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Q06507

- ATF4_MOUSE

UniProt

Q06507 - ATF4_MOUSE

Protein

Cyclic AMP-dependent transcription factor ATF-4

Gene

Atf4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.7 Publications

    GO - Molecular functioni

    1. core promoter sequence-specific DNA binding Source: UniProtKB
    2. DNA binding Source: MGI
    3. protein binding Source: UniProtKB
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    6. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. circadian regulation of gene expression Source: UniProtKB
    2. circadian rhythm Source: UniProtKB
    3. gamma-aminobutyric acid signaling pathway Source: Ensembl
    4. gluconeogenesis Source: MGI
    5. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
    6. negative regulation of potassium ion transport Source: Ensembl
    7. positive regulation of neuron apoptotic process Source: UniProtKB
    8. positive regulation of transcription, DNA-templated Source: UniProtKB
    9. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    10. regulation of transcription, DNA-templated Source: UniProtKB
    11. regulation of transcription from RNA polymerase II promoter Source: MGI
    12. response to endoplasmic reticulum stress Source: UniProtKB

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_32838. ATF6-alpha activates chaperone genes.
    REACT_90370. ATF4 activates genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-4
    Short name:
    cAMP-dependent transcription factor ATF-4
    Alternative name(s):
    Activating transcription factor 4
    C/EBP-related ATF
    Short name:
    C/ATF
    Tax-responsive enhancer element-binding protein 67 homolog
    Short name:
    TaxREB67 homolog
    Gene namesi
    Name:Atf4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:88096. Atf4.

    Subcellular locationi

    Cytoplasm. Cell membrane. Nucleus. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
    Note: Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. Colocalizes with NEK6 in the centrosome By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. dendrite membrane Source: Ensembl
    3. microtubule organizing center Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB
    5. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Null mice exhibit an increase in serum insulin levels and low blood glucose levels. There is a decrease in total fat content, gonadal fat, lean mass and body weight. Serum levels of osteocalcin/BGLAP are decreased. PBK/AKT1-mediated phosphorylation of FOXO1 at 'Ser-258' is increased with a subsequent decrease of FOXO1-mediated transcriptional activity.1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi212 – 2121T → A: Promotes stabilization due to impaired ubiquitination; when associated with A-223; A-230; A-234 and A-247. 1 Publication
    Mutagenesisi218 – 2181S → A: Promotes stabilization due to impaired ubiquitination. 1 Publication
    Mutagenesisi223 – 2231S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-230; A-234 and A-247. 1 Publication
    Mutagenesisi230 – 2301S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-223; A-234 and A-247. 1 Publication
    Mutagenesisi234 – 2341S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-223; A-230 and A-247. 1 Publication
    Mutagenesisi247 – 2471S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-223; A-230 and A-234. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Cyclic AMP-dependent transcription factor ATF-4PRO_0000076585Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei212 – 2121Phosphothreonine1 Publication
    Modified residuei218 – 2181Phosphoserine1 Publication
    Modified residuei223 – 2231Phosphoserine1 Publication
    Modified residuei230 – 2301Phosphoserine1 Publication
    Modified residuei234 – 2341Phosphoserine1 Publication
    Modified residuei247 – 2471Phosphoserine1 Publication

    Post-translational modificationi

    Ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4.1 Publication
    Phosphorylated by NEK6 By similarity. Phosphorylated on the betaTrCP degron motif at Ser-218, followed by phosphorylation at Thr-212, Ser-223, Ser-230, Ser-234 and Ser-247, promoting interaction with BTRC and ubiquitination. Phosphorylation is promoted by mTORC1.By similarity1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ06507.

    PTM databases

    PhosphoSiteiQ06507.

    Expressioni

    Developmental stagei

    At E16.5, expressed in osteoblasts surrounding newly formed trabecular bone. At postnatal day 2, detected in most osteoblasts and lining cells. By postnatal week 4, is detected in fewer osteoblasts, but remains present in lining cells (at protein level).1 Publication

    Inductioni

    By ER stress. Expressed in a circadian manner in the liver with an increased expression seen during the light phase. Expressed in a circadian manner in the midbrain with an increased expression seen during the dark phase (at protein level). Expressed in a circadian manner also in the suprachiasmatic nucleus (SCN) of the brain, cerebral cortex, kidney and small intestine.3 Publications

    Gene expression databases

    ArrayExpressiQ06507.
    BgeeiQ06507.
    CleanExiMM_ATF4.
    GenevestigatoriQ06507.

    Interactioni

    Subunit structurei

    Binds DNA as a homo- or heterodimer. Interacts with CEP290 (via an N-terminal region). Interacts with NEK6, DAPK2 (isoform 2) and ZIPK/DAPK3. Interacts (via its leucine zipper domain) with GABBR1 and GABBR2 (via their C-termini) By similarity. Forms a heterodimer with TXLNG in osteoblasts. Interacts (via its DNA binding domain) with FOXO1 (C-terminal half); the interaction occurs in osteoblasts and regulates glucose homeostasis through suppression of beta-cell proliferation and a decrease in insulin production. Interacts with SATB2; the interaction results in enhanced DNA binding and transactivation by these transcription factors. Interacts with DDIT3/CHOP By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Trib3Q8K4K23EBI-77383,EBI-448962

    Protein-protein interaction databases

    BioGridi198235. 12 interactions.
    DIPiDIP-30969N.
    IntActiQ06507. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06507.
    SMRiQ06507. Positions 284-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini276 – 33964bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni278 – 29821Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni303 – 33937Interaction with GABBR1By similarityAdd
    BLAST
    Regioni304 – 33229Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi214 – 22310BetaTrCP degron motif

    Domaini

    The BetaTrCP degron motif promotes binding to BTRC when phosphorylated.1 Publication

    Sequence similaritiesi

    Belongs to the bZIP family.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG325856.
    GeneTreeiENSGT00530000063801.
    HOVERGENiHBG004301.
    KOiK04374.
    OMAiGECRELE.
    OrthoDBiEOG72JWGW.
    TreeFamiTF316136.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06507-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEMSFLNSE VLAGDLMSPF DQSGLGAEES LGLLDDYLEV AKHLKPHGFS    50
    SDKAGSSEWP AMDDGLASAS DTGKEDAFSG TDWMLEKMDL KEFDFDALFR 100
    MDDLETMPDE LLTTLDDTCD LFAPLVQETN KEPPQTVNPI GHLPESLIKV 150
    DQVAPFTFLQ PFPCSPGVLS STPEHSFSLE LGSEVDISEG DRKPDSAAYI 200
    TLIPPCVKEE DTPSDNDSGI CMSPESYLGS PQHSPSTSRA PPDNLPSPGG 250
    SRGSPRPKPY DPPGVSLTAK VKTEKLDKKL KKMEQNKTAA TRYRQKKRAE 300
    QEALTGECKE LEKKNEALKE KADSLAKEIQ YLKDLIEEVR KARGKKRVP 349
    Length:349
    Mass (Da):38,355
    Last modified:July 27, 2011 - v2
    Checksum:i0C3F895755B1C7B9
    GO

    Sequence cautioni

    The sequence AAA53043.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti345 – 3451K → Q in AAA40476. (PubMed:8506317)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13791 mRNA. Translation: AAA40476.1.
    M94087 mRNA. Translation: AAA53043.1. Different initiation.
    AK138657 mRNA. Translation: BAE23736.1.
    AK144777 mRNA. Translation: BAE26060.1.
    AK146193 mRNA. Translation: BAE26967.1.
    AK156298 mRNA. Translation: BAE33662.1.
    CH466550 Genomic DNA. Translation: EDL04604.1.
    CH466550 Genomic DNA. Translation: EDL04605.1.
    BC085169 mRNA. Translation: AAH85169.1.
    CCDSiCCDS37145.1.
    RefSeqiNP_001274109.1. NM_001287180.1.
    NP_033846.2. NM_009716.3.
    UniGeneiMm.641.

    Genome annotation databases

    EnsembliENSMUST00000109605; ENSMUSP00000105234; ENSMUSG00000042406.
    GeneIDi11911.
    KEGGimmu:11911.
    UCSCiuc007wvl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13791 mRNA. Translation: AAA40476.1 .
    M94087 mRNA. Translation: AAA53043.1 . Different initiation.
    AK138657 mRNA. Translation: BAE23736.1 .
    AK144777 mRNA. Translation: BAE26060.1 .
    AK146193 mRNA. Translation: BAE26967.1 .
    AK156298 mRNA. Translation: BAE33662.1 .
    CH466550 Genomic DNA. Translation: EDL04604.1 .
    CH466550 Genomic DNA. Translation: EDL04605.1 .
    BC085169 mRNA. Translation: AAH85169.1 .
    CCDSi CCDS37145.1.
    RefSeqi NP_001274109.1. NM_001287180.1.
    NP_033846.2. NM_009716.3.
    UniGenei Mm.641.

    3D structure databases

    ProteinModelPortali Q06507.
    SMRi Q06507. Positions 284-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198235. 12 interactions.
    DIPi DIP-30969N.
    IntActi Q06507. 2 interactions.

    PTM databases

    PhosphoSitei Q06507.

    Proteomic databases

    PRIDEi Q06507.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000109605 ; ENSMUSP00000105234 ; ENSMUSG00000042406 .
    GeneIDi 11911.
    KEGGi mmu:11911.
    UCSCi uc007wvl.1. mouse.

    Organism-specific databases

    CTDi 468.
    MGIi MGI:88096. Atf4.

    Phylogenomic databases

    eggNOGi NOG325856.
    GeneTreei ENSGT00530000063801.
    HOVERGENi HBG004301.
    KOi K04374.
    OMAi GECRELE.
    OrthoDBi EOG72JWGW.
    TreeFami TF316136.

    Enzyme and pathway databases

    Reactomei REACT_32838. ATF6-alpha activates chaperone genes.
    REACT_90370. ATF4 activates genes.

    Miscellaneous databases

    ChiTaRSi ATF4. mouse.
    NextBioi 279981.
    PROi Q06507.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q06507.
    Bgeei Q06507.
    CleanExi MM_ATF4.
    Genevestigatori Q06507.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements."
      Vallejo M., Ron D., Miller C.P., Habener J.F.
      Proc. Natl. Acad. Sci. U.S.A. 90:4679-4683(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
      Tissue: Adipocyte.
    2. "Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun."
      Chevray P.M., Nathans D.
      Proc. Natl. Acad. Sci. U.S.A. 89:5789-5793(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Embryo.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: BALB/c, C57BL/6J and NOD.
      Tissue: Lung, Spinal cord and Spleen.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye.
    6. "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death."
      Ohoka N., Yoshii S., Hattori T., Onozaki K., Hayashi H.
      EMBO J. 24:1243-1255(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice."
      Yu V.W., Ambartsoumian G., Verlinden L., Moir J.M., Prud'homme J., Gauthier C., Roughley P.J., St-Arnaud R.
      J. Cell Biol. 169:591-601(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TXLNG.
    8. "SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation."
      Dobreva G., Chahrour M., Dautzenberg M., Chirivella L., Kanzler B., Farinas I., Karsenty G., Grosschedl R.
      Cell 125:971-986(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SATB2.
    9. "FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes."
      Yu V.W., Akhouayri O., St-Arnaud R.
      Gene Expr. Patterns 9:335-340(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
    10. "Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA."
      Galehdar Z., Swan P., Fuerth B., Callaghan S.M., Park D.S., Cregan S.P.
      J. Neurosci. 30:16938-16948(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    11. "cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene."
      Koyanagi S., Hamdan A.M., Horiguchi M., Kusunose N., Okamoto A., Matsunaga N., Ohdo S.
      J. Biol. Chem. 286:32416-32423(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    12. "FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis."
      Kode A., Mosialou I., Silva B.C., Joshi S., Ferron M., Rached M.T., Kousteni S.
      J. Biol. Chem. 287:8757-8768(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, INTERACTION WITH FOXO1, FUNCTION.
    13. "Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain."
      Ushijima K., Koyanagi S., Sato Y., Ogata T., Matsunaga N., Fujimura A., Ohdo S.
      Mol. Pharmacol. 82:264-270(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    14. Cited for: FUNCTION, UBIQUITINATION, PHOSPHORYLATION AT THR-212; SER-218; SER-223; SER-230; SER-234 AND SER-247, MUTAGENESIS OF THR-212; SER-218; SER-223; SER-230; SER-234 AND SER-247.

    Entry informationi

    Entry nameiATF4_MOUSE
    AccessioniPrimary (citable) accession number: Q06507
    Secondary accession number(s): Q5U4B2, Q61906
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3