP00000382948; ENSG00000154727
GeneIDi2551
KEGGihsa:2551
UCSCiuc002ylx.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGABPA_HUMAN
AccessioniPrimary (citable) accession number: Q06546
Secondary accession number(s): Q12939
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome