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Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+Note: Binds 1 copper B ion per subunit.
  • hemeNote: Binds 2 heme groups per subunit.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi76Iron (heme A axial ligand)Curated1
Metal bindingi251Copper BCurated1
Metal bindingi255Copper BCurated1
Metal bindingi300Copper BCurated1
Metal bindingi301Copper BCurated1
Metal bindingi386Iron (heme A3 axial ligand)Curated1
Metal bindingi388Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Oxidase aa(3) subunit 1
Gene namesi
Name:ctaD
Ordered Locus Names:slr1137
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834611 – 551Cytochrome c oxidase subunit 1Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki251 ↔ 2551'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PaxDbiQ06473

Interactioni

Protein-protein interaction databases

STRINGi1148.SYNGTS_0714

Structurei

3D structure databases

ProteinModelPortaliQ06473
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000085274
InParanoidiQ06473
KOiK02274
OMAiMSFWLLP
PhylomeDBiQ06473

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR014241 Cyt_c_oxidase_su1_bac
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
TIGRFAMsiTIGR02891 CtaD_CoxA, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

Q06473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIAAENLTA NHPRRKWTDY FTFCVDHKVI GIQYLVTSFL FFFIGGSFAE
60 70 80 90 100
AMRTELATPS PDFVQPEMYN QLMTLHGTIM IFLWIVPAGA AFANYLIPLM
110 120 130 140 150
VGTEDMAFPR LNAVAFWLTP PGGILLISSF FVGAPQAGWT SYPPLSLLSG
160 170 180 190 200
KWGEELWILS LLLVGTSSIL GAINFVTTIL KMRIKDMDLH SMPLFCWAML
210 220 230 240 250
ATSSLILLST PVLASALILL SFDLIAGTSF FNPVGGGDPV VYQHLFWFYS
260 270 280 290 300
HPAVYIMILP FFGVISEVIP VHARKPIFGY RAIAYSSLAI SFLGLIVWAH
310 320 330 340 350
HMFTSGTPGW LRMFFMATTM LIAVPTGIKI FSWCGTLWGG KIQLNSAMLF
360 370 380 390 400
AFGFLSSFMI GGLTGVMVAS VPFDIHVHDT YFVVGHFHYV LFGGSAFALF
410 420 430 440 450
SGVYHWFPKM TGRMVNEPLG RLHFILTFIG MNLTFMPMHE LGLMGMNRRI
460 470 480 490 500
ALYDVEFQPL NVLSTIGAYV LAASTIPFVI NVFWSLFKGE KAARNPWRAL
510 520 530 540 550
TLEWQTASPP IIENFEEEPV LWCGPYDFGI DTELMDDEET VQTLIADAAG

S
Length:551
Mass (Da):61,349
Last modified:November 1, 1997 - v2
Checksum:iB291E7884ABE6503
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191 – 197SMPLFCW → VCPCFAG in CAA37777 (PubMed:8387368).Curated7
Sequence conflicti212V → L in CAA37777 (PubMed:8387368).Curated1
Sequence conflicti233P → R in CAA37777 (PubMed:8387368).Curated1
Sequence conflicti305S → H in CAA37777 (PubMed:8387368).Curated1
Sequence conflicti329 – 336KIFSWCGT → QNFQLVRY in CAA37777 (PubMed:8387368).Curated8
Sequence conflicti432N → D in CAA37777 (PubMed:8387368).Curated1
Sequence conflicti520 – 551VLWCG…DAAGS → CSGVVPTILVLTRS in CAA37777 (PubMed:8387368).CuratedAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53746 Genomic DNA Translation: CAA37777.1
BA000022 Genomic DNA Translation: BAA17289.1
PIRiS77442

Genome annotation databases

EnsemblBacteriaiBAA17289; BAA17289; BAA17289
KEGGisyn:slr1137

Similar proteinsi

Entry informationi

Entry nameiCOX1_SYNY3
AccessioniPrimary (citable) accession number: Q06473
Secondary accession number(s): P73261
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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