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Protein

Putative pyridoxal reductase

Gene

YPR127W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP+.By similarity

Miscellaneous

Present with 2190 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Pyridoxine + NADP+ = pyridoxal + NADPH.

Pathwayi: B6 vitamer degradation

This protein is involved in step 1 of the subpathway that synthesizes pyridoxal from pyridoxine (dehydrogenase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Putative pyridoxal reductase (YPR127W)
This subpathway is part of the pathway B6 vitamer degradation, which is itself part of Cofactor degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxal from pyridoxine (dehydrogenase route), the pathway B6 vitamer degradation and in Cofactor degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei60Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyciMetaCyc:G3O-34264-MONOMER
YEAST:G3O-34264-MONOMER
UniPathwayiUPA00192; UER00307

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pyridoxal reductase (EC:1.1.1.65)
Short name:
PL reductase
Short name:
PL-red
Gene namesi
Ordered Locus Names:YPR127W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR127W
SGDiS000006331 YPR127W

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002578161 – 345Putative pyridoxal reductaseAdd BLAST345

Proteomic databases

MaxQBiQ06494
PaxDbiQ06494
PRIDEiQ06494

PTM databases

iPTMnetiQ06494

Interactioni

Protein-protein interaction databases

BioGridi36294, 29 interactors
IntActiQ06494, 2 interactors
STRINGi4932.YPR127W

Structurei

3D structure databases

ProteinModelPortaliQ06494
SMRiQ06494
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

HOGENOMiHOG000250284
InParanoidiQ06494
KOiK05275
OMAiGHNEMLI
OrthoDBiEOG092C3NFQ

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
SUPFAMiSSF51430 SSF51430, 1 hit

Sequencei

Sequence statusi: Complete.

Q06494-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVADLKNNI HKLDTGYGLM SLTWRAEPIP QSQAFEAMHR VVELSRERGH
60 70 80 90 100
KAFFNVGEFY GPDFINLSYV HDFFAKYPDL RKDVVISCKG GADNATLTPR
110 120 130 140 150
GSHDDVVQSV KNSVSAIGGY IDIFEVARID TSLCTKGEVY PYESFEALAE
160 170 180 190 200
MISEGVIGGI SLSEVNEEQI RAIHKDWGKF LTCVEVELSL FSNDILHNGI
210 220 230 240 250
AKTCAELGLS IICYSPLGRG LLTGQLKSNA DIPEGDFRKS LKRFSDESLK
260 270 280 290 300
KNLTLVRFLQ EEIVDKRPQN NSITLAQLAL GWVKHWNKVP EYSGAKFIPI
310 320 330 340
PSGSSISKVN ENFDEQKTKL TDQEFNAINK YLTTFHTVGD RYEMA
Length:345
Mass (Da):38,601
Last modified:November 1, 1996 - v1
Checksum:iC443ED79F25EA106
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40828 Genomic DNA Translation: AAB68066.1
BK006949 Genomic DNA Translation: DAA11540.1
PIRiS69018
RefSeqiNP_015452.1, NM_001184224.1

Genome annotation databases

EnsemblFungiiYPR127W; YPR127W; YPR127W
GeneIDi856245
KEGGisce:YPR127W

Similar proteinsi

Entry informationi

Entry nameiPLR1_YEAST
AccessioniPrimary (citable) accession number: Q06494
Secondary accession number(s): D6W4C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health