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Q06473

- COX1_SYNY3

UniProt

Q06473 - COX1_SYNY3

Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Binds 1 copper B ion per subunit.
    Binds 2 heme groups per subunit.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi76 – 761Iron (heme A axial ligand)Curated
    Metal bindingi251 – 2511Copper BCurated
    Metal bindingi255 – 2551Copper BCurated
    Metal bindingi300 – 3001Copper BCurated
    Metal bindingi301 – 3011Copper BCurated
    Metal bindingi386 – 3861Iron (heme A3 axial ligand)Curated
    Metal bindingi388 – 3881Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 1
    Cytochrome c oxidase polypeptide I
    Oxidase aa(3) subunit 1
    Gene namesi
    Name:ctaD
    Ordered Locus Names:slr1137
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Cytochrome c oxidase subunit 1PRO_0000183461Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki251 ↔ 2551'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi1148.slr1137.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06473.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei283 – 30321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei313 – 33321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei348 – 36821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei382 – 40221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei424 – 44421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei466 – 48621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000085274.
    KOiK02274.
    OMAiHTFEKPP.
    OrthoDBiEOG6B35XR.
    PhylomeDBiQ06473.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06473-1 [UniParc]FASTAAdd to Basket

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    MTIAAENLTA NHPRRKWTDY FTFCVDHKVI GIQYLVTSFL FFFIGGSFAE    50
    AMRTELATPS PDFVQPEMYN QLMTLHGTIM IFLWIVPAGA AFANYLIPLM 100
    VGTEDMAFPR LNAVAFWLTP PGGILLISSF FVGAPQAGWT SYPPLSLLSG 150
    KWGEELWILS LLLVGTSSIL GAINFVTTIL KMRIKDMDLH SMPLFCWAML 200
    ATSSLILLST PVLASALILL SFDLIAGTSF FNPVGGGDPV VYQHLFWFYS 250
    HPAVYIMILP FFGVISEVIP VHARKPIFGY RAIAYSSLAI SFLGLIVWAH 300
    HMFTSGTPGW LRMFFMATTM LIAVPTGIKI FSWCGTLWGG KIQLNSAMLF 350
    AFGFLSSFMI GGLTGVMVAS VPFDIHVHDT YFVVGHFHYV LFGGSAFALF 400
    SGVYHWFPKM TGRMVNEPLG RLHFILTFIG MNLTFMPMHE LGLMGMNRRI 450
    ALYDVEFQPL NVLSTIGAYV LAASTIPFVI NVFWSLFKGE KAARNPWRAL 500
    TLEWQTASPP IIENFEEEPV LWCGPYDFGI DTELMDDEET VQTLIADAAG 550
    S 551
    Length:551
    Mass (Da):61,349
    Last modified:November 1, 1997 - v2
    Checksum:iB291E7884ABE6503
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 1977SMPLFCW → VCPCFAG in CAA37777. (PubMed:8387368)Curated
    Sequence conflicti212 – 2121V → L in CAA37777. (PubMed:8387368)Curated
    Sequence conflicti233 – 2331P → R in CAA37777. (PubMed:8387368)Curated
    Sequence conflicti305 – 3051S → H in CAA37777. (PubMed:8387368)Curated
    Sequence conflicti329 – 3368KIFSWCGT → QNFQLVRY in CAA37777. (PubMed:8387368)Curated
    Sequence conflicti432 – 4321N → D in CAA37777. (PubMed:8387368)Curated
    Sequence conflicti520 – 55132VLWCG…DAAGS → CSGVVPTILVLTRS in CAA37777. (PubMed:8387368)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53746 Genomic DNA. Translation: CAA37777.1.
    BA000022 Genomic DNA. Translation: BAA17289.1.
    PIRiS77442.
    RefSeqiNP_440609.1. NC_000911.1.
    YP_005650667.1. NC_017277.1.
    YP_007450492.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17289; BAA17289; BAA17289.
    GeneIDi953912.
    KEGGisyn:slr1137.
    syy:SYNGTS_0714.
    syz:MYO_17200.
    PATRICi23838412. VBISynSp132158_0773.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53746 Genomic DNA. Translation: CAA37777.1 .
    BA000022 Genomic DNA. Translation: BAA17289.1 .
    PIRi S77442.
    RefSeqi NP_440609.1. NC_000911.1.
    YP_005650667.1. NC_017277.1.
    YP_007450492.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q06473.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.slr1137.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17289 ; BAA17289 ; BAA17289 .
    GeneIDi 953912.
    KEGGi syn:slr1137.
    syy:SYNGTS_0714.
    syz:MYO_17200.
    PATRICi 23838412. VBISynSp132158_0773.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000085274.
    KOi K02274.
    OMAi HTFEKPP.
    OrthoDBi EOG6B35XR.
    PhylomeDBi Q06473.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a cta/CDE operon-like genomic region encoding subunits I-III of the cytochrome c oxidase of the cyanobacterium Synechocystis PCC 6803."
      Alge D., Peschek G.A.
      Biochem. Mol. Biol. Int. 29:511-525(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiCOX1_SYNY3
    AccessioniPrimary (citable) accession number: Q06473
    Secondary accession number(s): P73261
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3