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Protein

F-box protein YLR352W

Gene

YLR352W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).By similarity

Miscellaneous

Present with 125 molecules/cell in log phase SD medium.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-32426-MONOMER.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box protein YLR352W
Gene namesi
Ordered Locus Names:YLR352W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR352W.
SGDiS000004344. YLR352W.

Subcellular locationi

GO - Cellular componenti

  • SCF ubiquitin ligase complex Source: SGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002681891 – 807F-box protein YLR352WAdd BLAST807

Proteomic databases

MaxQBiQ06479.
PRIDEiQ06479.

PTM databases

iPTMnetiQ06479.

Interactioni

Subunit structurei

Interacts with SKP1 and CDC53. Component of the probable SCF(YBR352W) complex containing CDC53, SKP1, RBX1 and YBR352W.1 Publication

Protein-protein interaction databases

BioGridi31614. 83 interactors.
DIPiDIP-1631N.
IntActiQ06479. 4 interactors.
MINTiMINT-400372.
STRINGi4932.YLR352W.

Structurei

3D structure databases

ProteinModelPortaliQ06479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 266F-boxAdd BLAST47

Phylogenomic databases

HOGENOMiHOG000142076.
InParanoidiQ06479.
OMAiERGMYRY.
OrthoDBiEOG092C2EEA.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. L_dom-like.

Sequencei

Sequence statusi: Complete.

Q06479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDLKSKTLS SQSLGAAIPP EIVYQILTYQ FRDLLRNDHP GTAEKFNENL
60 70 80 90 100
TTFVKSNLTV NKTFSHICQV LIYRYCNLTT AKRFHGLLQT LKGNRCLCNK
110 120 130 140 150
IEVADFQELT SIGLGRSSEM NKMIKNLTNE TLLEFLMLTK ANLREFLACE
160 170 180 190 200
NIQDDLDDNI IKYILSPGKV LSVVDFCGCS GTTFTESFIK ALDKYYPNKS
210 220 230 240 250
IDQYRLEPIQ QNYQITCLGL NDCIDLPSHV LWKILKMLPE LQKLDLSHTS
260 270 280 290 300
IDDSTLYHGI PHWKNLTHLS LATCLQVTPR AVLEFFSHHP TITDPDNTST
310 320 330 340 350
LEWLNVSVIA HSSSWNEVHT MFLLKKLCQH GHNKTLQYLN IGGLPLHVAP
360 370 380 390 400
SFGEDPISES TYYYQCRDSL QFIKWNFPKL KSLSIKGNSI PISTLVEFLT
410 420 430 440 450
PIDQDHPNCA QKLKFLNISG NSYVNKWTIQ DSLLYTCSPS LVALEVSFDS
460 470 480 490 500
WQQIEKLNDR HEIIAYRYKN PNSVIKDIST AEQVKWKCYI DSSYGRRYWL
510 520 530 540 550
YKTDPFLNRD DLDSKSNLTR YDFEGHKIIE IINQPDFLKF AQSKIMLGCG
560 570 580 590 600
LVPQSGIRRK LCYRDLKPPV SQFLNRKGAI SLGDTPLPII TPTLPRGGWR
610 620 630 640 650
IIHNEDDNNS HVEDSQNHVN AIPRRNSLLS RPTLRSNNGS SSANPFAINV
660 670 680 690 700
SPASQIRDGL YWDRSVHDLR ELSLQEQRIQ ELADEQQELR TIANFEETDD
710 720 730 740 750
EYLHDPDLQR RRSQLHLFES SRSRSGNKTR PSLTGEHSSS ASFLSFSHFN
760 770 780 790 800
HLHKRKNYYF THPDEFVYDP KDPLTTQRYR LHFEIVNEYQ VFGCIERGMY

RYYSLKA
Length:807
Mass (Da):93,123
Last modified:November 1, 1996 - v1
Checksum:iA44090288065A7BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19102 Genomic DNA. Translation: AAB67750.1.
BK006945 Genomic DNA. Translation: DAA09656.1.
PIRiS51460.
RefSeqiNP_013456.1. NM_001182241.1.

Genome annotation databases

EnsemblFungiiYLR352W; YLR352W; YLR352W.
GeneIDi851066.
KEGGisce:YLR352W.

Similar proteinsi

Entry informationi

Entry nameiYL352_YEAST
AccessioniPrimary (citable) accession number: Q06479
Secondary accession number(s): D6VYZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names