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Protein

Galactose/lactose metabolism regulatory protein GAL80

Gene

GAL80

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a negative regulator for the gene expression of the lactose/galactose metabolic genes. It seems to block activation by the transcriptional activator LAC9 in the absence of an inducing sugar.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Carbohydrate metabolism, Galactose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose/lactose metabolism regulatory protein GAL80
Gene namesi
Name:GAL80
Ordered Locus Names:KLLA0A08162g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome A

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874261 – 457Galactose/lactose metabolism regulatory protein GAL80Add BLAST457

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_451363.1.

Structurei

Secondary structure

1457
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 10Combined sources3
Helixi13 – 15Combined sources3
Beta strandi18 – 23Combined sources6
Helixi31 – 34Combined sources4
Helixi36 – 42Combined sources7
Turni43 – 46Combined sources4
Beta strandi47 – 53Combined sources7
Helixi57 – 66Combined sources10
Beta strandi73 – 76Combined sources4
Helixi78 – 83Combined sources6
Beta strandi88 – 92Combined sources5
Helixi96 – 109Combined sources14
Beta strandi110 – 112Combined sources3
Beta strandi118 – 128Combined sources11
Helixi129 – 140Combined sources12
Beta strandi146 – 150Combined sources5
Helixi152 – 155Combined sources4
Helixi157 – 167Combined sources11
Turni168 – 171Combined sources4
Beta strandi173 – 182Combined sources10
Beta strandi184 – 191Combined sources8
Helixi196 – 199Combined sources4
Helixi201 – 203Combined sources3
Turni207 – 210Combined sources4
Helixi211 – 223Combined sources13
Beta strandi227 – 235Combined sources9
Beta strandi239 – 244Combined sources6
Turni246 – 248Combined sources3
Beta strandi254 – 256Combined sources3
Beta strandi262 – 270Combined sources9
Helixi271 – 273Combined sources3
Beta strandi275 – 281Combined sources7
Beta strandi283 – 285Combined sources3
Beta strandi288 – 290Combined sources3
Beta strandi292 – 301Combined sources10
Beta strandi303 – 308Combined sources6
Turni313 – 315Combined sources3
Beta strandi318 – 326Combined sources9
Beta strandi364 – 369Combined sources6
Helixi376 – 393Combined sources18
Beta strandi421 – 423Combined sources3
Helixi427 – 446Combined sources20
Turni453 – 456Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NVWX-ray2.10A/B2-457[»]
3E1KX-ray3.00A/C/E/G/I/K/M/O1-457[»]
ProteinModelPortaliQ06433.
SMRiQ06433.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06433.

Family & Domainsi

Sequence similaritiesi

To yeast GAL80.Curated

Phylogenomic databases

eggNOGiKOG2741. Eukaryota.
COG0673. LUCA.
HOGENOMiHOG000000744.
InParanoidiQ06433.
OMAiGRKSPYI.
OrthoDBiEOG092C37EF.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.

Sequencei

Sequence statusi: Complete.

Q06433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNNKRSKLS TVPSSRPIRV GFVGLTSGKS WVAKTHFLAI QQLSSQFQIV
60 70 80 90 100
ALYNPTLKSS LQTIEQLQLK HATGFDSLES FAQYKDIDMI VVSVKVPEHY
110 120 130 140 150
EVVKNILEHS SQNLNLRYLY VEWALAASVQ QAEELYSISQ QRANLQTIIC
160 170 180 190 200
LQGRKSPYIV RAKELISEGC IGDINSIEIS GNGGWYGYER PMRSPEYLYD
210 220 230 240 250
IESGVNLISN SFGHTIDVLQ YITGSYFQKI NAMISNNIPT QFLLDENGKR
260 270 280 290 300
TKETISKTCP DHLLFQGILE NGKVPVSCSF KGGTPVKKLT KNLVIDIHGT
310 320 330 340 350
KGDLKIEGDA GFVEISNLVL YFYGIKNGNG SSNGTDNNGA AAIKDKEKVT
360 370 380 390 400
KSPSPSTGTS EEEQTMEVFH LRNYNSVVGN ILRIYESIAD YHFLGKPESK
410 420 430 440 450
SSRGPDDLFA STKFDKQGFR FEGFPTFKDA IILHRLIDAV FRSDKEEKTL

DVSKIMI
Length:457
Mass (Da):51,043
Last modified:June 1, 1994 - v1
Checksum:iE8E68821837FC4DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21512 Genomic DNA. Translation: CAA79724.1.
CR382121 Genomic DNA. Translation: CAH02951.1.
PIRiA54604.
RefSeqiXP_451363.1. XM_451363.1.

Genome annotation databases

EnsemblFungiiCAH02951; CAH02951; KLLA0_A08162g.
GeneIDi2896324.
KEGGikla:KLLA0A08162g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21512 Genomic DNA. Translation: CAA79724.1.
CR382121 Genomic DNA. Translation: CAH02951.1.
PIRiA54604.
RefSeqiXP_451363.1. XM_451363.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NVWX-ray2.10A/B2-457[»]
3E1KX-ray3.00A/C/E/G/I/K/M/O1-457[»]
ProteinModelPortaliQ06433.
SMRiQ06433.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_451363.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAH02951; CAH02951; KLLA0_A08162g.
GeneIDi2896324.
KEGGikla:KLLA0A08162g.

Phylogenomic databases

eggNOGiKOG2741. Eukaryota.
COG0673. LUCA.
HOGENOMiHOG000000744.
InParanoidiQ06433.
OMAiGRKSPYI.
OrthoDBiEOG092C37EF.

Miscellaneous databases

EvolutionaryTraceiQ06433.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGAL80_KLULA
AccessioniPrimary (citable) accession number: Q06433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.