Q06475 (COX3_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 3
Cytochrome c oxidase polypeptide III
Oxidase aa(3) subunit 3

Gene names

Name:	ctaE
Ordered Locus Names:	slr1138

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 233	233	Cytochrome c oxidase subunit 3		PRO_0000183891
Regions
	Transmembrane	62 – 82	21	Helical; Potential
	Transmembrane	98 – 118	21	Helical; Potential
	Transmembrane	135 – 155	21	Helical; Potential
	Transmembrane	172 – 192	21	Helical; Potential
Experimental info
	Sequence conflict	1 – 13	13	MTSPM…ARDFW → MARPPGGFL Ref.1
	Sequence conflict	114 – 117	4	SFVM → R in CAA37778. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q06475 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 720A8F794DE17F43	FASTA	233	26,083
	10 20 30 40 50 60 MTSPMGPTAR DFWQNSRNSA TIQRLIVSPM QTTALSSDLN STYTPGEAHG HHGHPDLRMF 70 80 90 100 110 120 GVVLFLVAES AIFLGLFTAY LIYRSVMPAW PPEGTPELEL LLPGVNSIIL ISSSFVMHKG 130 140 150 160 170 180 QAAIRNNDNA GLQKWFGITA AMGIIFLAGQ MYEYFHLEMG LTTNLFASCF YVLTGFHGLH 190 200 210 220 230 VTFGLLLILS VLWRSRQPGH YSRTSHFGVE AAELYWHFVD VVWIVLFILV YLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a cta/CDE operon-like genomic region encoding subunits I-III of the cytochrome c oxidase of the cyanobacterium Synechocystis PCC 6803." Alge D., Peschek G.A. Biochem. Mol. Biol. Int. 29:511-525(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X53746 Genomic DNA. Translation: CAA37778.1. BA000022 Genomic DNA. Translation: BAA17290.1.
PIR	S77443.
RefSeq	NP_440610.1. NC_000911.1. YP_007450493.1. NC_020286.1.
3D structure databases
ProteinModelPortal	Q06475.
ModBase	Search...
Protein-protein interaction databases
STRING	1148.slr1138.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA17290; BAA17290; BAA17290.
GeneID	14616143. 953913.
KEGG	syn:slr1138.
PATRIC	23838414. VBISynSp132158_0774.
Phylogenomic databases
eggNOG	COG1845.
HOGENOM	HOG000086399.
KO	K02276.
OMA	ENHFPLE.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_SYNY3

Accession

Primary (citable) accession number: Q06475
Secondary accession number(s): P73262

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program