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Q06469 (CUR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Curing of [URE3] protein 1
Gene names
Name:CUR1
Ordered Locus Names:YPR158W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

Involved in the curing of prion [URE3]. Nuclear localization of this protein may suggest a role in transcription regulation, so it might exert an effect on [URE3] through known prion-curing chaperones or BTN2. Ref.3

Subcellular location

Nucleus Ref.3.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Curing of [URE3] protein 1
PRO_0000257830

Sequences

Sequence LengthMass (Da)Tools
Q06469 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 86FD6CD25D5C7F19

FASTA25229,163
        10         20         30         40         50         60 
MAAACICQPN LLEINVSDGP LDMIRKKRKI QQPQLRPPLR ENKCQPHFSV RKVNQSYIIS 

        70         80         90        100        110        120 
LHKEITCQLI AEIVKQKLSR IWEKVYIPSY ELISDKDGNQ IYVEQSVDEN RLTSEIMEKL 

       130        140        150        160        170        180 
DPNNIDIEAI EILFDDYHLE LSRLTNGIII SSANDHFYRE FSFNNIIDDN FKICGTSMSA 

       190        200        210        220        230        240 
DSFDKIYGVM WIEVPFNGNG LQNDSAVNRV STSHNQIEEL NDIEQEIRAF NISRSNQESI 

       250 
IKKEVSRRLN GR 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Curing of the [URE3] prion by Btn2p, a Batten disease-related protein."
Kryndushkin D.S., Shewmaker F., Wickner R.B.
EMBO J. 27:2725-2735(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U28371 Genomic DNA. Translation: AAB68055.1.
BK006949 Genomic DNA. Translation: DAA11570.1.
PIRS61142.
RefSeqNP_015484.1. NM_001184255.1.

3D structure databases

ProteinModelPortalQ06469.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36325. 11 interactions.
IntActQ06469. 1 interaction.
MINTMINT-553759.
STRING4932.YPR158W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPR158W; YPR158W; YPR158W.
GeneID856281.
KEGGsce:YPR158W.

Organism-specific databases

CYGDYPR158w.
SGDS000006362. CUR1.

Phylogenomic databases

eggNOGNOG46814.
GeneTreeENSGT00530000067023.
OrthoDBEOG7HHX35.

Enzyme and pathway databases

BioCycYEAST:G3O-34289-MONOMER.

Gene expression databases

GenevestigatorQ06469.

Family and domain databases

ProtoNetSearch...

Other

NextBio981604.

Entry information

Entry nameCUR1_YEAST
AccessionPrimary (citable) accession number: Q06469
Secondary accession number(s): D6W4F4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD