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Protein

Pre-mRNA-splicing factor URN1

Gene

URN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the spliceosome involved in mRNA processing.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-34283-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor URN1
Alternative name(s):
U2-U5-U6 snRNP, RES complex and NTC-interacting pre-mRNA-splicing factor 1
Gene namesi
Name:URN1
Ordered Locus Names:YPR152C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR152C.
SGDiS000006356. URN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444771 – 465Pre-mRNA-splicing factor URN1Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei150PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06525.
PRIDEiQ06525.

PTM databases

iPTMnetiQ06525.

Interactioni

Subunit structurei

Component of the precatalytic spliceosomal complex B. Interacts with PRP19.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AIM4P383056EBI-35138,EBI-20939
PRP19P325237EBI-35138,EBI-493

Protein-protein interaction databases

BioGridi36319. 235 interactors.
DIPiDIP-2017N.
IntActiQ06525. 69 interactors.
MINTiMINT-401712.

Structurei

Secondary structure

1465
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi216 – 225Combined sources10
Turni230 – 232Combined sources3
Helixi235 – 241Combined sources7
Beta strandi242 – 244Combined sources3
Helixi247 – 249Combined sources3
Helixi253 – 264Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JUCNMR-A212-266[»]
ProteinModelPortaliQ06525.
SMRiQ06525.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06525.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 32WWPROSITE-ProRule annotationAdd BLAST32
Domaini212 – 266FFAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi119 – 192Glu-richAdd BLAST74

Sequence similaritiesi

Contains 1 FF domain.Curated
Contains 1 WW domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000141866.
InParanoidiQ06525.
OMAiEPTKYHY.
OrthoDBiEOG092C53R7.

Family and domain databases

Gene3Di1.10.10.440. 1 hit.
InterProiIPR002713. FF_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF01846. FF. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00441. FF. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
SSF81698. SSF81698. 1 hit.
PROSITEiPS51676. FF. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGEWQEFKT PAGKKYYYNK NTKQSRWEKP NLKKGSNLES NAKESQTERK
60 70 80 90 100
PTFSLELVNG WHLIIYNDGT KLYFNDDSKE FKNDISQEDD SRCRSLIESL
110 120 130 140 150
DKEKLVLLIG VARGYTMREE DIDKILESCN EEIHLFKRNQ DEVERKDEIS
160 170 180 190 200
EEAGDVKSPL QESHTGLVSG YGSSSGEEDE EEDEEEDEEN EEQIVNQDIS
210 220 230 240 250
IIDDLNRIDT DDIDERNIFF ELFDRYKLDK FSTWSLQSKK IENDPDFYKI
260 270 280 290 300
RDDTVRESLF EEWCGERSGN ATAEESDSED NSEDDSEVLE PTKYHYLAQI
310 320 330 340 350
VANAGTIAPD TIPQDIRKQQ KALYKAYKIK EYIPSKRDQD KFVSQLLFYY
360 370 380 390 400
KTFDLEQRKE IFCDCLRDHE RDFTGAVESL RQDKELIDRW QTLLKAPADS
410 420 430 440 450
SSIEDILLSI EHRCCVSPIV VTEPRYYVVG ILEKTVVWVR WLAAEVGPSS
460
RFTPVGAGNE PINPE
Length:465
Mass (Da):54,139
Last modified:November 1, 1996 - v1
Checksum:iB32285888B7DB772
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40829 Genomic DNA. Translation: AAB68289.1.
AY692740 Genomic DNA. Translation: AAT92759.1.
BK006949 Genomic DNA. Translation: DAA11564.1.
PIRiS69038.
RefSeqiNP_015478.1. NM_001184249.1.

Genome annotation databases

EnsemblFungiiYPR152C; YPR152C; YPR152C.
GeneIDi856275.
KEGGisce:YPR152C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40829 Genomic DNA. Translation: AAB68289.1.
AY692740 Genomic DNA. Translation: AAT92759.1.
BK006949 Genomic DNA. Translation: DAA11564.1.
PIRiS69038.
RefSeqiNP_015478.1. NM_001184249.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JUCNMR-A212-266[»]
ProteinModelPortaliQ06525.
SMRiQ06525.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36319. 235 interactors.
DIPiDIP-2017N.
IntActiQ06525. 69 interactors.
MINTiMINT-401712.

PTM databases

iPTMnetiQ06525.

Proteomic databases

MaxQBiQ06525.
PRIDEiQ06525.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR152C; YPR152C; YPR152C.
GeneIDi856275.
KEGGisce:YPR152C.

Organism-specific databases

EuPathDBiFungiDB:YPR152C.
SGDiS000006356. URN1.

Phylogenomic databases

HOGENOMiHOG000141866.
InParanoidiQ06525.
OMAiEPTKYHY.
OrthoDBiEOG092C53R7.

Enzyme and pathway databases

BioCyciYEAST:G3O-34283-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ06525.
PROiQ06525.

Family and domain databases

Gene3Di1.10.10.440. 1 hit.
InterProiIPR002713. FF_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF01846. FF. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00441. FF. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
SSF81698. SSF81698. 1 hit.
PROSITEiPS51676. FF. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiURN1_YEAST
AccessioniPrimary (citable) accession number: Q06525
Secondary accession number(s): D6W4E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1310 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.