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Q06485

- ATG33_YEAST

UniProt

Q06485 - ATG33_YEAST

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Protein

Autophagy-related protein 33

Gene

ATG33

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the selective degradation of mitochondria via autophagy during starvation and at post-log phase.2 Publications

GO - Biological processi

  1. mitochondrion degradation Source: SGD
Complete GO annotation...

Keywords - Biological processi

Autophagy

Enzyme and pathway databases

BioCyciYEAST:G3O-32428-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 33
Gene namesi
Name:ATG33
Ordered Locus Names:YLR356W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR356w.
SGDiS000004348. ATG33.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Autophagy-related protein 33PRO_0000247213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei127 – 1271Phosphoserine2 Publications
Modified residuei129 – 1291Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06485.
PaxDbiQ06485.

Expressioni

Gene expression databases

GenevestigatoriQ06485.

Interactioni

Protein-protein interaction databases

BioGridi31618. 13 interactions.
DIPiDIP-4664N.
IntActiQ06485. 1 interaction.
MINTiMINT-481986.
STRINGi4932.YLR356W.

Structurei

3D structure databases

ProteinModelPortaliQ06485.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG33 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG68417.
GeneTreeiENSGT00530000067118.
InParanoidiQ06485.
OMAiGEDNHAS.
OrthoDBiEOG7HQNMP.

Sequencei

Sequence statusi: Complete.

Q06485-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVCLAITKG IAVSSIGLYS GLLASASLIT STTPLEVLTG SLTPTLTTLK
60 70 80 90 100
NAATALGAFA STFFCVSFFG APPSLRHPYL LYGMLVAPLS SFVLGCASNY
110 120 130 140 150
QSRKYSKVSK ESSLFPEDSK LAASELSDSI IDLGEDNHAS ENTPRDGKPA
160 170 180 190
ATTVSKPAEA LHTGPPIHTK NLIAATAIAI VGFVQAVIGV YGEGQFI
Length:197
Mass (Da):20,400
Last modified:November 1, 1996 - v1
Checksum:i4BA9F5CD485FB259
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19102 Genomic DNA. Translation: AAB67748.1.
AY558222 Genomic DNA. Translation: AAS56548.1.
BK006945 Genomic DNA. Translation: DAA09660.1.
PIRiS51464.
RefSeqiNP_013460.1. NM_001182245.1.

Genome annotation databases

EnsemblFungiiYLR356W; YLR356W; YLR356W.
GeneIDi851070.
KEGGisce:YLR356W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19102 Genomic DNA. Translation: AAB67748.1 .
AY558222 Genomic DNA. Translation: AAS56548.1 .
BK006945 Genomic DNA. Translation: DAA09660.1 .
PIRi S51464.
RefSeqi NP_013460.1. NM_001182245.1.

3D structure databases

ProteinModelPortali Q06485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31618. 13 interactions.
DIPi DIP-4664N.
IntActi Q06485. 1 interaction.
MINTi MINT-481986.
STRINGi 4932.YLR356W.

Proteomic databases

MaxQBi Q06485.
PaxDbi Q06485.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR356W ; YLR356W ; YLR356W .
GeneIDi 851070.
KEGGi sce:YLR356W.

Organism-specific databases

CYGDi YLR356w.
SGDi S000004348. ATG33.

Phylogenomic databases

eggNOGi NOG68417.
GeneTreei ENSGT00530000067118.
InParanoidi Q06485.
OMAi GEDNHAS.
OrthoDBi EOG7HQNMP.

Enzyme and pathway databases

BioCyci YEAST:G3O-32428-MONOMER.

Miscellaneous databases

NextBioi 967714.

Gene expression databases

Genevestigatori Q06485.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "A genomic screen for yeast mutants defective in selective mitochondria autophagy."
    Kanki T., Wang K., Baba M., Bartholomew C.R., Lynch-Day M.A., Du Z., Geng J., Mao K., Yang Z., Yen W.L., Klionsky D.J.
    Mol. Biol. Cell 20:4730-4738(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127 AND SER-129, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "A genomic screen for yeast mutants defective in mitophagy."
    Kanki T., Wang K., Klionsky D.J.
    Autophagy 6:278-280(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiATG33_YEAST
AccessioniPrimary (citable) accession number: Q06485
Secondary accession number(s): D6VYZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3