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Protein

Galactose/lactose metabolism regulatory protein GAL80

Gene

GAL80

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a negative regulator for the gene expression of the lactose/galactose metabolic genes. It seems to block activation by the transcriptional activator LAC9 in the absence of an inducing sugar.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Carbohydrate metabolism, Galactose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose/lactose metabolism regulatory protein GAL80
Gene namesi
Name:GAL80
Ordered Locus Names:KLLA0A08162g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome A

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Galactose/lactose metabolism regulatory protein GAL80PRO_0000087426Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_451363.1.

Structurei

Secondary structure

1
457
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 103Combined sources
Helixi13 – 153Combined sources
Beta strandi18 – 236Combined sources
Helixi31 – 344Combined sources
Helixi36 – 427Combined sources
Turni43 – 464Combined sources
Beta strandi47 – 537Combined sources
Helixi57 – 6610Combined sources
Beta strandi73 – 764Combined sources
Helixi78 – 836Combined sources
Beta strandi88 – 925Combined sources
Helixi96 – 10914Combined sources
Beta strandi110 – 1123Combined sources
Beta strandi118 – 12811Combined sources
Helixi129 – 14012Combined sources
Beta strandi146 – 1505Combined sources
Helixi152 – 1554Combined sources
Helixi157 – 16711Combined sources
Turni168 – 1714Combined sources
Beta strandi173 – 18210Combined sources
Beta strandi184 – 1918Combined sources
Helixi196 – 1994Combined sources
Helixi201 – 2033Combined sources
Turni207 – 2104Combined sources
Helixi211 – 22313Combined sources
Beta strandi227 – 2359Combined sources
Beta strandi239 – 2446Combined sources
Turni246 – 2483Combined sources
Beta strandi254 – 2563Combined sources
Beta strandi262 – 2709Combined sources
Helixi271 – 2733Combined sources
Beta strandi275 – 2817Combined sources
Beta strandi283 – 2853Combined sources
Beta strandi288 – 2903Combined sources
Beta strandi292 – 30110Combined sources
Beta strandi303 – 3086Combined sources
Turni313 – 3153Combined sources
Beta strandi318 – 3269Combined sources
Beta strandi364 – 3696Combined sources
Helixi376 – 39318Combined sources
Beta strandi421 – 4233Combined sources
Helixi427 – 44620Combined sources
Turni453 – 4564Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NVWX-ray2.10A/B2-457[»]
3E1KX-ray3.00A/C/E/G/I/K/M/O1-457[»]
ProteinModelPortaliQ06433.
SMRiQ06433. Positions 14-457.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06433.

Family & Domainsi

Sequence similaritiesi

To yeast GAL80.Curated

Phylogenomic databases

eggNOGiKOG2741. Eukaryota.
COG0673. LUCA.
HOGENOMiHOG000000744.
InParanoidiQ06433.
OMAiAPIRICI.
OrthoDBiEOG7GTTGR.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.

Sequencei

Sequence statusi: Complete.

Q06433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNNKRSKLS TVPSSRPIRV GFVGLTSGKS WVAKTHFLAI QQLSSQFQIV
60 70 80 90 100
ALYNPTLKSS LQTIEQLQLK HATGFDSLES FAQYKDIDMI VVSVKVPEHY
110 120 130 140 150
EVVKNILEHS SQNLNLRYLY VEWALAASVQ QAEELYSISQ QRANLQTIIC
160 170 180 190 200
LQGRKSPYIV RAKELISEGC IGDINSIEIS GNGGWYGYER PMRSPEYLYD
210 220 230 240 250
IESGVNLISN SFGHTIDVLQ YITGSYFQKI NAMISNNIPT QFLLDENGKR
260 270 280 290 300
TKETISKTCP DHLLFQGILE NGKVPVSCSF KGGTPVKKLT KNLVIDIHGT
310 320 330 340 350
KGDLKIEGDA GFVEISNLVL YFYGIKNGNG SSNGTDNNGA AAIKDKEKVT
360 370 380 390 400
KSPSPSTGTS EEEQTMEVFH LRNYNSVVGN ILRIYESIAD YHFLGKPESK
410 420 430 440 450
SSRGPDDLFA STKFDKQGFR FEGFPTFKDA IILHRLIDAV FRSDKEEKTL

DVSKIMI
Length:457
Mass (Da):51,043
Last modified:June 1, 1994 - v1
Checksum:iE8E68821837FC4DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21512 Genomic DNA. Translation: CAA79724.1.
CR382121 Genomic DNA. Translation: CAH02951.1.
PIRiA54604.
RefSeqiXP_451363.1. XM_451363.1.

Genome annotation databases

EnsemblFungiiCAH02951; CAH02951; KLLA0_A08162g.
GeneIDi2896324.
KEGGikla:KLLA0A08162g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21512 Genomic DNA. Translation: CAA79724.1.
CR382121 Genomic DNA. Translation: CAH02951.1.
PIRiA54604.
RefSeqiXP_451363.1. XM_451363.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NVWX-ray2.10A/B2-457[»]
3E1KX-ray3.00A/C/E/G/I/K/M/O1-457[»]
ProteinModelPortaliQ06433.
SMRiQ06433. Positions 14-457.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_451363.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAH02951; CAH02951; KLLA0_A08162g.
GeneIDi2896324.
KEGGikla:KLLA0A08162g.

Phylogenomic databases

eggNOGiKOG2741. Eukaryota.
COG0673. LUCA.
HOGENOMiHOG000000744.
InParanoidiQ06433.
OMAiAPIRICI.
OrthoDBiEOG7GTTGR.

Miscellaneous databases

EvolutionaryTraceiQ06433.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gal80 proteins of Kluyveromyces lactis and Saccharomyces cerevisiae are highly conserved but contribute differently to glucose repression of the galactose regulon."
    Zenke F.T., Zachariae W., Lunkes A., Breunig K.D.
    Mol. Cell. Biol. 13:7566-7576(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Entry informationi

Entry nameiGAL80_KLULA
AccessioniPrimary (citable) accession number: Q06433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.