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Protein

Phospholipase A1 1

Gene
N/A
Organism
Dolichovespula maculata (Bald-faced hornet) (Vespula maculata)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.

Catalytic activityi

Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.
Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei154 – 1541NucleophileBy similarity
Active sitei182 – 1821Charge relay systemPROSITE-ProRule annotation
Active sitei246 – 2461Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Protein family/group databases

ESTHERidolma-ppla1. Phospholipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A1 1 (EC:3.1.1.32, EC:3.1.1.4)
Alternative name(s):
Allergen Dol m I
Allergen: Dol m 1.01
OrganismiDolichovespula maculata (Bald-faced hornet) (Vespula maculata)
Taxonomic identifieri7441 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeDolichovespula

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei1667. Dol m 1.0101.
328. Dol m 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 7›7Sequence analysis
Propeptidei8 – 1710PRO_0000425186
Chaini18 – 317300Phospholipase A1 1PRO_0000017812Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 261By similarity
Glycosylationi25 – 251N-linked (GlcNAc...)
Disulfide bondi104 ↔ 244By similarity
Disulfide bondi193 ↔ 236By similarity
Disulfide bondi198 ↔ 278By similarity
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi256 ↔ 262By similarity
Disulfide bondi285 ↔ 310By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ06478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002334. Allerg_PlipaseA1.
IPR013818. Lipase_N.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSiPR00825. DOLALLERGEN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RLIMFVGDPS SSNELDRFSV CPFSNDTVKM IFLTRENRKH DFYTLDTMNR
60 70 80 90 100
HNEFKKSIIK RPVVFITHGF TSSATEKNFV AMSEALMHTG DFLIIMVDWR
110 120 130 140 150
MAACTDEYPG LKYMFYKAAV GNTRLVGNFI AMIAKKLVEQ YKVPMTNIRL
160 170 180 190 200
VGHSLGAHIS GFAGKRVQEL KLGKFSEIIG LDPAGPSFKK NDCSERICET
210 220 230 240 250
DAHYVQILHT SSNLGTERTL GTVDFYINNG SNQPGCRYII GETCSHTRAV
260 270 280 290 300
KYFTECIRRE CCLIGVPQSK NPQPVSKCTR NECVCVGLNA KKYPKRGSFY
310
VPVEAEAPYC NNNGKII
Length:317
Mass (Da):35,708
Last modified:June 1, 1994 - v1
Checksum:i0B2135FD453512D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti271 – 2711N → S.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66869 mRNA. Translation: CAA47341.1.
PIRiS32406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66869 mRNA. Translation: CAA47341.1.
PIRiS32406.

3D structure databases

ProteinModelPortaliQ06478.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1667. Dol m 1.0101.
328. Dol m 1.
ESTHERidolma-ppla1. Phospholipase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002334. Allerg_PlipaseA1.
IPR013818. Lipase_N.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSiPR00825. DOLALLERGEN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPA11_DOLMA
AccessioniPrimary (citable) accession number: Q06478
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 24, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.