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Protein

Curing of [URE3] protein 1

Gene

CUR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Involved in the curing of prion [URE3]. Nuclear localization of this protein may suggest a role in transcription regulation, so it might exert an effect on [URE3] through known prion-curing chaperones or BTN2.1 Publication

GO - Molecular functioni

  • chaperone binding Source: SGD

GO - Biological processi

  • cellular response to heat Source: SGD
  • intracellular protein transport Source: SGD
  • protein folding Source: SGD
  • protein localization to nucleus Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-34289-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Curing of [URE3] protein 1
Gene namesi
Name:CUR1
Ordered Locus Names:YPR158W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR158W.
SGDiS000006362. CUR1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002578301 – 252Curing of [URE3] protein 1Add BLAST252

Interactioni

GO - Molecular functioni

  • chaperone binding Source: SGD

Protein-protein interaction databases

BioGridi36325. 27 interactors.
IntActiQ06469. 1 interactor.
MINTiMINT-553759.
STRINGi4932.YPR158W.

Structurei

3D structure databases

ProteinModelPortaliQ06469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000067023.
OrthoDBiEOG092C3DGY.

Sequencei

Sequence statusi: Complete.

Q06469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAACICQPN LLEINVSDGP LDMIRKKRKI QQPQLRPPLR ENKCQPHFSV
60 70 80 90 100
RKVNQSYIIS LHKEITCQLI AEIVKQKLSR IWEKVYIPSY ELISDKDGNQ
110 120 130 140 150
IYVEQSVDEN RLTSEIMEKL DPNNIDIEAI EILFDDYHLE LSRLTNGIII
160 170 180 190 200
SSANDHFYRE FSFNNIIDDN FKICGTSMSA DSFDKIYGVM WIEVPFNGNG
210 220 230 240 250
LQNDSAVNRV STSHNQIEEL NDIEQEIRAF NISRSNQESI IKKEVSRRLN

GR
Length:252
Mass (Da):29,163
Last modified:November 1, 1996 - v1
Checksum:i86FD6CD25D5C7F19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28371 Genomic DNA. Translation: AAB68055.1.
BK006949 Genomic DNA. Translation: DAA11570.1.
PIRiS61142.
RefSeqiNP_015484.1. NM_001184255.1.

Genome annotation databases

EnsemblFungiiYPR158W; YPR158W; YPR158W.
GeneIDi856281.
KEGGisce:YPR158W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCUR1_YEAST
AccessioniPrimary (citable) accession number: Q06469
Secondary accession number(s): D6W4F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names