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Protein

Autophagy-related protein 33

Gene

ATG33

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the selective degradation of mitochondria via autophagy during starvation and at post-log phase.2 Publications

GO - Biological processi

  • macroautophagy Source: SGD
  • mitophagy Source: SGD
Complete GO annotation...

Keywords - Biological processi

Autophagy

Enzyme and pathway databases

BioCyciYEAST:G3O-32428-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 33
Gene namesi
Name:ATG33
Ordered Locus Names:YLR356W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR356W.
SGDiS000004348. ATG33.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial membrane Source: UniProtKB-SubCell
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472131 – 197Autophagy-related protein 33Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06485.
PRIDEiQ06485.

PTM databases

iPTMnetiQ06485.

Interactioni

Protein-protein interaction databases

BioGridi31618. 12 interactors.
DIPiDIP-4664N.
IntActiQ06485. 1 interactor.
MINTiMINT-481986.

Structurei

3D structure databases

ProteinModelPortaliQ06485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG33 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000067118.
InParanoidiQ06485.
KOiK19717.
OMAiCHAKSKI.
OrthoDBiEOG092C5526.

Sequencei

Sequence statusi: Complete.

Q06485-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVCLAITKG IAVSSIGLYS GLLASASLIT STTPLEVLTG SLTPTLTTLK
60 70 80 90 100
NAATALGAFA STFFCVSFFG APPSLRHPYL LYGMLVAPLS SFVLGCASNY
110 120 130 140 150
QSRKYSKVSK ESSLFPEDSK LAASELSDSI IDLGEDNHAS ENTPRDGKPA
160 170 180 190
ATTVSKPAEA LHTGPPIHTK NLIAATAIAI VGFVQAVIGV YGEGQFI
Length:197
Mass (Da):20,400
Last modified:November 1, 1996 - v1
Checksum:i4BA9F5CD485FB259
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19102 Genomic DNA. Translation: AAB67748.1.
AY558222 Genomic DNA. Translation: AAS56548.1.
BK006945 Genomic DNA. Translation: DAA09660.1.
PIRiS51464.
RefSeqiNP_013460.1. NM_001182245.1.

Genome annotation databases

EnsemblFungiiYLR356W; YLR356W; YLR356W.
GeneIDi851070.
KEGGisce:YLR356W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19102 Genomic DNA. Translation: AAB67748.1.
AY558222 Genomic DNA. Translation: AAS56548.1.
BK006945 Genomic DNA. Translation: DAA09660.1.
PIRiS51464.
RefSeqiNP_013460.1. NM_001182245.1.

3D structure databases

ProteinModelPortaliQ06485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31618. 12 interactors.
DIPiDIP-4664N.
IntActiQ06485. 1 interactor.
MINTiMINT-481986.

PTM databases

iPTMnetiQ06485.

Proteomic databases

MaxQBiQ06485.
PRIDEiQ06485.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR356W; YLR356W; YLR356W.
GeneIDi851070.
KEGGisce:YLR356W.

Organism-specific databases

EuPathDBiFungiDB:YLR356W.
SGDiS000004348. ATG33.

Phylogenomic databases

GeneTreeiENSGT00530000067118.
InParanoidiQ06485.
KOiK19717.
OMAiCHAKSKI.
OrthoDBiEOG092C5526.

Enzyme and pathway databases

BioCyciYEAST:G3O-32428-MONOMER.

Miscellaneous databases

PROiQ06485.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiATG33_YEAST
AccessioniPrimary (citable) accession number: Q06485
Secondary accession number(s): D6VYZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.