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Q06507

- ATF4_MOUSE

UniProt

Q06507 - ATF4_MOUSE

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Protein

Cyclic AMP-dependent transcription factor ATF-4

Gene

Atf4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.7 Publications

GO - Molecular functioni

  1. core promoter sequence-specific DNA binding Source: UniProtKB
  2. DNA binding Source: MGI
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. circadian regulation of gene expression Source: UniProtKB
  2. circadian rhythm Source: UniProtKB
  3. gamma-aminobutyric acid signaling pathway Source: Ensembl
  4. gluconeogenesis Source: MGI
  5. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
  6. negative regulation of potassium ion transport Source: Ensembl
  7. positive regulation of neuron apoptotic process Source: UniProtKB
  8. positive regulation of transcription, DNA-templated Source: UniProtKB
  9. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  10. positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
  11. regulation of transcription, DNA-templated Source: UniProtKB
  12. regulation of transcription from RNA polymerase II promoter Source: MGI
  13. response to endoplasmic reticulum stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_32838. ATF6-alpha activates chaperone genes.
REACT_90370. ATF4 activates genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-4
Short name:
cAMP-dependent transcription factor ATF-4
Alternative name(s):
Activating transcription factor 4
C/EBP-related ATF
Short name:
C/ATF
Tax-responsive enhancer element-binding protein 67 homolog
Short name:
TaxREB67 homolog
Gene namesi
Name:Atf4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:88096. Atf4.

Subcellular locationi

Cytoplasm. Cell membrane. Nucleus. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. Colocalizes with NEK6 in the centrosome (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoskeleton Source: UniProtKB-KW
  3. dendrite membrane Source: Ensembl
  4. nucleus Source: UniProtKB
  5. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Null mice exhibit an increase in serum insulin levels and low blood glucose levels. There is a decrease in total fat content, gonadal fat, lean mass and body weight. Serum levels of osteocalcin/BGLAP are decreased. PBK/AKT1-mediated phosphorylation of FOXO1 at 'Ser-258' is increased with a subsequent decrease of FOXO1-mediated transcriptional activity.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi212 – 2121T → A: Promotes stabilization due to impaired ubiquitination; when associated with A-223; A-230; A-234 and A-247. 1 Publication
Mutagenesisi218 – 2181S → A: Promotes stabilization due to impaired ubiquitination. 1 Publication
Mutagenesisi223 – 2231S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-230; A-234 and A-247. 1 Publication
Mutagenesisi230 – 2301S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-223; A-234 and A-247. 1 Publication
Mutagenesisi234 – 2341S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-223; A-230 and A-247. 1 Publication
Mutagenesisi247 – 2471S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-223; A-230 and A-234. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Cyclic AMP-dependent transcription factor ATF-4PRO_0000076585Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei212 – 2121Phosphothreonine1 Publication
Modified residuei218 – 2181Phosphoserine1 Publication
Modified residuei223 – 2231Phosphoserine1 Publication
Modified residuei230 – 2301Phosphoserine1 Publication
Modified residuei234 – 2341Phosphoserine1 Publication
Modified residuei247 – 2471Phosphoserine1 Publication

Post-translational modificationi

Ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4.1 Publication
Phosphorylated by NEK6 (By similarity). Phosphorylated on the betaTrCP degron motif at Ser-218, followed by phosphorylation at Thr-212, Ser-223, Ser-230, Ser-234 and Ser-247, promoting interaction with BTRC and ubiquitination. Phosphorylation is promoted by mTORC1.By similarity1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ06507.

PTM databases

PhosphoSiteiQ06507.

Expressioni

Developmental stagei

At E16.5, expressed in osteoblasts surrounding newly formed trabecular bone. At postnatal day 2, detected in most osteoblasts and lining cells. By postnatal week 4, is detected in fewer osteoblasts, but remains present in lining cells (at protein level).1 Publication

Inductioni

By ER stress. Expressed in a circadian manner in the liver with an increased expression seen during the light phase. Expressed in a circadian manner in the midbrain with an increased expression seen during the dark phase (at protein level). Expressed in a circadian manner also in the suprachiasmatic nucleus (SCN) of the brain, cerebral cortex, kidney and small intestine.3 Publications

Gene expression databases

BgeeiQ06507.
CleanExiMM_ATF4.
ExpressionAtlasiQ06507. baseline and differential.
GenevestigatoriQ06507.

Interactioni

Subunit structurei

Binds DNA as a homo- or heterodimer. Interacts with CEP290 (via an N-terminal region). Interacts with NEK6, DAPK2 (isoform 2) and ZIPK/DAPK3. Interacts (via its leucine zipper domain) with GABBR1 and GABBR2 (via their C-termini) (By similarity). Forms a heterodimer with TXLNG in osteoblasts. Interacts (via its DNA binding domain) with FOXO1 (C-terminal half); the interaction occurs in osteoblasts and regulates glucose homeostasis through suppression of beta-cell proliferation and a decrease in insulin production. Interacts with SATB2; the interaction results in enhanced DNA binding and transactivation by these transcription factors. Interacts with DDIT3/CHOP (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Dapk3O547843EBI-77383,EBI-77359
Trib3Q8K4K23EBI-77383,EBI-448962

Protein-protein interaction databases

BioGridi198235. 12 interactions.
DIPiDIP-30969N.
IntActiQ06507. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ06507.
SMRiQ06507. Positions 284-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini276 – 33964bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni278 – 29821Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni303 – 33937Interaction with GABBR1By similarityAdd
BLAST
Regioni304 – 33229Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi214 – 22310BetaTrCP degron motif

Domaini

The BetaTrCP degron motif promotes binding to BTRC when phosphorylated.1 Publication

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG325856.
GeneTreeiENSGT00530000063801.
HOVERGENiHBG004301.
InParanoidiQ06507.
KOiK04374.
OMAiGECRELE.
OrthoDBiEOG72JWGW.
TreeFamiTF316136.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06507-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEMSFLNSE VLAGDLMSPF DQSGLGAEES LGLLDDYLEV AKHLKPHGFS
60 70 80 90 100
SDKAGSSEWP AMDDGLASAS DTGKEDAFSG TDWMLEKMDL KEFDFDALFR
110 120 130 140 150
MDDLETMPDE LLTTLDDTCD LFAPLVQETN KEPPQTVNPI GHLPESLIKV
160 170 180 190 200
DQVAPFTFLQ PFPCSPGVLS STPEHSFSLE LGSEVDISEG DRKPDSAAYI
210 220 230 240 250
TLIPPCVKEE DTPSDNDSGI CMSPESYLGS PQHSPSTSRA PPDNLPSPGG
260 270 280 290 300
SRGSPRPKPY DPPGVSLTAK VKTEKLDKKL KKMEQNKTAA TRYRQKKRAE
310 320 330 340
QEALTGECKE LEKKNEALKE KADSLAKEIQ YLKDLIEEVR KARGKKRVP
Length:349
Mass (Da):38,355
Last modified:July 27, 2011 - v2
Checksum:i0C3F895755B1C7B9
GO

Sequence cautioni

The sequence AAA53043.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti345 – 3451K → Q in AAA40476. (PubMed:8506317)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13791 mRNA. Translation: AAA40476.1.
M94087 mRNA. Translation: AAA53043.1. Different initiation.
AK138657 mRNA. Translation: BAE23736.1.
AK144777 mRNA. Translation: BAE26060.1.
AK146193 mRNA. Translation: BAE26967.1.
AK156298 mRNA. Translation: BAE33662.1.
CH466550 Genomic DNA. Translation: EDL04604.1.
CH466550 Genomic DNA. Translation: EDL04605.1.
BC085169 mRNA. Translation: AAH85169.1.
CCDSiCCDS37145.1.
RefSeqiNP_001274109.1. NM_001287180.1.
NP_033846.2. NM_009716.3.
UniGeneiMm.641.

Genome annotation databases

EnsembliENSMUST00000109605; ENSMUSP00000105234; ENSMUSG00000042406.
GeneIDi11911.
KEGGimmu:11911.
UCSCiuc007wvl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13791 mRNA. Translation: AAA40476.1 .
M94087 mRNA. Translation: AAA53043.1 . Different initiation.
AK138657 mRNA. Translation: BAE23736.1 .
AK144777 mRNA. Translation: BAE26060.1 .
AK146193 mRNA. Translation: BAE26967.1 .
AK156298 mRNA. Translation: BAE33662.1 .
CH466550 Genomic DNA. Translation: EDL04604.1 .
CH466550 Genomic DNA. Translation: EDL04605.1 .
BC085169 mRNA. Translation: AAH85169.1 .
CCDSi CCDS37145.1.
RefSeqi NP_001274109.1. NM_001287180.1.
NP_033846.2. NM_009716.3.
UniGenei Mm.641.

3D structure databases

ProteinModelPortali Q06507.
SMRi Q06507. Positions 284-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198235. 12 interactions.
DIPi DIP-30969N.
IntActi Q06507. 3 interactions.

PTM databases

PhosphoSitei Q06507.

Proteomic databases

PRIDEi Q06507.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000109605 ; ENSMUSP00000105234 ; ENSMUSG00000042406 .
GeneIDi 11911.
KEGGi mmu:11911.
UCSCi uc007wvl.1. mouse.

Organism-specific databases

CTDi 468.
MGIi MGI:88096. Atf4.

Phylogenomic databases

eggNOGi NOG325856.
GeneTreei ENSGT00530000063801.
HOVERGENi HBG004301.
InParanoidi Q06507.
KOi K04374.
OMAi GECRELE.
OrthoDBi EOG72JWGW.
TreeFami TF316136.

Enzyme and pathway databases

Reactomei REACT_32838. ATF6-alpha activates chaperone genes.
REACT_90370. ATF4 activates genes.

Miscellaneous databases

ChiTaRSi ATF4. mouse.
NextBioi 279981.
PROi Q06507.
SOURCEi Search...

Gene expression databases

Bgeei Q06507.
CleanExi MM_ATF4.
ExpressionAtlasi Q06507. baseline and differential.
Genevestigatori Q06507.

Family and domain databases

InterProi IPR004827. bZIP.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements."
    Vallejo M., Ron D., Miller C.P., Habener J.F.
    Proc. Natl. Acad. Sci. U.S.A. 90:4679-4683(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
    Tissue: Adipocyte.
  2. "Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun."
    Chevray P.M., Nathans D.
    Proc. Natl. Acad. Sci. U.S.A. 89:5789-5793(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Embryo.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/c, C57BL/6J and NOD.
    Tissue: Lung, Spinal cord and Spleen.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.
  6. "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death."
    Ohoka N., Yoshii S., Hattori T., Onozaki K., Hayashi H.
    EMBO J. 24:1243-1255(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice."
    Yu V.W., Ambartsoumian G., Verlinden L., Moir J.M., Prud'homme J., Gauthier C., Roughley P.J., St-Arnaud R.
    J. Cell Biol. 169:591-601(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TXLNG.
  8. "SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation."
    Dobreva G., Chahrour M., Dautzenberg M., Chirivella L., Kanzler B., Farinas I., Karsenty G., Grosschedl R.
    Cell 125:971-986(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SATB2.
  9. "FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes."
    Yu V.W., Akhouayri O., St-Arnaud R.
    Gene Expr. Patterns 9:335-340(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
  10. "Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA."
    Galehdar Z., Swan P., Fuerth B., Callaghan S.M., Park D.S., Cregan S.P.
    J. Neurosci. 30:16938-16948(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  11. "cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene."
    Koyanagi S., Hamdan A.M., Horiguchi M., Kusunose N., Okamoto A., Matsunaga N., Ohdo S.
    J. Biol. Chem. 286:32416-32423(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  12. "FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis."
    Kode A., Mosialou I., Silva B.C., Joshi S., Ferron M., Rached M.T., Kousteni S.
    J. Biol. Chem. 287:8757-8768(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, INTERACTION WITH FOXO1, FUNCTION.
  13. "Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain."
    Ushijima K., Koyanagi S., Sato Y., Ogata T., Matsunaga N., Fujimura A., Ohdo S.
    Mol. Pharmacol. 82:264-270(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  14. Cited for: FUNCTION, UBIQUITINATION, PHOSPHORYLATION AT THR-212; SER-218; SER-223; SER-230; SER-234 AND SER-247, MUTAGENESIS OF THR-212; SER-218; SER-223; SER-230; SER-234 AND SER-247.

Entry informationi

Entry nameiATF4_MOUSE
AccessioniPrimary (citable) accession number: Q06507
Secondary accession number(s): Q5U4B2, Q61906
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3