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Q06473

- COX1_SYNY3

UniProt

Q06473 - COX1_SYNY3

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Protein

Cytochrome c oxidase subunit 1

Gene
ctaD, slr1137
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B ion per subunit.
Binds 2 heme groups per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Iron (heme A axial ligand) Inferred
Metal bindingi251 – 2511Copper B Inferred
Metal bindingi255 – 2551Copper B Inferred
Metal bindingi300 – 3001Copper B Inferred
Metal bindingi301 – 3011Copper B Inferred
Metal bindingi386 – 3861Iron (heme A3 axial ligand) Inferred
Metal bindingi388 – 3881Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Oxidase aa(3) subunit 1
Gene namesi
Name:ctaD
Ordered Locus Names:slr1137
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921Helical; Reviewed predictionAdd
BLAST
Transmembranei79 – 9921Helical; Reviewed predictionAdd
BLAST
Transmembranei113 – 13321Helical; Reviewed predictionAdd
BLAST
Transmembranei156 – 17621Helical; Reviewed predictionAdd
BLAST
Transmembranei205 – 22521Helical; Reviewed predictionAdd
BLAST
Transmembranei245 – 26521Helical; Reviewed predictionAdd
BLAST
Transmembranei283 – 30321Helical; Reviewed predictionAdd
BLAST
Transmembranei313 – 33321Helical; Reviewed predictionAdd
BLAST
Transmembranei348 – 36821Helical; Reviewed predictionAdd
BLAST
Transmembranei382 – 40221Helical; Reviewed predictionAdd
BLAST
Transmembranei424 – 44421Helical; Reviewed predictionAdd
BLAST
Transmembranei466 – 48621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Cytochrome c oxidase subunit 1PRO_0000183461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki251 ↔ 2551'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Protein-protein interaction databases

STRINGi1148.slr1137.

Structurei

3D structure databases

ProteinModelPortaliQ06473.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
KOiK02274.
OMAiHTFEKPP.
OrthoDBiEOG6B35XR.
PhylomeDBiQ06473.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06473-1 [UniParc]FASTAAdd to Basket

« Hide

MTIAAENLTA NHPRRKWTDY FTFCVDHKVI GIQYLVTSFL FFFIGGSFAE    50
AMRTELATPS PDFVQPEMYN QLMTLHGTIM IFLWIVPAGA AFANYLIPLM 100
VGTEDMAFPR LNAVAFWLTP PGGILLISSF FVGAPQAGWT SYPPLSLLSG 150
KWGEELWILS LLLVGTSSIL GAINFVTTIL KMRIKDMDLH SMPLFCWAML 200
ATSSLILLST PVLASALILL SFDLIAGTSF FNPVGGGDPV VYQHLFWFYS 250
HPAVYIMILP FFGVISEVIP VHARKPIFGY RAIAYSSLAI SFLGLIVWAH 300
HMFTSGTPGW LRMFFMATTM LIAVPTGIKI FSWCGTLWGG KIQLNSAMLF 350
AFGFLSSFMI GGLTGVMVAS VPFDIHVHDT YFVVGHFHYV LFGGSAFALF 400
SGVYHWFPKM TGRMVNEPLG RLHFILTFIG MNLTFMPMHE LGLMGMNRRI 450
ALYDVEFQPL NVLSTIGAYV LAASTIPFVI NVFWSLFKGE KAARNPWRAL 500
TLEWQTASPP IIENFEEEPV LWCGPYDFGI DTELMDDEET VQTLIADAAG 550
S 551
Length:551
Mass (Da):61,349
Last modified:November 1, 1997 - v2
Checksum:iB291E7884ABE6503
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1977SMPLFCW → VCPCFAG in CAA37777. 1 Publication
Sequence conflicti212 – 2121V → L in CAA37777. 1 Publication
Sequence conflicti233 – 2331P → R in CAA37777. 1 Publication
Sequence conflicti305 – 3051S → H in CAA37777. 1 Publication
Sequence conflicti329 – 3368KIFSWCGT → QNFQLVRY in CAA37777. 1 Publication
Sequence conflicti432 – 4321N → D in CAA37777. 1 Publication
Sequence conflicti520 – 55132VLWCG…DAAGS → CSGVVPTILVLTRS in CAA37777. 1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53746 Genomic DNA. Translation: CAA37777.1.
BA000022 Genomic DNA. Translation: BAA17289.1.
PIRiS77442.
RefSeqiNP_440609.1. NC_000911.1.
YP_005650667.1. NC_017277.1.
YP_007450492.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17289; BAA17289; BAA17289.
GeneIDi953912.
KEGGisyn:slr1137.
syy:SYNGTS_0714.
syz:MYO_17200.
PATRICi23838412. VBISynSp132158_0773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53746 Genomic DNA. Translation: CAA37777.1 .
BA000022 Genomic DNA. Translation: BAA17289.1 .
PIRi S77442.
RefSeqi NP_440609.1. NC_000911.1.
YP_005650667.1. NC_017277.1.
YP_007450492.1. NC_020286.1.

3D structure databases

ProteinModelPortali Q06473.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.slr1137.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA17289 ; BAA17289 ; BAA17289 .
GeneIDi 953912.
KEGGi syn:slr1137.
syy:SYNGTS_0714.
syz:MYO_17200.
PATRICi 23838412. VBISynSp132158_0773.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
KOi K02274.
OMAi HTFEKPP.
OrthoDBi EOG6B35XR.
PhylomeDBi Q06473.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a cta/CDE operon-like genomic region encoding subunits I-III of the cytochrome c oxidase of the cyanobacterium Synechocystis PCC 6803."
    Alge D., Peschek G.A.
    Biochem. Mol. Biol. Int. 29:511-525(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiCOX1_SYNY3
AccessioniPrimary (citable) accession number: Q06473
Secondary accession number(s): P73261
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

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