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Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi214Copper ACurated1
Metal bindingi249Copper ACurated1
Metal bindingi253Copper ACurated1
Metal bindingi257Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Synonyms:coxB
Ordered Locus Names:slr1136
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000606521 – 332Cytochrome c oxidase subunit 2Add BLAST312

Proteomic databases

PaxDbiQ06474
PRIDEiQ06474

Interactioni

Protein-protein interaction databases

IntActiQ06474, 2 interactors
STRINGi1148.SYNGTS_0713

Structurei

3D structure databases

ProteinModelPortaliQ06474
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000232614
InParanoidiQ06474
KOiK02275
OMAiVVGKQWM
PhylomeDBiQ06474

Family and domain databases

Gene3Di1.10.287.90, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06474-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIPGSVITL LIGVVITVVS LWYGQNHGLM PVAASADAEK VDGIFNYMMT
60 70 80 90 100
IATGLFLLVE GVLVYCLIRF RRRKDDQTDG PPIEGNVPLE ILWTAIPTVI
110 120 130 140 150
VFTLAVYSFE VYNNLGGLDP TISRDNAGQQ MAHNHMGHMG SMGNMVAMAG
160 170 180 190 200
DGDVALGIGL DSEEQGVNPL MVDVKGIQYA WIFTYPETGI ISGELHAPID
210 220 230 240 250
RPVQLNMEAG DVIHAFWIPQ LRLKQDVIPG RGSTLVFNAS TPGQYPVICA
260 270 280 290 300
ELCGAYHGGM KSVFYAHTPE EYDDWVAANA PAPTESMAMT LPKATTAMTP
310 320 330
NEYLAPYAKE MGVQTEALAQ LKDQTSPVGD LL
Length:332
Mass (Da):35,917
Last modified:November 1, 1997 - v2
Checksum:i314F15C8F8D4AD26
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti240 – 244STPGQ → RHPWA (PubMed:8383492).Curated5
Sequence conflicti240 – 244STPGQ → RHPWA (PubMed:8387368).Curated5
Sequence conflicti320 – 332QLKDQ…VGDLL → N (PubMed:8383492).CuratedAdd BLAST13
Sequence conflicti320 – 332QLKDQ…VGDLL → N (PubMed:8387368).CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53746 Genomic DNA Translation: CAA37776.1
BA000022 Genomic DNA Translation: BAA17288.1
PIRiS77441

Genome annotation databases

EnsemblBacteriaiBAA17288; BAA17288; BAA17288
KEGGisyn:slr1136

Similar proteinsi

Entry informationi

Entry nameiCOX2_SYNY3
AccessioniPrimary (citable) accession number: Q06474
Secondary accession number(s): P77963
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health