Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lysophosphatidic acid:oleoyl-CoA acyltransferase 1

Gene

LOA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acyl-CoA-dependent lysophosphatidic acid acyltransferase with preference for oleoyl-CoA. Involved in triacylglyceride homeostasis and lipid droplet formation. Involved in vacuolar protein sorting.2 Publications

Miscellaneous

Present with 6630 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular triglyceride homeostasis Source: SGD
  • lipid metabolic process Source: UniProtKB-KW
  • lipid particle organization Source: SGD

Keywordsi

Molecular functionTransferase
Biological processLipid metabolism, Phospholipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:G3O-34274-MONOMER
YEAST:G3O-34274-MONOMER
BRENDAi2.3.1.51 984

Chemistry databases

SwissLipidsiSLP:000000079

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid:oleoyl-CoA acyltransferase 1 (EC:2.3.1.51)
Short name:
LPAAT
Short name:
Lysophosphatidic acid acyltransferase
Alternative name(s):
Vacuolar protein sorting-associated protein 66
Gene namesi
Name:LOA1
Synonyms:VPS66
Ordered Locus Names:YPR139C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR139C
SGDiS000006343 LOA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659081 – 300Lysophosphatidic acid:oleoyl-CoA acyltransferase 1Add BLAST300

Proteomic databases

MaxQBiQ06508
PaxDbiQ06508
PRIDEiQ06508

Interactioni

Protein-protein interaction databases

BioGridi36308, 27 interactors
IntActiQ06508, 5 interactors
MINTiQ06508
STRINGi4932.YPR139C

Structurei

3D structure databases

ProteinModelPortaliQ06508
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi101 – 106HXXXXD motif6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000001006
InParanoidiQ06508
OMAiNWRDKGT
OrthoDBiEOG092C3CHS

Sequencei

Sequence statusi: Complete.

Q06508-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYTNWRDN GTGIAPFLPN TIRKPSKVMT ACLLGILGVK TIIMLPLIML
60 70 80 90 100
YLLTGQNNLL GLILKFTFSW KEEITVQGIK KRDVRKSKHY PQKGKLYICN
110 120 130 140 150
CTSPLDAFSV VLLAQGPVTL LVPSNDIVYK VSIREFINFI LAGGLDIKLY
160 170 180 190 200
GHEVAELSQL GNTVNFMFAE GTSCNGKSVL PFSITGKKLK EFIDPSITTM
210 220 230 240 250
NPAMAKTKKF ELQTIQIKTN KTAITTLPIS NMEYLSRFLN KGINVKCKIN
260 270 280 290 300
EPQVLSDNLE ELRVALNGGD KYKLVSRKLD VESKRNFVKE YISDQRKKRK
Length:300
Mass (Da):33,816
Last modified:November 1, 1996 - v1
Checksum:iD04AAB2CCF051D23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40829 Genomic DNA Translation: AAB68279.1
AY693235 Genomic DNA Translation: AAT93254.1
BK006949 Genomic DNA Translation: DAA11553.1
PIRiS69028
RefSeqiNP_015465.1, NM_001184236.1

Genome annotation databases

EnsemblFungiiYPR139C; YPR139C; YPR139C
GeneIDi856261
KEGGisce:YPR139C

Similar proteinsi

Entry informationi

Entry nameiLOA1_YEAST
AccessioniPrimary (citable) accession number: Q06508
Secondary accession number(s): D6W4D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health