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Protein

Putative pyridoxal reductase

Gene

YPR127W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP+.By similarity

Catalytic activityi

Pyridoxine + NADP+ = pyridoxal + NADPH.

Pathwayi: B6 vitamer degradation

This protein is involved in step 1 of the subpathway that synthesizes pyridoxal from pyridoxine (dehydrogenase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Putative pyridoxal reductase (YPR127W)
This subpathway is part of the pathway B6 vitamer degradation, which is itself part of Cofactor degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxal from pyridoxine (dehydrogenase route), the pathway B6 vitamer degradation and in Cofactor degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601Proton donorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:G3O-34264-MONOMER.
YEAST:G3O-34264-MONOMER.
UniPathwayiUPA00192; UER00307.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pyridoxal reductase (EC:1.1.1.65)
Short name:
PL reductase
Short name:
PL-red
Gene namesi
Ordered Locus Names:YPR127W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR127W.
SGDiS000006331. YPR127W.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Putative pyridoxal reductasePRO_0000257816Add
BLAST

Proteomic databases

MaxQBiQ06494.
PeptideAtlasiQ06494.

PTM databases

iPTMnetiQ06494.

Interactioni

Protein-protein interaction databases

BioGridi36294. 6 interactions.
IntActiQ06494. 1 interaction.
MINTiMINT-4506397.

Structurei

3D structure databases

ProteinModelPortaliQ06494.
SMRiQ06494. Positions 16-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

HOGENOMiHOG000250284.
InParanoidiQ06494.
KOiK05275.
OMAiTWRAEPI.
OrthoDBiEOG7966T7.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
SUPFAMiSSF51430. SSF51430. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06494-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVADLKNNI HKLDTGYGLM SLTWRAEPIP QSQAFEAMHR VVELSRERGH
60 70 80 90 100
KAFFNVGEFY GPDFINLSYV HDFFAKYPDL RKDVVISCKG GADNATLTPR
110 120 130 140 150
GSHDDVVQSV KNSVSAIGGY IDIFEVARID TSLCTKGEVY PYESFEALAE
160 170 180 190 200
MISEGVIGGI SLSEVNEEQI RAIHKDWGKF LTCVEVELSL FSNDILHNGI
210 220 230 240 250
AKTCAELGLS IICYSPLGRG LLTGQLKSNA DIPEGDFRKS LKRFSDESLK
260 270 280 290 300
KNLTLVRFLQ EEIVDKRPQN NSITLAQLAL GWVKHWNKVP EYSGAKFIPI
310 320 330 340
PSGSSISKVN ENFDEQKTKL TDQEFNAINK YLTTFHTVGD RYEMA
Length:345
Mass (Da):38,601
Last modified:November 1, 1996 - v1
Checksum:iC443ED79F25EA106
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40828 Genomic DNA. Translation: AAB68066.1.
BK006949 Genomic DNA. Translation: DAA11540.1.
PIRiS69018.
RefSeqiNP_015452.1. NM_001184224.1.

Genome annotation databases

EnsemblFungiiYPR127W; YPR127W; YPR127W.
GeneIDi856245.
KEGGisce:YPR127W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40828 Genomic DNA. Translation: AAB68066.1.
BK006949 Genomic DNA. Translation: DAA11540.1.
PIRiS69018.
RefSeqiNP_015452.1. NM_001184224.1.

3D structure databases

ProteinModelPortaliQ06494.
SMRiQ06494. Positions 16-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36294. 6 interactions.
IntActiQ06494. 1 interaction.
MINTiMINT-4506397.

PTM databases

iPTMnetiQ06494.

Proteomic databases

MaxQBiQ06494.
PeptideAtlasiQ06494.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR127W; YPR127W; YPR127W.
GeneIDi856245.
KEGGisce:YPR127W.

Organism-specific databases

EuPathDBiFungiDB:YPR127W.
SGDiS000006331. YPR127W.

Phylogenomic databases

HOGENOMiHOG000250284.
InParanoidiQ06494.
KOiK05275.
OMAiTWRAEPI.
OrthoDBiEOG7966T7.

Enzyme and pathway databases

UniPathwayiUPA00192; UER00307.
BioCyciMetaCyc:G3O-34264-MONOMER.
YEAST:G3O-34264-MONOMER.

Miscellaneous databases

NextBioi981513.
PROiQ06494.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
SUPFAMiSSF51430. SSF51430. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPLR1_YEAST
AccessioniPrimary (citable) accession number: Q06494
Secondary accession number(s): D6W4C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2190 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.