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Q06546

- GABPA_HUMAN

UniProt

Q06546 - GABPA_HUMAN

Protein

GA-binding protein alpha chain

Gene

GABPA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi320 – 40081ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. DNA binding Source: ProtInc
    3. protein binding Source: IntAct
    4. protein heterodimerization activity Source: MGI
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: BHF-UCL
    6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    7. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
    8. sequence-specific DNA binding transcription factor activity Source: ProtInc
    9. transcription coactivator activity Source: ProtInc
    10. transcription regulatory region DNA binding Source: MGI

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. in utero embryonic development Source: Ensembl
    3. negative regulation of megakaryocyte differentiation Source: Ensembl
    4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    6. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_200608. Transcriptional activation of mitochondrial biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GA-binding protein alpha chain
    Short name:
    GABP subunit alpha
    Alternative name(s):
    Nuclear respiratory factor 2 subunit alpha
    Transcription factor E4TF1-60
    Gene namesi
    Name:GABPA
    Synonyms:E4TF1A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:4071. GABPA.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear chromatin Source: BHF-UCL
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28485.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 454454GA-binding protein alpha chainPRO_0000204127Add
    BLAST

    Proteomic databases

    MaxQBiQ06546.
    PaxDbiQ06546.
    PeptideAtlasiQ06546.
    PRIDEiQ06546.

    PTM databases

    PhosphoSiteiQ06546.

    Expressioni

    Gene expression databases

    ArrayExpressiQ06546.
    BgeeiQ06546.
    CleanExiHS_GABPA.
    GenevestigatoriQ06546.

    Organism-specific databases

    HPAiCAB004411.
    HPA003258.
    HPA028791.

    Interactioni

    Subunit structurei

    Heterotetramer of two alpha and two beta subunits.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HCFC1P516102EBI-638925,EBI-396176

    Protein-protein interaction databases

    BioGridi108826. 24 interactions.
    IntActiQ06546. 3 interactions.
    MINTiMINT-189695.
    STRINGi9606.ENSP00000346886.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06546.
    SMRiQ06546. Positions 35-121, 168-254, 320-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini168 – 25184PNTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG252121.
    HOGENOMiHOG000285952.
    HOVERGENiHBG051687.
    InParanoidiQ06546.
    KOiK09441.
    OMAiGIPYDPV.
    OrthoDBiEOG7TXKGT.
    PhylomeDBiQ06546.
    TreeFamiTF350537.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR024668. GABP_asu_N.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR016312. TF_GA-bd_asu.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF11620. GABP-alpha. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001703. GABP_alpha. 1 hit.
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06546-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN    50
    LKKLLEPRLQ CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS 100
    YQGIEPKLNI LEIVKPADTV EVVIDPDAHH AESEAHLVEE AQVITLDGTK 150
    HITTISDETS EQVTRWAAAL EGYRKEQERL GIPYDPIQWS TDQVLHWVVW 200
    VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL WSHLELLRKY 250
    VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP 300
    RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL 350
    NQPELVAQKW GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV 400
    CDLKTLIGYS AAELNRLVTE CEQKKLAKMQ LHGIAQPVTA VALATASLQT 450
    EKDN 454
    Length:454
    Mass (Da):51,295
    Last modified:February 1, 1995 - v1
    Checksum:i1AF2ABBBC79191DD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti289 – 2902SS → RC in AAA65706. (PubMed:7799916)Curated
    Sequence conflicti440 – 4401A → V in AAA65706. (PubMed:7799916)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti291 – 2911A → V.
    Corresponds to variant rs2829897 [ dbSNP | Ensembl ].
    VAR_020315
    Natural varianti345 – 3451E → K.
    Corresponds to variant rs2829900 [ dbSNP | Ensembl ].
    VAR_020316

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13318 mRNA. Translation: BAA02575.1.
    U13044 mRNA. Translation: AAA65706.1.
    CCDSiCCDS13575.1.
    PIRiA48146.
    I38739.
    RefSeqiNP_001184226.1. NM_001197297.1.
    NP_002031.2. NM_002040.3.
    XP_005260995.1. XM_005260938.2.
    XP_005260996.1. XM_005260939.2.
    UniGeneiHs.473470.

    Genome annotation databases

    EnsembliENST00000354828; ENSP00000346886; ENSG00000154727.
    ENST00000400075; ENSP00000382948; ENSG00000154727.
    GeneIDi2551.
    KEGGihsa:2551.
    UCSCiuc002ylx.4. human.

    Polymorphism databases

    DMDMi729553.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13318 mRNA. Translation: BAA02575.1 .
    U13044 mRNA. Translation: AAA65706.1 .
    CCDSi CCDS13575.1.
    PIRi A48146.
    I38739.
    RefSeqi NP_001184226.1. NM_001197297.1.
    NP_002031.2. NM_002040.3.
    XP_005260995.1. XM_005260938.2.
    XP_005260996.1. XM_005260939.2.
    UniGenei Hs.473470.

    3D structure databases

    ProteinModelPortali Q06546.
    SMRi Q06546. Positions 35-121, 168-254, 320-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108826. 24 interactions.
    IntActi Q06546. 3 interactions.
    MINTi MINT-189695.
    STRINGi 9606.ENSP00000346886.

    PTM databases

    PhosphoSitei Q06546.

    Polymorphism databases

    DMDMi 729553.

    Proteomic databases

    MaxQBi Q06546.
    PaxDbi Q06546.
    PeptideAtlasi Q06546.
    PRIDEi Q06546.

    Protocols and materials databases

    DNASUi 2551.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354828 ; ENSP00000346886 ; ENSG00000154727 .
    ENST00000400075 ; ENSP00000382948 ; ENSG00000154727 .
    GeneIDi 2551.
    KEGGi hsa:2551.
    UCSCi uc002ylx.4. human.

    Organism-specific databases

    CTDi 2551.
    GeneCardsi GC21P027106.
    HGNCi HGNC:4071. GABPA.
    HPAi CAB004411.
    HPA003258.
    HPA028791.
    MIMi 600609. gene.
    neXtProti NX_Q06546.
    PharmGKBi PA28485.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG252121.
    HOGENOMi HOG000285952.
    HOVERGENi HBG051687.
    InParanoidi Q06546.
    KOi K09441.
    OMAi GIPYDPV.
    OrthoDBi EOG7TXKGT.
    PhylomeDBi Q06546.
    TreeFami TF350537.

    Enzyme and pathway databases

    Reactomei REACT_200608. Transcriptional activation of mitochondrial biogenesis.

    Miscellaneous databases

    ChiTaRSi GABPA. human.
    GeneWikii GABPA.
    GenomeRNAii 2551.
    NextBioi 10071.
    PROi Q06546.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q06546.
    Bgeei Q06546.
    CleanExi HS_GABPA.
    Genevestigatori Q06546.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR024668. GABP_asu_N.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR016312. TF_GA-bd_asu.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF11620. GABP-alpha. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001703. GABP_alpha. 1 hit.
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs."
      Watanabe H., Sawada J., Yano K., Yamaguchi K., Goto M., Handa H.
      Mol. Cell. Biol. 13:1385-1391(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain."
      Gugneja S., Virbasius J.V., Scarpulla R.C.
      Mol. Cell. Biol. 15:102-111(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGABPA_HUMAN
    AccessioniPrimary (citable) accession number: Q06546
    Secondary accession number(s): Q12939
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 147 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3