ID   COX3_SYNY3              Reviewed;         233 AA.
AC   Q06475; P73262;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   27-MAR-2024, entry version 140.
DE   RecName: Full=Cytochrome c oxidase subunit 3;
DE            EC=7.1.1.9;
DE   AltName: Full=Cytochrome aa3 subunit 3;
DE   AltName: Full=Cytochrome c oxidase polypeptide III;
DE   AltName: Full=Oxidase aa(3) subunit 3;
GN   Name=ctaE; OrderedLocusNames=slr1138;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Merismopediaceae;
OC   Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8387368;
RA   Alge D., Peschek G.A.;
RT   "Characterization of a cta/CDE operon-like genomic region encoding subunits
RT   I-III of the cytochrome c oxidase of the cyanobacterium Synechocystis PCC
RT   6803.";
RL   Biochem. Mol. Biol. Int. 29:511-525(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC         [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC         Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=7.1.1.9;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC       {ECO:0000305}.
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DR   EMBL; X53746; CAA37778.1; -; Genomic_DNA.
DR   EMBL; BA000022; BAA17290.1; -; Genomic_DNA.
DR   PIR; S77443; S77443.
DR   AlphaFoldDB; Q06475; -.
DR   SMR; Q06475; -.
DR   STRING; 1148.gene:10498153; -.
DR   PaxDb; 1148-1652368; -.
DR   EnsemblBacteria; BAA17290; BAA17290; BAA17290.
DR   KEGG; syn:slr1138; -.
DR   eggNOG; COG1845; Bacteria.
DR   InParanoid; Q06475; -.
DR   PhylomeDB; Q06475; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR   GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR   CDD; cd00386; Heme_Cu_Oxidase_III_like; 1.
DR   Gene3D; 1.20.120.80; Cytochrome c oxidase, subunit III, four-helix bundle; 1.
DR   InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR   InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR   InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR   InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR   PANTHER; PTHR11403:SF7; CYTOCHROME C OXIDASE SUBUNIT 3; 1.
DR   PANTHER; PTHR11403; CYTOCHROME C OXIDASE SUBUNIT III; 1.
DR   Pfam; PF00510; COX3; 1.
DR   SUPFAM; SSF81452; Cytochrome c oxidase subunit III-like; 1.
DR   PROSITE; PS50253; COX3; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Translocase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..233
FT                   /note="Cytochrome c oxidase subunit 3"
FT                   /id="PRO_0000183891"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        1..13
FT                   /note="MTSPMGPTARDFW -> MARPPGGFL (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        114..117
FT                   /note="SFVM -> R (in Ref. 1; CAA37778)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   233 AA;  26083 MW;  720A8F794DE17F43 CRC64;
     MTSPMGPTAR DFWQNSRNSA TIQRLIVSPM QTTALSSDLN STYTPGEAHG HHGHPDLRMF
     GVVLFLVAES AIFLGLFTAY LIYRSVMPAW PPEGTPELEL LLPGVNSIIL ISSSFVMHKG
     QAAIRNNDNA GLQKWFGITA AMGIIFLAGQ MYEYFHLEMG LTTNLFASCF YVLTGFHGLH
     VTFGLLLILS VLWRSRQPGH YSRTSHFGVE AAELYWHFVD VVWIVLFILV YLL
//