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Q06473 (COX1_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Oxidase aa(3) subunit 1
Gene names
Name:ctaD
Ordered Locus Names:slr1137
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Binds 1 copper B ion per subunit.

Binds 2 heme groups per subunit.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Cytochrome c oxidase subunit 1
PRO_0000183461

Regions

Transmembrane29 – 4921Helical; Potential
Transmembrane79 – 9921Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane205 – 22521Helical; Potential
Transmembrane245 – 26521Helical; Potential
Transmembrane283 – 30321Helical; Potential
Transmembrane313 – 33321Helical; Potential
Transmembrane348 – 36821Helical; Potential
Transmembrane382 – 40221Helical; Potential
Transmembrane424 – 44421Helical; Potential
Transmembrane466 – 48621Helical; Potential

Sites

Metal binding761Iron (heme A axial ligand) Probable
Metal binding2511Copper B Probable
Metal binding2551Copper B Probable
Metal binding3001Copper B Probable
Metal binding3011Copper B Probable
Metal binding3861Iron (heme A3 axial ligand) Probable
Metal binding3881Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link251 ↔ 2551'-histidyl-3'-tyrosine (His-Tyr) By similarity

Experimental info

Sequence conflict191 – 1977SMPLFCW → VCPCFAG in CAA37777. Ref.1
Sequence conflict2121V → L in CAA37777. Ref.1
Sequence conflict2331P → R in CAA37777. Ref.1
Sequence conflict3051S → H in CAA37777. Ref.1
Sequence conflict329 – 3368KIFSWCGT → QNFQLVRY in CAA37777. Ref.1
Sequence conflict4321N → D in CAA37777. Ref.1
Sequence conflict520 – 55132VLWCG…DAAGS → CSGVVPTILVLTRS in CAA37777. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q06473 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: B291E7884ABE6503

FASTA55161,349
        10         20         30         40         50         60 
MTIAAENLTA NHPRRKWTDY FTFCVDHKVI GIQYLVTSFL FFFIGGSFAE AMRTELATPS 

        70         80         90        100        110        120 
PDFVQPEMYN QLMTLHGTIM IFLWIVPAGA AFANYLIPLM VGTEDMAFPR LNAVAFWLTP 

       130        140        150        160        170        180 
PGGILLISSF FVGAPQAGWT SYPPLSLLSG KWGEELWILS LLLVGTSSIL GAINFVTTIL 

       190        200        210        220        230        240 
KMRIKDMDLH SMPLFCWAML ATSSLILLST PVLASALILL SFDLIAGTSF FNPVGGGDPV 

       250        260        270        280        290        300 
VYQHLFWFYS HPAVYIMILP FFGVISEVIP VHARKPIFGY RAIAYSSLAI SFLGLIVWAH 

       310        320        330        340        350        360 
HMFTSGTPGW LRMFFMATTM LIAVPTGIKI FSWCGTLWGG KIQLNSAMLF AFGFLSSFMI 

       370        380        390        400        410        420 
GGLTGVMVAS VPFDIHVHDT YFVVGHFHYV LFGGSAFALF SGVYHWFPKM TGRMVNEPLG 

       430        440        450        460        470        480 
RLHFILTFIG MNLTFMPMHE LGLMGMNRRI ALYDVEFQPL NVLSTIGAYV LAASTIPFVI 

       490        500        510        520        530        540 
NVFWSLFKGE KAARNPWRAL TLEWQTASPP IIENFEEEPV LWCGPYDFGI DTELMDDEET 

       550 
VQTLIADAAG S 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a cta/CDE operon-like genomic region encoding subunits I-III of the cytochrome c oxidase of the cyanobacterium Synechocystis PCC 6803."
Alge D., Peschek G.A.
Biochem. Mol. Biol. Int. 29:511-525(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53746 Genomic DNA. Translation: CAA37777.1.
BA000022 Genomic DNA. Translation: BAA17289.1.
PIRS77442.
RefSeqNP_440609.1. NC_000911.1.
YP_005650667.1. NC_017277.1.
YP_007450492.1. NC_020286.1.

3D structure databases

ProteinModelPortalQ06473.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1148.slr1137.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17289; BAA17289; BAA17289.
GeneID953912.
KEGGsyn:slr1137.
syy:SYNGTS_0714.
syz:MYO_17200.
PATRIC23838412. VBISynSp132158_0773.

Phylogenomic databases

eggNOGCOG0843.
HOGENOMHOG000085274.
KOK02274.
OMAHTFEKPP.
OrthoDBEOG6B35XR.
PhylomeDBQ06473.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
TIGRFAMsTIGR02891. CtaD_CoxA. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_SYNY3
AccessionPrimary (citable) accession number: Q06473
Secondary accession number(s): P73261
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways