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Protein

Sodium-dependent phosphate transport protein 2A

Gene

Slc34a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.1 Publication

Miscellaneous

The cotransport has a Na+:Pi stoichiometry of 3:1 and is electrogenic.
PTH induces lysosomal degradation of the cotransporter.

GO - Molecular functioni

  • PDZ domain binding Source: RGD
  • protein homodimerization activity Source: RGD
  • sodium:phosphate symporter activity Source: GO_Central
  • sodium-dependent phosphate transmembrane transporter activity Source: RGD

GO - Biological processi

  • arsenate ion transmembrane transport Source: RGD
  • bone remodeling Source: RGD
  • cellular phosphate ion homeostasis Source: GO_Central
  • cellular response to metal ion Source: RGD
  • cellular response to parathyroid hormone stimulus Source: RGD
  • cellular response to staurosporine Source: RGD
  • dentinogenesis Source: RGD
  • gentamycin metabolic process Source: RGD
  • glycoprotein metabolic process Source: RGD
  • indole metabolic process Source: RGD
  • kidney development Source: RGD
  • ossification Source: RGD
  • phosphate ion homeostasis Source: RGD
  • phosphate ion transport Source: RGD
  • positive regulation of membrane potential Source: RGD
  • positive regulation of phosphate transmembrane transport Source: RGD
  • positive regulation of sodium-dependent phosphate transport Source: RGD
  • protein homooligomerization Source: RGD
  • response to cadmium ion Source: RGD
  • response to drug Source: RGD
  • response to estradiol Source: RGD
  • response to growth hormone Source: RGD
  • response to lead ion Source: RGD
  • response to magnesium ion Source: RGD
  • response to mercury ion Source: RGD
  • response to nutrient Source: RGD
  • response to parathyroid hormone Source: RGD
  • response to peptide Source: RGD
  • response to peptide hormone Source: RGD
  • response to potassium ion Source: RGD
  • response to thyroid hormone Source: RGD
  • response to vitamin A Source: RGD
  • sodium-dependent phosphate transport Source: RGD
  • tricarboxylic acid metabolic process Source: RGD

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-RNO-427589 Type II Na+/Pi cotransporters
R-RNO-5683826 Surfactant metabolism

Protein family/group databases

TCDBi2.A.58.1.1 the phosphate:na(+) symporter (pnas) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 2A
Short name:
Sodium-phosphate transport protein 2A
Alternative name(s):
Na(+)-dependent phosphate cotransporter 2A
Sodium/phosphate cotransporter 2A
Short name:
Na(+)/Pi cotransporter 2A
Short name:
NaPi-2a
Solute carrier family 34 member 1Imported
Gene namesi
Name:Slc34a1Imported
Synonyms:Slc17a2Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi3708 Slc34a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 103CytoplasmicSequence analysisAdd BLAST103
Transmembranei104 – 125Helical; Name=M1Sequence analysisAdd BLAST22
Topological domaini126 – 145ExtracellularSequence analysisAdd BLAST20
Transmembranei146 – 163Helical; Name=M2Sequence analysisAdd BLAST18
Topological domaini164 – 216CytoplasmicSequence analysisAdd BLAST53
Transmembranei217 – 236Helical; Name=M3Sequence analysisAdd BLAST20
Topological domaini237 – 345ExtracellularSequence analysisAdd BLAST109
Transmembranei346 – 368Helical; Name=M4Sequence analysisAdd BLAST23
Topological domaini369 – 410CytoplasmicSequence analysisAdd BLAST42
Transmembranei411 – 434Helical; Name=M5Sequence analysisAdd BLAST24
Topological domaini435 – 464ExtracellularSequence analysisAdd BLAST30
Transmembranei465 – 485Helical; Name=M6Sequence analysisAdd BLAST21
Topological domaini486 – 511CytoplasmicSequence analysisAdd BLAST26
Transmembranei512 – 532Helical; Name=M7Sequence analysisAdd BLAST21
Topological domaini533 – 537ExtracellularSequence analysis5
Transmembranei538 – 559Helical; Name=M8Sequence analysisAdd BLAST22
Topological domaini560 – 637CytoplasmicSequence analysisAdd BLAST78

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686101 – 637Sodium-dependent phosphate transport protein 2AAdd BLAST637

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei34PhosphoserineBy similarity1
Disulfide bondi225 ↔ 520Sequence analysis
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi306 ↔ 3341 Publication
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei506Phosphothreonine; by PKCSequence analysis1
Modified residuei605PhosphoserineCombined sources1
Modified residuei621PhosphothreonineCombined sources1
Modified residuei623PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ06496
PRIDEiQ06496

PTM databases

iPTMnetiQ06496
PhosphoSitePlusiQ06496

Expressioni

Tissue specificityi

Kidney.

Inductioni

By low-phosphate diet.1 Publication

Gene expression databases

BgeeiENSRNOG00000015262
GenevisibleiQ06496 RN

Interactioni

Subunit structurei

Interacts via its C-terminal region with PDZK2. Interacts with SLC9A3R1.By similarity

GO - Molecular functioni

  • PDZ domain binding Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031764

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC34A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8P Eukaryota
COG1283 LUCA
GeneTreeiENSGT00390000005032
HOGENOMiHOG000006550
HOVERGENiHBG006527
InParanoidiQ06496
KOiK14683
OMAiGKRTAKY
OrthoDBiEOG091G0DR5
PhylomeDBiQ06496
TreeFamiTF313981

Family and domain databases

InterProiView protein in InterPro
IPR003841 Na/Pi_transpt
IPR029848 Na/Pi_transpt_2A
PANTHERiPTHR10010 PTHR10010, 1 hit
PTHR10010:SF21 PTHR10010:SF21, 1 hit
PfamiView protein in Pfam
PF02690 Na_Pi_cotrans, 2 hits
TIGRFAMsiTIGR01013 2a58, 1 hit

Sequencei

Sequence statusi: Complete.

Q06496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSYSERLGG PAVSPLPVRG RHMVHGAAFA YVPSPQVLHR IPGTTTYAIS
60 70 80 90 100
SLSPVALTEH SCPYGEVLEC HDPLPAKLAQ EEEQKPEPRL SQKLAQVGTK
110 120 130 140 150
LLKVPLMLGF LYLFVCSLDV LSSAFQLAGG KVAGDIFKDN AILSNPVAGL
160 170 180 190 200
VVGILVTVLV QSSSTSTSII VSMVSSGLLE VSSAIPIIMG SNIGTSVTNT
210 220 230 240 250
IVALMQAGDR TDFRRAFAGA TVHDCFNWLS VLVLLPLEAA TGYLHHVTGL
260 270 280 290 300
VVASFNIRGG RDAPDLLKVI TEPFTKLIIQ LDKSVITSIA VGDESLRNHS
310 320 330 340 350
LIRIWCQPET KEASTSMSRV EAIGSLANTT MEKCNHIFVD TGLPDLAVGL
360 370 380 390 400
ILLAGSLVVL CTCLILLVKM LNSLLKGQVA NVIQKVINTD FPAPFTWVTG
410 420 430 440 450
YFAMVVGASM TFVVQSSSVF TSAITPLIGL GVISIERAYP LTLGSNIGTT
460 470 480 490 500
TTAILAALAS PREKLSSSFQ IALCHFFFNI SGILLWYPLP CTRLPIRMAK
510 520 530 540 550
ALGKRTAKYR WFAVLYLLVC FLLLPSLVFG ISMAGWQAMV GVGTPFGALL
560 570 580 590 600
AFVVLVNVLQ SRSPGHLPKW LQTWDFLPRW MHSLQPLDGL ITRATLCYAR
610 620 630
PEPRSPQLPP RVFLEELPPA TPSPRLALPA HHNATRL
Length:637
Mass (Da):68,707
Last modified:February 1, 1995 - v1
Checksum:i34D02E7817683F42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13257 mRNA Translation: AAC37608.1
BC078876 mRNA Translation: AAH78876.1
PIRiA48189
RefSeqiNP_037162.1, NM_013030.1
UniGeneiRn.92022

Genome annotation databases

EnsembliENSRNOT00000033749; ENSRNOP00000031764; ENSRNOG00000015262
GeneIDi25548
KEGGirno:25548
UCSCiRGD:3708 rat

Similar proteinsi

Entry informationi

Entry nameiNPT2A_RAT
AccessioniPrimary (citable) accession number: Q06496
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health