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Protein

Lysophosphatidic acid:oleoyl-CoA acyltransferase 1

Gene

LOA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acyl-CoA-dependent lysophosphatidic acid acyltransferase with preference for oleoyl-CoA. Involved in triacylglyceride homeostasis and lipid droplet formation. Involved in vacuolar protein sorting.2 Publications

Catalytic activityi

Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular triglyceride homeostasis Source: SGD
  • lipid metabolic process Source: UniProtKB-KW
  • lipid particle organization Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid metabolism, Phospholipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:G3O-34274-MONOMER.
YEAST:G3O-34274-MONOMER.
BRENDAi2.3.1.51. 984.

Chemistry databases

SwissLipidsiSLP:000000079.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid:oleoyl-CoA acyltransferase 1 (EC:2.3.1.51)
Short name:
LPAAT
Short name:
Lysophosphatidic acid acyltransferase
Alternative name(s):
Vacuolar protein sorting-associated protein 66
Gene namesi
Name:LOA1
Synonyms:VPS66
Ordered Locus Names:YPR139C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR139C.
SGDiS000006343. LOA1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: SGD
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • lipid particle Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659081 – 300Lysophosphatidic acid:oleoyl-CoA acyltransferase 1Add BLAST300

Proteomic databases

MaxQBiQ06508.
PRIDEiQ06508.

Interactioni

Protein-protein interaction databases

BioGridi36308. 24 interactors.
IntActiQ06508. 4 interactors.
MINTiMINT-4083874.

Structurei

3D structure databases

ProteinModelPortaliQ06508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi101 – 106HXXXXD motif6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000001006.
InParanoidiQ06508.
OMAiMFLEGTC.
OrthoDBiEOG092C3CHS.

Sequencei

Sequence statusi: Complete.

Q06508-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYTNWRDN GTGIAPFLPN TIRKPSKVMT ACLLGILGVK TIIMLPLIML
60 70 80 90 100
YLLTGQNNLL GLILKFTFSW KEEITVQGIK KRDVRKSKHY PQKGKLYICN
110 120 130 140 150
CTSPLDAFSV VLLAQGPVTL LVPSNDIVYK VSIREFINFI LAGGLDIKLY
160 170 180 190 200
GHEVAELSQL GNTVNFMFAE GTSCNGKSVL PFSITGKKLK EFIDPSITTM
210 220 230 240 250
NPAMAKTKKF ELQTIQIKTN KTAITTLPIS NMEYLSRFLN KGINVKCKIN
260 270 280 290 300
EPQVLSDNLE ELRVALNGGD KYKLVSRKLD VESKRNFVKE YISDQRKKRK
Length:300
Mass (Da):33,816
Last modified:November 1, 1996 - v1
Checksum:iD04AAB2CCF051D23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40829 Genomic DNA. Translation: AAB68279.1.
AY693235 Genomic DNA. Translation: AAT93254.1.
BK006949 Genomic DNA. Translation: DAA11553.1.
PIRiS69028.
RefSeqiNP_015465.1. NM_001184236.1.

Genome annotation databases

EnsemblFungiiYPR139C; YPR139C; YPR139C.
GeneIDi856261.
KEGGisce:YPR139C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40829 Genomic DNA. Translation: AAB68279.1.
AY693235 Genomic DNA. Translation: AAT93254.1.
BK006949 Genomic DNA. Translation: DAA11553.1.
PIRiS69028.
RefSeqiNP_015465.1. NM_001184236.1.

3D structure databases

ProteinModelPortaliQ06508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36308. 24 interactors.
IntActiQ06508. 4 interactors.
MINTiMINT-4083874.

Chemistry databases

SwissLipidsiSLP:000000079.

Proteomic databases

MaxQBiQ06508.
PRIDEiQ06508.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR139C; YPR139C; YPR139C.
GeneIDi856261.
KEGGisce:YPR139C.

Organism-specific databases

EuPathDBiFungiDB:YPR139C.
SGDiS000006343. LOA1.

Phylogenomic databases

HOGENOMiHOG000001006.
InParanoidiQ06508.
OMAiMFLEGTC.
OrthoDBiEOG092C3CHS.

Enzyme and pathway databases

BioCyciMetaCyc:G3O-34274-MONOMER.
YEAST:G3O-34274-MONOMER.
BRENDAi2.3.1.51. 984.

Miscellaneous databases

PROiQ06508.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiLOA1_YEAST
AccessioniPrimary (citable) accession number: Q06508
Secondary accession number(s): D6W4D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6630 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.