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Q06495

- NPT2A_HUMAN

UniProt

Q06495 - NPT2A_HUMAN

Protein

Sodium-dependent phosphate transport protein 2A

Gene

SLC34A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. sodium-dependent phosphate transmembrane transporter activity Source: UniProtKB
    3. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. arsenate ion transmembrane transport Source: Ensembl
    2. bone remodeling Source: Ensembl
    3. cellular response to metal ion Source: Ensembl
    4. cellular response to parathyroid hormone stimulus Source: Ensembl
    5. cellular response to staurosporine Source: Ensembl
    6. dentinogenesis Source: Ensembl
    7. gentamycin metabolic process Source: Ensembl
    8. glycoprotein metabolic process Source: Ensembl
    9. indole metabolic process Source: Ensembl
    10. ion transport Source: Reactome
    11. kidney development Source: Ensembl
    12. ossification Source: Ensembl
    13. phosphate ion homeostasis Source: UniProtKB
    14. phosphate ion transport Source: UniProtKB
    15. positive regulation of membrane potential Source: Ensembl
    16. positive regulation of phosphate transmembrane transport Source: Ensembl
    17. positive regulation of sodium-dependent phosphate transport Source: Ensembl
    18. protein homooligomerization Source: Ensembl
    19. response to cadmium ion Source: UniProtKB
    20. response to drug Source: Ensembl
    21. response to estradiol Source: Ensembl
    22. response to growth hormone Source: Ensembl
    23. response to lead ion Source: UniProtKB
    24. response to magnesium ion Source: Ensembl
    25. response to mercury ion Source: UniProtKB
    26. response to potassium ion Source: Ensembl
    27. response to thyroid hormone Source: Ensembl
    28. response to vitamin A Source: Ensembl
    29. sodium ion transport Source: UniProtKB-KW
    30. transmembrane transport Source: Reactome
    31. tricarboxylic acid metabolic process Source: Ensembl

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_19411. Type II Na+/Pi cotransporters.
    SignaLinkiQ06495.

    Protein family/group databases

    TCDBi2.A.58.1.5. the phosphate:na(+) symporter (pnas) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent phosphate transport protein 2A
    Short name:
    Sodium-phosphate transport protein 2A
    Alternative name(s):
    Na(+)-dependent phosphate cotransporter 2A
    NaPi-3
    Sodium/phosphate cotransporter 2A
    Short name:
    Na(+)/Pi cotransporter 2A
    Short name:
    NaPi-2a
    Solute carrier family 34 member 1
    Gene namesi
    Name:SLC34A1
    Synonyms:NPT2, SLC17A2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:11019. SLC34A1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. brush border membrane Source: UniProtKB
    4. cell surface Source: Ensembl
    5. endosome Source: Ensembl
    6. integral component of plasma membrane Source: UniProtKB
    7. membrane raft Source: Ensembl
    8. perinuclear region of cytoplasm Source: Ensembl
    9. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Nephrolithiasis/osteoporosis, hypophosphatemic, 1 (NPHLOP1) [MIM:612286]: A disease characterized by decreased renal phosphate absorption, renal phosphate wasting, hypophosphatemia, hyperphosphaturia, hypercalciuria, nephrolithiasis and osteoporosis.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481A → F in NPHLOP1; causes hypophosphatemic urolithiasis; results in lower phosphate current, decreases affinity for phosphate and decreases phosphate uptake compared to wild-type; shows a dominant-negative effect; requires 2 nucleotide substitutions. 1 Publication
    VAR_024765
    Natural varianti147 – 1471V → M in NPHLOP1; causes hypophosphatemic osteoporosis; results in lower phosphate current, decreases affinity for phosphate and decreases phosphate uptake compared to wild-type; shows a dominant-negative effect. 1 Publication
    VAR_024766
    Fanconi renotubular syndrome 2 (FRTS2) [MIM:613388]: A disease due to a generalized dysfunction of the proximal kidney tubule resulting in decreased solute and water reabsorption. Patients have polydipsia and polyuria with phosphaturia, glycosuria and aminoaciduria. They may develop hypophosphatemic rickets or osteomalacia, acidosis and a tendency toward dehydration. Some eventually develop renal insufficiency.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti160 – 1601V → VILVTVLV in FRTS2; loss of function in the homozygous state. 1 Publication
    VAR_063812

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi612286. phenotype.
    613388. phenotype.
    Orphaneti244305. Dominant hypophosphatemia with nephrolithiasis or osteoporosis.
    3337. Primary Fanconi syndrome.
    PharmGKBiPA35887.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 639639Sodium-dependent phosphate transport protein 2APRO_0000068607Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi225 ↔ 522By similarity
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi306 ↔ 336By similarity
    Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Modified residuei508 – 5081Phosphothreonine; by PKCSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ06495.
    PRIDEiQ06495.

    PTM databases

    PhosphoSiteiQ06495.

    Expressioni

    Tissue specificityi

    Kidney and lung.

    Gene expression databases

    ArrayExpressiQ06495.
    BgeeiQ06495.
    CleanExiHS_SLC17A2.
    HS_SLC34A1.
    GenevestigatoriQ06495.

    Organism-specific databases

    HPAiHPA051255.

    Interactioni

    Subunit structurei

    Interacts via its C-terminal region with PDZK2 By similarity. Interacts with SLC9A3R1.By similarity1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000321424.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06495.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 103103CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini126 – 14520ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini164 – 1652CytoplasmicSequence Analysis
    Topological domaini186 – 347162ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini371 – 41242CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini437 – 46630ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini488 – 51326CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini535 – 5395ExtracellularSequence Analysis
    Topological domaini562 – 63978CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei104 – 12522Helical; Name=M1Sequence AnalysisAdd
    BLAST
    Transmembranei146 – 16318Helical; Name=M2Sequence AnalysisAdd
    BLAST
    Transmembranei166 – 18520Helical; Name=M3Sequence AnalysisAdd
    BLAST
    Transmembranei348 – 37023Helical; Name=M4Sequence AnalysisAdd
    BLAST
    Transmembranei413 – 43624Helical; Name=M5Sequence AnalysisAdd
    BLAST
    Transmembranei467 – 48721Helical; Name=M6Sequence AnalysisAdd
    BLAST
    Transmembranei514 – 53421Helical; Name=M7Sequence AnalysisAdd
    BLAST
    Transmembranei540 – 56122Helical; Name=M8Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SLC34A transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1283.
    HOGENOMiHOG000070039.
    HOVERGENiHBG079110.
    InParanoidiQ06495.
    KOiK14683.
    OMAiHDPLPAK.
    OrthoDBiEOG72ZCDP.
    PhylomeDBiQ06495.
    TreeFamiTF313981.

    Family and domain databases

    InterProiIPR003841. Na/Pi_transpt.
    [Graphical view]
    PfamiPF02690. Na_Pi_cotrans. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR01013. 2a58. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q06495-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLSYGERLGS PAVSPLPVRG GHVMRGTAFA YVPSPQVLHR IPGTSAYAFP    50
    SLGPVALAEH TCPCGEVLER HEPLPAKLAL EEEQKPESRL VPKLRQAGAM 100
    LLKVPLMLTF LYLFVCSLDM LSSAFQLAGG KVAGDIFKDN AILSNPVAGL 150
    VVGILVTVLV QSSSTSTSII VSMVSSGLLE VSSAIPIIMG SNIGTSVTNT 200
    IVALMQAGDR TDFRRAFAGA TVHDCFNWLS VLVLLPLEAA TGYLHHITRL 250
    VVASFNIHGG RDAPDLLKII TEPFTKLIIQ LDESVITSIA TGDESLRNHS 300
    LIQIWCHPDS LQAPTSMSRA EANSSQTLGN ATMEKCNHIF VDTGLPDLAV 350
    GLILLAGSLV LLCTCLILLV KMLNSLLKGQ VAKVIQKVIN TDFPAPFTWV 400
    TGYFAMVVGA SMTFVVQSSS VFTSAITPLI GLGVISIERA YPLTLGSNIG 450
    TTTTAILAAL ASPREKLSSA FQIALCHFFF NISGILLWYP VPCTRLPIRM 500
    AKALGKRTAK YRWFAVLYLL VCFLLLPSLV FGISMAGWQV MVGVGTPFGA 550
    LLAFVVLINV LQSRSPGHLP KWLQTWDFLP RWMHSLKPLD HLITRATLCC 600
    ARPEPRSPPL PPRVFLEELP PATPSPRLAL PAHHNATRL 639
    Length:639
    Mass (Da):68,937
    Last modified:February 1, 1995 - v1
    Checksum:i65D21D968C35D61B
    GO
    Isoform 2 (identifier: Q06495-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         313-639: APTSMSRAEA...LPAHHNATRL → QNLEGREITHFDLRKKQAMEDSSVPHCP

    Show »
    Length:340
    Mass (Da):36,603
    Checksum:i829AAD6A913307A4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481A → F in NPHLOP1; causes hypophosphatemic urolithiasis; results in lower phosphate current, decreases affinity for phosphate and decreases phosphate uptake compared to wild-type; shows a dominant-negative effect; requires 2 nucleotide substitutions. 1 Publication
    VAR_024765
    Natural varianti147 – 1471V → M in NPHLOP1; causes hypophosphatemic osteoporosis; results in lower phosphate current, decreases affinity for phosphate and decreases phosphate uptake compared to wild-type; shows a dominant-negative effect. 1 Publication
    VAR_024766
    Natural varianti160 – 1601V → VILVTVLV in FRTS2; loss of function in the homozygous state. 1 Publication
    VAR_063812

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei313 – 639327APTSM…NATRL → QNLEGREITHFDLRKKQAME DSSVPHCP in isoform 2. 1 PublicationVSP_042311Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13258 mRNA. Translation: AAA36354.1.
    AK298299 mRNA. Translation: BAG60555.1.
    AC145098 Genomic DNA. No translation available.
    CCDSiCCDS4418.1. [Q06495-1]
    CCDS54953.1. [Q06495-2]
    PIRiB48189.
    RefSeqiNP_001161051.1. NM_001167579.1. [Q06495-2]
    NP_003043.3. NM_003052.4. [Q06495-1]
    XP_005266031.1. XM_005265974.1. [Q06495-1]
    UniGeneiHs.936.

    Genome annotation databases

    EnsembliENST00000324417; ENSP00000321424; ENSG00000131183. [Q06495-1]
    ENST00000512593; ENSP00000423022; ENSG00000131183. [Q06495-2]
    GeneIDi6569.
    KEGGihsa:6569.
    UCSCiuc003mgk.4. human. [Q06495-1]
    uc021yis.1. human. [Q06495-2]

    Polymorphism databases

    DMDMi730113.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13258 mRNA. Translation: AAA36354.1 .
    AK298299 mRNA. Translation: BAG60555.1 .
    AC145098 Genomic DNA. No translation available.
    CCDSi CCDS4418.1. [Q06495-1 ]
    CCDS54953.1. [Q06495-2 ]
    PIRi B48189.
    RefSeqi NP_001161051.1. NM_001167579.1. [Q06495-2 ]
    NP_003043.3. NM_003052.4. [Q06495-1 ]
    XP_005266031.1. XM_005265974.1. [Q06495-1 ]
    UniGenei Hs.936.

    3D structure databases

    ProteinModelPortali Q06495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000321424.

    Protein family/group databases

    TCDBi 2.A.58.1.5. the phosphate:na(+) symporter (pnas) family.

    PTM databases

    PhosphoSitei Q06495.

    Polymorphism databases

    DMDMi 730113.

    Proteomic databases

    PaxDbi Q06495.
    PRIDEi Q06495.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324417 ; ENSP00000321424 ; ENSG00000131183 . [Q06495-1 ]
    ENST00000512593 ; ENSP00000423022 ; ENSG00000131183 . [Q06495-2 ]
    GeneIDi 6569.
    KEGGi hsa:6569.
    UCSCi uc003mgk.4. human. [Q06495-1 ]
    uc021yis.1. human. [Q06495-2 ]

    Organism-specific databases

    CTDi 6569.
    GeneCardsi GC05P176812.
    HGNCi HGNC:11019. SLC34A1.
    HPAi HPA051255.
    MIMi 182309. gene.
    612286. phenotype.
    613388. phenotype.
    neXtProti NX_Q06495.
    Orphaneti 244305. Dominant hypophosphatemia with nephrolithiasis or osteoporosis.
    3337. Primary Fanconi syndrome.
    PharmGKBi PA35887.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1283.
    HOGENOMi HOG000070039.
    HOVERGENi HBG079110.
    InParanoidi Q06495.
    KOi K14683.
    OMAi HDPLPAK.
    OrthoDBi EOG72ZCDP.
    PhylomeDBi Q06495.
    TreeFami TF313981.

    Enzyme and pathway databases

    Reactomei REACT_19411. Type II Na+/Pi cotransporters.
    SignaLinki Q06495.

    Miscellaneous databases

    GeneWikii Sodium/phosphate_cotransporter.
    GenomeRNAii 6569.
    NextBioi 25559.
    PROi Q06495.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q06495.
    Bgeei Q06495.
    CleanExi HS_SLC17A2.
    HS_SLC34A1.
    Genevestigatori Q06495.

    Family and domain databases

    InterProi IPR003841. Na/Pi_transpt.
    [Graphical view ]
    Pfami PF02690. Na_Pi_cotrans. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR01013. 2a58. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism."
      Courbebaisse M., Leroy C., Bakouh N., Salaun C., Beck L., Grandchamp B., Planelles G., Hall R.A., Friedlander G., Prie D.
      PLoS ONE 7:E34764-E34764(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SLC9A3R1.
    5. "Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter."
      Prie D., Huart V., Bakouh N., Planelles G., Dellis O., Gerard B., Hulin P., Benque-Blanchet F., Silve C., Grandchamp B., Friedlander G.
      N. Engl. J. Med. 347:983-991(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS NPHLOP1 PHE-48 AND MET-147, CHARACTERIZATION OF VARIANTS NPHLOP1 PHE-48 AND MET-147.
    6. Cited for: VARIANT FRTS2 ILE-LEU-VAL-THR-VAL-LEU-VAL-160 INS, CHARACTERIZATION OF VARIANT FRTS2 ILE-LEU-VAL-THR-VAL-LEU-VAL-160 INS.

    Entry informationi

    Entry nameiNPT2A_HUMAN
    AccessioniPrimary (citable) accession number: Q06495
    Secondary accession number(s): B4DPE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3