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Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi214 – 2141Copper ACurated
Metal bindingi249 – 2491Copper ACurated
Metal bindingi253 – 2531Copper ACurated
Metal bindingi257 – 2571Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Synonyms:coxB
Ordered Locus Names:slr1136
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei48 – 6821HelicalSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 332312Cytochrome c oxidase subunit 2PRO_0000006065Add
BLAST

Proteomic databases

PaxDbiQ06474.

Interactioni

Protein-protein interaction databases

IntActiQ06474. 2 interactions.
STRINGi1148.slr1136.

Structurei

3D structure databases

ProteinModelPortaliQ06474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000232614.
InParanoidiQ06474.
KOiK02275.
OMAiQDVIPGQ.
OrthoDBiEOG68SVXT.
PhylomeDBiQ06474.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06474-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIPGSVITL LIGVVITVVS LWYGQNHGLM PVAASADAEK VDGIFNYMMT
60 70 80 90 100
IATGLFLLVE GVLVYCLIRF RRRKDDQTDG PPIEGNVPLE ILWTAIPTVI
110 120 130 140 150
VFTLAVYSFE VYNNLGGLDP TISRDNAGQQ MAHNHMGHMG SMGNMVAMAG
160 170 180 190 200
DGDVALGIGL DSEEQGVNPL MVDVKGIQYA WIFTYPETGI ISGELHAPID
210 220 230 240 250
RPVQLNMEAG DVIHAFWIPQ LRLKQDVIPG RGSTLVFNAS TPGQYPVICA
260 270 280 290 300
ELCGAYHGGM KSVFYAHTPE EYDDWVAANA PAPTESMAMT LPKATTAMTP
310 320 330
NEYLAPYAKE MGVQTEALAQ LKDQTSPVGD LL
Length:332
Mass (Da):35,917
Last modified:November 1, 1997 - v2
Checksum:i314F15C8F8D4AD26
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti240 – 2445STPGQ → RHPWA (PubMed:8383492).Curated
Sequence conflicti240 – 2445STPGQ → RHPWA (PubMed:8387368).Curated
Sequence conflicti320 – 33213QLKDQ…VGDLL → N (PubMed:8383492).CuratedAdd
BLAST
Sequence conflicti320 – 33213QLKDQ…VGDLL → N (PubMed:8387368).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53746 Genomic DNA. Translation: CAA37776.1.
BA000022 Genomic DNA. Translation: BAA17288.1.
PIRiS77441.
RefSeqiNP_440608.1. NC_000911.1.
YP_005650666.1. NC_017277.1.
YP_007450491.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17288; BAA17288; BAA17288.
KEGGisyn:slr1136.
PATRICi23838410. VBISynSp132158_0772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53746 Genomic DNA. Translation: CAA37776.1.
BA000022 Genomic DNA. Translation: BAA17288.1.
PIRiS77441.
RefSeqiNP_440608.1. NC_000911.1.
YP_005650666.1. NC_017277.1.
YP_007450491.1. NC_020286.1.

3D structure databases

ProteinModelPortaliQ06474.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ06474. 2 interactions.
STRINGi1148.slr1136.

Proteomic databases

PaxDbiQ06474.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17288; BAA17288; BAA17288.
KEGGisyn:slr1136.
PATRICi23838410. VBISynSp132158_0772.

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000232614.
InParanoidiQ06474.
KOiK02275.
OMAiQDVIPGQ.
OrthoDBiEOG68SVXT.
PhylomeDBiQ06474.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the ctaC (coxB) gene as part of an operon encoding subunits I, II, and III of the cytochrome c oxidase (cytochrome aa3) in the cyanobacterium Synechocystis PCC 6803."
    Alge D., Peschek G.A.
    Biochem. Biophys. Res. Commun. 191:9-17(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterization of a cta/CDE operon-like genomic region encoding subunits I-III of the cytochrome c oxidase of the cyanobacterium Synechocystis PCC 6803."
    Alge D., Peschek G.A.
    Biochem. Mol. Biol. Int. 29:511-525(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiCOX2_SYNY3
AccessioniPrimary (citable) accession number: Q06474
Secondary accession number(s): P77963
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: April 1, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.