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Q06474 (COX2_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene names
Name:ctaC
Synonyms:coxB
Ordered Locus Names:slr1136
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 332312Cytochrome c oxidase subunit 2
PRO_0000006065

Regions

Transmembrane48 – 6821Helical; Potential
Transmembrane87 – 10721Helical; Potential

Sites

Metal binding2141Copper A Probable
Metal binding2491Copper A Probable
Metal binding2531Copper A Probable
Metal binding2571Copper A Probable

Experimental info

Sequence conflict240 – 2445STPGQ → RHPWA Ref.1
Sequence conflict240 – 2445STPGQ → RHPWA Ref.2
Sequence conflict320 – 33213QLKDQ…VGDLL → N Ref.1
Sequence conflict320 – 33213QLKDQ…VGDLL → N Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q06474 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 314F15C8F8D4AD26

FASTA33235,917
        10         20         30         40         50         60 
MKIPGSVITL LIGVVITVVS LWYGQNHGLM PVAASADAEK VDGIFNYMMT IATGLFLLVE 

        70         80         90        100        110        120 
GVLVYCLIRF RRRKDDQTDG PPIEGNVPLE ILWTAIPTVI VFTLAVYSFE VYNNLGGLDP 

       130        140        150        160        170        180 
TISRDNAGQQ MAHNHMGHMG SMGNMVAMAG DGDVALGIGL DSEEQGVNPL MVDVKGIQYA 

       190        200        210        220        230        240 
WIFTYPETGI ISGELHAPID RPVQLNMEAG DVIHAFWIPQ LRLKQDVIPG RGSTLVFNAS 

       250        260        270        280        290        300 
TPGQYPVICA ELCGAYHGGM KSVFYAHTPE EYDDWVAANA PAPTESMAMT LPKATTAMTP 

       310        320        330 
NEYLAPYAKE MGVQTEALAQ LKDQTSPVGD LL 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of the ctaC (coxB) gene as part of an operon encoding subunits I, II, and III of the cytochrome c oxidase (cytochrome aa3) in the cyanobacterium Synechocystis PCC 6803."
Alge D., Peschek G.A.
Biochem. Biophys. Res. Commun. 191:9-17(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Characterization of a cta/CDE operon-like genomic region encoding subunits I-III of the cytochrome c oxidase of the cyanobacterium Synechocystis PCC 6803."
Alge D., Peschek G.A.
Biochem. Mol. Biol. Int. 29:511-525(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53746 Genomic DNA. Translation: CAA37776.1.
BA000022 Genomic DNA. Translation: BAA17288.1.
PIRS77441.
RefSeqNP_440608.1. NC_000911.1.
YP_005650666.1. NC_017277.1.
YP_007450491.1. NC_020286.1.

3D structure databases

ProteinModelPortalQ06474.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ06474. 2 interactions.
STRING1148.slr1136.

Proteomic databases

PaxDbQ06474.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17288; BAA17288; BAA17288.
GeneID12256358.
14616141.
953911.
KEGGsyn:slr1136.
syy:SYNGTS_0713.
syz:MYO_17190.
PATRIC23838410. VBISynSp132158_0772.

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000232614.
KOK02275.
OMAQDVIPGQ.
OrthoDBEOG68SVXT.
PhylomeDBQ06474.
ProtClustDBCLSK892771.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_SYNY3
AccessionPrimary (citable) accession number: Q06474
Secondary accession number(s): P77963
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families