ID   YL352_YEAST             Reviewed;         807 AA.
AC   Q06479;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 63.
DE   RecName: Full=F-box protein YLR352W;
GN   OrderedLocusNames=YLR352W;
OS   Saccharomyces cerevisiae (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204511 / S288c / AB972;
RX   MEDLINE=97313267; PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B.,
RA   Ansorge W., Benes V., Brueckner M., Delius H., Dubois E.,
RA   Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U.,
RA   Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K.,
RA   Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T.,
RA   Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E.,
RA   Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M.,
RA   Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C.,
RA   Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M.,
RA   Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H.,
RA   Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A.,
RA   Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [2]
RP   INTERACTION WITH CDC53 AND SKP1, IDENTIFICATION BY MASS SPECTROMETRY,
RP   AND DOMAIN F-BOX.
RX   MEDLINE=21180374; PubMed=11283612; DOI=10.1038/35070067;
RA   Seol J.H., Shevchenko A., Shevchenko A., Deshaies R.J.;
RT   "Skp1 forms multiple protein complexes, including RAVE, a regulator of
RT   V-ATPase assembly.";
RL   Nat. Cell Biol. 3:384-391(2001).
RN   [3]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   MEDLINE=22923965; PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
RA   Dephoure N., O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-
CC       box protein) E3 ubiquitin-protein ligase complex which mediates
CC       the ubiquitination and subsequent proteasomal degradation of
CC       target proteins. Probably recognizes and binds to phosphorylated
CC       target proteins (By similarity).
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with SKP1 and CDC53. Component of the probable
CC       SCF(YBR352W) complex containing CDC53, SKP1, RBX1 and YBR352W.
CC   -!- INTERACTION:
CC       P52286:SKP1; NbExp=1; IntAct=EBI-35627, EBI-4090;
CC   -!- MISCELLANEOUS: Present with 125 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Contains 1 F-box domain.
CC   -!- SIMILARITY: Contains 3 LRR (leucine-rich) repeats.
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DR   EMBL; U19102; AAB67750.1; -; Genomic_DNA.
DR   PIR; S51460; S51460.
DR   RefSeq; NP_013456.1; -.
DR   DIP; DIP:1631N; -.
DR   IntAct; Q06479; 5.
DR   PeptideAtlas; Q06479; -.
DR   PRIDE; Q06479; -.
DR   Ensembl; YLR352W; Saccharomyces cerevisiae.
DR   GeneID; 851066; -.
DR   GenomeReviews; Y13138_GR; YLR352W.
DR   KEGG; sce:YLR352W; -.
DR   NMPDR; fig|4932.3.peg.4478; -.
DR   CYGD; YLR352w; -.
DR   SGD; S000004344; YLR352W.
DR   HOGENOM; Q06479; -.
DR   OMA; Q06479; ERGMYRY.
DR   NextBio; 967702; -.
DR   ArrayExpress; Q06479; -.
DR   GermOnline; YLR352W; Saccharomyces cerevisiae.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0019941; P:modification-dependent protein catabolic pr...; IEA:UniProtKB-KW.
DR   PROSITE; PS50181; FBOX; FALSE_NEG.
PE   1: Evidence at protein level;
KW   Complete proteome; Leucine-rich repeat; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN         1    807       F-box protein YLR352W.
FT                                /FTId=PRO_0000268189.
FT   REPEAT        1     25       LRR 1.
FT   DOMAIN      220    266       F-box.
FT   REPEAT      377    400       LRR 2.
FT   REPEAT      666    691       LRR 3.
SQ   SEQUENCE   807 AA;  93123 MW;  A44090288065A7BD CRC64;
     MPDLKSKTLS SQSLGAAIPP EIVYQILTYQ FRDLLRNDHP GTAEKFNENL TTFVKSNLTV
     NKTFSHICQV LIYRYCNLTT AKRFHGLLQT LKGNRCLCNK IEVADFQELT SIGLGRSSEM
     NKMIKNLTNE TLLEFLMLTK ANLREFLACE NIQDDLDDNI IKYILSPGKV LSVVDFCGCS
     GTTFTESFIK ALDKYYPNKS IDQYRLEPIQ QNYQITCLGL NDCIDLPSHV LWKILKMLPE
     LQKLDLSHTS IDDSTLYHGI PHWKNLTHLS LATCLQVTPR AVLEFFSHHP TITDPDNTST
     LEWLNVSVIA HSSSWNEVHT MFLLKKLCQH GHNKTLQYLN IGGLPLHVAP SFGEDPISES
     TYYYQCRDSL QFIKWNFPKL KSLSIKGNSI PISTLVEFLT PIDQDHPNCA QKLKFLNISG
     NSYVNKWTIQ DSLLYTCSPS LVALEVSFDS WQQIEKLNDR HEIIAYRYKN PNSVIKDIST
     AEQVKWKCYI DSSYGRRYWL YKTDPFLNRD DLDSKSNLTR YDFEGHKIIE IINQPDFLKF
     AQSKIMLGCG LVPQSGIRRK LCYRDLKPPV SQFLNRKGAI SLGDTPLPII TPTLPRGGWR
     IIHNEDDNNS HVEDSQNHVN AIPRRNSLLS RPTLRSNNGS SSANPFAINV SPASQIRDGL
     YWDRSVHDLR ELSLQEQRIQ ELADEQQELR TIANFEETDD EYLHDPDLQR RRSQLHLFES
     SRSRSGNKTR PSLTGEHSSS ASFLSFSHFN HLHKRKNYYF THPDEFVYDP KDPLTTQRYR
     LHFEIVNEYQ VFGCIERGMY RYYSLKA
//