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Q06474

- COX2_SYNY3

UniProt

Q06474 - COX2_SYNY3

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Protein

Cytochrome c oxidase subunit 2

Gene
ctaC, coxB, slr1136
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi214 – 2141Copper A Inferred
Metal bindingi249 – 2491Copper A Inferred
Metal bindingi253 – 2531Copper A Inferred
Metal bindingi257 – 2571Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Synonyms:coxB
Ordered Locus Names:slr1136
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei48 – 6821Helical; Reviewed predictionAdd
BLAST
Transmembranei87 – 10721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 332312Cytochrome c oxidase subunit 2PRO_0000006065Add
BLAST

Proteomic databases

PaxDbiQ06474.

Interactioni

Protein-protein interaction databases

IntActiQ06474. 2 interactions.
STRINGi1148.slr1136.

Structurei

3D structure databases

ProteinModelPortaliQ06474.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000232614.
KOiK02275.
OMAiQDVIPGQ.
OrthoDBiEOG68SVXT.
PhylomeDBiQ06474.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06474-1 [UniParc]FASTAAdd to Basket

« Hide

MKIPGSVITL LIGVVITVVS LWYGQNHGLM PVAASADAEK VDGIFNYMMT    50
IATGLFLLVE GVLVYCLIRF RRRKDDQTDG PPIEGNVPLE ILWTAIPTVI 100
VFTLAVYSFE VYNNLGGLDP TISRDNAGQQ MAHNHMGHMG SMGNMVAMAG 150
DGDVALGIGL DSEEQGVNPL MVDVKGIQYA WIFTYPETGI ISGELHAPID 200
RPVQLNMEAG DVIHAFWIPQ LRLKQDVIPG RGSTLVFNAS TPGQYPVICA 250
ELCGAYHGGM KSVFYAHTPE EYDDWVAANA PAPTESMAMT LPKATTAMTP 300
NEYLAPYAKE MGVQTEALAQ LKDQTSPVGD LL 332
Length:332
Mass (Da):35,917
Last modified:November 1, 1997 - v2
Checksum:i314F15C8F8D4AD26
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti240 – 2445STPGQ → RHPWA1 Publication
Sequence conflicti240 – 2445STPGQ → RHPWA1 Publication
Sequence conflicti320 – 33213QLKDQ…VGDLL → N1 PublicationAdd
BLAST
Sequence conflicti320 – 33213QLKDQ…VGDLL → N1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53746 Genomic DNA. Translation: CAA37776.1.
BA000022 Genomic DNA. Translation: BAA17288.1.
PIRiS77441.
RefSeqiNP_440608.1. NC_000911.1.
YP_005650666.1. NC_017277.1.
YP_007450491.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17288; BAA17288; BAA17288.
GeneIDi953911.
KEGGisyn:slr1136.
syy:SYNGTS_0713.
syz:MYO_17190.
PATRICi23838410. VBISynSp132158_0772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53746 Genomic DNA. Translation: CAA37776.1 .
BA000022 Genomic DNA. Translation: BAA17288.1 .
PIRi S77441.
RefSeqi NP_440608.1. NC_000911.1.
YP_005650666.1. NC_017277.1.
YP_007450491.1. NC_020286.1.

3D structure databases

ProteinModelPortali Q06474.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q06474. 2 interactions.
STRINGi 1148.slr1136.

Proteomic databases

PaxDbi Q06474.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA17288 ; BAA17288 ; BAA17288 .
GeneIDi 953911.
KEGGi syn:slr1136.
syy:SYNGTS_0713.
syz:MYO_17190.
PATRICi 23838410. VBISynSp132158_0772.

Phylogenomic databases

eggNOGi COG1622.
HOGENOMi HOG000232614.
KOi K02275.
OMAi QDVIPGQ.
OrthoDBi EOG68SVXT.
PhylomeDBi Q06474.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the ctaC (coxB) gene as part of an operon encoding subunits I, II, and III of the cytochrome c oxidase (cytochrome aa3) in the cyanobacterium Synechocystis PCC 6803."
    Alge D., Peschek G.A.
    Biochem. Biophys. Res. Commun. 191:9-17(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterization of a cta/CDE operon-like genomic region encoding subunits I-III of the cytochrome c oxidase of the cyanobacterium Synechocystis PCC 6803."
    Alge D., Peschek G.A.
    Biochem. Mol. Biol. Int. 29:511-525(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiCOX2_SYNY3
AccessioniPrimary (citable) accession number: Q06474
Secondary accession number(s): P77963
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi