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Q06481

- APLP2_HUMAN

UniProt

Q06481 - APLP2_HUMAN

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Protein
Amyloid-like protein 2
Gene
APLP2, APPL2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts By similarity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei320 – 3212Reactive bond By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. heparin binding Source: InterPro
  3. identical protein binding Source: IntAct
  4. protein binding Source: UniProtKB
  5. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
  6. transition metal ion binding Source: InterPro

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
  2. cellular copper ion homeostasis Source: Ensembl
  3. cholesterol metabolic process Source: Ensembl
  4. embryo development Source: Ensembl
  5. extracellular matrix organization Source: Ensembl
  6. forebrain development Source: Ensembl
  7. locomotory behavior Source: Ensembl
  8. mating behavior Source: Ensembl
  9. midbrain development Source: Ensembl
  10. neuromuscular process controlling balance Source: Ensembl
  11. regulation of epidermal growth factor-activated receptor activity Source: Ensembl
  12. regulation of protein binding Source: Ensembl
  13. suckling behavior Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ06481.

Protein family/group databases

MEROPSiI02.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid-like protein 2
Short name:
APLP-2
Alternative name(s):
APPH
Amyloid protein homolog
CDEI box-binding protein
Short name:
CDEBP
Gene namesi
Name:APLP2
Synonyms:APPL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:598. APLP2.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein Reviewed prediction. Nucleus Reviewed prediction

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 692661Extracellular Reviewed prediction
Add
BLAST
Transmembranei693 – 71624Helical; Reviewed prediction
Add
BLAST
Topological domaini717 – 76347Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24885.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 Reviewed prediction
Add
BLAST
Chaini32 – 763732Amyloid-like protein 2
PRO_0000000207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi310 ↔ 360 By similarity
Disulfide bondi319 ↔ 343 By similarity
Disulfide bondi335 ↔ 356 By similarity

Post-translational modificationi

The BPTI/Kunitz inhibitor domain is O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ06481.
PaxDbiQ06481.
PRIDEiQ06481.

PTM databases

PhosphoSiteiQ06481.

Miscellaneous databases

PMAP-CutDBQ06481.

Expressioni

Tissue specificityi

Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.

Gene expression databases

ArrayExpressiQ06481.
BgeeiQ06481.
CleanExiHS_APLP2.
HS_APPL2.
GenevestigatoriQ06481.

Organism-specific databases

HPAiHPA039319.

Interactioni

Subunit structurei

Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-79306,EBI-79306
APLP1P516932EBI-79306,EBI-74648
APPP05067-42EBI-79306,EBI-302641
DEDDO756183EBI-79306,EBI-1043164
ETS1P149212EBI-79306,EBI-913209
JUNP054123EBI-79306,EBI-852823
MED12Q930742EBI-79306,EBI-394357

Protein-protein interaction databases

BioGridi106831. 23 interactions.
DIPiDIP-31047N.
IntActiQ06481. 20 interactions.
MINTiMINT-1186713.
STRINGi9606.ENSP00000263574.

Structurei

3D structure databases

ProteinModelPortaliQ06481.
SMRiQ06481. Positions 47-204, 309-566, 735-761.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini306 – 36459BPTI/Kunitz inhibitor
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni749 – 76315Interaction with DAB2 By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi750 – 7556NPXY motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi215 – 28066Asp/Glu-rich (highly acidic)
Add
BLAST
Compositional biasi215 – 23117Poly-Glu
Add
BLAST

Sequence similaritiesi

Belongs to the APP family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289770.
HOVERGENiHBG000051.
InParanoidiQ06481.
KOiK08117.
OMAiRMEVCEN.
OrthoDBiEOG7RNJZP.
PhylomeDBiQ06481.
TreeFamiTF317274.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.410.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR019543. APP_amyloid_C.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
SMARTiSM00006. A4_EXTRA. 1 hit.
SM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q06481-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP    50
QIAMFCGKLN MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI 100
TNVMEANQRV SIDNWCRRDK KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ 150
FFHKERMEVC ENHQHWHTVV KEACLTQGMT LYSYGMLLPC GVDQFHGTEY 200
VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF PTEADLEDFT 250
EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK 300
EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF 350
ESEDYCMAVC KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR 400
HRNRMDRVKK EWEEAELQAK NLPKAERQTL IQHFQAMVKA LEKEAASEKQ 450
QLVETHLARV EAMLNDRRRM ALENYLAALQ SDPPRPHRIL QALRRYVRAE 500
NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR NQSLSLLYKV 550
PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH 600
PFHPFPALPE NEDTQPELYH PMKKGSGVGE QDGGLIGAEE KVINSKNKVD 650
ENMVIDETLD VKEMIFNAER VGGLEEERES VGPLREDFSL SSSALIGLLV 700
IAVAIATVIV ISLVMLRKRQ YGTISHGIVE VDPMLTPEER HLNKMQNHGY 750
ENPTYKYLEQ MQI 763
Length:763
Mass (Da):86,956
Last modified:October 1, 1996 - v2
Checksum:iCA3A7D6DDB8A28D0
GO
Isoform 2 (identifier: Q06481-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-363: Missing.

Show »
Length:707
Mass (Da):80,721
Checksum:i1F45B94DAE88BC23
GO
Isoform 3 (identifier: Q06481-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     613-624: Missing.

Show »
Length:751
Mass (Da):85,487
Checksum:i788BCDC6E4487E18
GO
Isoform 4 (identifier: Q06481-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-363: Missing.
     364-364: I → V
     613-624: Missing.

Show »
Length:695
Mass (Da):79,238
Checksum:i728CA8ACBB7594FB
GO
Isoform 5 (identifier: Q06481-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-364: Missing.
     613-624: Missing.

Note: No experimental confirmation available.

Show »
Length:522
Mass (Da):59,151
Checksum:i993641BFC15ED6E0
GO
Isoform 6 (identifier: Q06481-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIE → MLRAPGELPR...ASVDRGNPLW
     613-624: Missing.

Show »
Length:761
Mass (Da):87,215
Checksum:iE87786F52F076C41
GO

Sequence cautioni

The sequence BAG54641.1 differs from that shown. Reason: Frameshift at position 81.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti632 – 6321D → N.
Corresponds to variant rs3740881 [ dbSNP | Ensembl ].
VAR_022039

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3535MAATG…AGYIE → MLRAPGELPRQAARCSLCRL GPGRGRAFFKWRCLPASVDR GNPLW in isoform 6.
VSP_046881Add
BLAST
Alternative sequencei136 – 364229Missing in isoform 5.
VSP_030921Add
BLAST
Alternative sequencei308 – 36356Missing in isoform 2 and isoform 4.
VSP_000018Add
BLAST
Alternative sequencei364 – 3641I → V in isoform 4.
VSP_046882
Alternative sequencei613 – 62412Missing in isoform 3, isoform 4, isoform 5 and isoform 6.
VSP_000019Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti224 – 2241E → D in AAD47291. 1 Publication
Sequence conflicti226 – 2272Missing in BAG54641. 1 Publication
Sequence conflicti543 – 5431S → I in AAA35526. 1 Publication
Sequence conflicti543 – 5431S → T in AAH04371. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S60099 mRNA. Translation: AAC60589.1.
L09209 mRNA. Translation: AAA35526.1.
L27631 mRNA. Translation: AAC41701.1.
Z22572 mRNA. Translation: CAA80295.1.
AK128162 mRNA. Translation: BAG54641.1. Frameshift.
L19597 mRNA. Translation: AAA35601.1.
L23113 mRNA. Translation: AAA36032.1.
L23114 mRNA. Translation: AAA36130.1.
AF168956 mRNA. Translation: AAD47291.1.
AP001183 Genomic DNA. No translation available.
AP003041 Genomic DNA. No translation available.
BC000373 mRNA. Translation: AAH00373.1.
BC004371 mRNA. Translation: AAH04371.1.
CCDSiCCDS44773.1. [Q06481-3]
CCDS44774.1. [Q06481-4]
CCDS44775.1. [Q06481-5]
CCDS58196.1. [Q06481-6]
CCDS8486.1. [Q06481-1]
PIRiA49321.
S41082.
RefSeqiNP_001135748.1. NM_001142276.1. [Q06481-3]
NP_001135749.1. NM_001142277.1. [Q06481-4]
NP_001135750.1. NM_001142278.1. [Q06481-5]
NP_001230228.1. NM_001243299.1. [Q06481-6]
NP_001633.1. NM_001642.2. [Q06481-1]
UniGeneiHs.370247.

Genome annotation databases

EnsembliENST00000263574; ENSP00000263574; ENSG00000084234. [Q06481-1]
ENST00000278756; ENSP00000278756; ENSG00000084234. [Q06481-6]
ENST00000338167; ENSP00000345444; ENSG00000084234. [Q06481-3]
ENST00000345598; ENSP00000263575; ENSG00000084234. [Q06481-5]
ENST00000528499; ENSP00000435914; ENSG00000084234. [Q06481-4]
GeneIDi334.
KEGGihsa:334.
UCSCiuc001qfp.3. human. [Q06481-3]
uc001qfs.3. human. [Q06481-5]
uc001qfv.3. human. [Q06481-2]
uc010sby.2. human. [Q06481-1]

Polymorphism databases

DMDMi1703344.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S60099 mRNA. Translation: AAC60589.1 .
L09209 mRNA. Translation: AAA35526.1 .
L27631 mRNA. Translation: AAC41701.1 .
Z22572 mRNA. Translation: CAA80295.1 .
AK128162 mRNA. Translation: BAG54641.1 . Frameshift.
L19597 mRNA. Translation: AAA35601.1 .
L23113 mRNA. Translation: AAA36032.1 .
L23114 mRNA. Translation: AAA36130.1 .
AF168956 mRNA. Translation: AAD47291.1 .
AP001183 Genomic DNA. No translation available.
AP003041 Genomic DNA. No translation available.
BC000373 mRNA. Translation: AAH00373.1 .
BC004371 mRNA. Translation: AAH04371.1 .
CCDSi CCDS44773.1. [Q06481-3 ]
CCDS44774.1. [Q06481-4 ]
CCDS44775.1. [Q06481-5 ]
CCDS58196.1. [Q06481-6 ]
CCDS8486.1. [Q06481-1 ]
PIRi A49321.
S41082.
RefSeqi NP_001135748.1. NM_001142276.1. [Q06481-3 ]
NP_001135749.1. NM_001142277.1. [Q06481-4 ]
NP_001135750.1. NM_001142278.1. [Q06481-5 ]
NP_001230228.1. NM_001243299.1. [Q06481-6 ]
NP_001633.1. NM_001642.2. [Q06481-1 ]
UniGenei Hs.370247.

3D structure databases

ProteinModelPortali Q06481.
SMRi Q06481. Positions 47-204, 309-566, 735-761.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106831. 23 interactions.
DIPi DIP-31047N.
IntActi Q06481. 20 interactions.
MINTi MINT-1186713.
STRINGi 9606.ENSP00000263574.

Protein family/group databases

MEROPSi I02.016.

PTM databases

PhosphoSitei Q06481.

Polymorphism databases

DMDMi 1703344.

Proteomic databases

MaxQBi Q06481.
PaxDbi Q06481.
PRIDEi Q06481.

Protocols and materials databases

DNASUi 334.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263574 ; ENSP00000263574 ; ENSG00000084234 . [Q06481-1 ]
ENST00000278756 ; ENSP00000278756 ; ENSG00000084234 . [Q06481-6 ]
ENST00000338167 ; ENSP00000345444 ; ENSG00000084234 . [Q06481-3 ]
ENST00000345598 ; ENSP00000263575 ; ENSG00000084234 . [Q06481-5 ]
ENST00000528499 ; ENSP00000435914 ; ENSG00000084234 . [Q06481-4 ]
GeneIDi 334.
KEGGi hsa:334.
UCSCi uc001qfp.3. human. [Q06481-3 ]
uc001qfs.3. human. [Q06481-5 ]
uc001qfv.3. human. [Q06481-2 ]
uc010sby.2. human. [Q06481-1 ]

Organism-specific databases

CTDi 334.
GeneCardsi GC11P129939.
HGNCi HGNC:598. APLP2.
HPAi HPA039319.
MIMi 104776. gene.
neXtProti NX_Q06481.
PharmGKBi PA24885.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289770.
HOVERGENi HBG000051.
InParanoidi Q06481.
KOi K08117.
OMAi RMEVCEN.
OrthoDBi EOG7RNJZP.
PhylomeDBi Q06481.
TreeFami TF317274.

Enzyme and pathway databases

SignaLinki Q06481.

Miscellaneous databases

ChiTaRSi APLP2. human.
GeneWikii APLP2.
GenomeRNAii 334.
NextBioi 1383.
PMAP-CutDB Q06481.
PROi Q06481.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q06481.
Bgeei Q06481.
CleanExi HS_APLP2.
HS_APPL2.
Genevestigatori Q06481.

Family and domain databases

Gene3Di 3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.410.10. 1 hit.
InterProi IPR008155. Amyloid_glyco.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR019543. APP_amyloid_C.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view ]
Pfami PF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view ]
PRINTSi PR00203. AMYLOIDA4.
PR00759. BASICPTASE.
SMARTi SM00006. A4_EXTRA. 1 hit.
SM00131. KU. 1 hit.
[Graphical view ]
SUPFAMi SSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEi PS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family."
    Sprecher C.A., Grant F.J., Grimm G., O'Hara P.J., Norris F., Norris K., Foster D.C.
    Biochemistry 32:4481-4486(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor."
    Wasco W., Gurubhagavatula S., Paradis M., Romano D.M., Sisodia S.S., Hyman B.T., Neve R.L., Tanzi R.E.
    Nat. Genet. 5:95-99(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein."
    von der Kammer H., Hanes J., Klaudiny J., Scheit K.H.
    DNA Cell Biol. 13:1137-1143(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Ovary.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  5. "Cloning of a protein that binds to a recognition sequence in the APP promoter."
    Vostrov A.A., Quitschke W.W., Schwarzman A.L., Blangy A., Cuzin F., Wesley U.V., Hagag N.G., Goldgaber D.
    Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-763 (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 229-763 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    Tissue: Brain.
  6. "A new special gene in human testis (HSD-2)."
    Wang L., Miao S., Fan H., Wang H.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
    Tissue: Lung and Pancreas.
  9. "Expression, purification and characterization of a Kunitz-type protease inhibitor domain from human amyloid precursor protein homolog."
    Petersen L.C., Bjorn S.E., Norris F., Norris K., Sprecher C., Foster D.C.
    FEBS Lett. 338:53-57(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 305-362 (ISOFORMS 1/3), FUNCTION, GLYCOSYLATION.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAPLP2_HUMAN
AccessioniPrimary (citable) accession number: Q06481
Secondary accession number(s): B3KXX9
, H7BXI4, Q13861, Q14594, Q14662, Q71U10, Q7M4L3, Q9BT36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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