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Q06433 (GAL80_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Galactose/lactose metabolism regulatory protein GAL80
Gene names
Name:GAL80
Ordered Locus Names:KLLA0A08162g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is a negative regulator for the gene expression of the lactose/galactose metabolic genes. It seems to block activation by the transcriptional activator LAC9 in the absence of an inducing sugar.

Sequence similarities

To yeast GAL80.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Galactose/lactose metabolism regulatory protein GAL80
PRO_0000087426

Secondary structure

1 ............................................................................ 457
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q06433 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: E8E68821837FC4DE

FASTA45751,043
        10         20         30         40         50         60 
MNNNKRSKLS TVPSSRPIRV GFVGLTSGKS WVAKTHFLAI QQLSSQFQIV ALYNPTLKSS 

        70         80         90        100        110        120 
LQTIEQLQLK HATGFDSLES FAQYKDIDMI VVSVKVPEHY EVVKNILEHS SQNLNLRYLY 

       130        140        150        160        170        180 
VEWALAASVQ QAEELYSISQ QRANLQTIIC LQGRKSPYIV RAKELISEGC IGDINSIEIS 

       190        200        210        220        230        240 
GNGGWYGYER PMRSPEYLYD IESGVNLISN SFGHTIDVLQ YITGSYFQKI NAMISNNIPT 

       250        260        270        280        290        300 
QFLLDENGKR TKETISKTCP DHLLFQGILE NGKVPVSCSF KGGTPVKKLT KNLVIDIHGT 

       310        320        330        340        350        360 
KGDLKIEGDA GFVEISNLVL YFYGIKNGNG SSNGTDNNGA AAIKDKEKVT KSPSPSTGTS 

       370        380        390        400        410        420 
EEEQTMEVFH LRNYNSVVGN ILRIYESIAD YHFLGKPESK SSRGPDDLFA STKFDKQGFR 

       430        440        450 
FEGFPTFKDA IILHRLIDAV FRSDKEEKTL DVSKIMI

« Hide

References

« Hide 'large scale' references
[1]"Gal80 proteins of Kluyveromyces lactis and Saccharomyces cerevisiae are highly conserved but contribute differently to glucose repression of the galactose regulon."
Zenke F.T., Zachariae W., Lunkes A., Breunig K.D.
Mol. Cell. Biol. 13:7566-7576(1993) [PubMed: 8246973] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome evolution in yeasts."
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. expand/collapse author list , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
Nature 430:35-44(2004) [PubMed: 15229592] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z21512 Genomic DNA. Translation: CAA79724.1.
CR382121 Genomic DNA. Translation: CAH02951.1.
PIRA54604.
RefSeqXP_451363.1. XM_451363.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2NVWX-ray2.10A/B2-457[»]
3E1KX-ray3.00A/C/E/G/I/K/M/O1-457[»]
ProteinModelPortalQ06433.
SMRQ06433. Positions 14-457.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ06433.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2896324.
GenomeReviewsGene locus KLLA0A08162g in contig CR382121_GR.
KEGGkla:KLLA0A08162g.

Phylogenomic databases

eggNOGfuNOG12343.
HOGENOMHBG203551.
OMAIYESIAD.
OrthoDBEOG4HMNK1.

Family and domain databases

InterProIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGAL80_KLULA
AccessionPrimary (citable) accession number: Q06433
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: December 14, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents