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Q06473

- COX1_SYNY3

UniProt

Q06473 - COX1_SYNY3

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Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+Note: Binds 1 copper B ion per subunit.
  • hemeNote: Binds 2 heme groups per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Iron (heme A axial ligand)Curated
Metal bindingi251 – 2511Copper BCurated
Metal bindingi255 – 2551Copper BCurated
Metal bindingi300 – 3001Copper BCurated
Metal bindingi301 – 3011Copper BCurated
Metal bindingi386 – 3861Iron (heme A3 axial ligand)Curated
Metal bindingi388 – 3881Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Oxidase aa(3) subunit 1
Gene namesi
Name:ctaD
Ordered Locus Names:slr1137
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921HelicalSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence AnalysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence AnalysisAdd
BLAST
Transmembranei283 – 30321HelicalSequence AnalysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence AnalysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence AnalysisAdd
BLAST
Transmembranei382 – 40221HelicalSequence AnalysisAdd
BLAST
Transmembranei424 – 44421HelicalSequence AnalysisAdd
BLAST
Transmembranei466 – 48621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Cytochrome c oxidase subunit 1PRO_0000183461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki251 ↔ 2551'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Protein-protein interaction databases

STRINGi1148.slr1137.

Structurei

3D structure databases

ProteinModelPortaliQ06473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
InParanoidiQ06473.
KOiK02274.
OMAiHTFEKPP.
OrthoDBiEOG6B35XR.
PhylomeDBiQ06473.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06473-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIAAENLTA NHPRRKWTDY FTFCVDHKVI GIQYLVTSFL FFFIGGSFAE
60 70 80 90 100
AMRTELATPS PDFVQPEMYN QLMTLHGTIM IFLWIVPAGA AFANYLIPLM
110 120 130 140 150
VGTEDMAFPR LNAVAFWLTP PGGILLISSF FVGAPQAGWT SYPPLSLLSG
160 170 180 190 200
KWGEELWILS LLLVGTSSIL GAINFVTTIL KMRIKDMDLH SMPLFCWAML
210 220 230 240 250
ATSSLILLST PVLASALILL SFDLIAGTSF FNPVGGGDPV VYQHLFWFYS
260 270 280 290 300
HPAVYIMILP FFGVISEVIP VHARKPIFGY RAIAYSSLAI SFLGLIVWAH
310 320 330 340 350
HMFTSGTPGW LRMFFMATTM LIAVPTGIKI FSWCGTLWGG KIQLNSAMLF
360 370 380 390 400
AFGFLSSFMI GGLTGVMVAS VPFDIHVHDT YFVVGHFHYV LFGGSAFALF
410 420 430 440 450
SGVYHWFPKM TGRMVNEPLG RLHFILTFIG MNLTFMPMHE LGLMGMNRRI
460 470 480 490 500
ALYDVEFQPL NVLSTIGAYV LAASTIPFVI NVFWSLFKGE KAARNPWRAL
510 520 530 540 550
TLEWQTASPP IIENFEEEPV LWCGPYDFGI DTELMDDEET VQTLIADAAG

S
Length:551
Mass (Da):61,349
Last modified:November 1, 1997 - v2
Checksum:iB291E7884ABE6503
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1977SMPLFCW → VCPCFAG in CAA37777. (PubMed:8387368)Curated
Sequence conflicti212 – 2121V → L in CAA37777. (PubMed:8387368)Curated
Sequence conflicti233 – 2331P → R in CAA37777. (PubMed:8387368)Curated
Sequence conflicti305 – 3051S → H in CAA37777. (PubMed:8387368)Curated
Sequence conflicti329 – 3368KIFSWCGT → QNFQLVRY in CAA37777. (PubMed:8387368)Curated
Sequence conflicti432 – 4321N → D in CAA37777. (PubMed:8387368)Curated
Sequence conflicti520 – 55132VLWCG…DAAGS → CSGVVPTILVLTRS in CAA37777. (PubMed:8387368)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53746 Genomic DNA. Translation: CAA37777.1.
BA000022 Genomic DNA. Translation: BAA17289.1.
PIRiS77442.
RefSeqiNP_440609.1. NC_000911.1.
YP_005650667.1. NC_017277.1.
YP_007450492.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17289; BAA17289; BAA17289.
GeneIDi953912.
KEGGisyn:slr1137.
PATRICi23838412. VBISynSp132158_0773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53746 Genomic DNA. Translation: CAA37777.1 .
BA000022 Genomic DNA. Translation: BAA17289.1 .
PIRi S77442.
RefSeqi NP_440609.1. NC_000911.1.
YP_005650667.1. NC_017277.1.
YP_007450492.1. NC_020286.1.

3D structure databases

ProteinModelPortali Q06473.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.slr1137.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA17289 ; BAA17289 ; BAA17289 .
GeneIDi 953912.
KEGGi syn:slr1137.
PATRICi 23838412. VBISynSp132158_0773.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
InParanoidi Q06473.
KOi K02274.
OMAi HTFEKPP.
OrthoDBi EOG6B35XR.
PhylomeDBi Q06473.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a cta/CDE operon-like genomic region encoding subunits I-III of the cytochrome c oxidase of the cyanobacterium Synechocystis PCC 6803."
    Alge D., Peschek G.A.
    Biochem. Mol. Biol. Int. 29:511-525(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiCOX1_SYNY3
AccessioniPrimary (citable) accession number: Q06473
Secondary accession number(s): P73261
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3