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Q06481

- APLP2_HUMAN

UniProt

Q06481 - APLP2_HUMAN

Protein

Amyloid-like protein 2

Gene

APLP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 155 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei320 – 3212Reactive bondBy similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. heparin binding Source: InterPro
    3. identical protein binding Source: IntAct
    4. protein binding Source: UniProtKB
    5. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
    6. transition metal ion binding Source: InterPro

    GO - Biological processi

    1. cellular copper ion homeostasis Source: Ensembl
    2. cholesterol metabolic process Source: Ensembl
    3. embryo development Source: Ensembl
    4. extracellular matrix organization Source: Ensembl
    5. forebrain development Source: Ensembl
    6. G-protein coupled receptor signaling pathway Source: UniProtKB
    7. locomotory behavior Source: Ensembl
    8. mating behavior Source: Ensembl
    9. midbrain development Source: Ensembl
    10. neuromuscular process controlling balance Source: Ensembl
    11. regulation of epidermal growth factor-activated receptor activity Source: Ensembl
    12. regulation of protein binding Source: Ensembl
    13. suckling behavior Source: Ensembl

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ06481.

    Protein family/group databases

    MEROPSiI02.016.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amyloid-like protein 2
    Short name:
    APLP-2
    Alternative name(s):
    APPH
    Amyloid protein homolog
    CDEI box-binding protein
    Short name:
    CDEBP
    Gene namesi
    Name:APLP2
    Synonyms:APPL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:598. APLP2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB
    3. membrane Source: UniProtKB
    4. nucleus Source: UniProtKB
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24885.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 763732Amyloid-like protein 2PRO_0000000207Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi310 ↔ 360PROSITE-ProRule annotation
    Disulfide bondi319 ↔ 343PROSITE-ProRule annotation
    Disulfide bondi335 ↔ 356PROSITE-ProRule annotation

    Post-translational modificationi

    The BPTI/Kunitz inhibitor domain is O-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ06481.
    PaxDbiQ06481.
    PRIDEiQ06481.

    PTM databases

    PhosphoSiteiQ06481.

    Miscellaneous databases

    PMAP-CutDBQ06481.

    Expressioni

    Tissue specificityi

    Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.

    Gene expression databases

    ArrayExpressiQ06481.
    BgeeiQ06481.
    CleanExiHS_APLP2.
    HS_APPL2.
    GenevestigatoriQ06481.

    Organism-specific databases

    HPAiHPA039319.

    Interactioni

    Subunit structurei

    Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-79306,EBI-79306
    APLP1P516932EBI-79306,EBI-74648
    APPP05067-42EBI-79306,EBI-302641
    DEDDO756183EBI-79306,EBI-1043164
    ETS1P149212EBI-79306,EBI-913209
    JUNP054123EBI-79306,EBI-852823
    MED12Q930742EBI-79306,EBI-394357

    Protein-protein interaction databases

    BioGridi106831. 23 interactions.
    DIPiDIP-31047N.
    IntActiQ06481. 20 interactions.
    MINTiMINT-1186713.
    STRINGi9606.ENSP00000263574.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06481.
    SMRiQ06481. Positions 47-204, 309-566, 735-761.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 692661ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini717 – 76347CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei693 – 71624HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini306 – 36459BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni749 – 76315Interaction with DAB2By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi750 – 7556NPXY motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi215 – 28066Asp/Glu-rich (highly acidic)Add
    BLAST
    Compositional biasi215 – 23117Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the APP family.Curated
    Contains 1 BPTI/Kunitz inhibitor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG289770.
    HOVERGENiHBG000051.
    InParanoidiQ06481.
    KOiK08117.
    OMAiRMEVCEN.
    OrthoDBiEOG7RNJZP.
    PhylomeDBiQ06481.
    TreeFamiTF317274.

    Family and domain databases

    Gene3Di3.30.1490.140. 1 hit.
    3.90.570.10. 1 hit.
    4.10.410.10. 1 hit.
    InterProiIPR008155. Amyloid_glyco.
    IPR011178. Amyloid_glyco_Cu-bd.
    IPR024329. Amyloid_glyco_E2_domain.
    IPR008154. Amyloid_glyco_extra.
    IPR019744. Amyloid_glyco_extracell_CS.
    IPR015849. Amyloid_glyco_heparin-bd.
    IPR019745. Amyloid_glyco_intracell_CS.
    IPR019543. APP_amyloid_C.
    IPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    [Graphical view]
    PfamiPF10515. APP_amyloid. 1 hit.
    PF12924. APP_Cu_bd. 1 hit.
    PF12925. APP_E2. 1 hit.
    PF02177. APP_N. 1 hit.
    PF00014. Kunitz_BPTI. 1 hit.
    [Graphical view]
    PRINTSiPR00203. AMYLOIDA4.
    PR00759. BASICPTASE.
    SMARTiSM00006. A4_EXTRA. 1 hit.
    SM00131. KU. 1 hit.
    [Graphical view]
    SUPFAMiSSF109843. SSF109843. 1 hit.
    SSF56491. SSF56491. 1 hit.
    SSF57362. SSF57362. 1 hit.
    SSF89811. SSF89811. 1 hit.
    PROSITEiPS00319. A4_EXTRA. 1 hit.
    PS00320. A4_INTRA. 1 hit.
    PS00280. BPTI_KUNITZ_1. 1 hit.
    PS50279. BPTI_KUNITZ_2. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q06481-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP    50
    QIAMFCGKLN MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI 100
    TNVMEANQRV SIDNWCRRDK KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ 150
    FFHKERMEVC ENHQHWHTVV KEACLTQGMT LYSYGMLLPC GVDQFHGTEY 200
    VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF PTEADLEDFT 250
    EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK 300
    EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF 350
    ESEDYCMAVC KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR 400
    HRNRMDRVKK EWEEAELQAK NLPKAERQTL IQHFQAMVKA LEKEAASEKQ 450
    QLVETHLARV EAMLNDRRRM ALENYLAALQ SDPPRPHRIL QALRRYVRAE 500
    NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR NQSLSLLYKV 550
    PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH 600
    PFHPFPALPE NEDTQPELYH PMKKGSGVGE QDGGLIGAEE KVINSKNKVD 650
    ENMVIDETLD VKEMIFNAER VGGLEEERES VGPLREDFSL SSSALIGLLV 700
    IAVAIATVIV ISLVMLRKRQ YGTISHGIVE VDPMLTPEER HLNKMQNHGY 750
    ENPTYKYLEQ MQI 763
    Length:763
    Mass (Da):86,956
    Last modified:October 1, 1996 - v2
    Checksum:iCA3A7D6DDB8A28D0
    GO
    Isoform 2 (identifier: Q06481-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         308-363: Missing.

    Show »
    Length:707
    Mass (Da):80,721
    Checksum:i1F45B94DAE88BC23
    GO
    Isoform 3 (identifier: Q06481-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         613-624: Missing.

    Show »
    Length:751
    Mass (Da):85,487
    Checksum:i788BCDC6E4487E18
    GO
    Isoform 4 (identifier: Q06481-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         308-363: Missing.
         364-364: I → V
         613-624: Missing.

    Show »
    Length:695
    Mass (Da):79,238
    Checksum:i728CA8ACBB7594FB
    GO
    Isoform 5 (identifier: Q06481-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         136-364: Missing.
         613-624: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:522
    Mass (Da):59,151
    Checksum:i993641BFC15ED6E0
    GO
    Isoform 6 (identifier: Q06481-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-35: MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIE → MLRAPGELPR...ASVDRGNPLW
         613-624: Missing.

    Show »
    Length:761
    Mass (Da):87,215
    Checksum:iE87786F52F076C41
    GO

    Sequence cautioni

    The sequence BAG54641.1 differs from that shown. Reason: Frameshift at position 81.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti224 – 2241E → D in AAD47291. 1 PublicationCurated
    Sequence conflicti226 – 2272Missing in BAG54641. (PubMed:14702039)Curated
    Sequence conflicti543 – 5431S → I in AAA35526. (PubMed:8485127)Curated
    Sequence conflicti543 – 5431S → T in AAH04371. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti632 – 6321D → N.
    Corresponds to variant rs3740881 [ dbSNP | Ensembl ].
    VAR_022039

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3535MAATG…AGYIE → MLRAPGELPRQAARCSLCRL GPGRGRAFFKWRCLPASVDR GNPLW in isoform 6. CuratedVSP_046881Add
    BLAST
    Alternative sequencei136 – 364229Missing in isoform 5. 1 PublicationVSP_030921Add
    BLAST
    Alternative sequencei308 – 36356Missing in isoform 2 and isoform 4. 1 PublicationVSP_000018Add
    BLAST
    Alternative sequencei364 – 3641I → V in isoform 4. 1 PublicationVSP_046882
    Alternative sequencei613 – 62412Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 3 PublicationsVSP_000019Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S60099 mRNA. Translation: AAC60589.1.
    L09209 mRNA. Translation: AAA35526.1.
    L27631 mRNA. Translation: AAC41701.1.
    Z22572 mRNA. Translation: CAA80295.1.
    AK128162 mRNA. Translation: BAG54641.1. Frameshift.
    L19597 mRNA. Translation: AAA35601.1.
    L23113 mRNA. Translation: AAA36032.1.
    L23114 mRNA. Translation: AAA36130.1.
    AF168956 mRNA. Translation: AAD47291.1.
    AP001183 Genomic DNA. No translation available.
    AP003041 Genomic DNA. No translation available.
    BC000373 mRNA. Translation: AAH00373.1.
    BC004371 mRNA. Translation: AAH04371.1.
    CCDSiCCDS44773.1. [Q06481-3]
    CCDS44774.1. [Q06481-4]
    CCDS44775.1. [Q06481-5]
    CCDS58196.1. [Q06481-6]
    CCDS8486.1. [Q06481-1]
    PIRiA49321.
    S41082.
    RefSeqiNP_001135748.1. NM_001142276.1. [Q06481-3]
    NP_001135749.1. NM_001142277.1. [Q06481-4]
    NP_001135750.1. NM_001142278.1. [Q06481-5]
    NP_001230228.1. NM_001243299.1. [Q06481-6]
    NP_001633.1. NM_001642.2. [Q06481-1]
    UniGeneiHs.370247.

    Genome annotation databases

    EnsembliENST00000263574; ENSP00000263574; ENSG00000084234. [Q06481-1]
    ENST00000278756; ENSP00000278756; ENSG00000084234. [Q06481-6]
    ENST00000338167; ENSP00000345444; ENSG00000084234. [Q06481-3]
    ENST00000345598; ENSP00000263575; ENSG00000084234. [Q06481-5]
    ENST00000528499; ENSP00000435914; ENSG00000084234. [Q06481-4]
    GeneIDi334.
    KEGGihsa:334.
    UCSCiuc001qfp.3. human. [Q06481-3]
    uc001qfs.3. human. [Q06481-5]
    uc001qfv.3. human. [Q06481-2]
    uc010sby.2. human. [Q06481-1]

    Polymorphism databases

    DMDMi1703344.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S60099 mRNA. Translation: AAC60589.1 .
    L09209 mRNA. Translation: AAA35526.1 .
    L27631 mRNA. Translation: AAC41701.1 .
    Z22572 mRNA. Translation: CAA80295.1 .
    AK128162 mRNA. Translation: BAG54641.1 . Frameshift.
    L19597 mRNA. Translation: AAA35601.1 .
    L23113 mRNA. Translation: AAA36032.1 .
    L23114 mRNA. Translation: AAA36130.1 .
    AF168956 mRNA. Translation: AAD47291.1 .
    AP001183 Genomic DNA. No translation available.
    AP003041 Genomic DNA. No translation available.
    BC000373 mRNA. Translation: AAH00373.1 .
    BC004371 mRNA. Translation: AAH04371.1 .
    CCDSi CCDS44773.1. [Q06481-3 ]
    CCDS44774.1. [Q06481-4 ]
    CCDS44775.1. [Q06481-5 ]
    CCDS58196.1. [Q06481-6 ]
    CCDS8486.1. [Q06481-1 ]
    PIRi A49321.
    S41082.
    RefSeqi NP_001135748.1. NM_001142276.1. [Q06481-3 ]
    NP_001135749.1. NM_001142277.1. [Q06481-4 ]
    NP_001135750.1. NM_001142278.1. [Q06481-5 ]
    NP_001230228.1. NM_001243299.1. [Q06481-6 ]
    NP_001633.1. NM_001642.2. [Q06481-1 ]
    UniGenei Hs.370247.

    3D structure databases

    ProteinModelPortali Q06481.
    SMRi Q06481. Positions 47-204, 309-566, 735-761.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106831. 23 interactions.
    DIPi DIP-31047N.
    IntActi Q06481. 20 interactions.
    MINTi MINT-1186713.
    STRINGi 9606.ENSP00000263574.

    Protein family/group databases

    MEROPSi I02.016.

    PTM databases

    PhosphoSitei Q06481.

    Polymorphism databases

    DMDMi 1703344.

    Proteomic databases

    MaxQBi Q06481.
    PaxDbi Q06481.
    PRIDEi Q06481.

    Protocols and materials databases

    DNASUi 334.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263574 ; ENSP00000263574 ; ENSG00000084234 . [Q06481-1 ]
    ENST00000278756 ; ENSP00000278756 ; ENSG00000084234 . [Q06481-6 ]
    ENST00000338167 ; ENSP00000345444 ; ENSG00000084234 . [Q06481-3 ]
    ENST00000345598 ; ENSP00000263575 ; ENSG00000084234 . [Q06481-5 ]
    ENST00000528499 ; ENSP00000435914 ; ENSG00000084234 . [Q06481-4 ]
    GeneIDi 334.
    KEGGi hsa:334.
    UCSCi uc001qfp.3. human. [Q06481-3 ]
    uc001qfs.3. human. [Q06481-5 ]
    uc001qfv.3. human. [Q06481-2 ]
    uc010sby.2. human. [Q06481-1 ]

    Organism-specific databases

    CTDi 334.
    GeneCardsi GC11P129939.
    HGNCi HGNC:598. APLP2.
    HPAi HPA039319.
    MIMi 104776. gene.
    neXtProti NX_Q06481.
    PharmGKBi PA24885.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289770.
    HOVERGENi HBG000051.
    InParanoidi Q06481.
    KOi K08117.
    OMAi RMEVCEN.
    OrthoDBi EOG7RNJZP.
    PhylomeDBi Q06481.
    TreeFami TF317274.

    Enzyme and pathway databases

    SignaLinki Q06481.

    Miscellaneous databases

    ChiTaRSi APLP2. human.
    GeneWikii APLP2.
    GenomeRNAii 334.
    NextBioi 1383.
    PMAP-CutDB Q06481.
    PROi Q06481.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q06481.
    Bgeei Q06481.
    CleanExi HS_APLP2.
    HS_APPL2.
    Genevestigatori Q06481.

    Family and domain databases

    Gene3Di 3.30.1490.140. 1 hit.
    3.90.570.10. 1 hit.
    4.10.410.10. 1 hit.
    InterProi IPR008155. Amyloid_glyco.
    IPR011178. Amyloid_glyco_Cu-bd.
    IPR024329. Amyloid_glyco_E2_domain.
    IPR008154. Amyloid_glyco_extra.
    IPR019744. Amyloid_glyco_extracell_CS.
    IPR015849. Amyloid_glyco_heparin-bd.
    IPR019745. Amyloid_glyco_intracell_CS.
    IPR019543. APP_amyloid_C.
    IPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    [Graphical view ]
    Pfami PF10515. APP_amyloid. 1 hit.
    PF12924. APP_Cu_bd. 1 hit.
    PF12925. APP_E2. 1 hit.
    PF02177. APP_N. 1 hit.
    PF00014. Kunitz_BPTI. 1 hit.
    [Graphical view ]
    PRINTSi PR00203. AMYLOIDA4.
    PR00759. BASICPTASE.
    SMARTi SM00006. A4_EXTRA. 1 hit.
    SM00131. KU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109843. SSF109843. 1 hit.
    SSF56491. SSF56491. 1 hit.
    SSF57362. SSF57362. 1 hit.
    SSF89811. SSF89811. 1 hit.
    PROSITEi PS00319. A4_EXTRA. 1 hit.
    PS00320. A4_INTRA. 1 hit.
    PS00280. BPTI_KUNITZ_1. 1 hit.
    PS50279. BPTI_KUNITZ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family."
      Sprecher C.A., Grant F.J., Grimm G., O'Hara P.J., Norris F., Norris K., Foster D.C.
      Biochemistry 32:4481-4486(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. "Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor."
      Wasco W., Gurubhagavatula S., Paradis M., Romano D.M., Sisodia S.S., Hyman B.T., Neve R.L., Tanzi R.E.
      Nat. Genet. 5:95-99(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein."
      von der Kammer H., Hanes J., Klaudiny J., Scheit K.H.
      DNA Cell Biol. 13:1137-1143(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Ovary.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.
    5. "Cloning of a protein that binds to a recognition sequence in the APP promoter."
      Vostrov A.A., Quitschke W.W., Schwarzman A.L., Blangy A., Cuzin F., Wesley U.V., Hagag N.G., Goldgaber D.
      Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-763 (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 229-763 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
      Tissue: Brain.
    6. "A new special gene in human testis (HSD-2)."
      Wang L., Miao S., Fan H., Wang H.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
      Tissue: Lung and Pancreas.
    9. "Expression, purification and characterization of a Kunitz-type protease inhibitor domain from human amyloid precursor protein homolog."
      Petersen L.C., Bjorn S.E., Norris F., Norris K., Sprecher C., Foster D.C.
      FEBS Lett. 338:53-57(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 305-362 (ISOFORMS 1/3), FUNCTION, GLYCOSYLATION.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAPLP2_HUMAN
    AccessioniPrimary (citable) accession number: Q06481
    Secondary accession number(s): B3KXX9
    , H7BXI4, Q13861, Q14594, Q14662, Q71U10, Q7M4L3, Q9BT36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 155 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3