Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein aristaless

Gene

al

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi85 – 14460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • antennal morphogenesis Source: FlyBase
  • chaeta development Source: FlyBase
  • elongation of arista core Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • leg disc development Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • positive regulation of Notch signaling pathway Source: FlyBase
  • proximal/distal pattern formation, imaginal disc Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein aristaless
Gene namesi
Name:al
ORF Names:CG3935
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000061. al.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: FlyBase
  • protein complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Flies display a reduction in size of the arista and scutellum, a reduction or complete absence of the tarsal claws, irregularities of the sternopleural bristles and of the wing vein, and a bending of the wing blade.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Homeobox protein aristalessPRO_0000048811Add
BLAST

Proteomic databases

PaxDbiQ06453.

Expressioni

Tissue specificityi

Expressed during embryonic development, in distinct epidermal patterns in head, thorax and abdomen and in an endodermal pattern in the anterior intestinal tract.1 Publication

Developmental stagei

First expressed in 4-8 hours old embryos, peaks in 8-12 hours old embryos and continues through development up to late larval stage. In the head region, detected at stage 10 in the maxillary and labial segment primordia, and in later stages, in the prospective antennal and mandibular segment. In the epidermis, expression is seen from stage 11 in thoracic and abdominal lateral patches. Expression in the intestinal tract begins at stage 13, continues through stages 14 and 15 in the endoderm of the anterior midgut and at stage 16, is found in the posterior end. Expression in the imaginal disks is seen from late third-instar larvae in the prospective thorax, claw organ, antenna, scutellum and wing blade.1 Publication

Gene expression databases

BgeeiQ06453.
GenevisibleiQ06453. DM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UbxP839493EBI-188244,EBI-202590

Protein-protein interaction databases

BioGridi59464. 9 interactions.
DIPiDIP-23247N.
IntActiQ06453. 3 interactions.
MINTiMINT-827785.
STRINGi7227.FBpp0077713.

Structurei

Secondary structure

1
408
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi94 – 10613Combined sources
Helixi112 – 12211Combined sources
Helixi126 – 14015Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A01X-ray2.70B/F80-146[»]
3A02X-ray1.00A91-146[»]
3LNQX-ray2.25A87-144[»]
ProteinModelPortaliQ06453.
SMRiQ06453. Positions 91-141.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06453.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi378 – 39114OARPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi251 – 28333Pro-richAdd
BLAST
Compositional biasi290 – 36071Gln/Pro-richAdd
BLAST
Compositional biasi362 – 3665Poly-Pro

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118958.
InParanoidiQ06453.
KOiK09452.
OMAiGGTNSPI.
OrthoDBiEOG7XPZ60.
PhylomeDBiQ06453.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGISEEIKLE ELPQEAKLAH PDAVVLVDRA PGSSAASAGA ALTVSMSVSG
60 70 80 90 100
GAPSGASGAS GGTNSPVSDG NSDCEADEYA PKRKQRRYRT TFTSFQLEEL
110 120 130 140 150
EKAFSRTHYP DVFTREELAM KIGLTEARIQ VWFQNRRAKW RKQEKVGPQS
160 170 180 190 200
HPYNPYLPGG AATMQTVVGA ALPPNPFTHL GFQLRKPFDA QHAANLAAFR
210 220 230 240 250
YPHLSAAPMI PSGYFNQFQR APPHMLPHGM AGMYSPSSSF QSLLANMTAV
260 270 280 290 300
PRGTPLGKPP ALLVGSPDLH SPNHMLASPP TSPASGHASQ HQQHPTAHPP
310 320 330 340 350
PPQAPPQMPV GVQPAQLSPQ HLVGIALTQQ ASSLSPTQTS PVALTLSHSP
360 370 380 390 400
QRQLPPPSHQ APPPPPRAAT PPEDRRTSSI AALRLKAREH ELKLELLRQN

GHGNDVVS
Length:408
Mass (Da):43,657
Last modified:March 1, 2005 - v2
Checksum:i7641316A4A77BD8D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti254 – 2541T → P in AAA28840 (PubMed:8093690).Curated
Sequence conflicti321 – 3211H → Q in AAA28840 (PubMed:8093690).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08401 mRNA. Translation: AAA28840.1.
AE014134 Genomic DNA. Translation: AAF51505.1.
AY121696 mRNA. Translation: AAM52023.1.
PIRiA40685.
RefSeqiNP_722629.1. NM_164382.2.
UniGeneiDm.6423.

Genome annotation databases

EnsemblMetazoaiFBtr0078053; FBpp0077713; FBgn0000061.
GeneIDi33208.
KEGGidme:Dmel_CG3935.
UCSCiCG3935-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08401 mRNA. Translation: AAA28840.1.
AE014134 Genomic DNA. Translation: AAF51505.1.
AY121696 mRNA. Translation: AAM52023.1.
PIRiA40685.
RefSeqiNP_722629.1. NM_164382.2.
UniGeneiDm.6423.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A01X-ray2.70B/F80-146[»]
3A02X-ray1.00A91-146[»]
3LNQX-ray2.25A87-144[»]
ProteinModelPortaliQ06453.
SMRiQ06453. Positions 91-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59464. 9 interactions.
DIPiDIP-23247N.
IntActiQ06453. 3 interactions.
MINTiMINT-827785.
STRINGi7227.FBpp0077713.

Proteomic databases

PaxDbiQ06453.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078053; FBpp0077713; FBgn0000061.
GeneIDi33208.
KEGGidme:Dmel_CG3935.
UCSCiCG3935-RA. d. melanogaster.

Organism-specific databases

CTDi33208.
FlyBaseiFBgn0000061. al.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118958.
InParanoidiQ06453.
KOiK09452.
OMAiGGTNSPI.
OrthoDBiEOG7XPZ60.
PhylomeDBiQ06453.

Miscellaneous databases

EvolutionaryTraceiQ06453.
GenomeRNAii33208.
NextBioi782439.
PROiQ06453.

Gene expression databases

BgeeiQ06453.
GenevisibleiQ06453. DM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila."
    Schneitz K., Spielmann P., Noll M.
    Genes Dev. 7:114-129(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    Tissue: Embryo.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiAL_DROME
AccessioniPrimary (citable) accession number: Q06453
Secondary accession number(s): Q9VPP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: March 1, 2005
Last modified: May 11, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.