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Q06455

- MTG8_HUMAN

UniProt

Q06455 - MTG8_HUMAN

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Protein

Protein CBFA2T1

Gene
RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei30 – 312Breakpoint for translocation to form AML1-MTG8 in AML-M2

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri515 – 55137MYND-typeAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. identical protein binding Source: IntAct
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: UniProtKB
  5. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. fat cell differentiation Source: Ensembl
  2. generation of precursor metabolites and energy Source: ProtInc
  3. regulation of DNA binding Source: Ensembl
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CBFA2T1
Alternative name(s):
Cyclin-D-related protein
Eight twenty one protein
Protein ETO
Protein MTG8
Zinc finger MYND domain-containing protein 2
Gene namesi
Name:RUNX1T1
Synonyms:AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:1535. RUNX1T1.

Subcellular locationi

Nucleus
Note: Colocalizes with ATN1 in discrete nuclear dots.1 Publication

GO - Cellular componenti

  1. nuclear matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.4 Publications
Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Note: The disease may be caused by mutations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi125 – 1251K → A or D: Loss of interaction with TCF12. 1 Publication
Mutagenesisi126 – 1261L → A: Loss of interaction with TCF12. 1 Publication
Mutagenesisi128 – 1281R → D: Loss of interaction with TCF12. 1 Publication
Mutagenesisi129 – 1291F → A: Loss of interaction with TCF12. 2 Publications
Mutagenesisi129 – 1291F → K: Abolishes interaction with corepressor. 2 Publications
Mutagenesisi136 – 1361F → A: Abolishes interaction with corepressor. 1 Publication
Mutagenesisi170 – 1701Q → A: Abolishes interaction with corepressor. 1 Publication
Mutagenesisi173 – 1731T → Q: Abolishes interaction with corepressor. 1 Publication
Mutagenesisi175 – 1751F → A: Abolishes interaction with corepressor. 1 Publication
Mutagenesisi177 – 1771L → A: Abolishes interaction with corepressor. 1 Publication
Mutagenesisi178 – 1781R → A or D: Loss of interaction with TCF12. 1 Publication
Mutagenesisi184 – 1841F → A: Loss of interaction with TCF12. 1 Publication
Mutagenesisi547 – 5471H → A: Causes unfolding of the MYND-type zinc finger domain. 1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi114500. phenotype.
Orphaneti102724. Acute myeloid leukemia with t(8;21)(q22;q22) translocation.
PharmGKBiPA26111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 604604Protein CBFA2T1PRO_0000218299Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411Phosphoserine1 Publication
Modified residuei417 – 4171Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ06455.
PRIDEiQ06455.

PTM databases

PhosphoSiteiQ06455.

Expressioni

Tissue specificityi

Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.

Gene expression databases

ArrayExpressiQ06455.
BgeeiQ06455.
GenevestigatoriQ06455.

Interactioni

Subunit structurei

Homotetramer. Heterotetramer with CBFA2T2 and CBFA2T3. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-743342,EBI-743342
SP1P080472EBI-743342,EBI-298336

Protein-protein interaction databases

BioGridi107310. 41 interactions.
DIPiDIP-29401N.
IntActiQ06455. 12 interactions.
MINTiMINT-1439547.

Structurei

Secondary structure

1
604
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi121 – 1233
Helixi125 – 13511
Helixi137 – 1404
Helixi142 – 15615
Helixi162 – 17211
Beta strandi173 – 1764
Beta strandi179 – 1813
Helixi182 – 1865
Helixi189 – 19911
Helixi200 – 2023
Helixi209 – 2124
Helixi347 – 39953
Helixi444 – 46522
Beta strandi512 – 5143
Beta strandi516 – 5183
Beta strandi524 – 5263
Turni527 – 5293
Beta strandi533 – 5364
Helixi537 – 5426
Helixi544 – 5474
Turni548 – 5503

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WQ6X-ray2.00A/B335-403[»]
2DJ8NMR-A505-551[»]
2H7BNMR-A120-222[»]
2KNHNMR-A119-216[»]
2KYGNMR-C437-467[»]
2OD1NMR-A510-559[»]
2ODDNMR-A510-559[»]
2PP4NMR-A119-225[»]
4JOLX-ray2.91A/B/C/D338-400[»]
ProteinModelPortaliQ06455.
SMRiQ06455. Positions 119-216, 341-400, 437-467, 510-559.

Miscellaneous databases

EvolutionaryTraceiQ06455.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini120 – 21596TAFHAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni337 – 38347Important for oligomerizationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi57 – 604Poly-Pro
Compositional biasi102 – 1087Poly-Ser
Compositional biasi290 – 2978Poly-Pro
Compositional biasi408 – 4136Poly-Ser

Domaini

The TAFH domain mediates interaction with transcription regulators.1 Publication

Sequence similaritiesi

Belongs to the CBFA2T family.
Contains 1 TAFH (NHR1) domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri515 – 55137MYND-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG79810.
HOVERGENiHBG000169.
KOiK10053.
OMAiPPNGYSN.
OrthoDBiEOG70W3D2.
PhylomeDBiQ06455.
TreeFamiTF106303.

Family and domain databases

InterProiIPR013289. ETO.
IPR013290. MTG8.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view]
PANTHERiPTHR10379:SF5. PTHR10379:SF5. 1 hit.
PfamiPF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PRINTSiPR01875. ETOFAMILY.
PR01876. MTG8PROTEIN.
SMARTiSM00549. TAFH. 1 hit.
[Graphical view]
PROSITEiPS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform MTG8B (identifier: Q06455-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MISVKRNTWR ALSLVIGDCR KKGNFEYCQD RTEKHSTMPD SPVDVKTQSR    50
LTPPTMPPPP TTQGAPRTSS FTPTTLTNGT SHSPTALNGA PSPPNGFSNG 100
PSSSSSSSLA NQQLPPACGA RQLSKLKRFL TTLQQFGNDI SPEIGERVRT 150
LVLGLVNSTL TIEEFHSKLQ EATNFPLRPF VIPFLKANLP LLQRELLHCA 200
RLAKQNPAQY LAQHEQLLLD ASTTSPVDSS ELLLDVNENG KRRTPDRTKE 250
NGFDREPLHS EHPSKRPCTI SPGQRYSPNN GLSYQPNGLP HPTPPPPQHY 300
RLDDMAIAHH YRDSYRHPSH RDLRDRNRPM GLHGTRQEEM IDHRLTDREW 350
AEEWKHLDHL LNCIMDMVEK TRRSLTVLRR CQEADREELN YWIRRYSDAE 400
DLKKGGGSSS SHSRQQSPVN PDPVALDAHR EFLHRPASGY VPEEIWKKAE 450
EAVNEVKRQA MTELQKAVSE AERKAHDMIT TERAKMERTV AEAKRQAAED 500
ALAVINQQED SSESCWNCGR KASETCSGCN TARYCGSFCQ HKDWEKHHHI 550
CGQTLQAQQQ GDTPAVSSSV TPNSGAGSPM DTPPAATPRS TTPGTPSTIE 600
TTPR 604
Length:604
Mass (Da):67,566
Last modified:November 1, 1997 - v2
Checksum:iC3D2452F96E65679
GO
Isoform MTG8A (identifier: Q06455-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MISVKRNTWRALSLVIGDCRKKGNFEYCQ → MP

Show »
Length:577
Mass (Da):64,396
Checksum:i70E84F0120C11C3B
GO
Isoform 3 (identifier: Q06455-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MISVKRNTWRALSLVIGDCRKKGNFEYCQ → MCHPDKAFTSDKLQCVFNEYKAAVWVPPRPRPLSRAPLPE

Show »
Length:615
Mass (Da):68,746
Checksum:i4FB11B0FAEC56B07
GO
Isoform 4 (identifier: Q06455-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Show »
Length:567
Mass (Da):63,212
Checksum:i44AADF2EC7032050
GO

Sequence cautioni

The sequence AAH05850.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA03247.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti386 – 3861R → W in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036321
Natural varianti395 – 3951R → W in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036322
Natural varianti471 – 4711A → V in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036323

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3737Missing in isoform 4. VSP_045442Add
BLAST
Alternative sequencei1 – 2929MISVK…FEYCQ → MCHPDKAFTSDKLQCVFNEY KAAVWVPPRPRPLSRAPLPE in isoform 3. VSP_044558Add
BLAST
Alternative sequencei1 – 2929MISVK…FEYCQ → MP in isoform MTG8A. VSP_003327Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti427 – 4271D → G in AAC26143. 1 Publication
Sequence conflicti455 – 4551E → G in BAH12630. 1 Publication
Sequence conflicti506 – 5061N → S in BAH12630. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14821 mRNA. Translation: BAA03558.1.
D13979 mRNA. Translation: BAA03089.1. Sequence problems.
D14289 mRNA. Translation: BAA03247.1. Different initiation.
AF018282
, AF018271, AF018272, AF018273, AF018274, AF018275, AF018276, AF018277, AF018278, AF018279, AF018281 Genomic DNA. Translation: AAC28932.1.
AF018282
, AF018270, AF018272, AF018273, AF018274, AF018275, AF018276, AF018277, AF018278, AF018279, AF018281 Genomic DNA. Translation: AAC28931.1.
AF018283 mRNA. Translation: AAC26143.1.
AK297616 mRNA. Translation: BAH12630.1.
BT009871 mRNA. Translation: AAP88873.1.
CR456792 mRNA. Translation: CAG33073.1.
AC103680 Genomic DNA. No translation available.
AC104339 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91685.1.
BC005850 mRNA. Translation: AAH05850.1. Different initiation.
BC067078 mRNA. Translation: AAH67078.2.
AF181450 Genomic DNA. No translation available.
D43638 mRNA. Translation: BAA07755.1.
X79990 mRNA. Translation: CAA56311.1.
S74096 Genomic DNA. Translation: AAB32126.1.
S74092 Genomic DNA. No translation available.
S78158 mRNA. Translation: AAB34819.2. Sequence problems.
S78159 mRNA. Translation: AAB34820.2. Sequence problems.
D14822 mRNA. Translation: BAA03559.1. Sequence problems.
D14823 mRNA. Translation: BAA03560.1. Sequence problems.
S50186 Genomic DNA. No translation available.
CCDSiCCDS47891.1. [Q06455-2]
CCDS56544.1. [Q06455-3]
CCDS6256.1. [Q06455-1]
CCDS6257.1. [Q06455-4]
PIRiA57784.
C57784.
RefSeqiNP_001185554.1. NM_001198625.1. [Q06455-2]
NP_001185555.1. NM_001198626.1. [Q06455-1]
NP_001185556.1. NM_001198627.1. [Q06455-1]
NP_001185557.1. NM_001198628.1. [Q06455-1]
NP_001185558.1. NM_001198629.1. [Q06455-1]
NP_001185559.1. NM_001198630.1. [Q06455-1]
NP_001185560.1. NM_001198631.1. [Q06455-1]
NP_001185561.1. NM_001198632.1. [Q06455-2]
NP_001185562.1. NM_001198633.1.
NP_001185563.1. NM_001198634.1. [Q06455-3]
NP_001185608.1. NM_001198679.1.
NP_004340.1. NM_004349.3. [Q06455-2]
NP_783552.1. NM_175634.2. [Q06455-1]
NP_783553.1. NM_175635.2. [Q06455-4]
NP_783554.1. NM_175636.2. [Q06455-4]
XP_006716739.1. XM_006716676.1. [Q06455-4]
UniGeneiHs.368431.
Hs.739194.

Genome annotation databases

EnsembliENST00000265814; ENSP00000265814; ENSG00000079102. [Q06455-1]
ENST00000360348; ENSP00000353504; ENSG00000079102. [Q06455-4]
ENST00000396218; ENSP00000379520; ENSG00000079102. [Q06455-2]
ENST00000422361; ENSP00000390137; ENSG00000079102. [Q06455-4]
ENST00000436581; ENSP00000402257; ENSG00000079102. [Q06455-3]
ENST00000518844; ENSP00000430728; ENSG00000079102. [Q06455-2]
ENST00000520724; ENSP00000428742; ENSG00000079102. [Q06455-4]
ENST00000523629; ENSP00000428543; ENSG00000079102. [Q06455-1]
GeneIDi862.
KEGGihsa:862.
UCSCiuc003yfb.2. human. [Q06455-1]
uc003yfc.2. human. [Q06455-2]

Polymorphism databases

DMDMi2498595.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14821 mRNA. Translation: BAA03558.1 .
D13979 mRNA. Translation: BAA03089.1 . Sequence problems.
D14289 mRNA. Translation: BAA03247.1 . Different initiation.
AF018282
, AF018271 , AF018272 , AF018273 , AF018274 , AF018275 , AF018276 , AF018277 , AF018278 , AF018279 , AF018281 Genomic DNA. Translation: AAC28932.1 .
AF018282
, AF018270 , AF018272 , AF018273 , AF018274 , AF018275 , AF018276 , AF018277 , AF018278 , AF018279 , AF018281 Genomic DNA. Translation: AAC28931.1 .
AF018283 mRNA. Translation: AAC26143.1 .
AK297616 mRNA. Translation: BAH12630.1 .
BT009871 mRNA. Translation: AAP88873.1 .
CR456792 mRNA. Translation: CAG33073.1 .
AC103680 Genomic DNA. No translation available.
AC104339 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91685.1 .
BC005850 mRNA. Translation: AAH05850.1 . Different initiation.
BC067078 mRNA. Translation: AAH67078.2 .
AF181450 Genomic DNA. No translation available.
D43638 mRNA. Translation: BAA07755.1 .
X79990 mRNA. Translation: CAA56311.1 .
S74096 Genomic DNA. Translation: AAB32126.1 .
S74092 Genomic DNA. No translation available.
S78158 mRNA. Translation: AAB34819.2 . Sequence problems.
S78159 mRNA. Translation: AAB34820.2 . Sequence problems.
D14822 mRNA. Translation: BAA03559.1 . Sequence problems.
D14823 mRNA. Translation: BAA03560.1 . Sequence problems.
S50186 Genomic DNA. No translation available.
CCDSi CCDS47891.1. [Q06455-2 ]
CCDS56544.1. [Q06455-3 ]
CCDS6256.1. [Q06455-1 ]
CCDS6257.1. [Q06455-4 ]
PIRi A57784.
C57784.
RefSeqi NP_001185554.1. NM_001198625.1. [Q06455-2 ]
NP_001185555.1. NM_001198626.1. [Q06455-1 ]
NP_001185556.1. NM_001198627.1. [Q06455-1 ]
NP_001185557.1. NM_001198628.1. [Q06455-1 ]
NP_001185558.1. NM_001198629.1. [Q06455-1 ]
NP_001185559.1. NM_001198630.1. [Q06455-1 ]
NP_001185560.1. NM_001198631.1. [Q06455-1 ]
NP_001185561.1. NM_001198632.1. [Q06455-2 ]
NP_001185562.1. NM_001198633.1.
NP_001185563.1. NM_001198634.1. [Q06455-3 ]
NP_001185608.1. NM_001198679.1.
NP_004340.1. NM_004349.3. [Q06455-2 ]
NP_783552.1. NM_175634.2. [Q06455-1 ]
NP_783553.1. NM_175635.2. [Q06455-4 ]
NP_783554.1. NM_175636.2. [Q06455-4 ]
XP_006716739.1. XM_006716676.1. [Q06455-4 ]
UniGenei Hs.368431.
Hs.739194.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WQ6 X-ray 2.00 A/B 335-403 [» ]
2DJ8 NMR - A 505-551 [» ]
2H7B NMR - A 120-222 [» ]
2KNH NMR - A 119-216 [» ]
2KYG NMR - C 437-467 [» ]
2OD1 NMR - A 510-559 [» ]
2ODD NMR - A 510-559 [» ]
2PP4 NMR - A 119-225 [» ]
4JOL X-ray 2.91 A/B/C/D 338-400 [» ]
ProteinModelPortali Q06455.
SMRi Q06455. Positions 119-216, 341-400, 437-467, 510-559.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107310. 41 interactions.
DIPi DIP-29401N.
IntActi Q06455. 12 interactions.
MINTi MINT-1439547.

PTM databases

PhosphoSitei Q06455.

Polymorphism databases

DMDMi 2498595.

Proteomic databases

PaxDbi Q06455.
PRIDEi Q06455.

Protocols and materials databases

DNASUi 862.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265814 ; ENSP00000265814 ; ENSG00000079102 . [Q06455-1 ]
ENST00000360348 ; ENSP00000353504 ; ENSG00000079102 . [Q06455-4 ]
ENST00000396218 ; ENSP00000379520 ; ENSG00000079102 . [Q06455-2 ]
ENST00000422361 ; ENSP00000390137 ; ENSG00000079102 . [Q06455-4 ]
ENST00000436581 ; ENSP00000402257 ; ENSG00000079102 . [Q06455-3 ]
ENST00000518844 ; ENSP00000430728 ; ENSG00000079102 . [Q06455-2 ]
ENST00000520724 ; ENSP00000428742 ; ENSG00000079102 . [Q06455-4 ]
ENST00000523629 ; ENSP00000428543 ; ENSG00000079102 . [Q06455-1 ]
GeneIDi 862.
KEGGi hsa:862.
UCSCi uc003yfb.2. human. [Q06455-1 ]
uc003yfc.2. human. [Q06455-2 ]

Organism-specific databases

CTDi 862.
GeneCardsi GC08M092971.
HGNCi HGNC:1535. RUNX1T1.
MIMi 114500. phenotype.
133435. gene.
neXtProti NX_Q06455.
Orphaneti 102724. Acute myeloid leukemia with t(8;21)(q22;q22) translocation.
PharmGKBi PA26111.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79810.
HOVERGENi HBG000169.
KOi K10053.
OMAi PPNGYSN.
OrthoDBi EOG70W3D2.
PhylomeDBi Q06455.
TreeFami TF106303.

Miscellaneous databases

ChiTaRSi RUNX1T1. human.
EvolutionaryTracei Q06455.
GeneWikii RUNX1T1.
GenomeRNAii 862.
NextBioi 3586.
PROi Q06455.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q06455.
Bgeei Q06455.
Genevestigatori Q06455.

Family and domain databases

InterProi IPR013289. ETO.
IPR013290. MTG8.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view ]
PANTHERi PTHR10379:SF5. PTHR10379:SF5. 1 hit.
Pfami PF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view ]
PRINTSi PR01875. ETOFAMILY.
PR01876. MTG8PROTEIN.
SMARTi SM00549. TAFH. 1 hit.
[Graphical view ]
PROSITEi PS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript."
    Miyoshi H., Kozu T., Shimizu K., Enomoto K., Maseki N., Kaneko Y., Kamada N., Ohki M.
    EMBO J. 12:2715-2721(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MTG8B), VARIANT AML1-MTG8/ETO FUSION IN AML-M2.
    Tissue: Fetal brain.
  2. "Structure and expression of the human MTG8/ETO gene."
    Wolford J.K., Prochazka M.
    Gene 212:103-109(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM MTG8B).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MTG8A).
  6. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Muscle.
  9. "The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved putative transcription factor."
    Erickson P.F., Robinson M., Owens G., Drabkin H.A.
    Cancer Res. 54:1782-1786(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-604.
  10. "Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2."
    Tighe J.E., Calabi F.
    Blood 84:2115-2121(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 334-432, VARIANT AML1-MTG8/ETO FUSION.
  11. "Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription."
    Wood J.D., Nucifora F.C. Jr., Duan K., Zhang C., Wang J., Kim Y., Schilling G., Sacchi N., Liu J.M., Ross C.A.
    J. Cell Biol. 150:939-948(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATN1, SUBCELLULAR LOCATION, FUNCTION.
  12. "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies."
    Hoogeveen A.T., Rossetti S., Stoyanova V., Schonkeren J., Fenaroli A., Schiaffonati L., van Unen L., Sacchi N.
    Oncogene 21:6703-6712(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CBFA2T3.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41 AND SER-417, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity."
    Liu Y., Cheney M.D., Gaudet J.J., Chruszcz M., Lukasik S.M., Sugiyama D., Lary J., Cole J., Dauter Z., Minor W., Speck N.A., Bushweller J.H.
    Cancer Cell 9:249-260(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 335-403, SUBUNIT, INTERACTION WITH HDAC1; HDAC2; HDAC3; TCF12; NCOR1; NCOR2; SIN3A; CBFA2T2 AND CBFA2T3.
  16. "The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domain."
    Plevin M.J., Zhang J., Guo C., Roeder R.G., Ikura M.
    Proc. Natl. Acad. Sci. U.S.A. 103:10242-10247(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 120-222, INTERACTION WITH TCF12, FUNCTION, MUTAGENESIS OF LYS-125; LEU-126; ARG-128; PHE-129; ARG-178 AND PHE-184.
  17. "Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity."
    Liu Y., Chen W., Gaudet J., Cheney M.D., Roudaia L., Cierpicki T., Klet R.C., Hartman K., Laue T.M., Speck N.A., Bushweller J.H.
    Cancer Cell 11:483-497(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 510-559 IN COMPLEX WITH ZINC IONS AND NCOR2, MUTAGENESIS OF HIS-547, INTERACTION WITH NCOR1 AND NCOR2.
  18. "A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription."
    Wei Y., Liu S., Lausen J., Woodrell C., Cho S., Biris N., Kobayashi N., Wei Y., Yokoyama S., Werner M.H.
    Nat. Struct. Mol. Biol. 14:653-661(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 119-225, INTERACTION WITH NCOR1 AND TCF12, MUTAGENESIS OF PHE-129; PHE-136; GLN-170; THR-173; PHE-175 AND LEU-177, DOMAIN.
  19. "Solution structure of ZF-MYND domain of protein CBFA2TI (protein MTG8)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 505-551.
  20. "Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells."
    Era T., Asou N., Kunisada T., Yamasaki H., Asou H., Kamada N., Nishikawa S., Yamaguchi K., Takatsuki K.
    Genes Chromosomes Cancer 13:25-33(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT AML1-MTG8/ETO FUSION IN AML-M2.
  21. "Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction."
    Kozu T., Miyoshi H., Shimizu K., Maseki N., Kaneko Y., Asou H., Kamada N., Ohki M.
    Blood 82:1270-1276(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT AML1-MTG8/ETO FUSION IN AML-M2.
  22. "Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells."
    Nisson P.E., Watkins P.C., Sacchi N.
    Cancer Genet. Cytogenet. 63:81-88(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT AML1-MTG8/ETO FUSION IN AML-M2.
  23. Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-386; TRP-395 AND VAL-471.

Entry informationi

Entry nameiMTG8_HUMAN
AccessioniPrimary (citable) accession number: Q06455
Secondary accession number(s): B7Z4P4
, E7EPN4, O14784, Q06456, Q14873, Q16239, Q16346, Q16347, Q6IBL1, Q6NXH1, Q7Z4J5, Q92479, Q9BRZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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