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Q06469

- CUR1_YEAST

UniProt

Q06469 - CUR1_YEAST

Protein

Curing of [URE3] protein 1

Gene

CUR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in the curing of prion [URE3]. Nuclear localization of this protein may suggest a role in transcription regulation, so it might exert an effect on [URE3] through known prion-curing chaperones or BTN2.1 Publication

    GO - Molecular functioni

    1. chaperone binding Source: SGD

    GO - Biological processi

    1. cellular response to heat Source: SGD
    2. intracellular protein transport Source: SGD
    3. protein folding Source: SGD
    4. protein localization to nucleus Source: SGD
    5. regulation of transcription, DNA-templated Source: UniProtKB-KW
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34289-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Curing of [URE3] protein 1
    Gene namesi
    Name:CUR1
    Ordered Locus Names:YPR158W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPR158w.
    SGDiS000006362. CUR1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 252252Curing of [URE3] protein 1PRO_0000257830Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ06469.

    Interactioni

    Protein-protein interaction databases

    BioGridi36325. 11 interactions.
    IntActiQ06469. 1 interaction.
    MINTiMINT-553759.
    STRINGi4932.YPR158W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG46814.
    GeneTreeiENSGT00530000067023.
    OMAiISSANDH.
    OrthoDBiEOG7HHX35.

    Sequencei

    Sequence statusi: Complete.

    Q06469-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAACICQPN LLEINVSDGP LDMIRKKRKI QQPQLRPPLR ENKCQPHFSV    50
    RKVNQSYIIS LHKEITCQLI AEIVKQKLSR IWEKVYIPSY ELISDKDGNQ 100
    IYVEQSVDEN RLTSEIMEKL DPNNIDIEAI EILFDDYHLE LSRLTNGIII 150
    SSANDHFYRE FSFNNIIDDN FKICGTSMSA DSFDKIYGVM WIEVPFNGNG 200
    LQNDSAVNRV STSHNQIEEL NDIEQEIRAF NISRSNQESI IKKEVSRRLN 250
    GR 252
    Length:252
    Mass (Da):29,163
    Last modified:November 1, 1996 - v1
    Checksum:i86FD6CD25D5C7F19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28371 Genomic DNA. Translation: AAB68055.1.
    BK006949 Genomic DNA. Translation: DAA11570.1.
    PIRiS61142.
    RefSeqiNP_015484.1. NM_001184255.1.

    Genome annotation databases

    EnsemblFungiiYPR158W; YPR158W; YPR158W.
    GeneIDi856281.
    KEGGisce:YPR158W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28371 Genomic DNA. Translation: AAB68055.1 .
    BK006949 Genomic DNA. Translation: DAA11570.1 .
    PIRi S61142.
    RefSeqi NP_015484.1. NM_001184255.1.

    3D structure databases

    ProteinModelPortali Q06469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36325. 11 interactions.
    IntActi Q06469. 1 interaction.
    MINTi MINT-553759.
    STRINGi 4932.YPR158W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPR158W ; YPR158W ; YPR158W .
    GeneIDi 856281.
    KEGGi sce:YPR158W.

    Organism-specific databases

    CYGDi YPR158w.
    SGDi S000006362. CUR1.

    Phylogenomic databases

    eggNOGi NOG46814.
    GeneTreei ENSGT00530000067023.
    OMAi ISSANDH.
    OrthoDBi EOG7HHX35.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34289-MONOMER.

    Miscellaneous databases

    NextBioi 981604.

    Gene expression databases

    Genevestigatori Q06469.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Curing of the [URE3] prion by Btn2p, a Batten disease-related protein."
      Kryndushkin D.S., Shewmaker F., Wickner R.B.
      EMBO J. 27:2725-2735(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCUR1_YEAST
    AccessioniPrimary (citable) accession number: Q06469
    Secondary accession number(s): D6W4F4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3