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Q06485

- ATG33_YEAST

UniProt

Q06485 - ATG33_YEAST

Protein

Autophagy-related protein 33

Gene

ATG33

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in the selective degradation of mitochondria via autophagy during starvation and at post-log phase.2 Publications

    GO - Biological processi

    1. mitochondrion degradation Source: SGD

    Keywords - Biological processi

    Autophagy

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32428-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autophagy-related protein 33
    Gene namesi
    Name:ATG33
    Ordered Locus Names:YLR356W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLR356w.
    SGDiS000004348. ATG33.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 197197Autophagy-related protein 33PRO_0000247213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei127 – 1271Phosphoserine2 Publications
    Modified residuei129 – 1291Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ06485.
    PaxDbiQ06485.

    Expressioni

    Gene expression databases

    GenevestigatoriQ06485.

    Interactioni

    Protein-protein interaction databases

    BioGridi31618. 12 interactions.
    DIPiDIP-4664N.
    IntActiQ06485. 1 interaction.
    MINTiMINT-481986.
    STRINGi4932.YLR356W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06485.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATG33 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG68417.
    GeneTreeiENSGT00530000067118.
    OMAiGEDNHAS.
    OrthoDBiEOG7HQNMP.

    Sequencei

    Sequence statusi: Complete.

    Q06485-1 [UniParc]FASTAAdd to Basket

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    MSVCLAITKG IAVSSIGLYS GLLASASLIT STTPLEVLTG SLTPTLTTLK    50
    NAATALGAFA STFFCVSFFG APPSLRHPYL LYGMLVAPLS SFVLGCASNY 100
    QSRKYSKVSK ESSLFPEDSK LAASELSDSI IDLGEDNHAS ENTPRDGKPA 150
    ATTVSKPAEA LHTGPPIHTK NLIAATAIAI VGFVQAVIGV YGEGQFI 197
    Length:197
    Mass (Da):20,400
    Last modified:November 1, 1996 - v1
    Checksum:i4BA9F5CD485FB259
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19102 Genomic DNA. Translation: AAB67748.1.
    AY558222 Genomic DNA. Translation: AAS56548.1.
    BK006945 Genomic DNA. Translation: DAA09660.1.
    PIRiS51464.
    RefSeqiNP_013460.1. NM_001182245.1.

    Genome annotation databases

    EnsemblFungiiYLR356W; YLR356W; YLR356W.
    GeneIDi851070.
    KEGGisce:YLR356W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19102 Genomic DNA. Translation: AAB67748.1 .
    AY558222 Genomic DNA. Translation: AAS56548.1 .
    BK006945 Genomic DNA. Translation: DAA09660.1 .
    PIRi S51464.
    RefSeqi NP_013460.1. NM_001182245.1.

    3D structure databases

    ProteinModelPortali Q06485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31618. 12 interactions.
    DIPi DIP-4664N.
    IntActi Q06485. 1 interaction.
    MINTi MINT-481986.
    STRINGi 4932.YLR356W.

    Proteomic databases

    MaxQBi Q06485.
    PaxDbi Q06485.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR356W ; YLR356W ; YLR356W .
    GeneIDi 851070.
    KEGGi sce:YLR356W.

    Organism-specific databases

    CYGDi YLR356w.
    SGDi S000004348. ATG33.

    Phylogenomic databases

    eggNOGi NOG68417.
    GeneTreei ENSGT00530000067118.
    OMAi GEDNHAS.
    OrthoDBi EOG7HQNMP.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32428-MONOMER.

    Miscellaneous databases

    NextBioi 967714.

    Gene expression databases

    Genevestigatori Q06485.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "A genomic screen for yeast mutants defective in selective mitochondria autophagy."
      Kanki T., Wang K., Baba M., Bartholomew C.R., Lynch-Day M.A., Du Z., Geng J., Mao K., Yang Z., Yen W.L., Klionsky D.J.
      Mol. Biol. Cell 20:4730-4738(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127 AND SER-129, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "A genomic screen for yeast mutants defective in mitophagy."
      Kanki T., Wang K., Klionsky D.J.
      Autophagy 6:278-280(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiATG33_YEAST
    AccessioniPrimary (citable) accession number: Q06485
    Secondary accession number(s): D6VYZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3