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Q06469

- CUR1_YEAST

UniProt

Q06469 - CUR1_YEAST

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Protein

Curing of [URE3] protein 1

Gene

CUR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

Involved in the curing of prion [URE3]. Nuclear localization of this protein may suggest a role in transcription regulation, so it might exert an effect on [URE3] through known prion-curing chaperones or BTN2.1 Publication

GO - Molecular functioni

  1. chaperone binding Source: SGD

GO - Biological processi

  1. cellular response to heat Source: SGD
  2. intracellular protein transport Source: SGD
  3. protein folding Source: SGD
  4. protein localization to nucleus Source: SGD
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-34289-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Curing of [URE3] protein 1
Gene namesi
Name:CUR1
Ordered Locus Names:YPR158W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR158w.
SGDiS000006362. CUR1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Curing of [URE3] protein 1PRO_0000257830Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ06469.

Interactioni

Protein-protein interaction databases

BioGridi36325. 12 interactions.
IntActiQ06469. 1 interaction.
MINTiMINT-553759.
STRINGi4932.YPR158W.

Structurei

3D structure databases

ProteinModelPortaliQ06469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG46814.
GeneTreeiENSGT00530000067023.
OMAiISSANDH.
OrthoDBiEOG7HHX35.

Sequencei

Sequence statusi: Complete.

Q06469-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAACICQPN LLEINVSDGP LDMIRKKRKI QQPQLRPPLR ENKCQPHFSV
60 70 80 90 100
RKVNQSYIIS LHKEITCQLI AEIVKQKLSR IWEKVYIPSY ELISDKDGNQ
110 120 130 140 150
IYVEQSVDEN RLTSEIMEKL DPNNIDIEAI EILFDDYHLE LSRLTNGIII
160 170 180 190 200
SSANDHFYRE FSFNNIIDDN FKICGTSMSA DSFDKIYGVM WIEVPFNGNG
210 220 230 240 250
LQNDSAVNRV STSHNQIEEL NDIEQEIRAF NISRSNQESI IKKEVSRRLN

GR
Length:252
Mass (Da):29,163
Last modified:November 1, 1996 - v1
Checksum:i86FD6CD25D5C7F19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28371 Genomic DNA. Translation: AAB68055.1.
BK006949 Genomic DNA. Translation: DAA11570.1.
PIRiS61142.
RefSeqiNP_015484.1. NM_001184255.1.

Genome annotation databases

EnsemblFungiiYPR158W; YPR158W; YPR158W.
GeneIDi856281.
KEGGisce:YPR158W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28371 Genomic DNA. Translation: AAB68055.1 .
BK006949 Genomic DNA. Translation: DAA11570.1 .
PIRi S61142.
RefSeqi NP_015484.1. NM_001184255.1.

3D structure databases

ProteinModelPortali Q06469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36325. 12 interactions.
IntActi Q06469. 1 interaction.
MINTi MINT-553759.
STRINGi 4932.YPR158W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR158W ; YPR158W ; YPR158W .
GeneIDi 856281.
KEGGi sce:YPR158W.

Organism-specific databases

CYGDi YPR158w.
SGDi S000006362. CUR1.

Phylogenomic databases

eggNOGi NOG46814.
GeneTreei ENSGT00530000067023.
OMAi ISSANDH.
OrthoDBi EOG7HHX35.

Enzyme and pathway databases

BioCyci YEAST:G3O-34289-MONOMER.

Miscellaneous databases

NextBioi 981604.

Gene expression databases

Genevestigatori Q06469.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Curing of the [URE3] prion by Btn2p, a Batten disease-related protein."
    Kryndushkin D.S., Shewmaker F., Wickner R.B.
    EMBO J. 27:2725-2735(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCUR1_YEAST
AccessioniPrimary (citable) accession number: Q06469
Secondary accession number(s): D6W4F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3