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Q06474

- COX2_SYNY3

UniProt

Q06474 - COX2_SYNY3

Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi214 – 2141Copper ACurated
    Metal bindingi249 – 2491Copper ACurated
    Metal bindingi253 – 2531Copper ACurated
    Metal bindingi257 – 2571Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 2
    Cytochrome c oxidase polypeptide II
    Oxidase aa(3) subunit 2
    Gene namesi
    Name:ctaC
    Synonyms:coxB
    Ordered Locus Names:slr1136
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 332312Cytochrome c oxidase subunit 2PRO_0000006065Add
    BLAST

    Proteomic databases

    PaxDbiQ06474.

    Interactioni

    Protein-protein interaction databases

    IntActiQ06474. 2 interactions.
    STRINGi1148.slr1136.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06474.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 6821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    HOGENOMiHOG000232614.
    KOiK02275.
    OMAiQDVIPGQ.
    OrthoDBiEOG68SVXT.
    PhylomeDBiQ06474.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q06474-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIPGSVITL LIGVVITVVS LWYGQNHGLM PVAASADAEK VDGIFNYMMT    50
    IATGLFLLVE GVLVYCLIRF RRRKDDQTDG PPIEGNVPLE ILWTAIPTVI 100
    VFTLAVYSFE VYNNLGGLDP TISRDNAGQQ MAHNHMGHMG SMGNMVAMAG 150
    DGDVALGIGL DSEEQGVNPL MVDVKGIQYA WIFTYPETGI ISGELHAPID 200
    RPVQLNMEAG DVIHAFWIPQ LRLKQDVIPG RGSTLVFNAS TPGQYPVICA 250
    ELCGAYHGGM KSVFYAHTPE EYDDWVAANA PAPTESMAMT LPKATTAMTP 300
    NEYLAPYAKE MGVQTEALAQ LKDQTSPVGD LL 332
    Length:332
    Mass (Da):35,917
    Last modified:November 1, 1997 - v2
    Checksum:i314F15C8F8D4AD26
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti240 – 2445STPGQ → RHPWA(PubMed:8383492)Curated
    Sequence conflicti240 – 2445STPGQ → RHPWA(PubMed:8387368)Curated
    Sequence conflicti320 – 33213QLKDQ…VGDLL → N(PubMed:8383492)CuratedAdd
    BLAST
    Sequence conflicti320 – 33213QLKDQ…VGDLL → N(PubMed:8387368)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53746 Genomic DNA. Translation: CAA37776.1.
    BA000022 Genomic DNA. Translation: BAA17288.1.
    PIRiS77441.
    RefSeqiNP_440608.1. NC_000911.1.
    YP_005650666.1. NC_017277.1.
    YP_007450491.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17288; BAA17288; BAA17288.
    GeneIDi953911.
    KEGGisyn:slr1136.
    syy:SYNGTS_0713.
    syz:MYO_17190.
    PATRICi23838410. VBISynSp132158_0772.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53746 Genomic DNA. Translation: CAA37776.1 .
    BA000022 Genomic DNA. Translation: BAA17288.1 .
    PIRi S77441.
    RefSeqi NP_440608.1. NC_000911.1.
    YP_005650666.1. NC_017277.1.
    YP_007450491.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q06474.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q06474. 2 interactions.
    STRINGi 1148.slr1136.

    Proteomic databases

    PaxDbi Q06474.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17288 ; BAA17288 ; BAA17288 .
    GeneIDi 953911.
    KEGGi syn:slr1136.
    syy:SYNGTS_0713.
    syz:MYO_17190.
    PATRICi 23838410. VBISynSp132158_0772.

    Phylogenomic databases

    eggNOGi COG1622.
    HOGENOMi HOG000232614.
    KOi K02275.
    OMAi QDVIPGQ.
    OrthoDBi EOG68SVXT.
    PhylomeDBi Q06474.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of the ctaC (coxB) gene as part of an operon encoding subunits I, II, and III of the cytochrome c oxidase (cytochrome aa3) in the cyanobacterium Synechocystis PCC 6803."
      Alge D., Peschek G.A.
      Biochem. Biophys. Res. Commun. 191:9-17(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Characterization of a cta/CDE operon-like genomic region encoding subunits I-III of the cytochrome c oxidase of the cyanobacterium Synechocystis PCC 6803."
      Alge D., Peschek G.A.
      Biochem. Mol. Biol. Int. 29:511-525(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiCOX2_SYNY3
    AccessioniPrimary (citable) accession number: Q06474
    Secondary accession number(s): P77963
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3