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Protein

Protein ARV1

Gene

ARV1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes. Regulates also the sphingolipid metabolism. Required for growth during anaerobiosis and sterol uptake.2 Publications

GO - Biological processi

  • endocytosis Source: SGD
  • ER to Golgi ceramide transport Source: SGD
  • GPI anchor biosynthetic process Source: SGD
  • intracellular sterol transport Source: SGD
  • regulation of plasma membrane sterol distribution Source: SGD
  • sphingolipid biosynthetic process Source: SGD
  • sterol import Source: SGD
  • sterol metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Lipid metabolism, Lipid transport, Sphingolipid metabolism, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32349-MONOMER.

Protein family/group databases

TCDBi9.A.19.1.1. the lipid intermediate transporter (arv1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ARV1
Gene namesi
Name:ARV1
Ordered Locus Names:YLR242C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR242C.
SGDiS000004232. ARV1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei248 – 270HelicalSequence analysisAdd BLAST23
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cortical endoplasmic reticulum Source: SGD
  • endoplasmic reticulum Source: SGD
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: SGD
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002281351 – 321Protein ARV1Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ06541.

Interactioni

Protein-protein interaction databases

BioGridi31509. 272 interactors.
DIPiDIP-5171N.
IntActiQ06541. 1 interactor.
MINTiMINT-527421.

Structurei

3D structure databases

ProteinModelPortaliQ06541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARV1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000246756.
InParanoidiQ06541.
OMAiSCTKLFP.
OrthoDBiEOG092C4MMR.

Family and domain databases

InterProiIPR007290. Arv1.
[Graphical view]
PANTHERiPTHR14467. PTHR14467. 3 hits.
PfamiPF04161. Arv1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICITCMRPV DSLYTVYSND HIQLTDCPYC QETVDKYVEI DNVLLFIDLL
60 70 80 90 100
LLKAGAYRHL VFNALELHLS KYPKRKALND CQCLRDYTQA LLFNVKNWFC
110 120 130 140 150
KYDRLNRLWL LLLSFEIYLT WVTEESKYIY YLNRNNNDGK LIMLSKKLPE
160 170 180 190 200
SFKWDSAIMR NTITSKVFTW SPPIQYLYFA SYCILDVSLF HTFTQYFILK
210 220 230 240 250
KLHWKHYSVS SKDVISYTIL LSYGAKIFPI LMLIWPYDTL ISMSIIKWVA
260 270 280 290 300
NLYIIESLKI VTNLSYWNII KIFISVSLLR YFMVKPILIV FVAKFNFSVI
310 320
KNLIHQEFIL LLQKSGTYLL L
Length:321
Mass (Da):38,194
Last modified:November 1, 1996 - v1
Checksum:i2898F797A5805433
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20865 Genomic DNA. Translation: AAB67397.1.
AY692846 Genomic DNA. Translation: AAT92865.1.
AY899245 mRNA. Translation: AAX83930.1.
BK006945 Genomic DNA. Translation: DAA09556.1.
PIRiS59388.
RefSeqiNP_013343.1. NM_001182129.1.

Genome annotation databases

EnsemblFungiiYLR242C; YLR242C; YLR242C.
GeneIDi850943.
KEGGisce:YLR242C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20865 Genomic DNA. Translation: AAB67397.1.
AY692846 Genomic DNA. Translation: AAT92865.1.
AY899245 mRNA. Translation: AAX83930.1.
BK006945 Genomic DNA. Translation: DAA09556.1.
PIRiS59388.
RefSeqiNP_013343.1. NM_001182129.1.

3D structure databases

ProteinModelPortaliQ06541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31509. 272 interactors.
DIPiDIP-5171N.
IntActiQ06541. 1 interactor.
MINTiMINT-527421.

Protein family/group databases

TCDBi9.A.19.1.1. the lipid intermediate transporter (arv1) family.

Proteomic databases

PRIDEiQ06541.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR242C; YLR242C; YLR242C.
GeneIDi850943.
KEGGisce:YLR242C.

Organism-specific databases

EuPathDBiFungiDB:YLR242C.
SGDiS000004232. ARV1.

Phylogenomic databases

HOGENOMiHOG000246756.
InParanoidiQ06541.
OMAiSCTKLFP.
OrthoDBiEOG092C4MMR.

Enzyme and pathway databases

BioCyciYEAST:G3O-32349-MONOMER.

Miscellaneous databases

PROiQ06541.

Family and domain databases

InterProiIPR007290. Arv1.
[Graphical view]
PANTHERiPTHR14467. PTHR14467. 3 hits.
PfamiPF04161. Arv1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARV1_YEAST
AccessioniPrimary (citable) accession number: Q06541
Secondary accession number(s): D6VYP0, Q2VQX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.